Peter Melby, MD

Director, WHO Collaborating Center for Tropical Diseases

  • 3642 Citations
  • 35 h-Index
1987 …2022

Research output per year

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Research Output

  • 3642 Citations
  • 35 h-Index
  • 85 Article
  • 4 Chapter
  • 1 Review article
2019

Stunting is preceded by intestinal mucosal damage and microbiome changes and is associated with systemic inflammation in a cohort of Peruvian infants

Zambruni, M., Ochoa, T. J., Somasunderam, A., Cabada, M. M., Morales, M. L., Mitreva, M., Rosa, B. A., Acosta, G. J., Vigo, N. I., Riveros, M., Arango, S., Durand, D., Berends, M. N., Melby, P. & Utay, N. S., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 101, 5, p. 1009-1017 9 p.

Research output: Contribution to journalArticle

2018

Efficacy of recombinase polymerase amplification to diagnose trypanosoma cruzi infection in dogs with cardiac alterations from an endemic Area of Mexico

Jimenez-Coello, M., Shelite, T., Castellanos, A., Saldarriaga, O., Rivero, R., Ortega-Pacheco, A., Acevedo-Arcique, C., Amaya-Guardia, K., Garg, N., Melby, P. & Travi, B., Aug 1 2018, In : Vector-Borne and Zoonotic Diseases. 18, 8, p. 417-423 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular diagnosis of protozoan parasites by Recombinase Polymerase Amplification

Castellanos, A., White, A. C., Melby, P. & Travi, B., Jun 1 2018, In : Acta Tropica. 182, p. 4-11 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

New Insights into the Pathogenesis and Treatment of Malnutrition

Thaxton, G. E., Melby, P., Manary, M. J. & Preidis, G. A., Jan 1 2018, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journalArticle

2017

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D., Jupiter, D., Melby, P. & Arcari, C. M., Nov 3 2017, In : PLoS Neglected Tropical Diseases. 11, 11, e0006062.

Research output: Contribution to journalArticle

48 Scopus citations

A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis

Peniche-Trujillo, A-G., Bonilla, D. L., Palma, G. I., Melby, P., Travi, B. & Osorio, E. Y., Jun 1 2017, In : PLoS One. 12, 6, e0179084.

Research output: Contribution to journalArticle

3 Scopus citations

Impact of childhood malnutrition on host defense and infection

Ibrahim, M. K., Zambruni, M., Melby, C. L. & Melby, P., Oct 1 2017, In : Clinical Microbiology Reviews. 30, 4, p. 919-971 53 p.

Research output: Contribution to journalReview article

33 Scopus citations

Splenic CD4+ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

Colorado, A., Osorio, E. Y., Saldarriaga, O. A., Travi, B., Kong, F., Spratt, H., Soong, L. & Melby, P., Jan 1 2017, In : PLoS One. 12, 1, e0169496.

Research output: Contribution to journalArticle

9 Scopus citations

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

Kong, F., Saldarriaga, O. A., Spratt, H., Osorio, E. Y., Travi, B., Luxon, B. A. & Melby, P., Jan 1 2017, In : PLoS Pathogens. 13, 1, e1006165.

Research output: Contribution to journalArticle

13 Scopus citations
2016

An Innovative Field-Applicable Molecular Test to Diagnose Cutaneous Leishmania Viannia spp. Infections

Saldarriaga, O. A., Castellanos, A., Porrozzi, R., Baldeviano, G. C., Lescano, A. G., de Los Santos, M. B., Fernandez, O. L., Saravia, N. G., Costa, E., Melby, P. & Travi, B., Apr 26 2016, In : PLoS Neglected Tropical Diseases. 10, 4, e0004638.

Research output: Contribution to journalArticle

13 Scopus citations

Cytokine mRNA expression in Peromyscus yucatanicus (Rodentia: Cricetidae) infected by Leishmania (Leishmania) mexicana

Loria-Cervera, E. N., Sosa-Bibiano, E. I., Van Wynsberghe, N. R., Saldarriaga, O. A., Melby, P. & Andrade-Narvaez, F. J., Jul 1 2016, In : Cytokine. 83, p. 176-181 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Animal models for the analysis of immune responses to leishmaniasis

Sacks, D. L. & Melby, P., 2015, In : Current Protocols in Immunology. 2015, p. 19.2.1-19.2.24

Research output: Contribution to journalArticle

15 Scopus citations

A novel molecular test to diagnose canine visceral leishmaniasis at the point of care

Castellanos, A., Saldarriaga, O. A., Tartaglino, L., Gacek, R., Temple, E., Sparks, H., Melby, P. & Travi, B., Nov 4 2015, In : American Journal of Tropical Medicine and Hygiene. 93, 5, p. 970-975 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
9 Scopus citations

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In : Clinical and Experimental Immunology. 182, 2, p. 109-18

Research output: Contribution to journalArticle

26 Scopus citations
2014

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection

Ibrahim, M. K., Barnes, J. L., Osorio, E. Y., Anstead, G. M., Jimenez, F., Osterholzer, J. J., Travi, B., Ahuja, S. S., White, A. C. & Melby, P., 2014, In : Infection and Immunity. 82, 8, p. 3098-3112 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Development of an ex vivo lymph node explant model for identification of novel molecules active against leishmania major

Peniche-Trujillo, A-G., Yaneth, O., Renslo, A. R., Frantz, D. E., Melby, P. & Travi, B., Jan 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis

Osorio, E. Y., Travi, B., da Cruz, A. M., Saldarriaga, O. A., Colorado, A. & Melby, P., 2014, In : PLoS Pathogens. 10, 6, e1004165.

Research output: Contribution to journalArticle

24 Scopus citations

In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

Valencia-Pacheco, G., Loría-Cervera, E. N., Sosa-Bibiano, E. I., Canché-Pool, E. B., Vargas-Gonzalez, A., Melby, P. & Andrade-Narvaez, F. J., 2014, In : Cytokine. 69, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

Espitia, C. M., Saldarriaga, O. A., Travi, B., Osorio, E. Y., Hernandez, A., Band, M., Patel, M. J., Colorado, A., Cappello, M., Pekosz, A. & Melby, P., Nov 26 2014, In : BMC Immunology. 15, 1, 51.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas

Andrus, J., Bottazzi, M. E., Chow, J., Goraleski, K. A., Fisher-Hoch, S. P., Lambuth, J. K., Lee, B. Y., Margolis, H. S., McCormick, J. B., Melby, P., Murray, K. O., Rico-Hesse, R., Valenzuela, J. G. & Hotez, P. J., Jun 2013, In : PLoS Neglected Tropical Diseases. 7, 6, e2021.

Research output: Contribution to journalArticle

12 Scopus citations

The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

Ibrahim, M. K., Barnes, J. L., Anstead, G. M., Jimenez, F., Travi, B., Peniche-Trujillo, A-G., Osorio, E. Y., Ahuja, S. S. & Melby, P., Aug 2013, In : PLoS Neglected Tropical Diseases. 7, 8, e2329.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Host defenses to protozoa

Melby, P. & Anstead, G. M., Dec 12 2012, Clinical Immunology: Principles and Practice: Fourth Edition. Elsevier Inc., p. 356-366 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

Saldarriaga, O. A., Travi, B., Choudhury, G. G. & Melby, P., Jul 2012, In : Journal of Leukocyte Biology. 92, 1, p. 205-218 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis

Soong, L., Henard, C. A. & Melby, P., Nov 2012, In : Seminars in Immunopathology. 34, 6, p. 735-751 17 p.

Research output: Contribution to journalArticle

59 Scopus citations

Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression

Osorio, E. Y., Zhao, W., Espitia, C., Saldarriaga, O., Hawel, L., Byus, C. V., Travi, B. & Melby, P., Jan 2012, In : PLoS Pathogens. 8, 1, e1002417.

Research output: Contribution to journalArticle

32 Scopus citations
2011

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system

Osorio, Y., Travi, B., Renslo, A. R., Peniche-Trujillo, A-G. & Melby, P., Feb 2011, PLoS Neglected Tropical Diseases. 2 ed. Vol. 5. e962

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Scopus citations
2010

CCR2 plays a critical role in dendritic cell maturation: Possible role of CCL2 and NF-κB

Jimenez, F., Quinones, M. P., Martinez, H. G., Estrada, C. A., Clark, K., Garavito, E., Ibarra, J., Melby, P. & Ahuja, S. S., May 15 2010, In : Journal of Immunology. 184, 10, p. 5571-5581 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis

Espitia, C. M., Zhao, W., Saldarriaga, O., Osorio, Y., Harrison, L. M., Cappello, M., Travi, B. & Melby, P., Jun 22 2010, In : BMC Immunology. 11, 31.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes

Travi, B., Osorio, E. Y., Saldarriaga, O. A., Cadena, H., Tabares, C. J., Peniche-Trujillo, A-G., Lee, S. & Melby, P., Dec 2009, In : American Journal of Tropical Medicine and Hygiene. 81, 6, p. 994-1003 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Leishmania

Ogden, G. B. & Melby, P. C., Jan 1 2009, Encyclopedia of Microbiology. Elsevier Inc., p. 663-673 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
10 Scopus citations

Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: Importance of liposomal delivery and CpG motifs

Gowen, B. B., Fairman, J., Dow, S., Troyer, R., Wong, M. H., Jung, K. H., Melby, P. & Morrey, J. D., Jan 2009, In : Antiviral Research. 81, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced cardiomyocyte death

Venkatachalam, K., Venkatesan, B., Valente, A. J., Melby, P., Nandish, S., Reusch, J. E. B., Clark, R. A. & Chandrasekar, B., May 22 2009, In : Journal of Biological Chemistry. 284, 21, p. 14414-14427 14 p.

Research output: Contribution to journalArticle

72 Scopus citations
2008

Immune responses to protozoans

Melby, P. & Anstead, G. M., 2008, Clinical Immunology. Elsevier Ltd, p. 433-445 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen

Gowen, B. B., Judge, J. W., Wong, M. H., Jung, K. H., Aylsworth, C. F., Melby, P., Rosenberg, B. & Morrey, J. D., Aug 2008, In : International Immunopharmacology. 8, 8, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
31 Scopus citations
2006

Biological activity of hamster interferon-gamma is modulated by the carboxyl-terminal tail

Zhao, W., Valencia, A. Z. & Melby, P., Jun 2006, In : Cytokine. 34, 5-6, p. 243-251 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium

Quinones, M. P., Jimenez, F., Martinez, H., Estrada, C. A., Willmon, O., Dudley, M., Kuziel, W. A., Melby, P., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., May 2006, In : Journal of Molecular Medicine. 84, 6, p. 503-512 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs

Saldarriaga, O. A., Travi, B., Park, W., Perez, L. E. & Melby, P., Mar 10 2006, In : Vaccine. 24, 11, p. 1928-1940 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia

Kerr, S. F., Emmons, L. H., Melby, P., Liu, C., Perez, L. E., Villegas, M. & Miranda, R., Dec 2006, In : American Journal of Tropical Medicine and Hygiene. 75, 6, p. 1069-1073 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Quantification of canine cytokines using real time reverse transcriptase polymerase chain reaction.

Saldarriaga, O. A., Travi, B. & Melby, P., Oct 2006, In : Biomédica : revista del Instituto Nacional de Salud. 26 Suppl 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen

Perez, L. E., Chandrasekar, B., Saldarriaga, O. A., Zhao, W., Arteaga, L. T., Travi, B. & Melby, P., May 1 2006, In : Journal of Immunology. 176, 9, p. 5519-5528 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Selective enhancement of the type 1 cytokine response by expression of a canine interleukin (IL)-12 fused heterodimeric DNA

Saldarriaga, O. A., Perez, L. E., Travi, B. & Melby, P., Apr 15 2006, In : Veterinary Immunology and Immunopathology. 110, 3-4, p. 377-388 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2003

CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

Rao, A. R., Quinones, M. P., Garavito, E., Kalkonde, Y., Jimenez, F., Gibbons, C., Perez, J., Melby, P., Kuziel, W., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., Oct 1 2003, In : Journal of Immunology. 171, 9, p. 4875-4885 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Chemokine-cytokine cross-talk: The ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-κB pathway

Chandrasekar, B., Melby, P., Sarau, H. M., Raveendran, M., Perla, R. P., Marelli-Berg, F. M., Dulin, N. O. & Singh, I. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4675-4686 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Fractalkine (CX3CL1) stimulated by nuclear factor κB (NF-κB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

Chandrasekar, B., Mummidi, S., Perla, R. P., Bysani, S., Dulin, N. O., Liu, F. & Melby, P., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 547-558 12 p.

Research output: Contribution to journalArticle

120 Scopus citations

Multinutrient undernutrition dysregulates the resident macrophage proinflammatory cytokine network, nuclear factor-κB activation, and nitric oxide production

Anstead, G. M., Chandrasekar, B., Zhang, Q. & Melby, P., Dec 2003, In : Journal of Leukocyte Biology. 74, 6, p. 982-991 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Short report: A disseminated infection of Leishmania mexicana in an eastern woodrat, Neotoma floridana, collected in Texas

McHugh, C. P., Thies, M. L., Melby, P., Yantis, L. D., Raymond, R. W., Villegas, M. D. & Kerr, S. F., Nov 2003, In : American Journal of Tropical Medicine and Hygiene. 69, 5, p. 470-472 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis

Osorio, Y., Melby, P., Pirmez, C., Chandrasekar, B., Guarín, N. & Travi, B., Mar 2003, In : Parasite Immunology. 25, 3, p. 139-148 10 p.

Research output: Contribution to journalArticle

22 Scopus citations