Peter Melby, MD

Director, WHO Collaborating Center for Tropical Diseases

  • 3681 Citations
  • 35 h-Index
1987 …2022

Research output per year

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Research Output

  • 3681 Citations
  • 35 h-Index
  • 81 Article
  • 5 Review article
  • 4 Chapter
  • 1 Editorial
2003

The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis

Osorio, Y., Melby, P. C., Pirmez, C., Chandrasekar, B., Guarín, N. & Travi, B. L., Mar 1 2003, In : Parasite Immunology. 25, 3, p. 139-148 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2002

Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp.

Travi, B. L., Osorio, Y., Melby, P. C., Chandrasekar, B., Arteaga, L. & Saravia, N. G., Apr 29 2002, In : Infection and immunity. 70, 5, p. 2288-2296 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Recent developments in leishmaniasis

Melby, P. C., Oct 2002, In : Current opinion in infectious diseases. 15, 5, p. 485-490 6 p.

Research output: Contribution to journalReview article

39 Scopus citations

Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation

Yang, F., Liu, X. B., Quinones, M., Melby, P. C., Ghio, A. & Haile, D. J., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39786-39791 6 p.

Research output: Contribution to journalArticle

173 Scopus citations

Vaccination against cutaneous leishmaniasis: Current status

Melby, P. C., Jan 1 2002, In : American Journal of Clinical Dermatology. 3, 8, p. 557-570 14 p.

Research output: Contribution to journalReview article

30 Scopus citations
2001
Open Access
28 Scopus citations

Animal models for the analysis of immune responses to leishmaniasis.

Sacks, D. L. & Melby, P. C., May 2001, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 19, p. Unit 19.2

Research output: Contribution to journalArticle

13 Scopus citations

Immunocytochemical detection of Fcγ receptors in human atherosclerotic lesions

Ratcliffe, N. R., Kennedy, S. M., Peter, M. & Morganelli, Jul 2 2001, In : Immunology Letters. 77, 3, p. 169-174 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Leishmania donovani: Evolution and architecture of the splenic cellular immune response related to control of infection

Melby, P. C., Tabares, A., Restrepo, B. I., Cardona, A. E., McGuff, H. S. & Teale, J. M., Jan 1 2001, In : Experimental Parasitology. 99, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis

Melby, P. C., Yang, J., Zhao, W., Perez, L. E. & Cheng, J., Aug 4 2001, In : Infection and immunity. 69, 8, p. 4719-4725 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection

Anstead, G. M., Chandrasekar, B., Zhao, W., Yang, J., Perez, L. E. & Melby, P. C., Aug 4 2001, In : Infection and immunity. 69, 8, p. 4709-4718 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

The hamster as a model of human visceral leishmaniasis: Progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response

Melby, P. C., Chandrasekar, B., Zhao, W. & Coe, J. E., Feb 1 2001, In : Journal of Immunology. 166, 3, p. 1912-1920 9 p.

Research output: Contribution to journalArticle

Open Access
185 Scopus citations
2000
224 Scopus citations

Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Troyer, D. A. & Freeman, G. L., Jul 17 2000, In : Clinical and Experimental Immunology. 121, 1, p. 112-119 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library

Melby, P. C., Ogden, G. B., Flores, H. A., Zhao, W., Geldmacher, C., Biediger, N. M., Ahuja, S. K., Uranga, J. & Melendez, M., Jan 1 2000, In : Infection and immunity. 68, 10, p. 5595-5602 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite

Quinones, M., Ahuja, S. K., Melby, P. C., Pate, L., Reddick, R. L. & Ahuja, S. S., Aug 21 2000, In : Journal of Experimental Medicine. 192, 4, p. 507-515 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
1999

Defects in the generation of IFN-γ/are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1α-, or CCR2-deficient mice

Sato, N., Kuziel, W. A., Melby, P. C., Reddick, R. L., Kostecki, V., Zhao, W., Maeda, N., Ahuja, S. K. & Ahuja, S. S., Nov 15 1999, In : Journal of Immunology. 163, 10, p. 5519-5525 7 p.

Research output: Contribution to journalArticle

139 Scopus citations

Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection

Ahuja, S. S., Reddick, R. L., Sato, N., Montalbo, E., Kostecki, V., Zhao, W., Dolan, M. J., Melby, P. C. & Ahuja, S. K., Oct 1 1999, In : Journal of Immunology. 163, 7, p. 3890-3897 8 p.

Research output: Contribution to journalArticle

114 Scopus citations

Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases

Al-Abdely, H. M., Graybill, J. R., Loebenberg, D. & Melby, P. C., Dec 22 1999, In : Antimicrobial agents and chemotherapy. 43, 12, p. 2910-2914 5 p.

Research output: Contribution to journalArticle

70 Scopus citations
1998

Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis

Melby, P. C., Tryon, V. V., Chandrasekar, B. & Freeman, G. L., May 1 1998, In : Infection and immunity. 66, 5, p. 2135-2142 8 p.

Research output: Contribution to journalArticle

109 Scopus citations

Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous leishmaniasis and visceral leishmaniasis

Al-Abdely, H. M., Graybill, J. R., Bocanegra, R., Najvar, L., Montalbo, E., Regen, S. L. & Melby, P. C., Oct 1 1998, In : Antimicrobial Agents and Chemotherapy. 42, 10, p. 2542-2548 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major

Louzir, H., Melby, P. C., Salah, A. B., Marrakchi, H., Aoun, K., Ismail, R. B. & Dellagi, K., Jan 1 1998, In : Journal of Infectious Diseases. 177, 6, p. 1687-1695 9 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Pennica, D. & Freeman, G. L., Apr 1 1998, In : Immunology Letters. 61, 2-3, p. 89-95 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani

Melby, P. C., Yang, Y. Z., Cheng, J. & Zhao, W., Jan 1 1998, In : Infection and immunity. 66, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Troyer, D. A., Colston, J. T. & Freeman, G. L., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 925-934 10 p.

Research output: Contribution to journalArticle

61 Scopus citations
1996

Induction of macrophage killing of Leishmania donovani by human CD4+ T cell clones

Melby, P. C., Valencia-Pacheco, G. & Andrade-Narvaez, F., Dec 19 1996, In : Archives of Medical Research. 27, 4, p. 473-479 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Induction of proinflammatory cytokine expression in experimental acute chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Troyer, D. A. & Freeman, G. L., Jun 14 1996, In : Biochemical and Biophysical Research Communications. 223, 2, p. 365-371 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis

Melby, P. C., Andrade-Narvaez, F., Darnell, B. J. & Valencia-Pacheco, G., Sep 1996, In : FEMS Immunology and Medical Microbiology. 15, 2-3, p. 101-107 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Leishmaniasis in Texas: Epidemiology and clinical aspects of human cases

McHugh, C. P., Melby, P. C. & LaFon, S. G., Jan 1 1996, In : American Journal of Tropical Medicine and Hygiene. 55, 5, p. 547-555 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
1995

Lack of serological specificity of recombinant heat shock protein of Leishmania donovani

ARORA, SUNIL. K., MELBY, PETER. C. & SEHGAL, SHOBHA., Oct 1995, In : Immunology and Cell Biology. 73, 5, p. 446-451 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Recombinant Leishmania donovani heat shock protein 70 is recognized by T cells from immune individuals

Arora, S. K., Sehgal, S., Tryon, V. V. & Melby, P. C., Dec 1 1995, In : Immunology and Infectious Diseases. 5, 4, p. 282-286 5 p.

Research output: Contribution to journalArticle

1994

Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis

Melby, P. C., Andrade-Narvaez, F. J., Darnell, B. J., Valencia-Pacheco, G., Tryon, V. V. & Palomo-Cetina, A., Jan 1 1994, In : Infection and immunity. 62, 3, p. 837-842 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis

Cooper, A. M., Melby, P. C., Karp, C. L., Neva, F. & Sacks, D. L., May 1 1994, In : Clinical and Diagnostic Laboratory Immunology. 1, 3, p. 304-309 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
1993

Quantitative measurement of human cytokine gene expression by polymerase chain reaction

Melby, P. C., Darnell, B. J. & Tryon, V. V., Feb 26 1993, In : Journal of Immunological Methods. 159, 1-2, p. 235-244 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
1992

Cutaneous leishmaniasis: Review of 59 cases seen at the national institutes of health

Melby, P. C., Kreutzer, R. D., McMahon-Pratt, D., Gam, A. A. & Neva, F. A., Dec 1992, In : Clinical Infectious Diseases. 15, 6, p. 924-937 14 p.

Research output: Contribution to journalArticle

73 Scopus citations
1991

Serial features. Experimental Leishmaniasis in humans: Review

Melby, P. C., Jan 1 1991, In : Reviews of infectious diseases. 13, 5, p. 1009-1017 9 p.

Research output: Contribution to journalReview article

43 Scopus citations
1989

Concentration of pentostam® in human breast milk

Berman, J. D., Melby, P. C. & Neva, F. A., Dec 1989, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 83, 6, p. 784-785 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of antigens recognized by T cells in human leishmaniasis: Analysis of T-cell clones by immunoblotting

Melby, P. C. & Sacks, D. L., Jan 1 1989, In : Infection and immunity. 57, 10, p. 2971-2976 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting

Melby, P. C., Neva, F. A. & Sacks, D. L., Jan 1 1989, In : Journal of Clinical Investigation. 83, 6, p. 1868-1875 8 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
1987

Analysis of the heterogeneity of T-cell responses in human leishmaniasis

Melby, P. C. & Sacks, D. L., Jan 1 1987, In : Annales de l'Institut Pasteur - Immunology. 138, 5, p. 768-771 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Poststreptococcal glomerulonephritis in the elderly. Report of a case and review of the literature.

Melby, P. C., Musick, W. D., Luger, A. M. & Khanna, R., 1987, In : American journal of nephrology. 7, 3, p. 235-240 6 p.

Research output: Contribution to journalArticle

23 Scopus citations