Peter Melby

2023

A Preliminary Study to Compare Recombinase Polymerase Amplification-Lateral Flow and Quantitative PCR in the Detection of Cutaneous Leishmania in Communities from the Volta Region of Ghana

Yeboah, C., Mosore, M. T., Attram, N., Shelite, T. R., Akuffo, R. A., Addo, S. O., Behene, E., Agbodzi, B., Bentil, R. E., Fox, A. T., Wilson, M., Boakye, D., Letizia, A. G., Melby, P. C. & Travi, B. L., Feb 1 2023, In: Vector-Borne and Zoonotic Diseases. 23, 2, p. 75-80 6 p.

Research output: Contribution to journal › Article › peer-review

Hematological and Clinical Features Associated with Initial Poor Treatment Outcomes in Visceral Leishmaniasis Patients with and without HIV Coinfection in Gondar, Northwest Ethiopia

Ademe, M., Osorio, Y., Howe, R., Atnafu, S., Mulaw, T., Fikre, H., Travi, B. L., Hailu, A., Melby, P. C. & Abebe, T., Jan 2023, In: Tropical Medicine and Infectious Disease. 8, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE₂-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes

Osorio, E. Y., Uscanga-Palomeque, A., Patterson, G. T., Cordova, E., Travi, B. L., Soong, L. & Melby, P. C., Jan 11 2023, In: PLoS neglected tropical diseases. 17, 1, e0011040.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice

Liang, Y., Wang, H., Gonzales, C., Thiriot, J., Sunyakumthorn, P., Melby, P. C., Sun, J. & Soong, L., Dec 22 2022, In: Frontiers in immunology. 13, 1061031.

Research output: Contribution to journal › Article › peer-review

Open Access

Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host

Osorio, E. Y., Gugala, Z., Patterson, G. T., Palacios, G., Cordova, E., Uscanga-Palomeque, A., Travi, B. L. & Melby, P. C., Aug 2 2022, In: Frontiers in immunology. 13, 846246.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Pathologic Inflammation in Malnutrition Is Driven by Proinflammatory Intestinal Microbiota, Large Intestine Barrier Dysfunction, and Translocation of Bacterial Lipopolysaccharide

Patterson, G. T., Osorio, E. Y., Peniche-Trujillo, A-G., Dann, S. M., Cordova, E., Preidis, G. A., Suh, J. H., Ito, I., Saldarriaga, O. A., Loeffelholz, M., Ajami, N. J., Travi, B. L. & Melby, P. C., May 26 2022, In: Frontiers in immunology. 13, 846155.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Texas professionals are employing a one health approach to protect the United States against biosecurity threats

Dacso, M. M., Bente, D. A., Weaver, S. C., Kobinger, G. P., Melby, P. C., McLellan, S. L. F., Keiser, P. H., Hamer, S. A., Hamer, G. L., Parker, G. W., Douphrate, D. I., Rodriguez, A., Goodman, M. L., Ara & Gray, G. C., Dec 2022, In: One Health. 15, 100431.

Research output: Contribution to journal › Article › peer-review

Open Access

Water insecurity, food insecurity and social capital associated with a group-led microfinance programme in semi-rural Kenya

Goodman, M. L., Elliott, A., Melby, P. C. & Gitari, S., 2022, In: Global Public Health. 17, 12, p. 3399-3411 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2021

Diagnostic Efficacy of Recombinase-Polymerase-Amplification Coupled with Lateral Flow Strip Reading in Patients with Cutaneous Leishmaniasis from the Amazonas Rainforest of Perú

Travi, B. L., Delos Santos, M. B., Shelite, T. R., Santos, R. P., Rosales, L. A., Castellanos-Gonzalez, A., Saldarriaga, O. & Melby, P. C., Dec 2021, In: Vector-Borne and Zoonotic Diseases. 21, 12, p. 941-947 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Diagnostic performance of a recombinant polymerase amplification test—lateral flow (Rpa-lf) for cutaneous leishmaniasis in an endemic setting of Colombia

Cossio, A., Jojoa, J., Castro, M. D. M., Castillo, R. M., Osorio, L., Shelite, T. R., Saravia, N. G., Melby, P. C. & Travi, B. L., Apr 2021, In: PLoS neglected tropical diseases. 15, 4, e0009291.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Direct RT-PCR amplification of SARS-CoV-2 from clinical samples using a concentrated viral lysis-amplification buffer prepared with IGEPAL-630

Castellanos-Gonzalez, A., Shelite, T. R., Lloyd, N., Sadiqova, A., Ping, R., Williams-Bouyer, N., Melby, P. C. & Travi, B. L., Dec 2021, In: Scientific reports. 11, 1, 14204.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Environmental, metabolic, and inflammatory factors converge in the pathogenesis of moderate acute malnutrition in children: An observational cohort study

Patterson, G. T., Manthi, D., Osuna, F., Muia, A., Olack, B., Mbuchi, M., Saldarriaga, O. A., Ouma, L., Inziani, M., Yu, X., Otieno, P. & Melby, P. C., May 5 2021, In: American Journal of Tropical Medicine and Hygiene. 104, 5, p. 1877-1888 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Isothermal recombinase polymerase amplification-lateral flow detection of SARS-CoV-2, the etiological agent of COVID-19

Shelite, T. R., Uscanga-Palomeque, A., Castellanos-Gonzalez, A., Melby, P. C. & Travi, B. L., Oct 2021, In: Journal of Virological Methods. 296, 114227.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Isothermal Recombinase Polymerase Amplification-Lateral Flow Point-of-Care Diagnostic Test for Heartland Virus

Shelite, T. R., Bopp, N. E., Moncayo, A., Reynolds, E. S., Thangamani, S., Melby, P. C., Bloch, K., Aguilar, P. V. & Travi, B. L., Feb 2021, In: Vector-Borne and Zoonotic Diseases. 21, 2, p. 110-115 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2020

Efficacy of histamine h1 receptor antagonists azelastine and fexofenadine against cutaneous leishmania major infection

Penicheid, A. G., Osorio, E. Y., Melby, P. C. & Travi, B. L., Aug 2020, In: PLoS neglected tropical diseases. 14, 8, p. 1-17 17 p., e0008482.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

In-situ proliferation contributes to the accumulation of myeloid cells in the spleen during progressive experimental visceral leishmaniasis

Osorio, E. Y., Medina-Colorado, A. A., Travi, B. L. & Melby, P. C., Nov 2020, In: PloS one. 15, 11 November, e0242337.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2019

Stunting is preceded by intestinal mucosal damage and microbiome changes and is associated with systemic inflammation in a cohort of Peruvian infants

Zambruni, M., Ochoa, T. J., Somasunderam, A., Cabada, M. M., Morales, M. L., Mitreva, M., Rosa, B. A., Acosta, G. J., Vigo, N. I., Riveros, M., Arango, S., Durand, D., Berends, M. N., Melby, P. & Utay, N., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 5, p. 1009-1017 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2018

Efficacy of recombinase polymerase amplification to diagnose trypanosoma cruzi infection in dogs with cardiac alterations from an endemic Area of Mexico

Jimenez-Coello, M., Shelite, T., Castellanos-Gonzalez, A., Saldarriaga, O., Rivero, R., Ortega-Pacheco, A., Acevedo-Arcique, C., Amaya-Guardia, K., Garg, N., Melby, P. & Travi, B. L., Aug 1 2018, In: Vector-Borne and Zoonotic Diseases. 18, 8, p. 417-423 7 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Molecular diagnosis of protozoan parasites by Recombinase Polymerase Amplification

Castellanos-Gonzalez, A., White, A. C., Melby, P. & Travi, B., Jun 2018, In: Acta Tropica. 182, p. 4-11 8 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2017

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D. H., Jupiter, D., Melby, P. C. & Arcari, C. M., Nov 3 2017, In: PLoS neglected tropical diseases. 11, 11, e0006062.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis

Peniche-Trujillo, A-G., Bonilla, D. L., Palma, G. I., Melby, P. C., Travi, B. L. & Osorio, E. Y., Jun 2017, In: PloS one. 12, 6, e0179084.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Splenic CD4⁺ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

Colorado, A., Osorio, E. Y., Saldarriaga, O. A., Travi, B. L., Kong, F., Spratt, H., Soong, L. & Melby, P. C., Jan 2017, In: PloS one. 12, 1, e0169496.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

Kong, F., Saldarriaga, O. A., Spratt, H., Osorio, E. Y., Travi, B. L., Luxon, B. & Melby, P. C., Jan 2017, In: PLoS pathogens. 13, 1, e1006165.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2016

An Innovative Field-Applicable Molecular Test to Diagnose Cutaneous Leishmania Viannia spp. Infections

Saldarriaga, O. A., Castellanos-Gonzalez, A., Porrozzi, R., Baldeviano, G. C., Lescano, A. G., de Los Santos, M. B., Fernandez, O. L., Saravia, N. G., Costa, E., Melby, P. C. & Travi, B. L., Apr 26 2016, In: PLoS neglected tropical diseases. 10, 4, e0004638.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Cytokine mRNA expression in Peromyscus yucatanicus (Rodentia: Cricetidae) infected by Leishmania (Leishmania) mexicana

Loria-Cervera, E. N., Sosa-Bibiano, E. I., Van Wynsberghe, N. R., Saldarriaga, O. A., Melby, P. C. & Andrade-Narvaez, F. J., Jul 1 2016, In: Cytokine. 83, p. 176-181 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2015

Animal models for the analysis of immune responses to leishmaniasis

Sacks, D. L. & Melby, P. C., 2015, In: Current Protocols in Immunology. 2015, p. 19.2.1-19.2.24

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

A novel molecular test to diagnose canine visceral leishmaniasis at the point of care

Castellanos-Gonzalez, A., Saldarriaga, O. A., Tartaglino, L., Gacek, R., Temple, E., Sparks, H., Melby, P. C. & Travi, B. L., Nov 4 2015, In: American Journal of Tropical Medicine and Hygiene. 93, 5, p. 970-975 6 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Antileishmanial activity of disulfiram and thiuram disulfide analogs in an Ex Vivo model system is selectively enhanced by the addition of divalent metal ions

Peniche-Trujillo, A-G., Renslo, A. R., Melby, P. C. & Travi, B. L., Oct 1 2015, In: Antimicrobial agents and chemotherapy. 59, 10, p. 6463-6470 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2014

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection

Ibrahim, M. K., Barnes, J. L., Osorio, E. Y., Anstead, G. M., Jimenez, F., Osterholzer, J. J., Travi, B. L., Ahuja, S. S., White, A. C. & Melby, P. C., 2014, In: Infection and immunity. 82, 8, p. 3098-3112 15 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Development of an ex vivo lymph node explant model for identification of novel molecules active against leishmania major

Peniche-Trujillo, A-G., Yaneth, O., Renslo, A. R., Frantz, D. E., Melby, P. C. & Travi, B. L., Jan 2014, In: Antimicrobial agents and chemotherapy. 58, 1, p. 78-87 10 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis

Osorio, E. Y., Travi, B. L., da Cruz, A. M., Saldarriaga, O. A., Colorado, A. & Melby, P. C., Jun 2014, In: PLoS pathogens. 10, 6, e1004165.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

Valencia-Pacheco, G., Loría-Cervera, E. N., Sosa-Bibiano, E. I., Canché-Pool, E. B., Vargas-Gonzalez, A., Melby, P. C. & Andrade-Narvaez, F. J., Sep 2014, In: Cytokine. 69, 1, p. 56-61 6 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

Espitia, C. M., Saldarriaga, O. A., Travi, B. L., Osorio, E. Y., Hernandez, A., Band, M., Patel, M. J., Colorado, A., Cappello, M., Pekosz, A. & Melby, P. C., Nov 26 2014, In: BMC Immunology. 15, 1, 38.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2013

The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

Ibrahim, M. K., Barnes, J. L., Anstead, G. M., Jimenez, F., Travi, B. L., Peniche-Trujillo, A-G., Osorio, E. Y., Ahuja, S. S. & Melby, P. C., Aug 2013, In: PLoS neglected tropical diseases. 7, 8, e2329.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2012

Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

Saldarriaga, O. A., Travi, B. L., Choudhury, G. G. & Melby, P. C., Jul 2012, In: Journal of Leukocyte Biology. 92, 1, p. 205-218 14 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression

Osorio, E. Y., Zhao, W., Espitia, C., Saldarriaga, O., Hawel, L., Byus, C. V., Travi, B. L. & Melby, P. C., Jan 2012, In: PLoS pathogens. 8, 1, e1002417.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

2011

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system

Osorio, Y., Travi, B. L., Renslo, A. R., Peniche-Trujillo, A-G. & Melby, P. C., Feb 2011, In: PLoS neglected tropical diseases. 5, 2, e962.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2010

CCR2 plays a critical role in dendritic cell maturation: Possible role of CCL2 and NF-κB

Jimenez, F., Quinones, M. P., Martinez, H. G., Estrada, C. A., Clark, K., Garavito, E., Ibarra, J., Melby, P. C. & Ahuja, S. S., May 15 2010, In: Journal of Immunology. 184, 10, p. 5571-5581 11 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis

Espitia, C. M., Zhao, W., Saldarriaga, O., Osorio, Y., Harrison, L. M., Cappello, M., Travi, B. L. & Melby, P. C., Jun 22 2010, In: BMC Immunology. 11, 31.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2009

Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes

Travi, B. L., Osorio, E. Y., Saldarriaga, O. A., Cadena, H., Tabares, C. J., Peniche, A., Lee, S. & Melby, P. C., Dec 2009, In: American Journal of Tropical Medicine and Hygiene. 81, 6, p. 994-1003 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Malnutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages

Anstead, G. M., Zhang, Q. & Melby, P. C., Jul 2009, In: Prostaglandins Leukotrienes and Essential Fatty Acids. 81, 1, p. 41-51 11 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: Importance of liposomal delivery and CpG motifs

Gowen, B. B., Fairman, J., Dow, S., Troyer, R., Wong, M. H., Jung, K. H., Melby, P. C. & Morrey, J. D., Jan 2009, In: Antiviral research. 81, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced cardiomyocyte death

Venkatachalam, K., Venkatesan, B., Valente, A. J., Melby, P. C., Nandish, S., Reusch, J. E. B., Clark, R. A. & Chandrasekar, B., May 22 2009, In: Journal of Biological Chemistry. 284, 21, p. 14414-14427 14 p.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

2008

Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen

Gowen, B. B., Judge, J. W., Wong, M. H., Jung, K. H., Aylsworth, C. F., Melby, P. C., Rosenberg, B. & Morrey, J. D., Aug 2008, In: International Immunopharmacology. 8, 8, p. 1089-1094 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production

Osorio, Y., Bonilla, D. L., Peniche, A. G., Melby, P. C. & Travi, B. L., Jun 1 2008, In: Journal of Leukocyte Biology. 83, 6, p. 1413-1422 10 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2006

Biological activity of hamster interferon-gamma is modulated by the carboxyl-terminal tail

Zhao, W., Valencia, A. Z. & Melby, P. C., Jun 2006, In: Cytokine. 34, 5-6, p. 243-251 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium

Quinones, M. P., Jimenez, F., Martinez, H., Estrada, C. A., Willmon, O., Dudley, M., Kuziel, W. A., Melby, P. C., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., May 2006, In: Journal of Molecular Medicine. 84, 6, p. 503-512 10 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs

Saldarriaga, O. A., Travi, B. L., Park, W., Perez, L. E. & Melby, P. C., Mar 10 2006, In: Vaccine. 24, 11, p. 1928-1940 13 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia

Kerr, S. F., Emmons, L. H., Melby, P. C., Liu, C., Perez, L. E., Villegas, M. & Miranda, R., Dec 2006, In: American Journal of Tropical Medicine and Hygiene. 75, 6, p. 1069-1073 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Peter Melby, MD

Research output

Search results