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Peter Melby, MD

Director, WHO Collaborating Center for Tropical Diseases

  • 3597 Citations
  • 34 h-Index
1987 …2022

Research output per year

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Research Output

  • 3597 Citations
  • 34 h-Index
  • 81 Article
  • 5 Review article
  • 3 Chapter
  • 1 Editorial
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Article
2019

Stunting is preceded by intestinal mucosal damage and microbiome changes and is associated with systemic inflammation in a cohort of Peruvian infants

Zambruni, M., Ochoa, T. J., Somasunderam, A., Cabada, M. M., Morales, M. L., Mitreva, M., Rosa, B. A., Acosta, G. J., Vigo, N. I., Riveros, M., Arango, S., Durand, D., Berends, M. N., Melby, P. & Utay, N. S., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 101, 5, p. 1009-1017 9 p.

Research output: Contribution to journal › Article

2018

Efficacy of recombinase polymerase amplification to diagnose trypanosoma cruzi infection in dogs with cardiac alterations from an endemic Area of Mexico

Jimenez-Coello, M., Shelite, T., Castellanos, A., Saldarriaga, O., Rivero, R., Ortega-Pacheco, A., Acevedo-Arcique, C., Amaya-Guardia, K., Garg, N., Melby, P. & Travi, B., Aug 1 2018, In : Vector-Borne and Zoonotic Diseases. 18, 8, p. 417-423 7 p.

Research output: Contribution to journal › Article

5 Scopus citations

Molecular diagnosis of protozoan parasites by Recombinase Polymerase Amplification

Castellanos, A., White, A. C., Melby, P. & Travi, B., Jun 1 2018, In : Acta Tropica. 182, p. 4-11 8 p.

Research output: Contribution to journal › Article

7 Scopus citations

New Insights into the Pathogenesis and Treatment of Malnutrition

Thaxton, G. E., Melby, P., Manary, M. J. & Preidis, G. A., Jan 1 2018, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journal › Article

2017

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D., Jupiter, D., Melby, P. & Arcari, C. M., Nov 3 2017, In : PLoS Neglected Tropical Diseases. 11, 11, e0006062.

Research output: Contribution to journal › Article

48 Scopus citations

A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis

Peniche-Trujillo, A-G., Bonilla, D. L., Palma, G. I., Melby, P., Travi, B. & Osorio, E. Y., Jun 1 2017, In : PLoS One. 12, 6, e0179084.

Research output: Contribution to journal › Article

3 Scopus citations

Splenic CD4+ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

Colorado, A., Osorio, E. Y., Saldarriaga, O. A., Travi, B., Kong, F., Spratt, H., Soong, L. & Melby, P., Jan 1 2017, In : PLoS One. 12, 1, e0169496.

Research output: Contribution to journal › Article

9 Scopus citations

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

Kong, F., Saldarriaga, O. A., Spratt, H., Osorio, E. Y., Travi, B., Luxon, B. A. & Melby, P., Jan 1 2017, In : PLoS Pathogens. 13, 1, e1006165.

Research output: Contribution to journal › Article

13 Scopus citations
2016

An Innovative Field-Applicable Molecular Test to Diagnose Cutaneous Leishmania Viannia spp. Infections

Saldarriaga, O. A., Castellanos, A., Porrozzi, R., Baldeviano, G. C., Lescano, A. G., de Los Santos, M. B., Fernandez, O. L., Saravia, N. G., Costa, E., Melby, P. & Travi, B., Apr 26 2016, In : PLoS Neglected Tropical Diseases. 10, 4, e0004638.

Research output: Contribution to journal › Article

13 Scopus citations

Cytokine mRNA expression in Peromyscus yucatanicus (Rodentia: Cricetidae) infected by Leishmania (Leishmania) mexicana

Loria-Cervera, E. N., Sosa-Bibiano, E. I., Van Wynsberghe, N. R., Saldarriaga, O. A., Melby, P. & Andrade-Narvaez, F. J., Jul 1 2016, In : Cytokine. 83, p. 176-181 6 p.

Research output: Contribution to journal › Article

1 Scopus citations
2015

Animal models for the analysis of immune responses to leishmaniasis

Sacks, D. L. & Melby, P., 2015, In : Current Protocols in Immunology. 2015, p. 19.2.1-19.2.24

Research output: Contribution to journal › Article

15 Scopus citations

A novel molecular test to diagnose canine visceral leishmaniasis at the point of care

Castellanos, A., Saldarriaga, O. A., Tartaglino, L., Gacek, R., Temple, E., Sparks, H., Melby, P. & Travi, B., Nov 4 2015, In : American Journal of Tropical Medicine and Hygiene. 93, 5, p. 970-975 6 p.

Research output: Contribution to journal › Article

14 Scopus citations

Antileishmanial activity of disulfiram and thiuram disulfide analogs in an Ex Vivo model system is selectively enhanced by the addition of divalent metal ions

Peniche-Trujillo, A-G., Renslo, A. R., Melby, P. & Travi, B., Oct 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 10, p. 6463-6470 8 p.

Research output: Contribution to journal › Article

9 Scopus citations

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In : Clinical and Experimental Immunology. 182, 2, p. 109-18

Research output: Contribution to journal › Article

26 Scopus citations
2014

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection

Ibrahim, M. K., Barnes, J. L., Osorio, E. Y., Anstead, G. M., Jimenez, F., Osterholzer, J. J., Travi, B. L., Ahuja, S. S., White, A. C. & Melby, P. C., 2014, In : Infection and immunity. 82, 8, p. 3098-3112 15 p.

Research output: Contribution to journal › Article

8 Scopus citations

Development of an ex vivo lymph node explant model for identification of novel molecules active against leishmania major

Peniche, A. G., Yaneth, O., Renslo, A. R., Frantz, D. E., Melby, P. C. & Travi, B. L., Jan 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 78-87 10 p.

Research output: Contribution to journal › Article

10 Scopus citations

Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis

Osorio, E. Y., Travi, B. L., da Cruz, A. M., Saldarriaga, O. A., Medina, A. A. & Melby, P. C., Jun 2014, In : PLoS pathogens. 10, 6, e1004165.

Research output: Contribution to journal › Article

24 Scopus citations

In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

Valencia-Pacheco, G., Loría-Cervera, E. N., Sosa-Bibiano, E. I., Canché-Pool, E. B., Vargas-Gonzalez, A., Melby, P. C. & Andrade-Narvaez, F. J., Sep 2014, In : Cytokine. 69, 1, p. 56-61 6 p.

Research output: Contribution to journal › Article

16 Scopus citations

Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

Espitia, C. M., Saldarriaga, O. A., Travi, B. L., Osorio, E. Y., Hernandez, A., Band, M., Patel, M. J., Medina, A. A., Cappello, M., Pekosz, A. & Melby, P. C., Nov 26 2014, In : BMC Immunology. 15, 1, 51.

Research output: Contribution to journal › Article

6 Scopus citations
2013

The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

Ibrahim, M. K., Barnes, J. L., Anstead, G. M., Jimenez, F., Travi, B. L., Peniche, A. G., Osorio, E. Y., Ahuja, S. S. & Melby, P. C., Aug 2013, In : PLoS neglected tropical diseases. 7, 8, e2329.

Research output: Contribution to journal › Article

15 Scopus citations
2012

Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

Saldarriaga, O. A., Travi, B. L., Choudhury, G. G. & Melby, P. C., Jul 1 2012, In : Journal of Leukocyte Biology. 92, 1, p. 205-218 14 p.

Research output: Contribution to journal › Article

9 Scopus citations

Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression

Osorio, E. Y., Zhao, W., Espitia, C., Saldarriaga, O., Hawel, L., Byus, C. V., Travi, B. L. & Melby, P. C., Jan 1 2012, In : PLoS pathogens. 8, 1, e1002417.

Research output: Contribution to journal › Article

32 Scopus citations
2011

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system

Osorio, Y., Travi, B. L., Renslo, A. R., Peniche, A. G. & Melby, P. C., Feb 1 2011, In : PLoS neglected tropical diseases. 5, 2, e962.

Research output: Contribution to journal › Article

Open Access
2010

CCR2 plays a critical role in dendritic cell maturation: Possible role of CCL2 and NF-κB

Jimenez, F., Quinones, M. P., Martinez, H. G., Estrada, C. A., Clark, K., Garavito, E., Ibarra, J., Melby, P. C. & Ahuja, S. S., May 15 2010, In : Journal of Immunology. 184, 10, p. 5571-5581 11 p.

Research output: Contribution to journal › Article

62 Scopus citations

Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis

Espitia, C. M., Zhao, W., Saldarriaga, O., Osorio, Y., Harrison, L. M., Cappello, M., Travi, B. L. & Melby, P. C., Jun 22 2010, In : BMC Immunology. 11, 31.

Research output: Contribution to journal › Article

21 Scopus citations
2009

Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes

Travi, B. L., Osorio, E. Y., Saldarriaga, O. A., Cadena, H., Tabares, C. J., Peniche, A., Lee, S. & Melby, P. C., Dec 1 2009, In : American Journal of Tropical Medicine and Hygiene. 81, 6, p. 994-1003 10 p.

Research output: Contribution to journal › Article

19 Scopus citations

Malnutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages

Anstead, G. M., Zhang, Q. & Melby, P. C., Jul 1 2009, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 81, 1, p. 41-51 11 p.

Research output: Contribution to journal › Article

10 Scopus citations

Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: Importance of liposomal delivery and CpG motifs

Gowen, B. B., Fairman, J., Dow, S., Troyer, R., Wong, M. H., Jung, K. H., Melby, P. C. & Morrey, J. D., Jan 1 2009, In : Antiviral research. 81, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article

22 Scopus citations

WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced cardiomyocyte death

Venkatachalam, K., Venkatesan, B., Valente, A. J., Melby, P. C., Nandish, S., Reusch, J. E. B., Clark, R. A. & Chandrasekar, B., May 22 2009, In : Journal of Biological Chemistry. 284, 21, p. 14414-14427 14 p.

Research output: Contribution to journal › Article

72 Scopus citations
2008

Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen

Gowen, B. B., Judge, J. W., Wong, M. H., Jung, K. H., Aylsworth, C. F., Melby, P. C., Rosenberg, B. & Morrey, J. D., Aug 1 2008, In : International Immunopharmacology. 8, 8, p. 1089-1094 6 p.

Research output: Contribution to journal › Article

9 Scopus citations

Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production

Osorio, Y., Bonilla, D. L., Peniche, A. G., Melby, P. C. & Travi, B. L., Jun 1 2008, In : Journal of Leukocyte Biology. 83, 6, p. 1413-1422 10 p.

Research output: Contribution to journal › Article

31 Scopus citations
2006

Biological activity of hamster interferon-gamma is modulated by the carboxyl-terminal tail

Zhao, W., Valencia, A. Z. & Melby, P. C., Jun 1 2006, In : Cytokine. 34, 5-6, p. 243-251 9 p.

Research output: Contribution to journal › Article

3 Scopus citations

CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium

Quinones, M. P., Jimenez, F., Martinez, H., Estrada, C. A., Willmon, O., Dudley, M., Kuziel, W. A., Melby, P. C., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., May 1 2006, In : Journal of Molecular Medicine. 84, 6, p. 503-512 10 p.

Research output: Contribution to journal › Article

10 Scopus citations

Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs

Saldarriaga, O. A., Travi, B. L., Park, W., Perez, L. E. & Melby, P. C., Mar 10 2006, In : Vaccine. 24, 11, p. 1928-1940 13 p.

Research output: Contribution to journal › Article

34 Scopus citations

Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia

Kerr, S. F., Emmons, L. H., Melby, P. C., Liu, C., Perez, L. E., Villegas, M. & Miranda, R., Dec 1 2006, In : American Journal of Tropical Medicine and Hygiene. 75, 6, p. 1069-1073 5 p.

Research output: Contribution to journal › Article

9 Scopus citations

Quantification of canine cytokines using real time reverse transcriptase polymerase chain reaction.

Saldarriaga, O. A., Travi, B. L. & Melby, P. C., Oct 2006, In : Biomédica : revista del Instituto Nacional de Salud. 26 Suppl 1, p. 254-263 10 p.

Research output: Contribution to journal › Article

1 Scopus citations

Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen

Perez, L. E., Chandrasekar, B., Saldarriaga, O. A., Zhao, W., Arteaga, L. T., Travi, B. L. & Melby, P. C., May 1 2006, In : Journal of Immunology. 176, 9, p. 5519-5528 10 p.

Research output: Contribution to journal › Article

Open Access
36 Scopus citations

Selective enhancement of the type 1 cytokine response by expression of a canine interleukin (IL)-12 fused heterodimeric DNA

Saldarriaga, O. A., Perez, L. E., Travi, B. L. & Melby, P. C., Apr 15 2006, In : Veterinary Immunology and Immunopathology. 110, 3-4, p. 377-388 12 p.

Research output: Contribution to journal › Article

4 Scopus citations
2003

CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

Rao, A. R., Quinones, M. P., Garavito, E., Kalkonde, Y., Jimenez, F., Gibbons, C., Perez, J., Melby, P., Kuziel, W., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., Oct 1 2003, In : Journal of Immunology. 171, 9, p. 4875-4885 11 p.

Research output: Contribution to journal › Article

Open Access
28 Scopus citations

Chemokine-cytokine cross-talk: The ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-κB pathway

Chandrasekar, B., Melby, P. C., Sarau, H. M., Raveendran, M., Perla, R. P., Marelli-Berg, F. M., Dulin, N. O. & Singh, I. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4675-4686 12 p.

Research output: Contribution to journal › Article

77 Scopus citations

Fractalkine (CX3CL1) stimulated by nuclear factor κB (NF-κB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

Chandrasekar, B., Mummidi, S., Perla, R. P., Bysani, S., Dulin, N. O., Liu, F. & Melby, P. C., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 547-558 12 p.

Research output: Contribution to journal › Article

120 Scopus citations

Multinutrient undernutrition dysregulates the resident macrophage proinflammatory cytokine network, nuclear factor-κB activation, and nitric oxide production

Anstead, G. M., Chandrasekar, B., Zhang, Q. & Melby, P. C., Dec 1 2003, In : Journal of Leukocyte Biology. 74, 6, p. 982-991 10 p.

Research output: Contribution to journal › Article

35 Scopus citations

Short report: A disseminated infection of Leishmania mexicana in an eastern woodrat, Neotoma floridana, collected in Texas

McHugh, C. P., Thies, M. L., Melby, P. C., Yantis, L. D., Raymond, R. W., Villegas, M. D. & Kerr, S. F., Nov 1 2003, In : American Journal of Tropical Medicine and Hygiene. 69, 5, p. 470-472 3 p.

Research output: Contribution to journal › Article

15 Scopus citations

The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis

Osorio, Y., Melby, P. C., Pirmez, C., Chandrasekar, B., Guarín, N. & Travi, B. L., Mar 1 2003, In : Parasite Immunology. 25, 3, p. 139-148 10 p.

Research output: Contribution to journal › Article

22 Scopus citations
2002

Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp.

Travi, B. L., Osorio, Y., Melby, P. C., Chandrasekar, B., Arteaga, L. & Saravia, N. G., Apr 29 2002, In : Infection and immunity. 70, 5, p. 2288-2296 9 p.

Research output: Contribution to journal › Article

86 Scopus citations

Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation

Yang, F., Liu, X. B., Quinones, M., Melby, P. C., Ghio, A. & Haile, D. J., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39786-39791 6 p.

Research output: Contribution to journal › Article

173 Scopus citations
2001

Analysis of the peripheral immune response in patients with neurocysticercosis: Evidence for T cell reactivity to parasite glycoprotein and vesicular fluid antigens

Restrepo, B. I., Aguilar, M. I., Melby, P. C. & Teale, J. M., Jan 1 2001, In : American Journal of Tropical Medicine and Hygiene. 65, 4, p. 366-370 5 p.

Research output: Contribution to journal › Article

Open Access
28 Scopus citations

Animal models for the analysis of immune responses to leishmaniasis.

Sacks, D. L. & Melby, P. C., May 2001, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 19, p. Unit 19.2

Research output: Contribution to journal › Article

13 Scopus citations

Immunocytochemical detection of Fcγ receptors in human atherosclerotic lesions

Ratcliffe, N. R., Kennedy, S. M., Peter, M. & Morganelli, Jul 2 2001, In : Immunology Letters. 77, 3, p. 169-174 6 p.

Research output: Contribution to journal › Article

53 Scopus citations

Leishmania donovani: Evolution and architecture of the splenic cellular immune response related to control of infection

Melby, P. C., Tabares, A., Restrepo, B. I., Cardona, A. E., McGuff, H. S. & Teale, J. M., Jan 1 2001, In : Experimental Parasitology. 99, 1, p. 17-25 9 p.

Research output: Contribution to journal › Article

38 Scopus citations