Peter Melby, MD

Director, WHO Collaborating Center for Tropical Diseases

  • 3681 Citations
  • 35 h-Index
1987 …2022

Research output per year

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Research Output

  • 3681 Citations
  • 35 h-Index
  • 81 Article
  • 5 Review article
  • 4 Chapter
  • 1 Editorial
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Article

Analysis of the heterogeneity of T-cell responses in human leishmaniasis

Melby, P. C. & Sacks, D. L., Jan 1 1987, In : Annales de l'Institut Pasteur - Immunology. 138, 5, p. 768-771 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
28 Scopus citations

Animal models for the analysis of immune responses to leishmaniasis

Sacks, D. L. & Melby, P., 2015, In : Current Protocols in Immunology. 2015, p. 19.2.1-19.2.24

Research output: Contribution to journalArticle

17 Scopus citations

Animal models for the analysis of immune responses to leishmaniasis.

Sacks, D. L. & Melby, P. C., May 2001, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 19, p. Unit 19.2

Research output: Contribution to journalArticle

13 Scopus citations

An Innovative Field-Applicable Molecular Test to Diagnose Cutaneous Leishmania Viannia spp. Infections

Saldarriaga, O. A., Castellanos, A., Porrozzi, R., Baldeviano, G. C., Lescano, A. G., de Los Santos, M. B., Fernandez, O. L., Saravia, N. G., Costa, E., Melby, P. & Travi, B., Apr 26 2016, In : PLoS Neglected Tropical Diseases. 10, 4, e0004638.

Research output: Contribution to journalArticle

14 Scopus citations

A novel molecular test to diagnose canine visceral leishmaniasis at the point of care

Castellanos, A., Saldarriaga, O. A., Tartaglino, L., Gacek, R., Temple, E., Sparks, H., Melby, P. & Travi, B., Nov 4 2015, In : American Journal of Tropical Medicine and Hygiene. 93, 5, p. 970-975 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
10 Scopus citations

A review of the global epidemiology of scrub typhus

Xu, G., Walker, D., Jupiter, D., Melby, P. & Arcari, C. M., Nov 3 2017, In : PLoS Neglected Tropical Diseases. 11, 11, e0006062.

Research output: Contribution to journalArticle

53 Scopus citations

A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis

Peniche-Trujillo, A-G., Bonilla, D. L., Palma, G. I., Melby, P., Travi, B. & Osorio, E. Y., Jun 1 2017, In : PLoS One. 12, 6, e0179084.

Research output: Contribution to journalArticle

3 Scopus citations

Biological activity of hamster interferon-gamma is modulated by the carboxyl-terminal tail

Zhao, W., Valencia, A. Z. & Melby, P. C., Jun 1 2006, In : Cytokine. 34, 5-6, p. 243-251 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
224 Scopus citations

CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium

Quinones, M. P., Jimenez, F., Martinez, H., Estrada, C. A., Willmon, O., Dudley, M., Kuziel, W. A., Melby, P. C., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., May 1 2006, In : Journal of Molecular Medicine. 84, 6, p. 503-512 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

Rao, A. R., Quinones, M. P., Garavito, E., Kalkonde, Y., Jimenez, F., Gibbons, C., Perez, J., Melby, P., Kuziel, W., Reddick, R. L., Ahuja, S. K. & Ahuja, S. S., Oct 1 2003, In : Journal of Immunology. 171, 9, p. 4875-4885 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

CCR2 plays a critical role in dendritic cell maturation: Possible role of CCL2 and NF-κB

Jimenez, F., Quinones, M. P., Martinez, H. G., Estrada, C. A., Clark, K., Garavito, E., Ibarra, J., Melby, P. C. & Ahuja, S. S., May 15 2010, In : Journal of Immunology. 184, 10, p. 5571-5581 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Chemokine-cytokine cross-talk: The ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-κB pathway

Chandrasekar, B., Melby, P. C., Sarau, H. M., Raveendran, M., Perla, R. P., Marelli-Berg, F. M., Dulin, N. O. & Singh, I. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4675-4686 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes

Travi, B. L., Osorio, E. Y., Saldarriaga, O. A., Cadena, H., Tabares, C. J., Peniche, A., Lee, S. & Melby, P. C., Dec 1 2009, In : American Journal of Tropical Medicine and Hygiene. 81, 6, p. 994-1003 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis

Melby, P. C., Tryon, V. V., Chandrasekar, B. & Freeman, G. L., May 1 1998, In : Infection and immunity. 66, 5, p. 2135-2142 8 p.

Research output: Contribution to journalArticle

109 Scopus citations

Concentration of pentostam® in human breast milk

Berman, J. D., Melby, P. C. & Neva, F. A., Dec 1989, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 83, 6, p. 784-785 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cutaneous leishmaniasis: Review of 59 cases seen at the national institutes of health

Melby, P. C., Kreutzer, R. D., McMahon-Pratt, D., Gam, A. A. & Neva, F. A., Dec 1992, In : Clinical Infectious Diseases. 15, 6, p. 924-937 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Cytokine mRNA expression in Peromyscus yucatanicus (Rodentia: Cricetidae) infected by Leishmania (Leishmania) mexicana

Loria-Cervera, E. N., Sosa-Bibiano, E. I., Van Wynsberghe, N. R., Saldarriaga, O. A., Melby, P. & Andrade-Narvaez, F. J., Jul 1 2016, In : Cytokine. 83, p. 176-181 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Defects in the generation of IFN-γ/are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1α-, or CCR2-deficient mice

Sato, N., Kuziel, W. A., Melby, P. C., Reddick, R. L., Kostecki, V., Zhao, W., Maeda, N., Ahuja, S. K. & Ahuja, S. S., Nov 15 1999, In : Journal of Immunology. 163, 10, p. 5519-5525 7 p.

Research output: Contribution to journalArticle

139 Scopus citations

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection

Ibrahim, M. K., Barnes, J. L., Osorio, E. Y., Anstead, G. M., Jimenez, F., Osterholzer, J. J., Travi, B. L., Ahuja, S. S., White, A. C. & Melby, P. C., 2014, In : Infection and immunity. 82, 8, p. 3098-3112 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection

Ahuja, S. S., Reddick, R. L., Sato, N., Montalbo, E., Kostecki, V., Zhao, W., Dolan, M. J., Melby, P. C. & Ahuja, S. K., Oct 1 1999, In : Journal of Immunology. 163, 7, p. 3890-3897 8 p.

Research output: Contribution to journalArticle

114 Scopus citations

Development of an ex vivo lymph node explant model for identification of novel molecules active against leishmania major

Peniche, A. G., Yaneth, O., Renslo, A. R., Frantz, D. E., Melby, P. C. & Travi, B. L., Jan 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Troyer, D. A. & Freeman, G. L., Jul 17 2000, In : Clinical and Experimental Immunology. 121, 1, p. 112-119 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis

Espitia, C. M., Zhao, W., Saldarriaga, O., Osorio, Y., Harrison, L. M., Cappello, M., Travi, B. L. & Melby, P. C., Jun 22 2010, In : BMC Immunology. 11, 31.

Research output: Contribution to journalArticle

21 Scopus citations

Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous leishmaniasis and visceral leishmaniasis

Al-Abdely, H. M., Graybill, J. R., Bocanegra, R., Najvar, L., Montalbo, E., Regen, S. L. & Melby, P. C., Oct 1 1998, In : Antimicrobial Agents and Chemotherapy. 42, 10, p. 2542-2548 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Efficacy of recombinase polymerase amplification to diagnose trypanosoma cruzi infection in dogs with cardiac alterations from an endemic Area of Mexico

Jimenez-Coello, M., Shelite, T., Castellanos, A., Saldarriaga, O., Rivero, R., Ortega-Pacheco, A., Acevedo-Arcique, C., Amaya-Guardia, K., Garg, N., Melby, P. & Travi, B., Aug 1 2018, In : Vector-Borne and Zoonotic Diseases. 18, 8, p. 417-423 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases

Al-Abdely, H. M., Graybill, J. R., Loebenberg, D. & Melby, P. C., Dec 22 1999, In : Antimicrobial agents and chemotherapy. 43, 12, p. 2910-2914 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

Fractalkine (CX3CL1) stimulated by nuclear factor κB (NF-κB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

Chandrasekar, B., Mummidi, S., Perla, R. P., Bysani, S., Dulin, N. O., Liu, F. & Melby, P. C., Jul 15 2003, In : Biochemical Journal. 373, 2, p. 547-558 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp.

Travi, B. L., Osorio, Y., Melby, P. C., Chandrasekar, B., Arteaga, L. & Saravia, N. G., Apr 29 2002, In : Infection and immunity. 70, 5, p. 2288-2296 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis

Osorio, E. Y., Travi, B. L., da Cruz, A. M., Saldarriaga, O. A., Medina, A. A. & Melby, P. C., Jun 2014, In : PLoS pathogens. 10, 6, e1004165.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of antigens recognized by T cells in human leishmaniasis: Analysis of T-cell clones by immunoblotting

Melby, P. C. & Sacks, D. L., Jan 1 1989, In : Infection and immunity. 57, 10, p. 2971-2976 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

Saldarriaga, O. A., Travi, B. L., Choudhury, G. G. & Melby, P. C., Jul 1 2012, In : Journal of Leukocyte Biology. 92, 1, p. 205-218 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
46 Scopus citations

Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library

Melby, P. C., Ogden, G. B., Flores, H. A., Zhao, W., Geldmacher, C., Biediger, N. M., Ahuja, S. K., Uranga, J. & Melendez, M., Jan 1 2000, In : Infection and immunity. 68, 10, p. 5595-5602 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Immunocytochemical detection of Fcγ receptors in human atherosclerotic lesions

Ratcliffe, N. R., Kennedy, S. M., Peter, M. & Morganelli, Jul 2 2001, In : Immunology Letters. 77, 3, p. 169-174 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs

Saldarriaga, O. A., Travi, B. L., Park, W., Perez, L. E. & Melby, P. C., Mar 10 2006, In : Vaccine. 24, 11, p. 1928-1940 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major

Louzir, H., Melby, P. C., Salah, A. B., Marrakchi, H., Aoun, K., Ismail, R. B. & Dellagi, K., Jan 1 1998, In : Journal of Infectious Diseases. 177, 6, p. 1687-1695 9 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen

Gowen, B. B., Judge, J. W., Wong, M. H., Jung, K. H., Aylsworth, C. F., Melby, P. C., Rosenberg, B. & Morrey, J. D., Aug 1 2008, In : International Immunopharmacology. 8, 8, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis

Melby, P. C., Andrade-Narvaez, F. J., Darnell, B. J., Valencia-Pacheco, G., Tryon, V. V. & Palomo-Cetina, A., Jan 1 1994, In : Infection and immunity. 62, 3, p. 837-842 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Induction of macrophage killing of Leishmania donovani by human CD4+ T cell clones

Melby, P. C., Valencia-Pacheco, G. & Andrade-Narvaez, F., Dec 19 1996, In : Archives of Medical Research. 27, 4, p. 473-479 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Induction of proinflammatory cytokine expression in experimental acute chagasic cardiomyopathy

Chandrasekar, B., Melby, P. C., Troyer, D. A. & Freeman, G. L., Jun 14 1996, In : Biochemical and Biophysical Research Communications. 223, 2, p. 365-371 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

Valencia-Pacheco, G., Loría-Cervera, E. N., Sosa-Bibiano, E. I., Canché-Pool, E. B., Vargas-Gonzalez, A., Melby, P. C. & Andrade-Narvaez, F. J., Sep 2014, In : Cytokine. 69, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis

Melby, P. C., Andrade-Narvaez, F., Darnell, B. J. & Valencia-Pacheco, G., Sep 1996, In : FEMS Immunology and Medical Microbiology. 15, 2-3, p. 101-107 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Lack of serological specificity of recombinant heat shock protein of Leishmania donovani

ARORA, SUNIL. K., MELBY, PETER. C. & SEHGAL, SHOBHA., Oct 1995, In : Immunology and Cell Biology. 73, 5, p. 446-451 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia

Kerr, S. F., Emmons, L. H., Melby, P. C., Liu, C., Perez, L. E., Villegas, M. & Miranda, R., Dec 1 2006, In : American Journal of Tropical Medicine and Hygiene. 75, 6, p. 1069-1073 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Leishmania donovani: Evolution and architecture of the splenic cellular immune response related to control of infection

Melby, P. C., Tabares, A., Restrepo, B. I., Cardona, A. E., McGuff, H. S. & Teale, J. M., Jan 1 2001, In : Experimental Parasitology. 99, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis

Melby, P. C., Yang, J., Zhao, W., Perez, L. E. & Cheng, J., Aug 4 2001, In : Infection and immunity. 69, 8, p. 4719-4725 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Leishmaniasis in Texas: Epidemiology and clinical aspects of human cases

McHugh, C. P., Melby, P. C. & LaFon, S. G., Jan 1 1996, In : American Journal of Tropical Medicine and Hygiene. 55, 5, p. 547-555 9 p.

Research output: Contribution to journalArticle

54 Scopus citations