Pomila Singh, PhD, MS

Program Director, Cell Biology

  • 4128 Citations
  • 37 h-Index
1978 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Inhibition of LEF1-mediated DCLK1 by niclosamide attenuates colorectal cancer stemness

Park, S. Y., Kim, J. Y., Choi, J. H., Kim, J. H., Lee, C. J., Singh, P., Sarkar, S., Baek, J. H. & Nam, J. S., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1415-1429 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017
14 Scopus citations

FOXD3 regulates csc marker, dclk1-s, and invasive potential: Prognostic implications in colon cancer

Sarkar, S., O'Connell, M. R., Okugawa, Y., Lee, B. S., Toiyama, Y., Kusunoki, M., Daboval, R. D., Goel, A. & Singh, P., Dec 1 2017, In : Molecular Cancer Research. 15, 12, p. 1678-1691 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hormonal effects on gastrointestinal cancer growth

Townsend, C., Singh, P. & Thompson, J. C., Jan 1 2017, Growth of the Gastrointestinal Tract: Gastrointestinal Hormones and Growth Factors. CRC Press, p. 207-221 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer

Huynh, P. T., Beswick, E. J., Coronado, Y. A., Johnson, P., O'Connell, M. R., Watts, T., Singh, P., Qiu, S., Morris, K., Powell, D. W. & Pinchuk, I., Apr 15 2016, In : International Journal of Cancer. 138, 8, p. 1971-1981 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Epigenetic regulation of human DCLK-1 gene during coloncarcinogenesis: Clinical and mechanistic implications

Singh, P., O'Connell, M. & Shubhashish, S., Sep 1 2016, In : Stem Cell Investigation. 2016, SEP, 51.

Research output: Contribution to journalReview article

9 Scopus citations
2015

Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications

Oconnell, M. R., Sarkar, S., Luthra, G., Okugawa, Y., Toiyama, Y., Gajjar, A., Qiu, S., Goel, A. & Singh, P., Oct 8 2015, In : Scientific Reports. 5, 14983.

Research output: Contribution to journalArticle

26 Scopus citations

Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis

Kantara, C., O'Connell, M. R., Luthra, G., Gajjar, A., Sarkar, S., Ullrich, R. L. & Singh, P., Jan 31 2015, In : Laboratory Investigation. 95, 1, p. 100-112 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity

Kantara, C., Moya, S. M., Houchen, C. W., Umar, S., Ullrich, R. L., Singh, P. & Carney, D. H., Nov 1 2015, In : Laboratory Investigation. 95, 11, p. 1222-1233 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model

Andey, T., Marepally, S., Patel, A., Jackson, T., Sarkar, S., O'Connell, M., Reddy, R. C., Chellappan, S., Singh, P. & Singh, M., Jun 28 2014, In : Journal of Controlled Release. 184, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA

Kantara, C., O'Connell, M., Sarkar, S., Moya, S., Ullrich, R. & Singh, P., Jan 5 2014, In : Cancer Research. 74, 9, p. 2487-2498 12 p.

Research output: Contribution to journalArticle

68 Scopus citations
2013

Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2012

Clathrin mediates endocytosis of progastrin and activates MAPKs: Role of cell surface annexin A2

Sarkar, S., Kantara, C. & Singh, P., Apr 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 7, p. G712-G722

Research output: Contribution to journalArticle

13 Scopus citations

Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection

Chandrakesan, P., Ahmed, I., Chinthalapally, A., Singh, P., Awasthi, S., Anant, S. & Umar, S., Feb 1 2012, In : Infection and immunity. 80, 2, p. 753-767 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: Phenotypic differences between transformed and nontransformed stem cells

Sarkar, S., Kantara, C., Ortiz, I., Swiercz, R., Kuo, J., Davey, R., Escobar, K., Ullrich, R. & Singh, P., Oct 1 2012, In : International Journal of Cancer. 131, 7, p. E1088-E1099

Research output: Contribution to journalArticle

13 Scopus citations

Progastrin peptides increase the risk of developing colonic tumors: Impact on colonic stem cells

Singh, P., Sarkar, S., Kantara, C. & Maxwell, C., Dec 1 2012, In : Current Colorectal Cancer Reports. 8, 4, p. 277-289 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Annexin A2 mediates Up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells

Sarkar, S., Swiercz, R., Kantara, C., Hajjar, K. A. & Singh, P., Feb 2011, In : Gastroenterology. 140, 2, p. 583-595.e4

Research output: Contribution to journalArticle

42 Scopus citations
2010

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: Critical role of p38MAPK

Singh, P., Sarkar, S., Umar, S., Rengifo-Cam, W., Singh, A. P. & Wood, T. G., Apr 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 4, p. G551-G562

Research output: Contribution to journalArticle

9 Scopus citations

Novel changes in NF-κB activity during progression and regression phases of hyperplasia: Role of MEK, ERK, and p38

Chandrakesan, P., Ahmed, I., Anwar, T., Wang, Y., Sarkar, S., Singh, P., Peleg, S. & Umar, S., Oct 22 2010, In : Journal of Biological Chemistry. 285, 43, p. 33485-33498 14 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Functional cross-talk between β-catenin and NFκB signaling pathways in colonic crypts of mice in response to progastrin

Umar, S., Sarkar, S., Wang, Y. & Singh, P., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22274-22284 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

β-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia

Sellin, J. H., Wang, Y., Singh, P. & Umar, S., Jan 1 2009, In : Experimental Cell Research. 315, 1, p. 97-109 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo

Umar, S., Sarkar, S., Cowey, S. & Singh, P., Sep 18 2008, In : Oncogene. 27, 42, p. 5599-5611 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007
65 Scopus citations

Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-κB

Rengifo-Cam, W., Umar, S., Sarkar, S. & Singh, P., Aug 1 2007, In : Cancer Research. 67, 15, p. 7266-7274 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Role of Annexin-II in GI cancers: Interaction with gastrins/progastrins

Singh, P., Jul 8 2007, In : Cancer Letters. 252, 1, p. 19-35 17 p.

Research output: Contribution to journalShort survey

73 Scopus citations
11 Scopus citations

β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors

Pannequin, J., Delaunay, N., Buchert, M., Surrel, F., Bourgaux, J. F., Ryan, J., Boireau, S., Coelho, J., Pélegrin, A., Singh, P., Shulkes, A., Yim, M., Baldwin, G. S., Pignodel, C., Lambeau, G., Jay, P., Joubert, D. & Hollande, F., Nov 2007, In : Gastroenterology. 133, 5, p. 1554-1568 15 p.

Research output: Contribution to journalArticle

34 Scopus citations
2005

Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression

Cowey, S. L., Quast, M., Belalcazar, L. M., Wei, J., Deng, X., Given, R. & Singh, P., Jun 15 2005, In : Cancer. 103, 12, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004
8 Scopus citations

Intestinal Expression of Mutant and Wild-Type Progastrin Significantly Increases Colon Carcinogenesis in Response to Azoxymethane in Transgenic Mice

Cobb, S., Wood, T., Ceci, J., Varro, A., Velasco, M. & Singh, P., Mar 15 2004, In : Cancer. 100, 6, p. 1311-1323 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Locomotor activity and behavior of mutant mice deleted for gastrin gene expression

Singh, P., Cobb, S., Rengifo-Cam, W., Deng, X., Willis, W. & Li, Q., Mar 1 2004, In : Journal of Physiology and Pharmacology. 55, 1 II, p. 269-278 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: Targets for treatment

Rengifo-Cam, W. & Singh, P., Jul 14 2004, In : Current Pharmaceutical Design. 10, 19, p. 2345-2358 14 p.

Research output: Contribution to journalReview article

41 Scopus citations
2003

pp60c-Src kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro

Brown, D., Yallampalli, U., Owlia, A. & Singh, P., Jan 1 2003, In : Endocrinology. 144, 1, p. 201-211 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
35 Scopus citations

Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites

Singh, P., Lu, X., Cobb, S., Miller, B. T., Tarasova, N., Varro, A. & Owlia, A., Feb 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 2 47-2, p. G328-G339

Research output: Contribution to journalArticle

47 Scopus citations
2002

Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice

Cobb, S., Wood, T., Tessarollo, L., Velasco, M., Given, R., Varro, A., Tarasova, N. & Singh, P., Aug 2002, In : Gastroenterology. 123, 2, p. 516-530 15 p.

Research output: Contribution to journalArticle

29 Scopus citations
2001

Identification of a Novel Cis Element Required for Cell Density-dependent Down-regulation of Insulin-like Growth Factor-2 P3 Promoter Activity in CaCo2 Cells

Dai, B., Wu, H., Holthuizen, E. & Singh, P., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 6937-6944 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2000

Autocrine gastrins in colon cancer cells up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3

Wu, H., Rao, G. N., Dai, B. & Singh, P., Oct 20 2000, In : Journal of Biological Chemistry. 275, 42, p. 32491-32498 8 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Insulin-like growth factor system in growth, development and carcinogenesis

Singh, P., Dec 1 2000, In : Journal of Clinical Ligand Assay. 23, 3, p. 214-232 19 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt loci in response to AOM

Singh, P., Velasco, M., Given, R., Wargovich, M., Varro, A. & Wang, T. C., Mar 1 2000, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 278, 3 41-3, p. G390-G399

Research output: Contribution to journalArticle

73 Scopus citations

Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen

Singh, P., Velasco, M., Given, R., Varro, A. & Wang, T. C., Jul 2000, In : Gastroenterology. 119, 1, p. 162-171 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis

Singh, P., Dai, B., Wu, H. & Owlia, A., Jan 1 2000, In : Current Opinion in Gastroenterology. 16, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
1999

Transcriptional activation of insulin-like growth factor-binding protein-4 by 17β-estradiol in MCF-7 cells: Role of estrogen receptor-sp1 complexes

Qin, C., Singh, P. & Safe, S., Jan 1 1999, In : Endocrinology. 140, 6, p. 2501-2508 8 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations
1998

Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation

Singh, P., Dai, B., Given, R. L., Lu, X. & Holthuizen, P. E., Jan 1 1998, In : Gastroenterology. 114, 6, p. 1221-1229 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erratum: Differential activation of IGF-II promoters p3 and p4 in Caco- 2 cells during growth and differentiation (Gastroenterology (1998) 114 (1221- 1229))

Singh, P., Dai, B., Given, R. L., Lu, X. & Holthuizen, P. E., Jan 1 1998, In : Gastroenterology. 115, 3, 1 p.

Research output: Contribution to journalComment/debate

1997

Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: Endogenous regulation

Dai, B., Widen, S. G., Mifflin, R. & Singh, P., Jan 1 1997, In : Endocrinology. 138, 1, p. 332-343 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Involvement of nitric oxide pathway in prostaglandin F(2α)-induced preterm labor in rats

Dong, Y. L., Be Song Dai, S. D., Singh, P. & Yallampalli, C., Jan 1 1997, In : American journal of obstetrics and gynecology. 177, 4, p. 907-917 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
1996

Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells

Singh, P., Owlia, A., Varro, A., Dai, B., Rajaraman, S. & Wood, T., Sep 15 1996, In : Cancer Research. 56, 18, p. 4111-4115 5 p.

Research output: Contribution to journalArticle

88 Scopus citations

Gastrin gene products and gastrin receptors in colon cancer [2]

Singh, P. & Dickinson, C., Jan 1 1996, In : Gastroenterology. 111, 1, p. 268-269 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
80 Scopus citations