Pomila Singh, PhD, MS

Program Director, Cell Biology

  • 4150 Citations
  • 37 h-Index
1978 …2019

Research output per year

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Research Output

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Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression

Cowey, S. L., Quast, M., Belalcazar, L. M., Wei, J., Deng, X., Given, R. & Singh, P., Jun 15 2005, In : Cancer. 103, 12, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

A comparison of the insulinotropic and the insulin-inhibitory actions of gut peptides on newborn and adult rat islet cells

Ishizuka, J., Singh, P., Greeley, G. H., Townsend, C. M., Cooper, C. W., Tatemoto, K. & Thompson, J. C., Feb 1988, In : Pancreas. 3, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo

Umar, S., Sarkar, S., Cowey, S. & Singh, P., Sep 18 2008, In : Oncogene. 27, 42, p. 5599-5611 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

A direct effect of LHRH on anterior pituitary estrogen receptors in the female rat

Singh, P. & Muldoon, T. G., Jan 1982, In : Journal of Steroid Biochemistry. 16, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Age-related changes in gallbladder contractility and gallbladder cholecystokinin receptor population in the guinea pig

Poston, G. J., Singh, P., Maclellan, D. G., Yao, C. Z., Uchida, T., Townsend, C. M. & Thompson, J. C., 1988, In : Mechanisms of Ageing and Development. 46, 1-3, p. 225-236 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Androgen receptor in breast tissues-I. A new approach for the estimation of androgen receptors in the normal and cancerous mammary gland of women

Singh, P., Murugesan, K., Kapur, M. M. & Laumas, K. R., Jan 1 1979, In : Journal of Steroid Biochemistry. 11, 5-6, p. 1619-1628 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Annexin A2 mediates Up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells

Sarkar, S., Swiercz, R., Kantara, C., Hajjar, K. A. & Singh, P., Feb 2011, In : Gastroenterology. 140, 2, p. 583-595.e4

Research output: Contribution to journalArticle

43 Scopus citations
64 Scopus citations
14 Scopus citations

A novel bombesin receptor antagonist (2258U89), potently inhibits bombesin evoked release of gastrointestinal hormones from rats and dogs, in vitro and in vivo

Singh, P., Guo, Y. S., Kull, F. C. & Leban, J. J., Jul 2 1992, In : Regulatory Peptides. 40, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-κB

Rengifo-Cam, W., Umar, S., Sarkar, S. & Singh, P., Aug 1 2007, In : Cancer Research. 67, 15, p. 7266-7274 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
13 Scopus citations

Apparent lack of involvement of camp as a mediator of lhrh stimulation of nuclear estrogen receptor activity in the rat anterior pituitary

Singh, P., Bhalla, V. K. & Muldoon, T. G., Jan 1 1985, In : Neuroendocrinology. 40, 5, p. 430-437 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
13 Scopus citations

Autocrine gastrins in colon cancer cells up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3

Wu, H., Rao, G. N., Dai, B. & Singh, P., Oct 20 2000, In : Journal of Biological Chemistry. 275, 42, p. 32491-32498 8 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Baseline and luteinizing hormone-releasing hormone-perturbed patterns of estrogen receptor distribution in anterior pituitary cell nuclei

Singh, P. & Muldoon, T. G., Jan 1 1986, In : Endocrinology. 118, 6, p. 2355-2361 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Binding of insulin-like growth factor-I to rat uterus; variations during sensitization and decidualization

Chandrasekhar, Y., Narayan, S., Singh, P. & Nagamani, M., Jan 1 1990, In : Acta Endocrinologica. 123, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Bombesin inhibits growth of human pancreatic adenocarcinoma in nude mice

Alexander, R. W., Upp, J. R., Poston, G. J., Townsend, C. M., Singh, P. & Thompson, J. C., May 1988, In : Pancreas. 3, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model

Andey, T., Marepally, S., Patel, A., Jackson, T., Sarkar, S., O'Connell, M., Reddy, R. C., Chellappan, S., Singh, P. & Singh, M., Jun 28 2014, In : Journal of Controlled Release. 184, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer

Huynh, P. T., Beswick, E. J., Coronado, Y. A., Johnson, P., O'Connell, M. R., Watts, T., Singh, P., Qiu, S., Morris, K., Powell, D. W. & Pinchuk, I., Apr 15 2016, In : International Journal of Cancer. 138, 8, p. 1971-1981 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ceruloplasmin gene expression in human cancer cells

Kunapuli, S. P., Singh, H., Singh, P. & Kumar, A., Jun 8 1987, In : Life Sciences. 40, 23, p. 2225-2228 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Characterization of gastrin binding to colonic mucosal membranes of guinea pigs

Narayan, S., Chicione, L. & Singh, P., Jun 1 1992, In : Molecular and Cellular Biochemistry. 112, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Characterization of insulinlike growth factor I receptors in human colon cancer

Guo, Y. S., Narayan, S., Yallampalli, C. & Singh, P., Apr 1992, In : Gastroenterology. 102, 4 PART 1, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

156 Scopus citations

Characterization of secretin release in response to food and intraduodenal administration of fat and hydrochloric acid

Draviam, E. J., Gomez, G., Hashimoto, T., Miyashita, T., Hill, F. L. C., Uchida, T., Singh, P., Greeley, G. H. & Thompson, J. C., Apr 1 1991, In : Digestive Diseases and Sciences. 36, 4, p. 513-519 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Circadian rhythms in gastrin receptors in rat fundic stomach

Rubin, N. H., Singh, P., Alinder, G., Greeley, G. H., Rayford, P. L., Rietveld, WOP. J. & Thompson, J. C., Aug 1 1988, In : Digestive Diseases and Sciences. 33, 8, p. 931-937 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Clathrin mediates endocytosis of progastrin and activates MAPKs: Role of cell surface annexin A2

Sarkar, S., Kantara, C. & Singh, P., Apr 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 7, p. G712-G722

Research output: Contribution to journalArticle

13 Scopus citations

Clinical Significance of Gastrin Recentors in Human Colon Cancers

Udd, J. R., Singh, P., Townsend, C. M. & Thompson, J. C., Jan 15 1989, In : Cancer Research. 49, 2, p. 488-492 5 p.

Research output: Contribution to journalArticle

157 Scopus citations

Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: Endogenous regulation

Dai, B., Widen, S. G., Mifflin, R. & Singh, P., Jan 1 1997, In : Endocrinology. 138, 1, p. 332-343 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Contractile response of canine gallbladder and sphincter of Oddi to substance P and related peptides in vitro

Guo, Y. S., Singh, P., Gomez, G., Rajaraman, S. & Thompson, J. C., Jun 1 1989, In : Digestive Diseases and Sciences. 34, 6, p. 812-817 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Correlation of cholecystokinin receptors with gallbladder contractility in patients with gallstones

Upp, J. R., Nealon, W. H., Singh, P., Fagan, C. J., Jonas, A. S., Greeley, G. H. & Thompson, J. C., Jan 1 1987, In : Annals of surgery. 205, 6, p. 641-648 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

corticosteroids up-regulate gastrin receptors and stimulate growth of mouse colon cancer (MC-26) in vivo

Samad, Z., Townsend, C., Thompson, J. C. & Singh, P., Jan 1 1987, In : Surgical Forum. 38, p. 178-180 3 p.

Research output: Contribution to journalArticle

Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA

Kantara, C., O'Connell, M., Sarkar, S., Moya, S., Ullrich, R. & Singh, P., Jan 5 2014, In : Cancer Research. 74, 9, p. 2487-2498 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Cytosol and nuclear estradiol receptors in normal and cancerous breast tissue of women

Singh, P., Chattopadhyay, T., Kapur, M. M. & Laumas, K. R., Dec 1 1978, In : Indian Journal of Medical Research. 68, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice

Cobb, S., Wood, T., Tessarollo, L., Velasco, M., Given, R., Varro, A., Tarasova, N. & Singh, P., Aug 2002, In : Gastroenterology. 123, 2, p. 516-530 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Development and age-related changes in pancreatic cholecystokinin receptors and duodenal cholecystokinin in guinea pigs

Poston, G. J., Singh, P., Draviam, E. J., Upp, J. R. & Thompson, J. C., 1988, In : Mechanisms of Ageing and Development. 46, 1-3, p. 59-66 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation

Singh, P., Dai, B., Given, R. L., Lu, X. & Holthuizen, P. E., Jan 1 1998, In : Gastroenterology. 114, 6, p. 1221-1229 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Differential Effects of Ca2+ on Proliferation of Stomach, Colonic, and Pancreatic Cancer Cell Lines In Vitro

Guo, Y. S., Draviam, E., Townsend, C. & Singh, P., Jan 1 1990, In : Nutrition and Cancer. 14, 2

Research output: Contribution to journalArticle

17 Scopus citations

Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection

Chandrakesan, P., Ahmed, I., Chinthalapally, A., Singh, P., Awasthi, S., Anant, S. & Umar, S., Feb 1 2012, In : Infection and immunity. 80, 2, p. 753-767 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Down-regulation of pancreatic growth and gallbladder contractility by bile salts

Gomez, G., Townsend, C. M., Maani, R., Singh, P., Greeley, G. G. & Thompson, J. C., Jan 1989, In : The American Journal of Surgery. 157, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Early stages of gallstone formation in guinea pig are associated with decreased biliary sensitivity to cholecystokinin

Poston, G. J., Singh, P., Draviam, E., Yao, C. Z., Gomez, G. & Thompson, J. C., Aug 1 1992, In : Digestive Diseases and Sciences. 37, 8, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of aging on gastric acid secretion, serum gastrin, and antral gastrin content in rats

Khalil, T., Singh, P., Fujimura, M., Townsend, C. M., Greeley, G. H. & Thompson, J. C., Dec 1 1988, In : Digestive Diseases and Sciences. 33, 12, p. 1544-1548 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Effect of cyclic nucleotides on bombesin-evoked gastrin release from isolated perfused rat stomach

Guo, Y. S., Bhalla, V. K., Thompson, J. C. & Singh, P., Sep 1988, In : Regulatory Peptides. 22, 4, p. 361-369 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effect of estradiol on pancreatic amylase and cholecystokinin binding in ovariectomized guinea pigs

Guo, Y. S. & Singh, P., Sep 1989, In : Journal of Steroid Biochemistry. 33, 3, p. 459-464 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of gastrin-releasing peptide analogues on gastrin and somatostatin release from isolated rat stomach

Guo, Y. S., Mok, L., Cooper, C. W., Greeley, G. H., Thompson, J. C. & Singh, P., Jan 1 1987, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 253, 2, p. 16/2

Research output: Contribution to journalArticle

26 Scopus citations

Effect of Peptide YY on Cephalic, Gastric, and Intestinal Phases of Gastric Acid Secretion and on the Release of Gastrointestinal Hormones

Guo, Y. S., Singh, P., Gomez, G., Greeley, G. H. & Thompson, J. C., Jan 1 1987, In : Gastroenterology. 92, 5, p. 1202-1208 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effect of peptide YY on insulin release stimulated by 2-deoxyglucose and neuropeptides in dogs

Guo, Y. S., Singh, P., Debouno, J. F. & Thompson, J. C., Apr 1988, In : Pancreas. 3, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Effect of somatostatin and tamoxifen on the growth of human pancreatic cancers in nude mice

Poston, G. J., Townsend, C. M., Rajaraman, S., Thompson, J. C. & Singh, P., Mar 1990, In : Pancreas. 5, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Guo, Y. S., Thompson, J. C. & Singh, P., Feb 1989, In : Regulatory Peptides. 24, 2, p. 179-186 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications

Oconnell, M. R., Sarkar, S., Luthra, G., Okugawa, Y., Toiyama, Y., Gajjar, A., Qiu, S., Goel, A. & Singh, P., Oct 8 2015, In : Scientific Reports. 5, 14983.

Research output: Contribution to journalArticle

26 Scopus citations
58 Scopus citations