Research output per year
Research output per year
- 1 - 50 out of 142 results
Search results
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2024
C9orf72-associated dipeptide protein repeats form A11-positive oligomers in amyotrophic lateral sclerosis and frontotemporal dementia
Bhatt, N., Puangmalai, N., Sengupta, U., Jerez, C., Kidd, M., Gandhi, S. & Kayed, R., Feb 2024, In: Journal of Biological Chemistry. 300, 2, 105628.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Characterization of α-synuclein oligomers formed in the presence of lipid vesicles
Dasari, A. K. R., Sengupta, U., Viverette, E., Borgnia, M. J., Kayed, R. & Lim, K. H., Jul 2024, In: Biochemistry and Biophysics Reports. 38, p. 101687 101687.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates
McArthur, N., Kang, B., Rivera Moctezuma, F. G., Shaikh, A. T., Loeffler, K., Bhatt, N. N., Kidd, M., Zupancic, J. M., Desai, A. A., Djeddar, N., Bryksin, A., Tessier, P. M., Kayed, R., Wood, L. B. & Kane, R. S., 2024, (Accepted/In press) In: Biotechnology Progress.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation
Arar, S., Haque, M. A., Bhatt, N., Zhao, Y. & Kayed, R., Apr 3 2024, In: ACS chemical neuroscience. 15, 7, p. 1366-1377 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Shi, H., Mirzaei, N., Koronyo, Y., Davis, M. R., Robinson, E., Braun, G. M., Jallow, O., Rentsendorj, A., Ramanujan, V. K., Fert-Bober, J., Kramerov, A. A., Ljubimov, A. V., Schneider, L. S., Tourtellotte, W. G., Hawes, D., Schneider, J. A., Black, K. L., Kayed, R., Selenica, M. L. B. & Lee, D. C. & 2 others, , Jul 9 2024, In: Acta Neuropathologica. 148, 1, p. 3 3.Research output: Contribution to journal › Article › peer-review
Open Access -
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death
Theofilas, P., Wang, C., Butler, D., Morales, D. O., Petersen, C., Ambrose, A., Chin, B., Yang, T., Khan, S., Ng, R., Kayed, R., Karch, C. M., Miller, B. L., Gestwicki, J. E., Gan, L., Temple, S., Arkin, M. R. & Grinberg, L. T., Sep 2024, In: Molecular and Cellular Neuroscience. 130, 103954.Research output: Contribution to journal › Article › peer-review
Open Access -
Traumatic brain injury derived pathological tau polymorphs induce the distinct propagation pattern and neuroinflammatory response in wild type mice
Puangmalai, N., Bhatt, N., Bittar, A., Jerez, C., Shchankin, N. & Kayed, R., Jan 2024, In: Progress in Neurobiology. 232, 102562.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy
Luciani, M., Montalbano, M., Troncone, L., Bacchin, C., Uchida, K., Daniele, G., Wolf, B. J., Butler, H. M., Kiel, J., Berto, S., Gensemer, C., Moore, K., Morningstar, J., Diteepeng, T., Albayram, O., Abisambra, J. F., Norris, R. A., Di Salvo, T. G., Prosser, B. & Kayed, R. & 1 others, , May 1 2023, In: European Heart Journal. 44, 17, p. 1560-1570 11 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies
Montalbano, M., Majmundar, L., Sengupta, U., Fung, L. & Kayed, R., Jan 2023, In: Brain Pathology. 33, 1, e13112.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies
Moore, K., Sengupta, U., Puangmalai, N., Bhatt, N. & Kayed, R., May 2023, In: Molecular Neurobiology. 60, 5, p. 2691-2705 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy
Hussong, S. A., Banh, A. Q., Van Skike, C. E., Dorigatti, A. O., Hernandez, S. F., Hart, M. J., Ferran, B., Makhlouf, H., Gaczynska, M., Osmulski, P. A., McAllen, S. A., Dineley, K. T., Ungvari, Z., Perez, V. I., Kayed, R. & Galvan, V., Dec 2023, In: Nature communications. 14, 1, 2367.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
The Interplay Between Cholesterol and Amyloid-β on HT22 Cell Viability, Morphology, and Receptor Tyrosine Kinase Signaling
Robinson, M. J., Newbury, S., Singh, K., Leonenko, Z., Beazely, M. A. & Kayed, R., Dec 6 2023, In: Journal of Alzheimer's Disease. 96, 4, p. 1663-1683 21 p.Research output: Contribution to journal › Article › peer-review
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2022
Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease
Marcatti, M., Fracassi, A., Montalbano, M., Natarajan, C., Krishnan, B., Kayed, R. & Taglialatela, G., Apr 2022, In: Cellular and Molecular Life Sciences. 79, 4, 222.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein
Dhakal, S., Robang, A. S., Bhatt, N., Puangmalai, N., Fung, L., Kayed, R., Paravastu, A. K. & Rangachari, V., Nov 2022, In: Journal of Biological Chemistry. 298, 11, 102498.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Longitudinal characterization of retinal vasculature alterations with optical coherence tomography angiography in a mouse model of tauopathy
Buscho, S., Palacios, E., Xia, F., Shi, S., Li, S., Luisi, J., Kayed, R., Motamedi, M., Zhang, W. & Liu, H., Nov 2022, In: Experimental Eye Research. 224, 109240.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease
Puangmalai, N., Sengupta, U., Bhatt, N., Gaikwad, S., Montalbano, M., Bhuyan, A., Garcia, S., McAllen, S., Sonawane, M., Jerez, C., Zhao, Y. & Kayed, R., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101766.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Passive Immunotherapy Targeting Tau Oligomeric Strains Reverses Tauopathy Phenotypes in Aged Human-Tau Mice in a Mouse Model-Specific Manner
Bittar, A., Al-Lahham, R., Bhatt, N., Moore, K., Montalbano, M., Jerez, C., Fung, L., Mcallen, S., Ellsworth, A. & Kayed, R., Nov 22 2022, In: Journal of Alzheimer's Disease. 90, 3, p. 1103-1122 20 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
The amyloid concentric β-barrel hypothesis: Models of amyloid beta 42 oligomers and annular protofibrils
Durell, S. R., Kayed, R. & Guy, H. R., May 2022, In: Proteins: Structure, Function and Bioinformatics. 90, 5, p. 1190-1209 20 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles
Dasari, A. K. R., Dillard, L., Yi, S., Viverette, E., Hojjatian, A., Sengupta, U., Kayed, R., Taylor, K. A., Borgnia, M. J. & Lim, K. H., Sep 6 2022, In: Biochemistry. 61, 17, p. 1766-1773 8 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2021
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons
Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., Ericsson, M., Gorantla, S., Gendelman, H. E., Kayed, R., Ikezu, S., Luebke, J. I. & Ikezu, T., Jan 1 2021, In: Brain. 144, 1, p. 288-309 22 p.Research output: Contribution to journal › Article › peer-review
Open Access130 Scopus citations -
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Moreira, G. G., Cantrelle, F. X., Quezada, A., Carvalho, F. S., Cristóvão, J. S., Sengupta, U., Puangmalai, N., Carapeto, A. P., Rodrigues, M. S., Cardoso, I., Fritz, G., Herrera, F., Kayed, R., Landrieu, I. & Gomes, C. M., Dec 1 2021, In: Nature communications. 12, 1, 6292.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Early alterations of neurovascular unit in the retina in mouse models of tauopathy
Xia, F., Ha, Y., Shi, S., Li, Y., Li, S., Luisi, J., Kayed, R., Motamedi, M., Liu, H. & Zhang, W., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 51.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Infectious etiology and amyloidosis in Alzheimer's disease: The puzzle continues
Kayed, R., Aug 1 2021, In: Journal of Biological Chemistry. 297, 2, 100936.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers
Fernandez-Perez, E. J., Muñoz, B., Bascuñan, D. A., Peters, C., Riffo-Lepe, N. O., Espinoza, M. P., Morgan, P. J., Filippi, C., Bourboulou, R., Sengupta, U., Kayed, R., Epsztein, J. & Aguayo, L. G., Sep 2021, In: Aging cell. 20, 9, e13455.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Tau induces formation of α-synuclein filaments with distinct molecular conformations
Hojjatian, A., Dasari, A. K. R., Sengupta, U., Taylor, D., Daneshparvar, N., Yeganeh, F. A., Dillard, L., Michael, B., Griffin, R. G., Borgnia, M. J., Kayed, R., Taylor, K. A. & Lim, K. H., May 21 2021, In: Biochemical and Biophysical Research Communications. 554, p. 145-150 6 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes
Montalbano, M., Jaworski, E., Garcia, S., Ellsworth, A., McAllen, S., Routh, A. & Kayed, R., Dec 3 2021, In: Frontiers in Molecular Neuroscience. 14, 742790.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia
Gaikwad, S., Puangmalai, N., Bittar, A., Montalbano, M., Garcia, S., McAllen, S., Bhatt, N., Sonawane, M., Sengupta, U. & Kayed, R., Jul 20 2021, In: Cell Reports. 36, 3, 109419.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
2020
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein
Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
2019
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury
Bittar, A., Bhatt, N., Hasan, T. F., Montalbano, M., Puangmalai, N., Mcallen, S., Ellsworth, A., Carretero Murillo, M., Taglialatela, G., Lucke-Wold, B., Logsdon, A., Rosen, C., Turner, R. C. & Kayed, R., 2019, In: Brain Communications. 1, 1, fcz004.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
NLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D. & Latz, E. & 2 others, , Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.Research output: Contribution to journal › Article › peer-review
Open Access797 Scopus citations -
Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations
Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2018
AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation
Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In: Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Azure C Targets and Modulates Toxic Tau Oligomers
Lo Cascio, F. & Kayed, R., Jun 20 2018, In: ACS chemical neuroscience. 9, 6, p. 1317-1326 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides
Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In: Chemical Communications. 54, 72, p. 10120-10123 4 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits
Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease
Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies
Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior
Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412Research output: Contribution to journal › Article › peer-review
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Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations