• 2147 Citations
  • 30 h-Index
1992 …2020
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Personal profile

Personal profile

Division: Vaccinology

Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati.  He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.

Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.  His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.  Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.

Fingerprint Dive into the research topics where Richard Pyles is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Human Herpesvirus 2 Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Herpes Genitalis Medicine & Life Sciences
Guinea Pigs Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Respiratory Tract Infections Medicine & Life Sciences
Microbiota Medicine & Life Sciences
Mycoplasma genitalium Medicine & Life Sciences

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Projects 2014 2020

Research Output 1992 2019

  • 2147 Citations
  • 30 h-Index
  • 72 Article
  • 1 Review article

Associations of the microbiome and esophageal disease

Okereke, I., Hamilton, C., Wenholz, A., Jala, V., Giang, T., Reynolds, S., Miller, A. & Pyles, R., Jan 1 2019, In : Journal of Thoracic Disease. 11, p. S1588-S1593

Research output: Contribution to journalReview article

Esophageal Diseases
Gastroesophageal Reflux
Barrett Esophagus
1 Citation (Scopus)

Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K., Bourne, N. & Pyles, R., Jan 1 2019, In : Frontiers in Microbiology. 10, JAN, 03340.

Research output: Contribution to journalArticle

Open Access
Virus Replication
Epithelial Cells
Viral Load

Development of a novel ex vivo nasal epithelial cell model supporting colonization with human nasal microbiota

Charles, D. D., Fisher, J. R., Hoskinson, S. M., Medina-Colorado, A. A., Shen, Y. C., Chaaban, M., Widen, S., Eaves-Pyles, T., Maxwell, C. A., Miller, A. L., Popov, V. & Pyles, R., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, MAY, 165.

Research output: Contribution to journalArticle

Open Access
Epithelial Cells
Tissue Donors

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Virus Shedding
2 Citations (Scopus)

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

Human herpesvirus 2
Virus Shedding
viral shedding
Human Herpesvirus 2
guinea pigs