• 2238 Citations
  • 30 h-Index
1992 …2019

Research output per year

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Personal profile

Personal profile

Division: Vaccinology

Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati.  He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.

Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.  His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.  Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.

Research interests

  • COVID-19

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Projects

Research Output

  • 2238 Citations
  • 30 h-Index
  • 69 Article
  • 3 Review article
  • 1 Comment/debate

Associations of the microbiome and esophageal disease

Okereke, I., Hamilton, C., Wenholz, A., Jala, V., Giang, T., Reynolds, S., Miller, A. & Pyles, R., Jan 1 2019, In : Journal of Thoracic Disease. 11, p. S1588-S1593

Research output: Contribution to journalReview article

  • Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

    Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K., Bourne, N. & Pyles, R., Jan 1 2019, In : Frontiers in Microbiology. 10, JAN, 03340.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Development of a novel ex vivo nasal epithelial cell model supporting colonization with human nasal microbiota

    Charles, D. D., Fisher, J. R., Hoskinson, S. M., Medina-Colorado, A. A., Shen, Y. C., Chaaban, M., Widen, S., Eaves-Pyles, T., Maxwell, C. A., Miller, A. L., Popov, V. & Pyles, R., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, MAY, 165.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

    Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

    Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.

    Research output: Contribution to journalArticle

  • 2 Scopus citations