• 2023 Citations
  • 28 h-Index
1992 …2020
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Personal profile

Division: Vaccinology

Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati.  He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.

Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.  His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.  Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Human Herpesvirus 2 Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Herpes Genitalis Medicine & Life Sciences
Guinea Pigs Medicine & Life Sciences
Respiratory Tract Infections Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Mycoplasma genitalium Medicine & Life Sciences
Otitis Media Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2020

Research Output 1992 2019

  • 2023 Citations
  • 28 h-Index
  • 69 Article
1 Citation (Scopus)

Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K., Bourne, N. & Pyles, R., Jan 1 2019, In : Frontiers in Microbiology. 10, JAN, 03340.

Research output: Contribution to journalArticle

Open Access
Microbiota
Simplexvirus
Virus Replication
Epithelial Cells
Viral Load

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Virus Shedding
Foreskin
Perineum
Immunity

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

Human herpesvirus 2
Virus Shedding
viral shedding
Human Herpesvirus 2
guinea pigs
2 Citations (Scopus)

Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc

Vincent, K., Moss, J. A., Marzinke, M. A., Hendrix, C. W., Anton, P. A., Gunawardana, M., Dawson, L. N., Olive, T. J., Pyles, R. & Baum, M. M., Aug 1 2018, In : PLoS One. 13, 8, e0201952.

Research output: Contribution to journalArticle

Tenofovir
Anti-Retroviral Agents
Human immunodeficiency virus 1
pods
HIV-1
9 Citations (Scopus)

Production and transplantation of bioengineered lung into a large-animal model

Nichols, J., La Francesca, S., Niles, J. A., Vega, S. P., Argueta, L. B., Frank, L., Christiani, D. C., Pyles, R., Himes, B. E., Zhang, R., Li, S., Sakamoto, J., Rhudy, J., Hendricks, G., Begarani, F., Liu, X., Patrikeev, I., Pal, R., Usheva, E., Vargas, G. & 7 othersMiller, A., Woodson, L., Wacher, A., Grimaldo, M., Weaver, D., Mlcak, R. & Cortiella, J., Aug 1 2018, In : Science Translational Medicine. 10, 452, eaao3926.

Research output: Contribution to journalArticle

Lung Transplantation
Animal Models
Lung
Transplants
Tissue Survival