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Research Strategic Pillar
The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Personal profile
Division: Vaccinology
Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati. ?He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.
Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.? His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.? Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.
Research Strategic Pillar Keywords
- Life Span Health
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Collaborations and top research areas from the last five years
Projects
- 3 Completed
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Translational studies of the fecal microbiome associated with BIAFAC
Pyles, R. (PI)
Glenn Greenberg and Linda Vester Foundation ( Award # )
1/1/22 → 12/31/24
Project: Research project
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The Dynamics of Nasal Bacterial Ecology and S. aureus Antagonism
Pyles, R. (PI)
George Washington University ( Award #5R01AI12556204)
6/1/16 → 5/31/20
Project: Research project
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EL II: Anti-HIV/SHIV Efficacy of Combination Antiretroviral Intravaginal Rings
Pyles, R. (PI)
Oak Crest Institute of Science ( Award #5U19AI11304805)
8/11/14 → 7/31/19
Project: Research project
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The Gut Microbiome as a Modulator of Traumatic Brain Injury Pathology and Symptoms
Vonder Haar, C., Celorrio, M., Martens, K. M., Friess, S. H., Villapol, S., Urban, R. J., Pyles, R., Mychasiuk, R., Simon, D. & Dave, A., Nov 12 2025, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 45, 46Research output: Contribution to journal › Review article › peer-review
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Growth hormone treatment for neurologic symptoms of post-acute sequelae of COVID-19
Wright, T. J., Sheffield-Moore, M., Pyles, R. B., Randolph, K. M., McGovern, K. A., Danesi, C. P., Lindsay, S. E., Zaidan, M. F., Masel, B. E. & Urban, R. J., Jun 2024, In: Clinical and translational science. 17, 6, p. e13826 e13826.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Low growth hormone secretion associated with post-acute sequelae SARS-CoV-2 infection (PASC) neurologic symptoms: A case-control pilot study
Wright, T. J., Pyles, R. B., Sheffield-Moore, M., Deer, R., Randolph, K. M., McGovern, K. A., Danesi, C. P., Gilkison, C. R., Ward, W. W., Vargas, J. A., Armstrong, P. A., Lindsay, S. E., Zaidan, M. F., Seashore, J., Wexler, T. L., Masel, B. E. & Urban, R. J., Jan 1 2024, In: Molecular and Cellular Endocrinology. 579, p. 112071 112071.Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Scopus citations -
Prevalence of fatigue and cognitive impairment after traumatic brain injury
Wright, T. J., Elliott, T. R., Randolph, K. M., Pyles, R. B., Masel, B. E., Urban, R. J. & Sheffield-Moore, M., Mar 2024, In: PloS one. 19, 3 March, e0300910.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
The altered TBI fecal microbiome is stable and functionally distinct
Pyles, R. B., Miller, A. L., Urban, R. J., Sheffield-Moore, M., Wright, T. J., Maxwell, C. A., Randolph, K. M., Danesi, C. P., McGovern, K. A., Vargas, J., Armstrong, P., Kreber, L., Cumpa, G., Randall, K., Morrison, M. & Masel, B. E., Mar 13 2024, In: Frontiers in Molecular Neuroscience. 17, p. 1341808 1341808.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations