Projects per year
Personal profile
Research Strategic Pillar
Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Research interests
Dr. Cross’ research is centered on the biology and pathogenesis of high priority viral agents with a particular emphasis on elucidating mechanisms of vascular leak, coagulopathy, and immune derangement in viral hemorrhagic fever infections caused by filoviruses, arenaviruses, and bunyaviruses. His work utilizes a systems biology, molecular virology, and comparative pathogenesis approaches which utilize in vitro and in vivo models which accurately recapitulate human disease. The goal of this work is to dissect the events leading to disease or survival in order to develop medical countermeasures including vaccines, therapeutics, and diagnostics. Dr. Cross also has a long standing interest in the epidemiology and ecology of these viruses where a particular focus has been centered on mammalian reservoirs of viral infection.
Research Strategic Pillar Keywords
- Infectious/ Immunological Health
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Pathogenic Mammarenavirus and Orthohantavirus in Argentina
Cross, R. (PI)
7/1/23 → 11/30/24
Project: Research project
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Natural History Studies of Henipaviruses and Emerging Bat Borne Viruses
Cross, R. (PI)
US Department of Agriculture-ARS
8/22/22 → 4/30/27
Project: Research project
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Monoclonal antibody therapy demonstrates increased virulence of a lineage VII strain of Lassa virus in nonhuman primates
Woolsey, C., Cross, R. W., Prasad, A. N., Agans, K. N., Borisevich, V., Deer, D. J., Dobias, N. S., Fears, A. C., Harrison, M. B., Heinrich, M. L., Fenton, K., Garry, R. F., Branco, L. M. & Geisbert, T. W., Dec 2024, In: Emerging Microbes and Infections. 13, 1, p. 2301061 2301061.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Monoclonal antibody therapy protects nonhuman primates against mucosal exposure to Lassa virus
Cross, R. W., Fenton, K. A., Woolsey, C., Prasad, A. N., Borisevich, V., Agans, K. N., Deer, D. J., Dobias, N. S., Fears, A. C., Heinrich, M. L., Geisbert, J. B., Garry, R. F., Branco, L. M. & Geisbert, T. W., Feb 20 2024, In: Cell Reports Medicine. 5, 2, 101392.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus
Cross, R., Woolsey, C., Chu, V. C., Babusis, D., Bannister, R., Vermillion, M. S., Geleziunas, R., Barrett, K. T., Bunyan, E., Nguyen, A. Q., Cihlar, T., Porter, D. P., Prasad, A., Deer, D. J., Borisevich, V., Agans, K. N., Martinez, J., Harrison, M. B., Dobias, N. S. & Fenton, K. A. & 2 others, , Mar 15 2024, In: Science. 383, 6688, p. eadk6176 eadk6176.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates
Zeitlin, L., Cross, R. W., Courtney, W., Brandyn, R. W., Borisevich, V., Agans, K. N., Prasad, A., Deer, D. J., Stuart, L., McCavitt-Malvido, M., Kim, D. H., Pettitt, J., Crowe, J. E., Whaley, K. J., Veesler, D., Dimitrov, A., Abelson, D. M., Geisbert, T. W. & Broder, C. C., 2024, In: Science Translational Medicine. 16, 741, eadl2055.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection
To, A., Wong, T. A. S., Ball, A. H., Lieberman, M. M., Yalley-Ogunro, J., Cabus, M., Nezami, S., Paz, F., Elyard, H. A., Borisevich, V., Agans, K. N., Deer, D. J., Woolsey, C., Cross, R. W., Geisbert, T. W., Donini, O. & Lehrer, A. T., Jan 25 2024, In: Vaccine. 42, 3, p. 598-607 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations