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Robert Cross, PhD

  • 599 Citations
  • 15 h-Index
20102019
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Personal profile

Research interests

Dr. Cross’ research is centered on the biology and pathogenesis of high priority viral agents with a particular emphasis on elucidating mechanisms of vascular leak, coagulopathy, and immune derangement in viral hemorrhagic fever infections caused by filoviruses, arenaviruses, and bunyaviruses. His work utilizes a systems biology, molecular virology, and comparative pathogenesis approaches which utilize in vitro and in vivo models which accurately recapitulate human disease. The goal of this work is to dissect the events leading to disease or survival in order to develop medical countermeasures including vaccines, therapeutics, and diagnostics. Dr. Cross also has a long standing interest in the epidemiology and ecology of these viruses where a particular focus has been centered on mammalian reservoirs of viral infection.

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  • 30 Similar Profiles
Ebolavirus Medicine & Life Sciences
Lassa virus Medicine & Life Sciences
Lassa Fever Medicine & Life Sciences
Ferrets Medicine & Life Sciences
Ebola Hemorrhagic Fever Medicine & Life Sciences
Primates Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Marburgvirus Medicine & Life Sciences

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Research Output 2010 2019

  • 599 Citations
  • 15 h-Index
  • 33 Article
  • 3 Review article
  • 2 Chapter
  • 2 Comment/debate

Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

Satterfield, B. A., Borisevich, V., Foster, S. L., Rodriguez, S. E., Cross, R. W., Fenton, K. A., Agans, K. N., Basler, C. F., Geisbert, T. W. & Mire, C. E., Dec 1 2019, In : Scientific reports. 9, 1, 16710.

Research output: Contribution to journalArticle

Open Access
Nipah Virus
Ferrets
Virus Diseases
Mutation
Genes

Antibody therapy for Lassa fever

Cross, R., Hastie, K. M., Mire, C., Robinson, J. E., Geisbert, T., Branco, L. M., Ollmann Saphire, E. & Garry, R. F., Aug 1 2019, In : Current Opinion in Virology. 37, p. 97-104 8 p.

Research output: Contribution to journalReview article

Lassa Fever
Lassa virus
Monoclonal Antibodies
Antibodies
Epitopes
9 Citations (Scopus)

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C., He, S., Cross, R., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

Ebolavirus
Ferrets
Primates
Antibodies
Ebola Hemorrhagic Fever

Author Correction: Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants (Scientific Reports, (2017), 7, 1, (9730), 10.1038/s41598-017-09963-y)

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2019, In : Scientific reports. 9, 1, 7329.

Research output: Contribution to journalComment/debate

Open Access
Ebolavirus
Overlapping Genes
Gene Expression
Infection

A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge

Woolsey, C., Menicucci, A. R., Cross, R., Luthra, P., Agans, K. N., Borisevich, V., Geisbert, J. B., Mire, C., Fenton, K. A., Jankeel, A., Anand, S., Ebihara, H., Geisbert, T., Messaoudi, I. & Basler, C. F., Sep 17 2019, In : Cell Reports. 28, 12, p. 3032-3046.e6

Research output: Contribution to journalArticle

Open Access
Ebolavirus
Viruses
Virulence
Immunity
Interferon Type I