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Robert Cross, PhD

  • 628 Citations
  • 15 h-Index
20102020
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Personal profile

Research interests

Dr. Cross’ research is centered on the biology and pathogenesis of high priority viral agents with a particular emphasis on elucidating mechanisms of vascular leak, coagulopathy, and immune derangement in viral hemorrhagic fever infections caused by filoviruses, arenaviruses, and bunyaviruses. His work utilizes a systems biology, molecular virology, and comparative pathogenesis approaches which utilize in vitro and in vivo models which accurately recapitulate human disease. The goal of this work is to dissect the events leading to disease or survival in order to develop medical countermeasures including vaccines, therapeutics, and diagnostics. Dr. Cross also has a long standing interest in the epidemiology and ecology of these viruses where a particular focus has been centered on mammalian reservoirs of viral infection.

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Ebolavirus Medicine & Life Sciences
Lassa virus Medicine & Life Sciences
Lassa Fever Medicine & Life Sciences
Primates Medicine & Life Sciences
Ferrets Medicine & Life Sciences
Ebola Hemorrhagic Fever Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
Marburgvirus Medicine & Life Sciences

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Research Output 2010 2020

  • 628 Citations
  • 15 h-Index
  • 35 Article
  • 3 Review article
  • 2 Chapter
  • 2 Comment/debate

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Cross, R. W., Xu, R., Matassov, D., Hamm, S., Latham, T. E., Gerardi, C. S., Nowak, R. M., Geisbert, J. B., Ota-Setlik, A., Agans, K. N., Luckay, A., Witko, S. E., Soukieh, L., Deer, D. J., Mire, C. E., Feldmann, H., Happi, C., Fenton, K. A., Eldridge, J. H. & Geisbert, T. W., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access
Viral Hemorrhagic Fevers
Lassa virus
Primates
Glycoproteins
Vaccines

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Cohen-Dvashi, H., Amon, R., Agans, K. N., Cross, R. W., Borenstein-Katz, A., Mateo, M., Baize, S., Padler-Karavani, V., Geisbert, T. W. & Diskin, R., Dec 1 2020, In : Nature communications. 11, 1, 67.

Research output: Contribution to journalArticle

Open Access
Arenavirus
Tropics
Transferrin Receptors
Viruses
tropical regions

Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

Satterfield, B. A., Borisevich, V., Foster, S. L., Rodriguez, S. E., Cross, R. W., Fenton, K. A., Agans, K. N., Basler, C. F., Geisbert, T. W. & Mire, C. E., Dec 1 2019, In : Scientific reports. 9, 1, 16710.

Research output: Contribution to journalArticle

Open Access
Nipah Virus
Ferrets
Virus Diseases
Mutation
Genes

Antibody therapy for Lassa fever

Cross, R., Hastie, K. M., Mire, C., Robinson, J. E., Geisbert, T., Branco, L. M., Ollmann Saphire, E. & Garry, R. F., Aug 1 2019, In : Current Opinion in Virology. 37, p. 97-104 8 p.

Research output: Contribution to journalReview article

Lassa Fever
Lassa virus
Monoclonal Antibodies
Antibodies
Epitopes
10 Citations (Scopus)

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C., He, S., Cross, R., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

Ebolavirus
Ferrets
Primates
Antibodies
Ebola Hemorrhagic Fever