Personal profile
Research Strategic Pillar
The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Research interests
Dr. Cross’ research is centered on the biology and pathogenesis of high priority viral agents with a particular emphasis on elucidating mechanisms of vascular leak, coagulopathy, and immune derangement in viral hemorrhagic fever infections caused by filoviruses, arenaviruses, and bunyaviruses. His work utilizes a systems biology, molecular virology, and comparative pathogenesis approaches which utilize in vitro and in vivo models which accurately recapitulate human disease. The goal of this work is to dissect the events leading to disease or survival in order to develop medical countermeasures including vaccines, therapeutics, and diagnostics. Dr. Cross also has a long standing interest in the epidemiology and ecology of these viruses where a particular focus has been centered on mammalian reservoirs of viral infection.
Research Strategic Pillar Keywords
- Infectious/ Immunological Health
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Collaborations and top research areas from the last five years
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Therapeutic Efficacy of Hyperimmune Equine Serum against Ebola in Guinea Pigs
Cross, R. (PI)
University of Saskatchewan ( Award # )
11/1/25 → 5/31/26
Project: Research project
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Investigation of Nipah Virus Pathogenesis
Cross, R. (PI)
US Department of Agriculture-ARS ( Award #5830224052)
9/1/24 → 4/30/27
Project: Research project
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Natural History Studies of Henipaviruses and Emerging Bat Borne Viruses
Cross, R. (PI)
US Department of Agriculture-ARS ( Award #5830222028)
8/22/22 → 4/30/27
Project: Research project
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Pathogenic Mammarenavirus and Orthohantavirus in Argentina
Cross, R. (PI)
RTI International ( Award #5U01AI15137804)
7/1/23 → 11/30/24
Project: Research project
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A single-cycle recombinant VSV vaccine displaying the Hendra virus glycoprotein uniformly protects against Hendra and Nipah virus challenge
Pigeaud, D. D., Borisevich, V., Agans, K. N., Harrison, M. B., O’Toole, R., Martinez, J., Dobias, N. S., Woolsey, C., Fenton, K. A., Geisbert, T. W. & Cross, R. W., Dec 2026, In: npj Vaccines. 11, 1, 21.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and Optimization of First-in-Class Furopyrimidine-Based Inhibitors of Henipaviruses
Gaisina, I. N., Argade, M. D., Bott, R., Bradley, S. P., Tomorowicz, Ł., Alvarez, M., Galván Achi, J. M., Cross, R. W., Borisevich, V., O’Toole, R., Amaya, M., Zielinski, C. A., Gaisin, A. M., Nikolic, D., Carlier, P. R., Anantpadma, M., Moore, T. W., Broder, C. C., Geisbert, T. W. & Peet, N. P. & 1 others, , Jan 22 2026, In: Journal of medicinal chemistry. 69, 2, p. 1264-1285 22 p.Research output: Contribution to journal › Article › peer-review
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Oral 4′-fluorouridine rescues nonhuman primates from advanced Lassa fever
Cross, R. W., Turcinovic, J., Prasad, A. N., Borisevich, V., Agans, K. N., Deer, D. J., O’Toole, R., Dobias, N. S., Woolsey, C., Fenton, K. A. & Geisbert, T. W., Feb 26 2026, In: Nature. 650, 8103, p. 961-969 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Animal Models of Pathogenic New World Arenaviruses
Alvarado, A. V., Cross, R. W., Geisbert, T. W. & Woolsey, C., Jun 2025, In: Microorganisms. 13, 6, 1358.Research output: Contribution to journal › Review article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Evaluation of antigen and antibody assays for surveillance of Lassa virus in peri-domestic rodents in southeastern Sierra Leone: a cross-sectional study
Smither, A., Koninga, J., Kanneh, F. B., Foday, M., Boisen, M. L., Bond, N. G., Momoh, M., Sandi, J. D., Kanneh, L., Alhasan, F., Kanneh, I. M., Yillah, M. S., Grant, D. S., Bush, D. J., Nelson, D. K. S., Cruz, K. M., Klitting, R., Pauthner, M. G., Andersen, K. G. & Shaffer, J. G. & 4 others, , Nov 2025, In: The Lancet Microbe. 6, 11, 101188.Research output: Contribution to journal › Article › peer-review
Open Access