Projects per year
Personal profile
Research Strategic Pillar
Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Personal profile
Division: Clinical and Experimental Immunology and Infectious Disease
Dr. Garofalo is Professor of Pediatrics, Microbiology and Immunology, Pharmacology and Toxicology.? He received his undergraduate degree from Maturita’ Classica, Liceo Ginnasio G. Carducci, Milano, Italy and his MD at the University of the Studies of Milano in Italy. He completed his residency in pediatrics at Istituto di Scienze Biomediche, Ospedal S. Paolo, University of the Studies of Milano and his postdoctoral fellowship in Infectious Disease at the Children’s Hospital, State University of New York at Buffalo.
He is Vice Chair for Research and Director of the Division of Clinical and Experimental Immunology & Infectious Disease, in the Department of Pediatrics at UTMB. He is a pediatrician-scientist with more than twenty years of NIH, NASA, and DoD-funded clinical, translational and basic research on bronchiolitis. Dr. Garofalo is internationally recognized for his work on respiratory syncytial virus, with expertise in murine models of paramyxovirus infections and mouse immunology. He has mentored disadvantaged and underrepresented minority, pre and post-baccalaureate students and has experience in heading multidisciplinary teams. As a pediatrician, his expertise and funded research is in the areas of lung mucosal immunology, pathogenesis of respiratory infections, and genetic and environmental determinants of airway pathophysiology in children. Using comprehensive proteomics approaches he has characterized a novel oxidative-driven pathway of airway inflammation in infants. He has also led research teams in the area of lung diseases, including one of the CTSA multidisciplinary translational teams at UTMB, and he is co-PI of the NIAID-funded Program Project “Signaling in Airway Inflammation”.? He was recently the Project Leader of NASA funded research “Effect of Spaceflight on Innate Immunity to Respiratory Viral Infections, Mouse Immunology-2”, from Space Shuttle Discovery, STS-133, and the Project Leader on NASA research tissue sharing project “Effect of Spaceflight on Lung Gene and Protein Expression Profiles” from the last mission of Space Shuttle Atlantis, STS-135
Research interests
- Drug Discovery
Research Strategic Pillar Keywords
- Specialized Health
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Collaborations and top research areas from the last five years
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Extracellular Vesicles (EVs) Innate Immune Cargo in Respiratory Viral Infections
Garofalo, R. P. (PI)
National Institute of Allergy and Infectious Diseases
6/18/24 → 4/30/26
Project: Research project
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Admin Core
Garofalo, R. P. (PI)
National Institute of Allergy and Infectious Diseases
7/25/18 → 6/30/25
Project: Research project
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Innate Inhibitory Activity and Anti-SARS-CoV-2 Antibodies in Human Milk
Garofalo, R. P. (PI)
11/20/20 → 11/19/23
Project: Research project
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Fellow: Aline Haas de Mello; Role of Endogenous Hydrogen Sulfide and Trans-sulfuration Pathway in Antiviral T cell Immunity
Garofalo, R. P. (PI)
American Association of Immunologists
9/1/20 → 8/31/21
Project: Research project
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Role of the endogenous gasotransmitter H2S in ETS-mediated airway disease
Garofalo, R. P. (PI)
National Institute of Environmental Health Sciences
6/1/16 → 5/31/19
Project: Research project
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CXCL17 is a proinflammatory chemokine and promotes neutrophil trafficking
Lowry, E., Chellappa, R. C., Penaranda, B., Sawant, K. V., Wakamiya, M., Garofalo, R. P. & Rajarathnam, K., May 29 2024, In: Journal of Leukocyte Biology. 115, 6, p. 1177-1182 6 p.Research output: Contribution to journal › Article › peer-review
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Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
Sawant, K. V., Sepuru, K. M., Penaranda, B., Lowry, E., Garofalo, R. P. & Rajarathnam, K., Nov 24 2023, In: Journal of Leukocyte Biology. 114, 6, p. 666-671 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Micro-CT Features of Lung Consolidation, Collagen Deposition and Inflammation in Experimental RSV Infection Are Aggravated in the Absence of Nrf2
Ivanciuc, T., Patrikeev, I., Qu, Y., Motamedi, M., Jones-Hall, Y., Casola, A. & Garofalo, R. P., May 2023, In: Viruses. 15, 5, 1191.Research output: Contribution to journal › Article › peer-review
Open Access -
Parent tRNA Modification Status Determines the Induction of Functional tRNA-Derived RNA by Respiratory Syncytial Virus Infection
Choi, E. J., Wu, W., Zhang, K., Yuan, X., Deng, J., Ismail, D., Buck, D. L., Thomason, K. S., Garofalo, R. P., Zhang, S. & Bao, X., Jan 2023, In: Viruses. 15, 1, 57.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection
Qu, Y., Haas de Mello, A., Morris, D. R., Jones-Hall, Y. L., Ivanciuc, T., Sattler, R. A., Paessler, S., Menachery, V. D., Garofalo, R. P. & Casola, A., May 2023, In: Microbiology Spectrum. 11, 3Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations