• 21871 Citations
  • 86 h-Index
1973 …2022

Research output per year

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Research Output

2019

Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

Research output: Contribution to journalArticle

DNA polymerase θ accomplishes translesion synthesis opposite 1, N 6 -ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In : Genes and Development. 33, 5-6, p. 282-287 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In : Cell. 176, 6, p. 1295-1309.e15

Research output: Contribution to journalArticle

8 Scopus citations

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 16400.

Research output: Contribution to journalArticle

Open Access

Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

Research output: Contribution to journalArticle

2018

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In : Scientific Reports. 8, 1, 12702.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In : Scientific Reports. 7, 43904.

Research output: Contribution to journalArticle

7 Scopus citations

Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., 2017, In : Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Human DNA polymerase α in binary complex with a DNA: DNA template-primer

Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In : Scientific Reports. 6, 23784.

Research output: Contribution to journalArticle

12 Scopus citations

Response to Burgers et al.

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In : Molecular Cell. 61, 4, p. 494-495 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 1 2016, In : Science advances. 2, 10, e1601317.

Research output: Contribution to journalArticle

27 Scopus citations
2015

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In : Molecular Cell. 59, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

110 Scopus citations

Genetic control of replication through N1-methyladenine in human cells

Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In : Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In : Genes and Development. 29, 24, p. 2588-2602 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε

Jain, R., Vanamee, E. S., Dzikovski, B. G., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 301-308 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 13177-13185 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Crystal structure of yeast DNA polymerase ε catalytic domain

Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 14 2014, In : PloS one. 9, 4, e94835.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of two functional PCNA-binding domains in human DNA polymerase κ

Yoon, J. H., Acharya, N., Park, J., Basu, D., Prakash, S. & Prakash, L., Jul 2014, In : Genes to Cells. 19, 7, p. 594-601 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

The Architecture of Yeast DNA Polymerase ζ

Gómez-Llorente, Y., Malik, R., Jain, R., Choudhury, J. R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 17 2013, In : Cell Reports. 5, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012
4 Scopus citations

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In : Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
101 Scopus citations
16 Scopus citations

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In : Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

Research output: Contribution to journalArticle

54 Scopus citations
2011

DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

Acharya, N., Klassen, R., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17927-17932 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast

Gangavarapu, V., Maria, S. R. S., Prakash, S. & Prakash, L., May 1 2011, In : mBio. 2, 3

Research output: Contribution to journalArticle

12 Scopus citations

Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 29 2011, In : Journal of Molecular Biology. 408, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

Error-free replicative bypass of (6-4) photoproducts by DNA polymerase ζ in mouse and human cells

Yoon, J. H., Prakash, L. & Prakash, S., Jan 15 2010, In : Genes and Development. 24, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

57 Scopus citations
44 Scopus citations

Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase δ

Dieckman, L. M., Johnson, R. E., Prakash, S. & Washington, M. T., Aug 31 2010, In : Biochemistry. 49, 34, p. 7344-7350 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η

Silverstein, T. D., Jain, R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Nov 10 2010, In : Structure. 18, 11, p. 1463-1470 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural basis for the suppression of skin cancers by DNA polymerase

Silverstein, T. D., Johnson, R. E., Jain, R., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 24 2010, In : Nature. 465, 7301, p. 1039-1043 5 p.

Research output: Contribution to journalArticle

104 Scopus citations
2009

DNA Synthesis across an Abasic Lesion by Human DNA Polymerase ι

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 15 2009, In : Structure. 17, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
96 Scopus citations

Replication across Template T/U by Human DNA Polymerase-ι

Jain, R., Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jul 15 2009, In : Structure. 17, 7, p. 974-980 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reply to sabbioneda et al. Role of ubiquitin-binding motif of human DNA polymerase ν in translesion synthesis

Acharya, N., Yoon, J. H., Gali, H., Unk, I., Haracska, L., Johnson, R. E., Hurwitz, J., Prakash, L. & Prakash, S., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. E21

Research output: Contribution to journalLetter

1 Scopus citations

Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast

Pagès, V., Santa Maria, S. R., Prakash, L. & Prakash, S., Jun 15 2009, In : Genes and Development. 23, 12, p. 1438-1449 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase Δ

Swan, M. K., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Sep 1 2009, In : Nature Structural and Molecular Biology. 16, 9, p. 979-986 8 p.

Research output: Contribution to journalArticle

156 Scopus citations

Structural Insights into Yeast DNA Polymerase δ by Small Angle X-ray Scattering

Jain, R., Hammel, M., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 4 2009, In : Journal of Molecular Biology. 394, 3, p. 377-382 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Structure of human DNA polymerase κ inserting dATP opposite an 8-OxoG DNA lesion

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Swan, M. K., Choudhury, J. R., Johnson, R. E., Prakash, S., Prakash, L. & Aggarwal, A. K., Jun 2 2009, In : PloS one. 4, 6, e5766.

Research output: Contribution to journalArticle

39 Scopus citations

Structure of the Human Rev1-DNA-dNTP Ternary Complex

Swan, M. K., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jul 24 2009, In : Journal of Molecular Biology. 390, 4, p. 699-709 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Yeast Rev1 protein promotes complex formation of DNA polymerase ζ with Pol32 subunit of DNA polymerase δ

Acharya, N., Johnson, R. E., Pagès, V., Prakash, L. & Prakash, S., Jun 16 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 24, p. 9631-9636 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

Unk, I., Hajdú, I., Fátyol, K., Hurwitz, J., Yoon, J. H., Prakash, L., Prakash, S. & Haracska, L., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 10, p. 3768-3773 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

Pagès, V., Johnson, R. E., Prakash, L. & Prakash, S., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Protein-Template-Directed Synthesis across an Acrolein-Derived DNA Adduct by Yeast Rev1 DNA Polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 12 2008, In : Structure. 16, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

Zhuang, Z., Johnson, R. E., Haracska, L., Prakash, L., Prakash, S. & Benkovic, S. J., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5361-5366 6 p.

Research output: Contribution to journalArticle

95 Scopus citations

Requirement of Rad5 for DNA polymerase ζ-dependent translesion synthesis in Saccharomyces cerevisiae

Pagès, V., Bresson, A., Acharya, N., Prakash, S., Fuchs, R. P. & Prakash, L., Sep 2008, In : Genetics. 180, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase η in translesion DNA synthesis

Acharya, N., Yoon, J. H., Gali, H., Unk, I., Haracska, L., Johnson, R. E., Hurwitz, J., Prakash, L. & Prakash, S., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17724-17729 6 p.

Research output: Contribution to journalArticle

84 Scopus citations