• 22280 Citations
  • 87 h-Index
1973 …2020

Research output per year

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Research Output

2020

Corrigendum: DNA polymerase θ accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2020, In : Genes & development. 34, 1-2, p. 146 1 p.

Research output: Contribution to journalComment/debate

Open Access

Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 5918-5927 10 p.

Research output: Contribution to journalArticle

Open Access

Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

Malik, R., Kopylov, M., Gomez-Llorente, Y., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., 2020, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

2019

Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

DNA polymerase θ accomplishes translesion synthesis opposite 1, N 6 -ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In : Genes and Development. 33, 5-6, p. 282-287 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In : Cell. 176, 6, p. 1295-1309.e15

Research output: Contribution to journalArticle

17 Scopus citations

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 16400.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 13 2019, In : Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Feb 23 2018, In : Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In : Scientific reports. 8, 1, 12702.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In : Scientific reports. 7, 43904.

Research output: Contribution to journalArticle

8 Scopus citations

Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In : Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Human DNA polymerase α in binary complex with a DNA:DNA template-primer

Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In : Scientific reports. 6, 23784.

Research output: Contribution to journalArticle

14 Scopus citations

Response to Burgers et al.

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In : Molecular Cell. 61, 4, p. 494-495 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 2016, In : Science Advances. 2, 10, e1601317.

Research output: Contribution to journalArticle

30 Scopus citations
2015

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In : Molecular cell. 59, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

115 Scopus citations

Genetic control of replication through N1-methyladenine in human cells

Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In : Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In : Genes and Development. 29, 24, p. 2588-2602 15 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε

Jain, R., Vanamee, E. S., Dzikovski, B. G., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 301-308 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., 2014, In : Journal of Biological Chemistry. 289, 19, p. 13177-13185 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Crystal structure of yeast DNA polymerase ε catalytic domain

Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 14 2014, In : PloS one. 9, 4, e94835.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of two functional PCNA-binding domains in human DNA polymerase κ

Yoon, J. H., Acharya, N., Park, J., Basu, D., Prakash, S. & Prakash, L., Jul 2014, In : Genes to Cells. 19, 7, p. 594-601 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

The Architecture of Yeast DNA Polymerase ζ

Gómez-Llorente, Y., Malik, R., Jain, R., Choudhury, J. R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 17 2013, In : Cell Reports. 5, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012
5 Scopus citations

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In : Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
109 Scopus citations
17 Scopus citations

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In : Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
2011

DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

Acharya, N., Klassen, R., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17927-17932 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast

Gangavarapu, V., Maria, S. R. S., Prakash, S. & Prakash, L., 2011, In : mBio. 2, 3, e00079-11.

Research output: Contribution to journalArticle

12 Scopus citations

Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 29 2011, In : Journal of Molecular Biology. 408, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

Error-free replicative bypass of (6-4) photoproducts by DNA polymerase ζ in mouse and human cells

Yoon, J. H., Prakash, L. & Prakash, S., Jan 15 2010, In : Genes and Development. 24, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

60 Scopus citations
46 Scopus citations

Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase δ

Dieckman, L. M., Johnson, R. E., Prakash, S. & Washington, M. T., Aug 31 2010, In : Biochemistry. 49, 34, p. 7344-7350 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η

Silverstein, T. D., Jain, R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Nov 10 2010, In : Structure. 18, 11, p. 1463-1470 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structural basis for the suppression of skin cancers by DNA polymerase

Silverstein, T. D., Johnson, R. E., Jain, R., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 24 2010, In : Nature. 465, 7301, p. 1039-1043 5 p.

Research output: Contribution to journalArticle

107 Scopus citations
2009

DNA Synthesis across an Abasic Lesion by Human DNA Polymerase ι

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 15 2009, In : Structure. 17, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
102 Scopus citations

Replication across Template T/U by Human DNA Polymerase-ι

Jain, R., Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jul 15 2009, In : Structure. 17, 7, p. 974-980 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reply to sabbioneda et al. Role of ubiquitin-binding motif of human DNA polymerase ν in translesion synthesis

Acharya, N., Yoon, J. H., Gali, H., Unk, I., Haracska, L., Johnson, R. E., Hurwitz, J., Prakash, L. & Prakash, S., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. E21

Research output: Contribution to journalLetter

2 Scopus citations

Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast

Pagès, V., Santa Maria, S. R., Prakash, L. & Prakash, S., Jun 15 2009, In : Genes and Development. 23, 12, p. 1438-1449 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase Δ

Swan, M. K., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Sep 1 2009, In : Nature Structural and Molecular Biology. 16, 9, p. 979-986 8 p.

Research output: Contribution to journalArticle

162 Scopus citations

Structural Insights into Yeast DNA Polymerase δ by Small Angle X-ray Scattering

Jain, R., Hammel, M., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 4 2009, In : Journal of Molecular Biology. 394, 3, p. 377-382 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Structure of human DNA polymerase κ inserting dATP opposite an 8-OxoG DNA lesion

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Swan, M. K., Choudhury, J. R., Johnson, R. E., Prakash, S., Prakash, L. & Aggarwal, A. K., Jun 2 2009, In : PloS one. 4, 6, e5766.

Research output: Contribution to journalArticle

40 Scopus citations

Structure of the Human Rev1-DNA-dNTP Ternary Complex

Swan, M. K., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jul 24 2009, In : Journal of Molecular Biology. 390, 4, p. 699-709 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Yeast Rev1 protein promotes complex formation of DNA polymerase ζ with Pol32 subunit of DNA polymerase δ

Acharya, N., Johnson, R. E., Pagès, V., Prakash, L. & Prakash, S., Jun 16 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 24, p. 9631-9636 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

Unk, I., Hajdú, I., Fátyol, K., Hurwitz, J., Yoon, J. H., Prakash, L., Prakash, S. & Haracska, L., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 10, p. 3768-3773 6 p.

Research output: Contribution to journalArticle

143 Scopus citations

Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

Pagès, V., Johnson, R. E., Prakash, L. & Prakash, S., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Protein-Template-Directed Synthesis across an Acrolein-Derived DNA Adduct by Yeast Rev1 DNA Polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 12 2008, In : Structure. 16, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

45 Scopus citations