• 21994 Citations
  • 86 h-Index
1973 …2022

Research output per year

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Research Output

2003
76 Scopus citations

Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate

Washington, M. T., Wolfle, W. T., Spratt, T. E., Prakash, L. & Prakash, S., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5113-5118 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2002

Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini

Washington, M. T., Johnson, R. E., Prakash, L. & Prakash, S., Feb 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 1910-1914 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

Torres-Ramos, C. A., Prakash, S. & Prakash, L., Mar 25 2002, In : Molecular and cellular biology. 22, 7, p. 2419-2426 8 p.

Research output: Contribution to journalArticle

131 Scopus citations

Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription: Implications for Cockayne syndrome

Lee, S. K., Yu, S. L., Prakash, L. & Prakash, S., Jun 28 2002, In : Cell. 109, 7, p. 823-834 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Role of human DNA polymerase κ as an extender in translesion synthesis

Haracska, L., Prakash, L. & Prakash, S., Dec 10 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 25, p. 16000-16005 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Stimulation of 3′→5′ exonuclease and 3′-phosphodiesterase activities of yeast Apn2 by proliferating cell nuclear antigen

Unk, I., Haracska, L., Gomes, X. V., Burgers, P. M. J., Prakash, L. & Prakash, S., Sep 1 2002, In : Molecular and cellular biology. 22, 18, p. 6480-6486 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Stimulation of DNA synthesis activity of human DNA polymerase κ by PCNA

Haracska, L., Unk, I., Johnson, R. E., Phillips, B. B., Hurwitz, J., Prakash, L. & Prakash, S., Jan 1 2002, In : Molecular and cellular biology. 22, 3, p. 784-791 8 p.

Research output: Contribution to journalArticle

Open Access
145 Scopus citations

Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

Prakash, S. & Prakash, L., Aug 1 2002, In : Genes and Development. 16, 15, p. 1872-1883 12 p.

Research output: Contribution to journalReview article

267 Scopus citations
39 Scopus citations

Yeast Rev1 protein is a G template-specific DNA polymerase

Haracska, L., Prakash, S. & Prakash, L., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 15546-15551 6 p.

Research output: Contribution to journalArticle

124 Scopus citations
2001
52 Scopus citations

Accuracy of lesion bypass by yeast and human DNA polymerase η

Washington, M. T., Johnson, R. E., Prakash, L. & Prakash, S., Jul 17 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 15, p. 8355-8360 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Acidic residues critical for the activity and biological function of yeast DNA polymerase η

Kondratick, C. M., Washington, M. T., Prakash, S. & Prakash, L., Mar 1 2001, In : Molecular and Cellular Biology. 21, 6, p. 2018-2025 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Eukaryotic DNA Polymerases: Proposal for a Revised Nomenclature

Burgers, P. M. J., Koonin, E. V., Bruford, E., Blanco, L., Burtis, K. C., Christman, M. F., Copeland, W. C., Friedberg, E. C., Hanaoka, F., Hinkle, D. C., Lawrence, C. W., Nakanishi, M., Ohmori, H., Prakash, L., Prakash, S., Reynaud, C. A., Sugino, A., Todo, T., Wang, Z., Weill, J. C. & 1 others, Woodgate, R., Nov 23 2001, In : Journal of Biological Chemistry. 276, 47, p. 43487-43490 4 p.

Research output: Contribution to journalShort survey

261 Scopus citations

Fidelity and Damage Bypass Ability of Schizosaccharomyces pombe Eso1 Protein, Comprised of DNA Polymerase ηand Sister Chromatid Cohesion Protein Ctf7

Madril, A. C., Johnson, R. E., Washington, M. T., Prakash, L. & Prakash, S., Nov 16 2001, In : Journal of Biological Chemistry. 276, 46, p. 42857-42862 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inefficient Bypass of an Abasic Site by DNA Polymerase η

Haracska, L., Washington, M. T., Prakash, S. & Prakash, L., Mar 2 2001, In : Journal of Biological Chemistry. 276, 9, p. 6861-6866 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Interaction with PCNA is essential for yeast DNA polymerase η function

Haracska, L., Kondratick, C. M., Unk, I., Prakash, S. & Prakash, L., Jan 1 2001, In : Molecular cell. 8, 2, p. 407-415 9 p.

Research output: Contribution to journalArticle

164 Scopus citations

Mismatch extension ability of yeast and human DNA polymerase η

Washington, M. T., Johnson, R. E., Prakash, S. & Prakash, L., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2263-2266 4 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Physical and functional interactions of human DNA polymerase η with PCNA

Haracska, L., Johnson, R. E., Unk, I., Phillips, B., Hurwitz, J., Prakash, L. & Prakash, S., Oct 22 2001, In : Molecular and cellular biology. 21, 21, p. 7199-7206 8 p.

Research output: Contribution to journalArticle

195 Scopus citations

Requirement for yeast RAD26, a homolog of the human CSB gene, in elongation by RNA polymerase II

Lee, S. K., Yu, S. L., Prakash, L. & Prakash, S., Dec 13 2001, In : Molecular and Cellular Biology. 21, 24, p. 8651-8656 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Requirement of DNA polymerase η for error-free bypass of UV-induced CC and TC photoproducts

Yu, S. L., Johnson, R. E., Prakash, S. & Prakash, L., Jan 1 2001, In : Molecular and cellular biology. 21, 1, p. 185-188 4 p.

Research output: Contribution to journalArticle

113 Scopus citations

Role of DNA polymerase η in the bypass of a (6-4) TT photoproduct

Johnson, R. E., Haracska, L., Prakash, S. & Prakash, L., May 9 2001, In : Molecular and cellular biology. 21, 10, p. 3558-3563 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Roles of yeast DNA polymerases δ and ζ of Rev 1 in the bypass of abasic sites

Haracska, L., Unk, I., Johnson, R. E., Johansson, E., Burgers, P. M. J., Prakash, S. & Prakash, L., Apr 15 2001, In : Genes and Development. 15, 8, p. 945-954 10 p.

Research output: Contribution to journalArticle

262 Scopus citations

Structure of the Catalytic Core of S. cerevisiae DNA polymerase η: Implications for translesion DNA synthesis

Trincao, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L. & Aggarwal, A. K., Jan 1 2001, In : Molecular cell. 8, 2, p. 417-426 10 p.

Research output: Contribution to journalArticle

279 Scopus citations

Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

Haracska, L., Johnson, R. E., Unk, I., Phillips, B. B., Hurwitz, J., Prakash, L. & Prakash, S., Dec 4 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 25, p. 14256-14261 6 p.

Research output: Contribution to journalArticle

166 Scopus citations

The Y-family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P. P., Goodman, M. F., Hanaoka, F., Hinkle, D., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., Prakash, L., Prakash, S., Todo, T., Walker, G. C., Wang, Z. & Woodgate, R., Jan 1 2001, In : Molecular cell. 8, 1, p. 7-8 2 p.

Research output: Contribution to journalLetter

685 Scopus citations

Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N2-Guanine Adducts of 1,3-Butadiene Metabolites

Minko, I. G., Washington, M. T., Prakash, L., Prakash, S. & Lloyd, R. S., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2517-2522 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Yeast DNA polymerase η utilizes an induced-fit mechanism of nucleotide incorporation

Washington, M. T., Prakash, L. & Prakash, S., Dec 28 2001, In : Cell. 107, 7, p. 917-927 11 p.

Research output: Contribution to journalArticle

108 Scopus citations
2000

Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η

Washington, M. T., Johnson, R. E., Prakash, S. & Prakash, L., Mar 28 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 7, p. 3094-3099 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Apurinic endonuclease activity of yeast Apn2 protein

Unk, I., Haracska, L., Johnson, R. E., Prakash, S. & Prakash, L., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 22427-22434 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

Haracska, L., Yu, S. L., Johnson, R. E., Prakash, L. & Prakash, S., Dec 1 2000, In : Nature Genetics. 25, 4, p. 458-461 4 p.

Research output: Contribution to journalArticle

278 Scopus citations

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, pol ηThe XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase ηhRAD30 mutations in the variant form of xeroderma pigmentosum

Johnson, R. E., Prakash, S., Prakash, L., Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwoi, S., Tokio, K., Hanaoka, F., Johnson, R. E., Kondratick, C. M., Prakash, S. & Prakash, L., Dec 1 2000, In : Chemtracts. 13, 3, p. 203-210 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

Johnson, R. E., Washington, M. T., Haracska, L., Prakash, S. & Prakash, L., Aug 31 2000, In : Nature. 406, 6799, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

532 Scopus citations

Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast

Torres-Ramos, C. A., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2000, In : Molecular and Cellular Biology. 20, 10, p. 3522-3528 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Fidelity of human DNA polymerase η

Johnson, R. E., Washington, M. T., Prakash, S. & Prakash, L., Mar 17 2000, In : Journal of Biological Chemistry. 275, 11, p. 7447-7450 4 p.

Research output: Contribution to journalArticle

344 Scopus citations

Nucleotide excision repair in yeast

Prakash, S. & Prakash, L., Jun 30 2000, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 451, 1-2, p. 13-24 12 p.

Research output: Contribution to journalReview article

254 Scopus citations

Replication past O6-Methylguanine by yeast and human DNA polymerase η

Haracska, L., Prakash, S. & Prakash, L., Jan 1 2000, In : Molecular and cellular biology. 20, 21, p. 8001-8007 7 p.

Research output: Contribution to journalArticle

111 Scopus citations

Role of yeast and human DNA polymerase η in error-free replication of damaged DNA

Prakash, S., Johnson, R. E., Washington, M. T., Haracska, L., Kondratick, C. M. & Prakash, L., Dec 1 2000, In : Cold Spring Harbor Symposia on Quantitative Biology. 65, p. 51-59 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The human DINB1 gene encodes the DNA polymerase Polθ

Johnson, R. E., Prakash, S. & Prakash, L., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 3838-3843 6 p.

Research output: Contribution to journalArticle

155 Scopus citations
1999

Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA

Johnson, R. E., Washington, M. T., Prakash, S. & Prakash, L., Oct 26 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12224-12226 3 p.

Research output: Contribution to journalComment/debate

130 Scopus citations

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Polη

Johnson, R. E., Prakash, S. & Prakash, L., Feb 12 1999, In : Science. 283, 5404, p. 1001-1004 4 p.

Research output: Contribution to journalArticle

642 Scopus citations

Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase η

Washington, M. T., Johnson, R. E., Prakash, S. & Prakash, L., Dec 24 1999, In : Journal of Biological Chemistry. 274, 52, p. 36835-36838 4 p.

Research output: Contribution to journalArticle

153 Scopus citations

hRAD30 mutations in the variant form of xeroderma pigmentosum

Johnson, R. E., Kondratick, C. M., Prakash, S. & Prakash, L., Jul 9 1999, In : Science. 285, 5425, p. 263-265 3 p.

Research output: Contribution to journalArticle

629 Scopus citations

Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function

Johnson, R. E., Prakash, S. & Prakash, L., Jun 4 1999, In : Journal of Biological Chemistry. 274, 23, p. 15975-15977 3 p.

Research output: Contribution to journalArticle

103 Scopus citations

Requirement of yeast SGS1 and SRS2 genes for replication and transcription

Lee, S. K., Johnson, R. E., Yu, S. L., Prakash, L. & Prakash, S., Dec 17 1999, In : Science. 286, 5448, p. 2339-2342 4 p.

Research output: Contribution to journalArticle

121 Scopus citations

Synergistic interaction between yeast nucleotide excision repair factors NEF2 and NEF4 in the binding of ultraviolet-damaged DNA

Guzder, S. N., Sung, P., Prakash, L. & Prakash, S., Aug 20 1999, In : Journal of Biological Chemistry. 274, 34, p. 24257-24262 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
1998

Affinity of yeast nucleotide excision repair factor 2, consisting of the Rad4 and Rad23 proteins, for ultraviolet damaged DNA

Guzder, S. N., Sung, P., Prakash, L. & Prakash, S., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 31541-31546 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes

Habraken, Y., Sung, P., Prakash, L. & Prakash, S., Apr 17 1998, In : Journal of Biological Chemistry. 273, 16, p. 9837-9841 5 p.

Research output: Contribution to journalArticle

103 Scopus citations

Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 Å resolution

Worthylake, D. K., Prakash, S., Prakash, L. & Hill, C. P., Mar 13 1998, In : Journal of Biological Chemistry. 273, 11, p. 6271-6276 6 p.

Research output: Contribution to journalArticle

54 Scopus citations