• 21994 Citations
  • 86 h-Index
1973 …2022

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2007

Complex formation of yeast Rev1 with DNA polymerase η

Acharya, N., Haracska, L., Prakash, S. & Prakash, L., Dec 1 2007, In : Molecular and cellular biology. 27, 23, p. 8401-8408 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
45 Scopus citations

Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass

Lone, S., Townson, S. A., Uljon, S. N., Johnson, R. E., Brahma, A., Nair, D. T., Prakash, S., Prakash, L. & Aggarwal, A. K., Feb 23 2007, In : Molecular cell. 25, 4, p. 601-614 14 p.

Research output: Contribution to journalArticle

181 Scopus citations

Mutations in the ubiquitin binding UBZ motif of DNA polymerase η do not impair its function in translesion synthesis during replication

Acharya, N., Brahma, A., Haracska, L., Prakash, L. & Prakash, S., Oct 1 2007, In : Molecular and cellular biology. 27, 20, p. 7266-7272 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein

Howell, C. A., Prakash, S. & Washington, M. T., Nov 20 2007, In : Biochemistry. 46, 46, p. 13451-13459 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Requirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

Santa Maria, S. R., Gangavarapu, V., Johnson, R. E., Prakash, L. & Prakash, S., Dec 1 2007, In : Molecular and cellular biology. 27, 23, p. 8409-8418 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

Gangavarapu, V., Prakash, S. & Prakash, L., Nov 1 2007, In : Molecular and cellular biology. 27, 21, p. 7758-7764 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Yeast Rad5 Protein Required for Postreplication Repair Has a DNA Helicase Activity Specific for Replication Fork Regression

Blastyák, A., Pintér, L., Unk, I., Prakash, L., Prakash, S. & Haracska, L., Oct 12 2007, In : Molecular cell. 28, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

199 Scopus citations
2006

An Incoming Nucleotide Imposes an anti to syn Conformational Change on the Templating Purine in the Human DNA Polymerase-ι Active Site

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2006, In : Structure. 14, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

48 Scopus citations
32 Scopus citations
95 Scopus citations

Hoogsteen base pair formation promotes synthesis opposite the 1,N 6-ethenodeoxyadenosine lesion by human DNA polymerase ι

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jul 1 2006, In : Nature Structural and Molecular Biology. 13, 7, p. 619-625 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Human DNA polymerase κ forms nonproductive complexes with matched primer termini but not with mismatched primer termini

Carlson, K. D., Johnson, R. E., Prakash, L., Prakash, S. & Washington, M. T., Oct 24 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 43, p. 15776-15781 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

Unk, I., Hajdú, I., Fátyol, K., Szakál, B., Blastyák, A., Bermudez, V., Hurwitz, J., Prakash, L., Prakash, S. & Haracska, L., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18107-18112 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiae

Gangavarapu, V., Haracska, L., Unk, I., Johnson, R. E., Prakash, S. & Prakash, L., Oct 1 2006, In : Molecular and cellular biology. 26, 20, p. 7783-7790 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases ι and κ

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Jan 1 2006, In : Molecular and cellular biology. 26, 1, p. 381-386 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
38 Scopus citations

Role of Hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase ι

Johnson, R. E., Haracska, L., Prakash, L. & Prakash, S., Sep 1 2006, In : Molecular and cellular biology. 26, 17, p. 6435-6441 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
102 Scopus citations
2005

A single domain in human DNA polymerase ι mediates interaction with PCNA: Implications for translesion DNA synthesis

Haracska, L., Acharya, N., Unk, I., Johnson, R. E., Hurwitz, J., Prakash, L. & Prakash, S., Feb 1 2005, In : Molecular and cellular biology. 25, 3, p. 1183-1190 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
51 Scopus citations

Biochemistry: Rev1 employs a novel mechanism of DNA synthesis using a protein template

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Sep 30 2005, In : Science. 309, 5744, p. 2219-2222 4 p.

Research output: Contribution to journalArticle

178 Scopus citations

Complex formation of yeast Rev1 and Rev7 proteins: A novel role for the polymerase-associated domain

Acharya, N., Haracska, L., Johnson, R. E., Unk, I., Prakash, S. & Prakash, L., Nov 1 2005, In : Molecular and cellular biology. 25, 21, p. 9734-9740 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
27 Scopus citations

DNA polymerases: Hoogsteen base-pairing in DNA replication? (reply)

Aggarwal, A., Nair, D., Johnson, R., Prakash, L. & Prakash, S., Sep 14 2005, In : Nature. 437, 7057, p. E7

Research output: Contribution to journalArticle

2 Scopus citations

Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase κ

Wolfle, W. T., Washington, M. T., Kool, E. T., Spratt, T. E., Helquist, S. A., Prakash, L. & Prakash, S., Aug 1 2005, In : Molecular and cellular biology. 25, 16, p. 7137-7143 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Human DNA polymerase ι incorporates dCTP opposite template G via a G.C+ hoogsteen base pair

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 1 2005, In : Structure. 13, 10, p. 1569-1577 9 p.

Research output: Contribution to journalArticle

100 Scopus citations

Human DNA polymerase ι promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Oct 1 2005, In : Molecular and cellular biology. 25, 19, p. 8748-8754 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Trf4 and Trf5 proteins of Saccharomyces cerevisiae exhibit poly(A) RNA polymerase activity but no DNA polymerase activity

Haracska, L., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2005, In : Molecular and cellular biology. 25, 22, p. 10183-10189 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
2004

Crystal structure of the catalytic core of human DNA polymerase kappa

Uljon, S. N., Johnson, R. E., Edwards, T. A., Prakash, S., Prakash, L. & Aggarwal, A. K., Aug 1 2004, In : Structure. 12, 8, p. 1395-1404 10 p.

Research output: Contribution to journalArticle

84 Scopus citations

Dpo4 is hindered in extending a G·T mismatch by a reverse wobble

Trincao, J., Johnson, R. E., Wolfle, W. T., Escalante, C. R., Prakash, S., Prakash, L. & Aggarwal, A. K., May 1 2004, In : Nature Structural and Molecular Biology. 11, 5, p. 457-462 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases ι and κ

Washington, M. T., Minko, I. G., Johnson, R. E., Wolfle, W. T., Harris, T. M., Lloyd, R. S., Prakash, S. & Prakash, L., Jul 1 2004, In : Molecular and Cellular Biology. 24, 13, p. 5687-5693 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Efficient and error-free replication past a minor-groove N 2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase

Washington, M. T., Minko, I. G., Johnson, R. E., Haracska, L., Harris, T. M., Lloyd, R. S., Prakash, S. & Prakash, L., Aug 1 2004, In : Molecular and cellular biology. 24, 16, p. 6900-6906 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

Human DNA Polymerase ι Utilizes Different Nucleotide Incorporation Mechanisms Dependent upon the Template Base

Washington, M. T., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2004, In : Molecular and cellular biology. 24, 2, p. 936-943 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

Haracska, L., Torres-Ramos, C. A., Johnson, R. E., Prakash, S. & Prakash, L., May 1 2004, In : Molecular and cellular biology. 24, 10, p. 4267-4274 8 p.

Research output: Contribution to journalArticle

170 Scopus citations

Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

Nair, D. T., Johnson, R. E., Prakash, S., Prakash, L. & Aggarwal, A. K., Jul 15 2004, In : Nature. 430, 6997, p. 377-380 4 p.

Research output: Contribution to journalArticle

234 Scopus citations

Requirement of yeast Rad1-Rad10 nuclease for the removal of 3′-blocked termini from DNA strand breaks induced by reactive oxygen species

Guzder, S. N., Torres-Ramos, C., Johnson, R. E., Haracska, L., Prakash, L. & Prakash, S., Sep 15 2004, In : Genes and Development. 18, 18, p. 2283-2291 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair

Haracska, L., Prakash, L. & Prakash, S., Nov 15 2003, In : Genes and Development. 17, 22, p. 2777-2785 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases

Johnson, R. E., Trincao, J., Aggarwal, A. K., Prakash, S. & Prakash, L., Apr 1 2003, In : Molecular and Cellular Biology. 23, 8, p. 3008-3012 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Human DNA polymerase κ uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions

Wolfle, W. T., Washington, M. T., Prakash, L. & Prakash, S., Sep 1 2003, In : Genes and Development. 17, 17, p. 2191-2199 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
64 Scopus citations

Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase η

Washington, M. T., Helquist, S. A., Kool, E. T., Prakash, L. & Prakash, S., Jul 1 2003, In : Molecular and Cellular Biology. 23, 14, p. 5107-5112 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

The Mechanism of Nucleotide Incorporation by Human DNA Polymerase η Differs from That of the Yeast Enzyme

Washington, M. T., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2003, In : Molecular and cellular biology. 23, 22, p. 8316-8322 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

The stalling of transcription at abasic sites is highly mutagenic

Yu, S. L., Lee, S. K., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2003, In : Molecular and cellular biology. 23, 1, p. 382-388 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Translesion synthesis past acrolein-derived DNA adduct, γ-hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase η

Minko, I. G., Washington, M. T., Kanuri, M., Prakash, L., Prakash, S. & Lloyd, R. S., Jan 10 2003, In : Journal of Biological Chemistry. 278, 2, p. 784-790 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Yeast DNA polymerase zeta (ζ) is essential for error-free replication past thymine glycol

Johnson, R. E., Yu, S. L., Prakash, S. & Prakash, L., Jan 1 2003, In : Genes and Development. 17, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

77 Scopus citations
76 Scopus citations

Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate

Washington, M. T., Wolfle, W. T., Spratt, T. E., Prakash, L. & Prakash, S., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5113-5118 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2002

Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini

Washington, M. T., Johnson, R. E., Prakash, L. & Prakash, S., Feb 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 1910-1914 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

Torres-Ramos, C. A., Prakash, S. & Prakash, L., Mar 25 2002, In : Molecular and cellular biology. 22, 7, p. 2419-2426 8 p.

Research output: Contribution to journalArticle

131 Scopus citations