Shannon Clark, MD, MMS

  • 669 Citations
  • 14 h-Index
19992020
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Research Output 1999 2018

  • 669 Citations
  • 14 h-Index
  • 39 Article
  • 1 Chapter
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Article
2018

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Shah, M., Xu, M., Shah, P., Wang, X-M., Clark, S., Costantine, M., West, H. A., Nanovskaya, T., Ahmed, M., Abdel-Rahman, S., Venkataramanan, R., Caritis, S. N., Hankins, G. & Rytting, E., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Indomethacin
Pharmacokinetics
Pregnancy
Genotype
Tocolytic Agents
2 Citations (Scopus)

Prednisone Pharmacokinetics During Pregnancy and Lactation

Ryu, R. J., Easterling, T. R., Caritis, S. N., Venkataramanan, R., Umans, J. G., Ahmed, M., Clark, S., Kantrowitz-Gordon, I., Hays, K., Bennett, B., Honaker, M. T., Thummel, K. E., Shen, D. D. & Hebert, M. F., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Prednisone
Lactation
Prednisolone
Pharmacokinetics
Pregnancy
2017
10 Citations (Scopus)

Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial

Nanovskaya, T. N., Oncken, C., Fokina, V. M., Feinn, R. S., Clark, S. M., West, H., Jain, S. K., Ahmed, M. S. & Hankins, G. D. V., Apr 1 2017, In : American Journal of Obstetrics and Gynecology. 216, 4, p. 420.e1-420.e9

Research output: Contribution to journalArticle

Bupropion
Placebos
Smoking Cessation
Pregnancy
Substance Withdrawal Syndrome
1 Citation (Scopus)

Hemostatic Resuscitation in Peripartum Hysterectomy Pre- and Postmassive Transfusion Protocol Initiation

Dutta, E. H., Poole, A. T., Behnia, F., Dunn, H. E., Clark, S., Pacheco, L., Saade, G. & Hankins, G., Jan 12 2017, (Accepted/In press) In : American Journal of Perinatology.

Research output: Contribution to journalArticle

Peripartum Period
Hemostatics
Hysterectomy
Resuscitation
Erythrocytes
2016
10 Citations (Scopus)
Bupropion
Umbilical Cord
Amniotic Fluid
Pregnancy
Pharmaceutical Preparations
1 Citation (Scopus)

Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy

Koren, G., Clark, S., Hankins, G., Caritis, S. N., Umans, J. G., Miodovnik, M., Mattison, D. R. & Matok, I., Nov 24 2016, In : BMC Pregnancy and Childbirth. 16, 1, 371.

Research output: Contribution to journalArticle

Doxylamine
Pyridoxine
Nausea
Vomiting
Pregnancy
3 Citations (Scopus)

Effectiveness of doxylamine-pyridoxine for morning sickness

Koren, G., Hankins, G., Clark, S., Caritis, S. N., Miodovnik, M., Umans, J. G. & Mattison, D. R., May 1 2016, In : American Journal of Obstetrics and Gynecology. 214, 5, p. 664-666 3 p.

Research output: Contribution to journalArticle

Morning Sickness
Doxylamine
Pyridoxine
4 Citations (Scopus)

Pharmacokinetics of bupropion and its pharmacologically active metabolites in pregnancy

Fokina, V., Xu, M., Rytting, E., Abdel-Rahman, S., West, H., Oncken, C., Clark, S., Ahmed, M., Hankins, G. & Nanovskaya, T., 2016, In : Drug Metabolism and Disposition. 44, 11, p. 1832-1838 7 p.

Research output: Contribution to journalArticle

Bupropion
Pharmacokinetics
Pregnancy
Smoking Cessation
Alleles
11 Citations (Scopus)

Pravastatin Effects on Placental Prosurvival Molecular Pathways in a Mouse Model of Preeclampsia

Saad, A., Diken, Z. M., Kechichian, T. B., Clark, S., Olson, G., Saade, G. & Costantine, M., Nov 1 2016, In : Reproductive Sciences. 23, 11, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Pravastatin
Pre-Eclampsia
Placenta
Mitogen-Activated Protein Kinases
2015
16 Citations (Scopus)

A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy

Clark, S., Dunn, H. E. & Hankins, G., Nov 1 2015, In : Seminars in Perinatology. 39, 7, p. 548-555 8 p.

Research output: Contribution to journalArticle

Labetalol
Nifedipine
Hypertension
Pregnancy
Blood Pressure
36 Citations (Scopus)

Low Back Pain and Pelvic Girdle Pain in Pregnancy

Casagrande, D., Gugala, Z., Clark, S. & Lindsey, R., Sep 26 2015, In : Journal of the American Academy of Orthopaedic Surgeons. 23, 9, p. 539-549 11 p.

Research output: Contribution to journalArticle

Pelvic Girdle Pain
Low Back Pain
Human Body
Pregnancy
Joint Instability
14 Citations (Scopus)

Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial

Koren, G., Clark, S., Hankins, G., Caritis, S. N., Umans, J. G., Miodovnik, M., Mattison, D. R. & Matok, I., Mar 18 2015, In : BMC Pregnancy and Childbirth. 15, 1, 59.

Research output: Contribution to journalArticle

Doxylamine
Pyridoxine
Nausea
Vomiting
Randomized Controlled Trials
8 Citations (Scopus)

Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women

Pillai, V. C., Han, K., Beigi, R. H., Hankins, G., Clark, S., Hebert, M. F., Easterling, T. R., Zajicek, A., Ren, Z., Caritis, S. N. & Venkataramanan, R., Nov 1 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1042-1050 9 p.

Research output: Contribution to journalArticle

Oseltamivir
Pregnant Women
Pharmacokinetics
Population
Pregnancy
2014
12 Citations (Scopus)

Pharmacokinetics of indomethacin in pregnancy

Rytting, E., Nanovskaya, T., Wang, X-M., Vernikovskaya, D. I., Clark, S., Cochran, M., Abdel-Rahman, S. M., Venkataramanan, R., Caritis, S. N., Hankins, G. & Ahmed, M., 2014, In : Clinical Pharmacokinetics. 53, 6, p. 545-551 7 p.

Research output: Contribution to journalArticle

Indomethacin
Pharmacokinetics
Pregnancy
Premature Obstetric Labor
Fetal Blood
4 Citations (Scopus)

Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs

Matok, I., Clark, S., Caritis, S., Miodovnik, M., Umans, J. G., Hankins, G., Mattison, D. R. & Koren, G., Dec 1 2014, In : Journal of Clinical Pharmacology. 54, 12, p. 1429-1433 5 p.

Research output: Contribution to journalArticle

Morning Sickness
Pyridoxal
Pyridoxine
Vitamin B 6
Pyridoxal Phosphate
6 Citations (Scopus)

The outpatient management and special considerations of nausea and vomiting in pregnancy

Clark, S., Dutta, E. & Hankins, G., Dec 1 2014, In : Seminars in Perinatology. 38, 8, p. 496-502 7 p.

Research output: Contribution to journalArticle

Nausea
Vomiting
Outpatients
Pregnancy
Cost of Illness
2013
2 Citations (Scopus)

Characteristics of women with nausea and vomiting of pregnancy who chose to continue compassionate use of placebo after a randomised trial

Matok, I., Umans, J., Feghali, M. N., Clark, S., Caritis, S., Miodovnik, M., Hankins, G., Mattison, D. R., Nordeng, H. & Koren, G., Aug 2013, In : Journal of Obstetrics and Gynaecology. 33, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

Compassionate Use Trials
Nausea
Vomiting
Placebos
Pregnancy
6 Citations (Scopus)

Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy

Matok, I., Clark, S., Caritis, S., Miodovnik, M., Umans, J., Hankins, G. & Koren, G., Mar 2013, In : Journal of Clinical Pharmacology. 53, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

Doxylamine
Pyridoxine
First Pregnancy Trimester
Pharmacokinetics
Morning Sickness
2 Citations (Scopus)

Intrapartum asphyxia, neonatal encephalopathy, cerebral palsy, and obstetric interventions in the term and near-term infant

Clark, S., Basraon, S. K. & Hankins, G., Jan 2013, In : NeoReviews. 14, 1

Research output: Contribution to journalArticle

Asphyxia
Brain Diseases
Cerebral Palsy
Obstetrics
Parturition
23 Citations (Scopus)

Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic

Haas, D. M., Quinney, S. K., Clay, J. M., Renbarger, J. L., Hebert, M. F., Clark, S., Umans, J. G. & Caritis, S. N., 2013, In : American Journal of Perinatology. 30, 4, p. 275-282 8 p.

Research output: Contribution to journalArticle

Tocolytic Agents
Cytochrome P-450 CYP3A
Premature Obstetric Labor
Nifedipine
Pharmacokinetics
29 Citations (Scopus)

Tacrolimus placental transfer at delivery and neonatal exposure through breast milk

Zheng, S., Easterling, T. R., Hays, K., Umans, J. G., Miodovnik, M., Clark, S., Calamia, J. C., Thummel, K. E., Shen, D. D., Davis, C. L. & Hebert, M. F., Dec 2013, In : British Journal of Clinical Pharmacology. 76, 6, p. 988-996 9 p.

Research output: Contribution to journalArticle

Tacrolimus
Human Milk
Mothers
Fetal Blood
Umbilical Cord
6 Citations (Scopus)
Nausea
Vomiting
Quality of Life
Pregnancy
Pregnant Women
2012
15 Citations (Scopus)

A semi-mechanistic metabolism model of CYP3A substrates in pregnancy: Predicting changes in midazolam and nifedipine pharmacokinetics

Quinney, S. K., Mohamed, A. N., Hebert, M. F., Haas, D. M., Clark, S., Umans, J. G., Caritis, S. N. & Li, L., 2012, In : CPT: Pharmacometrics and Systems Pharmacology. 1, 1, e2.

Research output: Contribution to journalArticle

Nifedipine
Midazolam
Cytochrome P-450 CYP3A
Pharmacokinetics
Pregnancy
3 Citations (Scopus)

Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy

Costantine, M., Matok, I., Chiossi, G., Clark, S., Miodovnik, M., Umans, J. G., Caritis, S., Hankins, G. & Koren, G., Oct 2012, In : Therapeutic Drug Monitoring. 34, 5, p. 569-573 5 p.

Research output: Contribution to journalArticle

Doxylamine
Pyridoxine
Nausea
Vomiting
Pregnancy
1 Citation (Scopus)

Vaginal birth after cesarean and trial of labor after cesarean: What should we be recommending relative to maternal risk:benefit?

Clark, S., Carver, A. R. & Hankins, G., Jul 2012, In : Women's Health. 8, 4, p. 371-383 13 p.

Research output: Contribution to journalArticle

Vaginal Birth after Cesarean
Trial of Labor
Mothers
Uterine Rupture
Morbidity
2011
53 Citations (Scopus)

Pharmacokinetics of oseltamivir among pregnant and nonpregnant women

Beigi, R. H., Han, K., Venkataramanan, R., Hankins, G., Clark, S., Hebert, M. F., Easterling, T., Zajicek, A., Ren, Z., Mattison, D. R. & Caritis, S. N., Jun 2011, In : American Journal of Obstetrics and Gynecology. 204, 6 SUPPL.

Research output: Contribution to journalArticle

Oseltamivir
Pregnant Women
Pharmacokinetics
Pregnancy
Human Influenza
18 Citations (Scopus)

Pharmacotherapeutic Management of Nicotine Dependence in Pregnancy

Clark, S. & Nakad, R., Jun 2011, In : Obstetrics and Gynecology Clinics of North America. 38, 2, p. 297-311 15 p.

Research output: Contribution to journalArticle

Tobacco Use Disorder
Pregnancy
Counseling
Transdermal Patch
Health Educators
10 Citations (Scopus)

Pharmacotherapy and pregnancy: Highlights from the third international conference for individualized pharmacotherapy in pregnancy

Haas, D. M., Gallauresi, B., Shields, K., Zeitlin, D., Clark, S., Hebert, M. F., Ren, Z., Nallani, S. C., Meslin, E. M., Feibus, K. B., Koren, G., Goebel, W. S., Easterling, T., Denne, S. C., Flockhart, D. A. & Renbarger, J. L., Jun 2011, In : Clinical and Translational Science. 4, 3, p. 204-209 6 p.

Research output: Contribution to journalArticle

Drug therapy
Drug Therapy
Pregnancy
Obstetrics
Pharmaceutical Preparations
9 Citations (Scopus)

The role of oxidative stress in the developmental origin of adult hypertension

Ghulmiyyah, L. M., Costantine, M., Yin, H., Tamayo, E., Clark, S., Hankins, G., Saade, G. & Longo, M., Aug 2011, In : American Journal of Obstetrics and Gynecology. 205, 2

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Oxidative Stress
Peroxiredoxin III
Hypertension
2010
59 Citations (Scopus)

Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: A randomized placebo controlled trial

Koren, G., Clark, S., Hankins, G., Caritis, S. N., Miodovnik, M., Umans, J. G. & Mattison, D. R., Dec 2010, In : American Journal of Obstetrics and Gynecology. 203, 6

Research output: Contribution to journalArticle

Doxylamine
Pyridoxine
Nausea
Vomiting
Randomized Controlled Trials
90 Citations (Scopus)

Pharmacokinetics of metformin during pregnancy

Eyal, S., Easterling, T. R., Carr, D., Umans, J. G., Miodovnik, M., Hankins, G., Clark, S., Risler, L., Wang, J., Kelly, E. J., Shen, D. D. & Hebert, M. F., May 2010, In : Drug Metabolism and Disposition. 38, 5, p. 833-840 8 p.

Research output: Contribution to journalArticle

Metformin
Pharmacokinetics
Pregnancy
Human Milk
Postpartum Period
2009
15 Citations (Scopus)

Pharmacotherapy and pregnancy: Highlights from the second international conference for individualized pharmacotherapy in pregnancy

Haas, D. M., Hebert, M. F., Soldin, O. P., Flockhart, D. A., Madadi, P., Nocon, J. J., Chambers, C. D., Hankins, G., Clark, S., Wisner, K. L., Li, L., Renbarger, J. L. & Learman, L. A., Dec 2009, In : Clinical and Translational Science. 2, 6, p. 439-443 5 p.

Research output: Contribution to journalArticle

Drug therapy
Drug Therapy
Pregnancy
Obstetrics
Cytochrome P-450 CYP2D6
2008
36 Citations (Scopus)

Antenatal antecedents and the impact of obstetric care in the etiology of cerebral palsy

Clark, S., Ghulmiyyah, L. M. & Hankins, G., Dec 2008, In : Clinical Obstetrics and Gynecology. 51, 4, p. 775-786 12 p.

Research output: Contribution to journalArticle

Cerebral Palsy
Obstetrics
Very Low Birth Weight Infant
Pregnancy Complications
Asphyxia
2007

Amniotic fluid embolism: An obstetrical enigma

Clark, S., Maynard, S. L. & Hankins, G., Sep 1 2007, In : Expert Review of Obstetrics and Gynecology. 2, 5, p. 641-650 10 p.

Research output: Contribution to journalArticle

Amniotic Fluid Embolism
Emergencies
Cyanosis
Coma
Hypotension
4 Citations (Scopus)

Effect of a previous pregnancy on vascular function in endothelial nitric oxide synthase 3 knockout mice

Ghulmiyyah, L. M., Tamayo, E., Clark, S., Hankins, G., Anderson, G. D., Saade, G. & Longo, M., Sep 2007, In : American Journal of Obstetrics and Gynecology. 197, 3

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Knockout Mice
Blood Vessels
Pregnancy
Wild Animals
6 Citations (Scopus)
Foster Home Care
Nitric Oxide Synthase Type III
Fetal Development
Blood Vessels
Alleles
2006
112 Citations (Scopus)

Cesarean Section on Request at 39 Weeks: Impact on Shoulder Dystocia, Fetal Trauma, Neonatal Encephalopathy, and Intrauterine Fetal Demise

Hankins, G., Clark, S. & Munn, M., Oct 2006, In : Seminars in Perinatology. 30, 5, p. 276-287 12 p.

Research output: Contribution to journalArticle

Dystocia
Fetal Death
Brain Diseases
Cesarean Section
Brachial Plexus
22 Citations (Scopus)

Pharmacokinetics and pharmacotherapy of thionamides in pregnancy

Clark, S., Saade, G., Snodgrass, W. R. & Hankins, G., Aug 2006, In : Therapeutic Drug Monitoring. 28, 4, p. 477-483 7 p.

Research output: Contribution to journalArticle

Carbimazole
Methimazole
Drug therapy
Propylthiouracil
Pharmacokinetics
1999
10 Citations (Scopus)

Maternal oxygen transport variables during the third trimester of normal pregnancy

Hankins, G., Clark, S., Uckan, E. & Van Hook, J. W., 1999, In : American Journal of Obstetrics and Gynecology. 180, 2 I, p. 406-409 4 p.

Research output: Contribution to journalArticle

Third Pregnancy Trimester
Mothers
Oxygen
Pregnancy
Postpartum Period