Slobodan Paessler

2019

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

Maruyama, J., Mateer, E. J., Manning, J. T., Sattler, R., Seregin, A. V., Bukreyeva, N., Jones, F. R., Balint, J. P., Gabitzsch, E. S., Huang, C. & Paessler, S., Oct 23 2019, In : Vaccine. 37, 45, p. 6824-6831 8 p.

Research output: Contribution to journal › Article

Lassa virus

Lassa Fever

guinea pigs

fever

Guinea Pigs

2 Citations (Scopus)

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Mateer, E., Paessler, S. & Huang, C., Jan 26 2019, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journal › Article

RNA Virus Infections

Pattern Recognition Receptors

Arenavirus

Double-Stranded RNA

RNA

Current small animal models for LASV hearing loss

Sattler, R. A., Maruyama, J., Shehu, N. Y., Makishima, T. & Paessler, S., Aug 1 2019, In : Current Opinion in Virology. 37, p. 118-122 5 p.

Research output: Contribution to journal › Review article

Lassa virus

Hearing Loss

Animal Models

Western Africa

Mortality

Differential immune responses to hemorrhagic Fever-Causing arenaviruses

Mantlo, E., Paessler, S. & Huang, C., Dec 2019, In : Vaccines. 7, 4, 138.

Research output: Contribution to journal › Review article

Open Access

New World Arenaviruses

Arenavirus

Arenaviridae Infections

Fever

Old World Arenaviruses

1 Citation (Scopus)

Lassa virus diversity and feasibility for universal prophylactic vaccine [version 1; referees: 3 approved]

Lukashevich, I. S., Paessler, S. & de la Torre, J. C., Jan 1 2019, In : F1000Research. 8, 134.

Research output: Contribution to journal › Review article

Lassa virus

Viruses

Vaccines

Lassa Fever

Murinae

1 Citation (Scopus)

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

Maruyama, J., Manning, J. T., Mateer, E. J., Sattler, R., Bukreyeva, N., Huang, C. & Paessler, S., Jan 1 2019, In : mSphere. 4, 5, e00428-19.

Research output: Contribution to journal › Article

Open Access

Lassa Fever

Lassa virus

Guinea Pigs

Infection

Sierra Leone

Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors

Radosevic, D., Sencanski, M., Perovic, V., Veljkovic, N., Prljic, J., Veljkovic, V., Mantlo, E., Bukreyeva, N., Paessler, S. & Glisic, S., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journal › Article

Open Access

Drug Repositioning

Ion Channels

Human Influenza

Adamantane

Pharmaceutical Preparations

2018

3 Citations (Scopus)

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I., Erdenizmenli, M., Cunningham, K., Paessler, S. & Dineley, K., Jun 1 2018, In : Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journal › Article

Cocaine

Astrocytes

Antiviral Agents

Oxidative Stress

pioglitazone

5 Citations (Scopus)

Ibuprofen as a template molecule for drug design against Ebola virus

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S. & Veljkovic, V., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 5, p. 947-953 7 p.

Research output: Contribution to journal › Article

Ebolavirus

Ibuprofen

Drug Design

Ebola Hemorrhagic Fever

Viruses

23 Citations (Scopus)

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

Mateer, E. J., Huang, C., Shehu, N. Y. & Paessler, S., Feb 22 2018, In : PLoS Neglected Tropical Diseases. 12, 2, e0006187.

Research output: Contribution to journal › Review article

Lassa Fever

Sensorineural Hearing Loss

Public Health

Lassa virus

Animal Models

20 Citations (Scopus)

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

Tong, X., Smith, J., Bukreyeva, N., Koma, T., Manning, J., Kalkeri, R., Kwong, A. D. & Paessler, S., Jan 1 2018, In : Antiviral Research. 149, p. 34-40 7 p.

Research output: Contribution to journal › Article

IMP Dehydrogenase

Antiviral Agents

Lassa virus

Junin virus

Flaviviridae

7 Citations (Scopus)

Review of mammarenavirus biology and replication

Hallam, S. J., Koma, T., Maruyama, J. & Paessler, S., Aug 3 2018, In : Frontiers in Microbiology. 9, AUG, 1751.

Research output: Contribution to journal › Short survey

New World Arenaviruses

Junin virus

Arenavirus

Viruses

Lujo virus

3 Citations (Scopus)

Using electronic biology based platform to predict flu vaccine efficacy for 2018/2019

Veljkovic, V. & Paessler, S., Jan 1 2018, In : F1000Research. 7, 298.

Research output: Contribution to journal › Article

Influenza Vaccines

Vaccines

Public health

Public Health

Pandemics

5 Citations (Scopus)

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

Clark, L. E., Mahmutovic, S., Raymond, D. D., Dilanyan, T., Koma, T., Manning, J., Shankar, S., Levis, S. C., Briggiler, A. M., Enria, D. A., Wucherpfennig, K. W., Paessler, S. & Abraham, J., Dec 1 2018, In : Nature Communications. 9, 1, 1884.

Research output: Contribution to journal › Article

Arenavirus

fever

Antibody Binding Sites

vaccines

New World Arenaviruses

4 Citations (Scopus)

Visualization of double-stranded RNA colocalizing with pattern recognition receptors in arenavirus infected cells

Mateer, E. J., Paessler, S. & Huang, C., Jul 24 2018, In : Frontiers in cellular and infection microbiology. 8, JUL, 251.

Research output: Contribution to journal › Article

Arenavirus

Pattern Recognition Receptors

Double-Stranded RNA

New World Arenaviruses

Viral RNA

6 Citations (Scopus)

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S., Shan, C., Shi, P-Y., Beasley, D., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific Reports. 8, 1, 1882.

Research output: Contribution to journal › Article

Antibodies

Complement C1q

Viral Structures

Microcephaly

Asymptomatic Infections

2017

8 Citations (Scopus)

Absence of an N-linked glycosylation motif in the glycoprotein of the live-attenuated argentine hemorrhagic fever vaccine, candid #1, results in its improper processing, and reduced surface expression

Manning, J., Seregin, A. V., Yun, N. E., Koma, T., Huang, C., Barral, J., de la Torre, J. C. & Paessler, S., Feb 6 2017, In : Frontiers in cellular and infection microbiology. 7, FEB, 20.

Research output: Contribution to journal › Article

Junin virus

Glycosylation

Glycoproteins

Fever

Vaccines

2 Citations (Scopus)

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet

Veljkovic, V., Perovic, V., Anderluh, M., Paessler, S., Veljkovic, M., Glisic, S. & Nicolson, G., 2017, In : F1000Research. 6, 13.

Research output: Contribution to journal › Article

Nutrition

Nutrients

Electronic properties

Food

Food Preferences

7 Citations (Scopus)

Ebola Virus and Marburg Virus in Human Milk Are Inactivated by Holder Pasteurization

Hamilton Spence, E., Huff, M., Shattuck, K., Vickers, A., Yun, N. & Paessler, S., May 1 2017, In : Journal of Human Lactation. 33, 2, p. 351-354 4 p.

Research output: Contribution to journal › Article

Marburgvirus

Ebolavirus

Pasteurization

Human Milk

Milk Banks

7 Citations (Scopus)

Highly pathogenic New World arenavirus infection activates the pattern recognition receptor protein kinase R without attenuating virus replication in human cells

Huang, C., Kolokoltsova, O. A., Mateer, E. J., Koma, T. & Paessler, S., Oct 1 2017, In : Journal of Virology. 91, 20, e01090-17.

Research output: Contribution to journal › Article

Arenaviridae Infections

Junin virus

New World Arenaviruses

Arenavirus

Machupo virus

2 Citations (Scopus)

Lassa virus reverse genetics

Martínez-Sobrido, L., Paessler, S. & de la Torre, J. C., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 185-204 20 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Lassa virus

Reverse Genetics

Old World Arenaviruses

Lassa Fever

Viral Hemorrhagic Fevers

4 Citations (Scopus)

Live, attenuated Venezuelan equine encephalitis virus vaccine (TC83) causes persistent brain infection in mice with non-functional αβ T-cells

Taylor, K., Kolokoltsova, O., Ronca, S. E., Estes, M. & Paessler, S., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 81.

Research output: Contribution to journal › Article

Venezuelan Equine Encephalitis Viruses

Vaccines

T-Lymphocytes

Brain

Infection

3 Citations (Scopus)

MAVS is essential for primary CD4⁺ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. & Wang, T., 2017, In : Journal of Virology. 91, 6, e02097-16.

Research output: Contribution to journal › Article

West Nile virus

Virus Diseases

Antiviral Agents

Immunity

T-lymphocytes

Mouse model of neurological complications resulting from encephalitic alphavirus infection

Ronca, S. E., Smith, J., Koma, T., Miller, M. M., Yun, N., Dineley, K. & Paessler, S., Feb 7 2017, In : Frontiers in Microbiology. 8, FEB, 188.

Research output: Contribution to journal › Article

Alphavirus Infections

Neurological Models

Viral Encephalitis

Sensory Gating

Thalamus

4 Citations (Scopus)

Prediction of influenza vaccine effectiveness for the influenza season 2017/18 in the US

Veljkovic, V. & Paessler, S., Jan 1 2017, In : F1000Research. 6, 2067.

Research output: Contribution to journal › Article

Influenza Vaccines

Viruses

Human Influenza

Vaccines

Orthomyxoviridae

2016

23 Citations (Scopus)

Animal model of sensorineural hearing loss associated with Lassa virus infection

Yun, N. E., Ronca, S., Tamura, A., Koma, T., Seregin, A. V., Dineley, K., Miller, M., Cook, R., Shimizu, N., Walker, A. G., Smith, J. N., Fair, J. N., Wauquier, N., Bockarie, B., Khan, S. H., Makishima, T. & Paessler, S., 2016, In : Journal of Virology. 90, 6, p. 2920-2927 8 p.

Research output: Contribution to journal › Article

Lassa virus

Sensorineural Hearing Loss

Lassa Fever

hearing

Virus Diseases

267 Citations (Scopus)

Characterization of a novel murine model to study zika virus

Rossi, S., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R., Paessler, S., Vasilakis, N. & Weaver, S., Jun 1 2016, In : American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1362-1369 8 p.

Research output: Contribution to journal › Article

Viremia

Disease Outbreaks

Interferon alpha-beta Receptor

Microcephaly

Interferon Type I

5 Citations (Scopus)

Machupo virus expressing GPC of the Candid#1 vaccine strain of Junin virus is highly attenuated and immunogenic

Koma, T., Patterson, M., Huang, C., Seregin, A. V., Maharaj, P. D., Miller, M., Smith, J. N., Walker, A. G., Hallam, S. & Paessler, S., 2016, In : Journal of Virology. 90, 3, p. 1290-1297 8 p.

Research output: Contribution to journal › Article

Machupo virus

Junin virus

New World Arenaviruses

Vaccines

vaccines

18 Citations (Scopus)

Neurological sequelae resulting from encephalitic alphavirus infection

Ronca, S. E., Dineley, K. & Paessler, S., 2016, In : Frontiers in Microbiology. 7, JUN, 959.

Research output: Contribution to journal › Review article

Alphavirus Infections

Alphavirus

Arboviruses

Bites and Stings

Western Equine Encephalitis Viruses

11 Citations (Scopus)

Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection

Buzhdygan, T., Lisinicchia, J., Patel, V., Johnson, K., Neugebauer, V., Paessler, S., Jennings, K. & Gelman, B., Jun 1 2016, In : Journal of NeuroImmune Pharmacology. 11, 2, p. 279-293 15 p.

Research output: Contribution to journal › Article

HIV Infections

HIV

Neocortex

Neurotransmitter Agents

HIV-1

8 Citations (Scopus)

Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection

Veljkovic, V. & Paessler, S., 2016, In : F1000Research. 5, 190.

Research output: Contribution to journal › Comment/debate

Central America

South America

Influenza Vaccines

Influenza A virus

Viruses

1 Citation (Scopus)

Predicted enhanced human propensity of current avian-like H1N1 swine influenza virus from China

Veljkovic, V., Veljkovic, N., Paessler, S., Goeijenbier, M., Perovic, V., Glisic, S. & Muller, C. P., Nov 1 2016, In : PLoS One. 11, 11, e0165451.

Research output: Contribution to journal › Article

Influenza A virus

Pandemics

Orthomyxoviridae

Viruses

pandemic

3 Citations (Scopus)

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Koma, T., Huang, C., Aronson, J., Walker, A. G., Miller, M., Smith, J. N., Patterson, M. & Paessler, S., Aug 30 2016, In : PLoS Neglected Tropical Diseases. 10, 8, e0004969.

Research output: Contribution to journal › Article

New World Arenaviruses

Junin virus

Glycoproteins

Vaccines

American Hemorrhagic Fever

2015

12 Citations (Scopus)

Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-α/β and IFN-γ receptors (AG129) and comparison with the DENV-2 AG129 mouse model

Sarathy, V., Infante, E., Li, L., Campbell, G., Wang, T., Paessler, S., Beatty, P. R., Harris, E., Milligan, G., Bourne, N. & Barrett, A., Oct 1 2015, In : Journal of General Virology. 96, 10, p. 3035-3048 14 p.

Research output: Contribution to journal › Article

Dengue Virus

Dengue

Infection

Antiviral Agents

Vaccines

8 Citations (Scopus)

Evolution of 2014/15 H3N2 influenza viruses circulating in US: Consequences for vaccine effectiveness and possible new pandemic

Veljkovic, V., Paessler, S., Glisic, S., Prljic, J., Perovic, V. R., Veljkovic, N. & Scotch, M., 2015, In : Frontiers in Microbiology. 6, DEC, 01456.

Research output: Contribution to journal › Article

H3N2 Subtype Influenza A Virus

Influenza Vaccines

Pandemics

Orthomyxoviridae

Vaccines

18 Citations (Scopus)

Highly pathogenic New World and Old World human arenaviruses induce distinct interferon responses in human cells

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Ronca, S., Koma, T. & Paessler, S., 2015, In : Journal of Virology. 89, 14, p. 7079-7088 10 p.

Research output: Contribution to journal › Article

Old World Arenaviruses

Arenaviridae

New World Arenaviruses

Machupo virus

Lassa Fever

5 Citations (Scopus)

Improving attrition rates in Ebola virus drug discovery

Glisic, S., Paessler, S., Veljkovic, N., Perovic, V. R., Prljic, J. & Veljkovic, V., Sep 2 2015, In : Expert Opinion on Drug Discovery. 10, 9, p. 1025-1032 8 p.

Research output: Contribution to journal › Article

Ebolavirus

Drug Discovery

Ebola Hemorrhagic Fever

Disease Outbreaks

Pharmaceutical Preparations

8 Citations (Scopus)

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R. & Paessler, S., May 1 2015, In : F1000Research. 4, 104.

Research output: Contribution to journal › Article

Ebola Hemorrhagic Fever

Ibuprofen

Virus Diseases

Viruses

Computer Simulation

25 Citations (Scopus)

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage

Manning, J., Forrester, N. & Paessler, S., 2015, In : Frontiers in Microbiology. 6, OCT, 1037.

Research output: Contribution to journal › Article

Lassa virus

Mali

Cote d'Ivoire

Lassa Fever

Liberia

34 Citations (Scopus)

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In : Nature Immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journal › Article

Virus Diseases

Ligases

Ubiquitin

Histones

Interferons

18 Citations (Scopus)

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journal › Article

Junin virus

Virulence

glycoproteins

Glycoproteins

Fever

2014

7 Citations (Scopus)

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of Virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journal › Article

Machupo virus

New World Arenaviruses

American Hemorrhagic Fever

glycoproteins

Glycoproteins

75 Citations (Scopus)

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journal › Article

Viral RNA

Alphavirus

5' Untranslated Regions

RNA

Interferons

18 Citations (Scopus)

Epidemiology and pathogenesis of Bolivian hemorrhagic fever

Patterson, M., Grant, A. & Paessler, S., 2014, In : Current Opinion in Virology. 5, 1, p. 82-90 9 p.

Research output: Contribution to journal › Article

American Hemorrhagic Fever

New World Arenaviruses

Disease Outbreaks

Epidemiology

Rodent Control

1 Citation (Scopus)

Lymphocytic Choriomeningitis, Lassa Fever, and the South American Hemorrhagic Fevers (Arenaviruses)

Seregin, A., Yun, N. & Paessler, S., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2031-2037.e2

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Lujo virus

American Hemorrhagic Fever

Lymphocytic Choriomeningitis

New World Arenaviruses

Lassa Fever

10 Citations (Scopus)

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2933.

Research output: Contribution to journal › Article

Virus Diseases

Interferons

Viruses

New World Arenaviruses

Vaccines

4 Citations (Scopus)

Reactive astrogliosis in response to hemorrhagic fever virus: Microarray profile of Junin virus-infected human astrocytes

Kolokoltsova, O. A., Yun, N. E. & Paessler, S., Jul 11 2014, In : Virology Journal. 11, 1, 126.

Research output: Contribution to journal › Article

Junin virus

Astrocytes

Fever

Virus Diseases

Viruses

12 Citations (Scopus)

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 2014, In : Journal of Virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journal › Article

Machupo virus

New World Arenaviruses

Interferon Receptors

interferons

Knockout Mice

12 Citations (Scopus)

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C-T., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PLoS One. 9, 6, e99610.

Research output: Contribution to journal › Article

Junin virus

Virus Diseases

interferons

Viruses

Interferons

56 Citations (Scopus)

The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: Insights into the pathologic mechanisms of a new viral hemorrhagic fever

Liu, Y., Wu, B., Paessler, S., Walker, D., Tesh, R. B. & Yu, X. J., Feb 2014, In : Journal of Virology. 88, 3, p. 1781-1786 6 p.

Research output: Contribution to journal › Article

Viral Hemorrhagic Fevers

interferon-beta

thrombocytopenia

Interferon-beta

Virus Diseases

Slobodan Paessler, DVM, PhD