Slobodan Paessler, DVM, PhD

Director, ABSL3 Laboratory & GNL ABSL3 Laboratory

  • 2773 Citations
  • 31 h-Index
20032023
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Research Output 2003 2019

2019

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

Maruyama, J., Mateer, E. J., Manning, J. T., Sattler, R., Seregin, A. V., Bukreyeva, N., Jones, F. R., Balint, J. P., Gabitzsch, E. S., Huang, C. & Paessler, S., Oct 23 2019, In : Vaccine. 37, 45, p. 6824-6831 8 p.

Research output: Contribution to journalArticle

Lassa virus
Lassa Fever
guinea pigs
fever
Guinea Pigs
2 Citations (Scopus)
RNA Virus Infections
Pattern Recognition Receptors
Arenavirus
Double-Stranded RNA
RNA

Current small animal models for LASV hearing loss

Sattler, R. A., Maruyama, J., Shehu, N. Y., Makishima, T. & Paessler, S., Aug 1 2019, In : Current Opinion in Virology. 37, p. 118-122 5 p.

Research output: Contribution to journalReview article

Lassa virus
Hearing Loss
Animal Models
Western Africa
Mortality

Differential immune responses to hemorrhagic Fever-Causing arenaviruses

Mantlo, E., Paessler, S. & Huang, C., Dec 2019, In : Vaccines. 7, 4, 138.

Research output: Contribution to journalReview article

Open Access
New World Arenaviruses
Arenavirus
Arenaviridae Infections
Fever
Old World Arenaviruses
1 Citation (Scopus)

Lassa virus diversity and feasibility for universal prophylactic vaccine [version 1; referees: 3 approved]

Lukashevich, I. S., Paessler, S. & de la Torre, J. C., Jan 1 2019, In : F1000Research. 8, 134.

Research output: Contribution to journalReview article

Lassa virus
Viruses
Vaccines
Lassa Fever
Murinae
1 Citation (Scopus)

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

Maruyama, J., Manning, J. T., Mateer, E. J., Sattler, R., Bukreyeva, N., Huang, C. & Paessler, S., Jan 1 2019, In : mSphere. 4, 5, e00428-19.

Research output: Contribution to journalArticle

Open Access
Lassa Fever
Lassa virus
Guinea Pigs
Infection
Sierra Leone

Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors

Radosevic, D., Sencanski, M., Perovic, V., Veljkovic, N., Prljic, J., Veljkovic, V., Mantlo, E., Bukreyeva, N., Paessler, S. & Glisic, S., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Drug Repositioning
Ion Channels
Human Influenza
Adamantane
Pharmaceutical Preparations
2018
3 Citations (Scopus)

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I., Erdenizmenli, M., Cunningham, K., Paessler, S. & Dineley, K., Jun 1 2018, In : Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journalArticle

Cocaine
Astrocytes
Antiviral Agents
Oxidative Stress
pioglitazone
5 Citations (Scopus)

Ibuprofen as a template molecule for drug design against Ebola virus

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S. & Veljkovic, V., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 5, p. 947-953 7 p.

Research output: Contribution to journalArticle

Ebolavirus
Ibuprofen
Drug Design
Ebola Hemorrhagic Fever
Viruses
23 Citations (Scopus)

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

Mateer, E. J., Huang, C., Shehu, N. Y. & Paessler, S., Feb 22 2018, In : PLoS Neglected Tropical Diseases. 12, 2, e0006187.

Research output: Contribution to journalReview article

Lassa Fever
Sensorineural Hearing Loss
Public Health
Lassa virus
Animal Models
20 Citations (Scopus)

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

Tong, X., Smith, J., Bukreyeva, N., Koma, T., Manning, J., Kalkeri, R., Kwong, A. D. & Paessler, S., Jan 1 2018, In : Antiviral Research. 149, p. 34-40 7 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Antiviral Agents
Lassa virus
Junin virus
Flaviviridae
7 Citations (Scopus)

Review of mammarenavirus biology and replication

Hallam, S. J., Koma, T., Maruyama, J. & Paessler, S., Aug 3 2018, In : Frontiers in Microbiology. 9, AUG, 1751.

Research output: Contribution to journalShort survey

New World Arenaviruses
Junin virus
Arenavirus
Viruses
Lujo virus
3 Citations (Scopus)

Using electronic biology based platform to predict flu vaccine efficacy for 2018/2019

Veljkovic, V. & Paessler, S., Jan 1 2018, In : F1000Research. 7, 298.

Research output: Contribution to journalArticle

Influenza Vaccines
Vaccines
Public health
Public Health
Pandemics
5 Citations (Scopus)

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

Clark, L. E., Mahmutovic, S., Raymond, D. D., Dilanyan, T., Koma, T., Manning, J., Shankar, S., Levis, S. C., Briggiler, A. M., Enria, D. A., Wucherpfennig, K. W., Paessler, S. & Abraham, J., Dec 1 2018, In : Nature Communications. 9, 1, 1884.

Research output: Contribution to journalArticle

Arenavirus
fever
Antibody Binding Sites
vaccines
New World Arenaviruses
4 Citations (Scopus)
Arenavirus
Pattern Recognition Receptors
Double-Stranded RNA
New World Arenaviruses
Viral RNA
6 Citations (Scopus)

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S., Shan, C., Shi, P-Y., Beasley, D., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific Reports. 8, 1, 1882.

Research output: Contribution to journalArticle

Antibodies
Complement C1q
Viral Structures
Microcephaly
Asymptomatic Infections
2017
8 Citations (Scopus)
Junin virus
Glycosylation
Glycoproteins
Fever
Vaccines
2 Citations (Scopus)

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet

Veljkovic, V., Perovic, V., Anderluh, M., Paessler, S., Veljkovic, M., Glisic, S. & Nicolson, G., 2017, In : F1000Research. 6, 13.

Research output: Contribution to journalArticle

Nutrition
Nutrients
Electronic properties
Food
Food Preferences
7 Citations (Scopus)

Ebola Virus and Marburg Virus in Human Milk Are Inactivated by Holder Pasteurization

Hamilton Spence, E., Huff, M., Shattuck, K., Vickers, A., Yun, N. & Paessler, S., May 1 2017, In : Journal of Human Lactation. 33, 2, p. 351-354 4 p.

Research output: Contribution to journalArticle

Marburgvirus
Ebolavirus
Pasteurization
Human Milk
Milk Banks
7 Citations (Scopus)

Highly pathogenic New World arenavirus infection activates the pattern recognition receptor protein kinase R without attenuating virus replication in human cells

Huang, C., Kolokoltsova, O. A., Mateer, E. J., Koma, T. & Paessler, S., Oct 1 2017, In : Journal of Virology. 91, 20, e01090-17.

Research output: Contribution to journalArticle

Arenaviridae Infections
Junin virus
New World Arenaviruses
Arenavirus
Machupo virus
2 Citations (Scopus)

Lassa virus reverse genetics

Martínez-Sobrido, L., Paessler, S. & de la Torre, J. C., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 185-204 20 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lassa virus
Reverse Genetics
Old World Arenaviruses
Lassa Fever
Viral Hemorrhagic Fevers
4 Citations (Scopus)

Live, attenuated Venezuelan equine encephalitis virus vaccine (TC83) causes persistent brain infection in mice with non-functional αβ T-cells

Taylor, K., Kolokoltsova, O., Ronca, S. E., Estes, M. & Paessler, S., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 81.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Vaccines
T-Lymphocytes
Brain
Infection
3 Citations (Scopus)

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. & Wang, T., 2017, In : Journal of Virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

West Nile virus
Virus Diseases
Antiviral Agents
Immunity
T-lymphocytes

Mouse model of neurological complications resulting from encephalitic alphavirus infection

Ronca, S. E., Smith, J., Koma, T., Miller, M. M., Yun, N., Dineley, K. & Paessler, S., Feb 7 2017, In : Frontiers in Microbiology. 8, FEB, 188.

Research output: Contribution to journalArticle

Alphavirus Infections
Neurological Models
Viral Encephalitis
Sensory Gating
Thalamus
4 Citations (Scopus)

Prediction of influenza vaccine effectiveness for the influenza season 2017/18 in the US

Veljkovic, V. & Paessler, S., Jan 1 2017, In : F1000Research. 6, 2067.

Research output: Contribution to journalArticle

Influenza Vaccines
Viruses
Human Influenza
Vaccines
Orthomyxoviridae
2016
23 Citations (Scopus)

Animal model of sensorineural hearing loss associated with Lassa virus infection

Yun, N. E., Ronca, S., Tamura, A., Koma, T., Seregin, A. V., Dineley, K., Miller, M., Cook, R., Shimizu, N., Walker, A. G., Smith, J. N., Fair, J. N., Wauquier, N., Bockarie, B., Khan, S. H., Makishima, T. & Paessler, S., 2016, In : Journal of Virology. 90, 6, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

Lassa virus
Sensorineural Hearing Loss
Lassa Fever
hearing
Virus Diseases
267 Citations (Scopus)

Characterization of a novel murine model to study zika virus

Rossi, S., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R., Paessler, S., Vasilakis, N. & Weaver, S., Jun 1 2016, In : American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1362-1369 8 p.

Research output: Contribution to journalArticle

Viremia
Disease Outbreaks
Interferon alpha-beta Receptor
Microcephaly
Interferon Type I
5 Citations (Scopus)

Machupo virus expressing GPC of the Candid#1 vaccine strain of Junin virus is highly attenuated and immunogenic

Koma, T., Patterson, M., Huang, C., Seregin, A. V., Maharaj, P. D., Miller, M., Smith, J. N., Walker, A. G., Hallam, S. & Paessler, S., 2016, In : Journal of Virology. 90, 3, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

Machupo virus
Junin virus
New World Arenaviruses
Vaccines
vaccines
18 Citations (Scopus)

Neurological sequelae resulting from encephalitic alphavirus infection

Ronca, S. E., Dineley, K. & Paessler, S., 2016, In : Frontiers in Microbiology. 7, JUN, 959.

Research output: Contribution to journalReview article

Alphavirus Infections
Alphavirus
Arboviruses
Bites and Stings
Western Equine Encephalitis Viruses
11 Citations (Scopus)

Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection

Buzhdygan, T., Lisinicchia, J., Patel, V., Johnson, K., Neugebauer, V., Paessler, S., Jennings, K. & Gelman, B., Jun 1 2016, In : Journal of NeuroImmune Pharmacology. 11, 2, p. 279-293 15 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
Neocortex
Neurotransmitter Agents
HIV-1
8 Citations (Scopus)

Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection

Veljkovic, V. & Paessler, S., 2016, In : F1000Research. 5, 190.

Research output: Contribution to journalComment/debate

Central America
South America
Influenza Vaccines
Influenza A virus
Viruses
1 Citation (Scopus)

Predicted enhanced human propensity of current avian-like H1N1 swine influenza virus from China

Veljkovic, V., Veljkovic, N., Paessler, S., Goeijenbier, M., Perovic, V., Glisic, S. & Muller, C. P., Nov 1 2016, In : PLoS One. 11, 11, e0165451.

Research output: Contribution to journalArticle

Influenza A virus
Pandemics
Orthomyxoviridae
Viruses
pandemic
3 Citations (Scopus)

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Koma, T., Huang, C., Aronson, J., Walker, A. G., Miller, M., Smith, J. N., Patterson, M. & Paessler, S., Aug 30 2016, In : PLoS Neglected Tropical Diseases. 10, 8, e0004969.

Research output: Contribution to journalArticle

New World Arenaviruses
Junin virus
Glycoproteins
Vaccines
American Hemorrhagic Fever
2015
12 Citations (Scopus)
Dengue Virus
Dengue
Infection
Antiviral Agents
Vaccines
8 Citations (Scopus)

Evolution of 2014/15 H3N2 influenza viruses circulating in US: Consequences for vaccine effectiveness and possible new pandemic

Veljkovic, V., Paessler, S., Glisic, S., Prljic, J., Perovic, V. R., Veljkovic, N. & Scotch, M., 2015, In : Frontiers in Microbiology. 6, DEC, 01456.

Research output: Contribution to journalArticle

H3N2 Subtype Influenza A Virus
Influenza Vaccines
Pandemics
Orthomyxoviridae
Vaccines
18 Citations (Scopus)

Highly pathogenic New World and Old World human arenaviruses induce distinct interferon responses in human cells

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Ronca, S., Koma, T. & Paessler, S., 2015, In : Journal of Virology. 89, 14, p. 7079-7088 10 p.

Research output: Contribution to journalArticle

Old World Arenaviruses
Arenaviridae
New World Arenaviruses
Machupo virus
Lassa Fever
5 Citations (Scopus)

Improving attrition rates in Ebola virus drug discovery

Glisic, S., Paessler, S., Veljkovic, N., Perovic, V. R., Prljic, J. & Veljkovic, V., Sep 2 2015, In : Expert Opinion on Drug Discovery. 10, 9, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

Ebolavirus
Drug Discovery
Ebola Hemorrhagic Fever
Disease Outbreaks
Pharmaceutical Preparations
8 Citations (Scopus)

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R. & Paessler, S., May 1 2015, In : F1000Research. 4, 104.

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Ibuprofen
Virus Diseases
Viruses
Computer Simulation
25 Citations (Scopus)

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage

Manning, J., Forrester, N. & Paessler, S., 2015, In : Frontiers in Microbiology. 6, OCT, 1037.

Research output: Contribution to journalArticle

Lassa virus
Mali
Cote d'Ivoire
Lassa Fever
Liberia
34 Citations (Scopus)

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In : Nature Immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

Virus Diseases
Ligases
Ubiquitin
Histones
Interferons
18 Citations (Scopus)

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journalArticle

Junin virus
Virulence
glycoproteins
Glycoproteins
Fever
2014
7 Citations (Scopus)

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of Virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journalArticle

Machupo virus
New World Arenaviruses
American Hemorrhagic Fever
glycoproteins
Glycoproteins
75 Citations (Scopus)

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journalArticle

Viral RNA
Alphavirus
5' Untranslated Regions
RNA
Interferons
18 Citations (Scopus)

Epidemiology and pathogenesis of Bolivian hemorrhagic fever

Patterson, M., Grant, A. & Paessler, S., 2014, In : Current Opinion in Virology. 5, 1, p. 82-90 9 p.

Research output: Contribution to journalArticle

American Hemorrhagic Fever
New World Arenaviruses
Disease Outbreaks
Epidemiology
Rodent Control
1 Citation (Scopus)

Lymphocytic Choriomeningitis, Lassa Fever, and the South American Hemorrhagic Fevers (Arenaviruses)

Seregin, A., Yun, N. & Paessler, S., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2031-2037.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Lujo virus
American Hemorrhagic Fever
Lymphocytic Choriomeningitis
New World Arenaviruses
Lassa Fever
10 Citations (Scopus)

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2933.

Research output: Contribution to journalArticle

Virus Diseases
Interferons
Viruses
New World Arenaviruses
Vaccines
4 Citations (Scopus)

Reactive astrogliosis in response to hemorrhagic fever virus: Microarray profile of Junin virus-infected human astrocytes

Kolokoltsova, O. A., Yun, N. E. & Paessler, S., Jul 11 2014, In : Virology Journal. 11, 1, 126.

Research output: Contribution to journalArticle

Junin virus
Astrocytes
Fever
Virus Diseases
Viruses
12 Citations (Scopus)

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 2014, In : Journal of Virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Machupo virus
New World Arenaviruses
Interferon Receptors
interferons
Knockout Mice
12 Citations (Scopus)

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C-T., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PLoS One. 9, 6, e99610.

Research output: Contribution to journalArticle

Junin virus
Virus Diseases
interferons
Viruses
Interferons
56 Citations (Scopus)
Viral Hemorrhagic Fevers
interferon-beta
thrombocytopenia
Interferon-beta
Virus Diseases