Slobodan Paessler, DVM, PhD

Director, ABSL3 Laboratory & GNL ABSL3 Laboratory

  • 2773 Citations
  • 31 h-Index
20032023
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Research Output 2003 2019

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Article
2019

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

Maruyama, J., Mateer, E. J., Manning, J. T., Sattler, R., Seregin, A. V., Bukreyeva, N., Jones, F. R., Balint, J. P., Gabitzsch, E. S., Huang, C. & Paessler, S., Oct 23 2019, In : Vaccine. 37, 45, p. 6824-6831 8 p.

Research output: Contribution to journalArticle

Lassa virus
Lassa Fever
guinea pigs
fever
Guinea Pigs
2 Citations (Scopus)
RNA Virus Infections
Pattern Recognition Receptors
Arenavirus
Double-Stranded RNA
RNA
1 Citation (Scopus)

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

Maruyama, J., Manning, J. T., Mateer, E. J., Sattler, R., Bukreyeva, N., Huang, C. & Paessler, S., Jan 1 2019, In : mSphere. 4, 5, e00428-19.

Research output: Contribution to journalArticle

Open Access
Lassa Fever
Lassa virus
Guinea Pigs
Infection
Sierra Leone

Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors

Radosevic, D., Sencanski, M., Perovic, V., Veljkovic, N., Prljic, J., Veljkovic, V., Mantlo, E., Bukreyeva, N., Paessler, S. & Glisic, S., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Drug Repositioning
Ion Channels
Human Influenza
Adamantane
Pharmaceutical Preparations
2018
3 Citations (Scopus)

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I., Erdenizmenli, M., Cunningham, K., Paessler, S. & Dineley, K., Jun 1 2018, In : Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journalArticle

Cocaine
Astrocytes
Antiviral Agents
Oxidative Stress
pioglitazone
5 Citations (Scopus)

Ibuprofen as a template molecule for drug design against Ebola virus

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S. & Veljkovic, V., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 5, p. 947-953 7 p.

Research output: Contribution to journalArticle

Ebolavirus
Ibuprofen
Drug Design
Ebola Hemorrhagic Fever
Viruses
20 Citations (Scopus)

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

Tong, X., Smith, J., Bukreyeva, N., Koma, T., Manning, J., Kalkeri, R., Kwong, A. D. & Paessler, S., Jan 1 2018, In : Antiviral Research. 149, p. 34-40 7 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Antiviral Agents
Lassa virus
Junin virus
Flaviviridae
3 Citations (Scopus)

Using electronic biology based platform to predict flu vaccine efficacy for 2018/2019

Veljkovic, V. & Paessler, S., Jan 1 2018, In : F1000Research. 7, 298.

Research output: Contribution to journalArticle

Influenza Vaccines
Vaccines
Public health
Public Health
Pandemics
5 Citations (Scopus)

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

Clark, L. E., Mahmutovic, S., Raymond, D. D., Dilanyan, T., Koma, T., Manning, J., Shankar, S., Levis, S. C., Briggiler, A. M., Enria, D. A., Wucherpfennig, K. W., Paessler, S. & Abraham, J., Dec 1 2018, In : Nature Communications. 9, 1, 1884.

Research output: Contribution to journalArticle

Arenavirus
fever
Antibody Binding Sites
vaccines
New World Arenaviruses
4 Citations (Scopus)
Arenavirus
Pattern Recognition Receptors
Double-Stranded RNA
New World Arenaviruses
Viral RNA
6 Citations (Scopus)

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S., Shan, C., Shi, P-Y., Beasley, D., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific Reports. 8, 1, 1882.

Research output: Contribution to journalArticle

Antibodies
Complement C1q
Viral Structures
Microcephaly
Asymptomatic Infections
2017
8 Citations (Scopus)
Junin virus
Glycosylation
Glycoproteins
Fever
Vaccines
2 Citations (Scopus)

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet

Veljkovic, V., Perovic, V., Anderluh, M., Paessler, S., Veljkovic, M., Glisic, S. & Nicolson, G., 2017, In : F1000Research. 6, 13.

Research output: Contribution to journalArticle

Nutrition
Nutrients
Electronic properties
Food
Food Preferences
7 Citations (Scopus)

Ebola Virus and Marburg Virus in Human Milk Are Inactivated by Holder Pasteurization

Hamilton Spence, E., Huff, M., Shattuck, K., Vickers, A., Yun, N. & Paessler, S., May 1 2017, In : Journal of Human Lactation. 33, 2, p. 351-354 4 p.

Research output: Contribution to journalArticle

Marburgvirus
Ebolavirus
Pasteurization
Human Milk
Milk Banks
7 Citations (Scopus)

Highly pathogenic New World arenavirus infection activates the pattern recognition receptor protein kinase R without attenuating virus replication in human cells

Huang, C., Kolokoltsova, O. A., Mateer, E. J., Koma, T. & Paessler, S., Oct 1 2017, In : Journal of Virology. 91, 20, e01090-17.

Research output: Contribution to journalArticle

Arenaviridae Infections
Junin virus
New World Arenaviruses
Arenavirus
Machupo virus
4 Citations (Scopus)

Live, attenuated Venezuelan equine encephalitis virus vaccine (TC83) causes persistent brain infection in mice with non-functional αβ T-cells

Taylor, K., Kolokoltsova, O., Ronca, S. E., Estes, M. & Paessler, S., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 81.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Vaccines
T-Lymphocytes
Brain
Infection
3 Citations (Scopus)

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. & Wang, T., 2017, In : Journal of Virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

West Nile virus
Virus Diseases
Antiviral Agents
Immunity
T-lymphocytes

Mouse model of neurological complications resulting from encephalitic alphavirus infection

Ronca, S. E., Smith, J., Koma, T., Miller, M. M., Yun, N., Dineley, K. & Paessler, S., Feb 7 2017, In : Frontiers in Microbiology. 8, FEB, 188.

Research output: Contribution to journalArticle

Alphavirus Infections
Neurological Models
Viral Encephalitis
Sensory Gating
Thalamus
4 Citations (Scopus)

Prediction of influenza vaccine effectiveness for the influenza season 2017/18 in the US

Veljkovic, V. & Paessler, S., Jan 1 2017, In : F1000Research. 6, 2067.

Research output: Contribution to journalArticle

Influenza Vaccines
Viruses
Human Influenza
Vaccines
Orthomyxoviridae
2016
23 Citations (Scopus)

Animal model of sensorineural hearing loss associated with Lassa virus infection

Yun, N. E., Ronca, S., Tamura, A., Koma, T., Seregin, A. V., Dineley, K., Miller, M., Cook, R., Shimizu, N., Walker, A. G., Smith, J. N., Fair, J. N., Wauquier, N., Bockarie, B., Khan, S. H., Makishima, T. & Paessler, S., 2016, In : Journal of Virology. 90, 6, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

Lassa virus
Sensorineural Hearing Loss
Lassa Fever
hearing
Virus Diseases
267 Citations (Scopus)

Characterization of a novel murine model to study zika virus

Rossi, S., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R., Paessler, S., Vasilakis, N. & Weaver, S., Jun 1 2016, In : American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1362-1369 8 p.

Research output: Contribution to journalArticle

Viremia
Disease Outbreaks
Interferon alpha-beta Receptor
Microcephaly
Interferon Type I
5 Citations (Scopus)

Machupo virus expressing GPC of the Candid#1 vaccine strain of Junin virus is highly attenuated and immunogenic

Koma, T., Patterson, M., Huang, C., Seregin, A. V., Maharaj, P. D., Miller, M., Smith, J. N., Walker, A. G., Hallam, S. & Paessler, S., 2016, In : Journal of Virology. 90, 3, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

Machupo virus
Junin virus
New World Arenaviruses
Vaccines
vaccines
11 Citations (Scopus)

Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection

Buzhdygan, T., Lisinicchia, J., Patel, V., Johnson, K., Neugebauer, V., Paessler, S., Jennings, K. & Gelman, B., Jun 1 2016, In : Journal of NeuroImmune Pharmacology. 11, 2, p. 279-293 15 p.

Research output: Contribution to journalArticle

HIV Infections
HIV
Neocortex
Neurotransmitter Agents
HIV-1
1 Citation (Scopus)

Predicted enhanced human propensity of current avian-like H1N1 swine influenza virus from China

Veljkovic, V., Veljkovic, N., Paessler, S., Goeijenbier, M., Perovic, V., Glisic, S. & Muller, C. P., Nov 1 2016, In : PLoS One. 11, 11, e0165451.

Research output: Contribution to journalArticle

Influenza A virus
Pandemics
Orthomyxoviridae
Viruses
pandemic
3 Citations (Scopus)

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Koma, T., Huang, C., Aronson, J., Walker, A. G., Miller, M., Smith, J. N., Patterson, M. & Paessler, S., Aug 30 2016, In : PLoS Neglected Tropical Diseases. 10, 8, e0004969.

Research output: Contribution to journalArticle

New World Arenaviruses
Junin virus
Glycoproteins
Vaccines
American Hemorrhagic Fever
2015
12 Citations (Scopus)
Dengue Virus
Dengue
Infection
Antiviral Agents
Vaccines
8 Citations (Scopus)

Evolution of 2014/15 H3N2 influenza viruses circulating in US: Consequences for vaccine effectiveness and possible new pandemic

Veljkovic, V., Paessler, S., Glisic, S., Prljic, J., Perovic, V. R., Veljkovic, N. & Scotch, M., 2015, In : Frontiers in Microbiology. 6, DEC, 01456.

Research output: Contribution to journalArticle

H3N2 Subtype Influenza A Virus
Influenza Vaccines
Pandemics
Orthomyxoviridae
Vaccines
18 Citations (Scopus)

Highly pathogenic New World and Old World human arenaviruses induce distinct interferon responses in human cells

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Ronca, S., Koma, T. & Paessler, S., 2015, In : Journal of Virology. 89, 14, p. 7079-7088 10 p.

Research output: Contribution to journalArticle

Old World Arenaviruses
Arenaviridae
New World Arenaviruses
Machupo virus
Lassa Fever
5 Citations (Scopus)

Improving attrition rates in Ebola virus drug discovery

Glisic, S., Paessler, S., Veljkovic, N., Perovic, V. R., Prljic, J. & Veljkovic, V., Sep 2 2015, In : Expert Opinion on Drug Discovery. 10, 9, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

Ebolavirus
Drug Discovery
Ebola Hemorrhagic Fever
Disease Outbreaks
Pharmaceutical Preparations
8 Citations (Scopus)

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R. & Paessler, S., May 1 2015, In : F1000Research. 4, 104.

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Ibuprofen
Virus Diseases
Viruses
Computer Simulation
25 Citations (Scopus)

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage

Manning, J., Forrester, N. & Paessler, S., 2015, In : Frontiers in Microbiology. 6, OCT, 1037.

Research output: Contribution to journalArticle

Lassa virus
Mali
Cote d'Ivoire
Lassa Fever
Liberia
34 Citations (Scopus)

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In : Nature Immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

Virus Diseases
Ligases
Ubiquitin
Histones
Interferons
18 Citations (Scopus)

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journalArticle

Junin virus
Virulence
glycoproteins
Glycoproteins
Fever
2014
7 Citations (Scopus)

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of Virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journalArticle

Machupo virus
New World Arenaviruses
American Hemorrhagic Fever
glycoproteins
Glycoproteins
75 Citations (Scopus)

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journalArticle

Viral RNA
Alphavirus
5' Untranslated Regions
RNA
Interferons
18 Citations (Scopus)

Epidemiology and pathogenesis of Bolivian hemorrhagic fever

Patterson, M., Grant, A. & Paessler, S., 2014, In : Current Opinion in Virology. 5, 1, p. 82-90 9 p.

Research output: Contribution to journalArticle

American Hemorrhagic Fever
New World Arenaviruses
Disease Outbreaks
Epidemiology
Rodent Control
10 Citations (Scopus)

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2933.

Research output: Contribution to journalArticle

Virus Diseases
Interferons
Viruses
New World Arenaviruses
Vaccines
4 Citations (Scopus)

Reactive astrogliosis in response to hemorrhagic fever virus: Microarray profile of Junin virus-infected human astrocytes

Kolokoltsova, O. A., Yun, N. E. & Paessler, S., Jul 11 2014, In : Virology Journal. 11, 1, 126.

Research output: Contribution to journalArticle

Junin virus
Astrocytes
Fever
Virus Diseases
Viruses
12 Citations (Scopus)

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 2014, In : Journal of Virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

Machupo virus
New World Arenaviruses
Interferon Receptors
interferons
Knockout Mice
12 Citations (Scopus)

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C-T., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PLoS One. 9, 6, e99610.

Research output: Contribution to journalArticle

Junin virus
Virus Diseases
interferons
Viruses
Interferons
56 Citations (Scopus)
Viral Hemorrhagic Fevers
interferon-beta
thrombocytopenia
Interferon-beta
Virus Diseases
2013
37 Citations (Scopus)

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. & Brasier, A. R., Jun 2013, In : Journal of Virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Interferon Regulatory Factor-3
Respiratory Syncytial Virus Infections
cyclin-dependent kinase
interferons
17 Citations (Scopus)

Innate immune response to arenaviral infection: A focus on the highly pathogenic new world hemorrhagic arenaviruses

Koma, T., Huang, C., Kolokoltsova, O. A., Brasier, A. R. & Paessler, S., Dec 13 2013, In : Journal of Molecular Biology. 425, 24, p. 4893-4903 11 p.

Research output: Contribution to journalArticle

New World Arenaviruses
Innate Immunity
Arenaviridae Infections
Infection
Arenaviridae
27 Citations (Scopus)

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Yun, N. E., Seregin, A. V., Walker, D., Popov, V., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., 2013, In : Journal of Virology. 87, 19, p. 10908-10911 4 p.

Research output: Contribution to journalArticle

Lassa virus
Lassa Fever
fever
Arenavirus
Western Africa
139 Citations (Scopus)

Pathogenesis of the viral hemorrhagic fevers

Paessler, S. & Walker, D., Jan 2013, In : Annual Review of Pathology: Mechanisms of Disease. 8, p. 411-440 30 p.

Research output: Contribution to journalArticle

Viral Hemorrhagic Fevers
fever
Marburg Virus Disease
Ebola Hemorrhagic Fever
Fever
21 Citations (Scopus)

Pathogenesis of Venezuelan equine encephalitis

Taylor, K. G. & Paessler, S., Nov 29 2013, In : Veterinary Microbiology. 167, 1-2, p. 145-150 6 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalomyelitides
encephalitis
Equine Encephalomyelitis
pathogenesis
Encephalitis Viruses
5 Citations (Scopus)

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Peng, B., Borisevich, V., Popov, V., Zacks, M. A., Estes, D. M., Campbell, G. & Paessler, S., May 3 2013, In : Veterinary Microbiology. 163, 3-4, p. 223-234 12 p.

Research output: Contribution to journalArticle

Alphavirus
Interleukin-17
astrocytes
interleukin-8
Interleukin-8
2012
8 Citations (Scopus)

Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform

Gabitzsch, E. S., Balint-Junior, J. P., Xu, Y., Balcaitis, S., Sanders-Beer, B., Karl, J., Weinhold, K. J., Paessler, S. & Jones, F. R., Nov 26 2012, In : Vaccine. 30, 50, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Pandemics
pandemic
Virus Diseases
13 Citations (Scopus)

Effect of Ribavirin on Junin Virus Infection in Guinea Pigs

Salazar, M., Yun, N. E., Poussard, A. L., Smith, J. N., Smith, J. K., Kolokoltsova, O. A., Patterson, M. J., Linde, J. & Paessler, S., Jun 2012, In : Zoonoses and Public Health. 59, 4, p. 278-285 8 p.

Research output: Contribution to journalArticle

Junin virus
Ribavirin
Virus Diseases
guinea pigs
Guinea Pigs
31 Citations (Scopus)

Functional interferon system is required for clearance of Lassa virus

Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J., Smith, J. N., Soong, L. & Paessler, S., Mar 2012, In : Journal of Virology. 86, 6, p. 3389-3392 4 p.

Research output: Contribution to journalArticle

Lassa virus
interferons
Interferons
Lassa Fever
Endemic Diseases