Slobodan Paessler, DVM, PhD

Director, ABSL3 Laboratory & GNL ABSL3 Laboratory

  • 2886 Citations
  • 31 h-Index
20032023

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2020

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jan 1 2020, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

1 Scopus citations

Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein

Amanat, F., Duehr, J., Huang, C., Paessler, S., Tan, G. S. & Krammer, F., Feb 14 2020, In : Journal of virology. 94, 5

Research output: Contribution to journalArticle

1 Scopus citations

The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome

Manning, J. T., Yun, N. E., Seregin, A. V., Koma, T., Sattler, R. A., Ezeomah, C., Huang, C., de la Torre, J. C. & Paessler, S., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalArticle

2019
Open Access

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

Maruyama, J., Mateer, E. J., Manning, J. T., Sattler, R., Seregin, A. V., Bukreyeva, N., Jones, F. R., Balint, J. P., Gabitzsch, E. S., Huang, C. & Paessler, S., Oct 23 2019, In : Vaccine. 37, 45, p. 6824-6831 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

Maruyama, J., Manning, J. T., Mateer, E. J., Sattler, R., Bukreyeva, N., Huang, C. & Paessler, S., Jan 1 2019, In : mSphere. 4, 5, e00428-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Virtual screen for repurposing of drugs for candidate influenza a M2 ion-channel inhibitors

Radosevic, D., Sencanski, M., Perovic, V., Veljkovic, N., Prljic, J., Veljkovic, V., Mantlo, E., Bukreyeva, N., Paessler, S. & Glisic, S., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, MAR, 067.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I., Erdenizmenli, M., Cunningham, K., Paessler, S. & Dineley, K., Jun 1 2018, In : Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ibuprofen as a template molecule for drug design against Ebola virus

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S. & Veljkovic, V., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 5, p. 947-953 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

Tong, X., Smith, J., Bukreyeva, N., Koma, T., Manning, J., Kalkeri, R., Kwong, A. D. & Paessler, S., Jan 1 2018, In : Antiviral Research. 149, p. 34-40 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
Open Access

Using electronic biology based platform to predict flu vaccine efficacy for 2018/2019

Veljkovic, V. & Paessler, S., Jan 1 2018, In : F1000Research. 7, 298.

Research output: Contribution to journalArticle

3 Scopus citations

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

Clark, L. E., Mahmutovic, S., Raymond, D. D., Dilanyan, T., Koma, T., Manning, J. T., Shankar, S., Levis, S. C., Briggiler, A. M., Enria, D. A., Wucherpfennig, K. W., Paessler, S. & Abraham, J., Dec 1 2018, In : Nature communications. 9, 1, 1884.

Research output: Contribution to journalArticle

7 Scopus citations
4 Scopus citations

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific reports. 8, 1, 1882.

Research output: Contribution to journalArticle

7 Scopus citations
2017
9 Scopus citations

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet

Veljkovic, V., Perovic, V., Anderluh, M., Paessler, S., Veljkovic, M., Glisic, S. & Nicolson, G., 2017, In : F1000Research. 6, 13.

Research output: Contribution to journalArticle

2 Scopus citations

Ebola Virus and Marburg Virus in Human Milk Are Inactivated by Holder Pasteurization

Hamilton Spence, E., Huff, M., Shattuck, K., Vickers, A., Yun, N. & Paessler, S., May 1 2017, In : Journal of Human Lactation. 33, 2, p. 351-354 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Highly pathogenic New World arenavirus infection activates the pattern recognition receptor protein kinase R without attenuating virus replication in human cells

Huang, C., Kolokoltsova, O. A., Mateer, E. J., Koma, T. & Paessler, S., Oct 1 2017, In : Journal of Virology. 91, 20, e01090-17.

Research output: Contribution to journalArticle

7 Scopus citations

Live, attenuated Venezuelan equine encephalitis virus vaccine (TC83) causes persistent brain infection in mice with non-functional αβ T-cells

Taylor, K., Kolokoltsova, O., Ronca, S. E., Estes, M. & Paessler, S., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 81.

Research output: Contribution to journalArticle

5 Scopus citations

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B. H., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. D. & Wang, T., Jan 1 2017, In : Journal of virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

4 Scopus citations

Mouse model of neurological complications resulting from encephalitic alphavirus infection

Ronca, S. E., Smith, J., Koma, T., Miller, M. M., Yun, N., Dineley, K. & Paessler, S., Feb 7 2017, In : Frontiers in Microbiology. 8, FEB, 188.

Research output: Contribution to journalArticle

Prediction of influenza vaccine effectiveness for the influenza season 2017/18 in the US

Veljkovic, V. & Paessler, S., Jan 1 2017, In : F1000Research. 6, 2067.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Animal model of sensorineural hearing loss associated with Lassa virus infection

Yun, N. E., Ronca, S., Tamura, A., Koma, T., Seregin, A. V., Dineley, K. T., Miller, M., Cook, R., Shimizu, N., Walker, A. G., Smith, J. N., Fair, J. N., Wauquier, N., Bockarie, B., Khan, S. H., Makishima, T. & Paessler, S., Jan 1 2016, In : Journal of virology. 90, 6, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Characterization of a novel murine model to study zika virus

Rossi, S. L., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R. M., Paessler, S., Vasilakis, N. & Weaver, S. C., Jun 1 2016, In : American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1362-1369 8 p.

Research output: Contribution to journalArticle

277 Scopus citations

Machupo virus expressing GPC of the Candid#1 vaccine strain of Junin virus is highly attenuated and immunogenic

Koma, T., Patterson, M., Huang, C., Seregin, A. V., Maharaj, P. D., Miller, M., Smith, J. N., Walker, A. G., Hallam, S. & Paessler, S., 2016, In : Journal of Virology. 90, 3, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection

Buzhdygan, T., Lisinicchia, J., Patel, V., Johnson, K., Neugebauer, V., Paessler, S., Jennings, K. & Gelman, B., Jun 1 2016, In : Journal of Neuroimmune Pharmacology. 11, 2, p. 279-293 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Predicted enhanced human propensity of current avian-like H1N1 swine influenza virus from China

Veljkovic, V., Veljkovic, N., Paessler, S., Goeijenbier, M., Perovic, V., Glisic, S. & Muller, C. P., Nov 1 2016, In : PLoS One. 11, 11, e0165451.

Research output: Contribution to journalArticle

1 Scopus citations

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Koma, T., Huang, C., Aronson, J., Walker, A. G., Miller, M., Smith, J. N., Patterson, M. & Paessler, S., Aug 30 2016, In : PLoS Neglected Tropical Diseases. 10, 8, e0004969.

Research output: Contribution to journalArticle

3 Scopus citations
2015
14 Scopus citations

Evolution of 2014/15 H3N2 influenza viruses circulating in US: Consequences for vaccine effectiveness and possible new pandemic

Veljkovic, V., Paessler, S., Glisic, S., Prljic, J., Perovic, V. R., Veljkovic, N. & Scotch, M., Jan 1 2015, In : Frontiers in Microbiology. 6, DEC, 01456.

Research output: Contribution to journalArticle

8 Scopus citations

Highly pathogenic New World and Old World human arenaviruses induce distinct interferon responses in human cells

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Ronca, S., Koma, T. & Paessler, S., 2015, In : Journal of Virology. 89, 14, p. 7079-7088 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Improving attrition rates in Ebola virus drug discovery

Glisic, S., Paessler, S., Veljkovic, N., Perovic, V. R., Prljic, J. & Veljkovic, V., Sep 2 2015, In : Expert Opinion on Drug Discovery. 10, 9, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R. & Paessler, S., May 1 2015, In : F1000Research. 4, 104.

Research output: Contribution to journalArticle

8 Scopus citations

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage

Manning, J. T., Forrester, N. & Paessler, S., Jan 1 2015, In : Frontiers in Microbiology. 6, OCT, 1037.

Research output: Contribution to journalArticle

31 Scopus citations

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In : Nature Immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., Jan 1 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journalArticle

78 Scopus citations

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., Jun 2014, In : PLoS neglected tropical diseases. 8, 6, e2933.

Research output: Contribution to journalArticle

10 Scopus citations

Reactive astrogliosis in response to hemorrhagic fever virus: Microarray profile of Junin virus-infected human astrocytes

Kolokoltsova, O. A., Yun, N. E. & Paessler, S., Jul 11 2014, In : Virology journal. 11, 1, 126.

Research output: Contribution to journalArticle

4 Scopus citations

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 1 2014, In : Journal of virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C. T. K., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PloS one. 9, 6, e99610.

Research output: Contribution to journalArticle

12 Scopus citations
61 Scopus citations
2013

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 1 2013, In : Journal of virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

37 Scopus citations

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., Oct 28 2013, In : Journal of virology. 87, 19, p. 10908-10911 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Pathogenesis of Venezuelan equine encephalitis

Taylor, K. G. & Paessler, S., Nov 29 2013, In : Veterinary Microbiology. 167, 1-2, p. 145-150 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Peng, B. H., Borisevich, V., Popov, V. L., Zacks, M. A., Estes, D. M., Campbell, G. A. & Paessler, S., May 3 2013, In : Veterinary Microbiology. 163, 3-4, p. 223-234 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform

Gabitzsch, E. S., Balint-Junior, J. P., Xu, Y., Balcaitis, S., Sanders-Beer, B., Karl, J., Weinhold, K. J., Paessler, S. & Jones, F. R., Nov 26 2012, In : Vaccine. 30, 50, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

8 Scopus citations