Projects per year
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- 2 Similar Profiles
Venezuelan Equine Encephalitis Viruses
Medicine & Life Sciences
Viruses
Chemical Compounds
Nicotinamide N-Methyltransferase
Medicine & Life Sciences
Alphavirus
Medicine & Life Sciences
Nucleocapsid
Medicine & Life Sciences
Dengue Virus
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Aldehyde Reductase
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2021
Development of NNMT Inhibitors as Novel Interventions to Activate Quiescent Muscle Stem Cells and Improve Age-Related Muscle Degeneration
4/15/19 → 1/31/21
Project: Other project
Therapeutic development of novel orally-bioavailable small molecules to treat muscular dystrophies and sarcopenia
12/1/17 → 6/1/19
Project: Other project
Healthcare Entrepreneurship Program: A Cohesive Initiative Supporting the UT System Entrepreneurship Network
1/26/15 → 12/31/15
Project: Other project
Proof-of-principle in vivo efficacy study of dengue antrviral drug candidate
7/1/13 → 6/30/14
Project: Other project
Research Output 1985 2019
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
Neelakantan, H., Brightwell, C. R., Graber, T., Maroto, R., Wang, H. Y. L., McHardy, S. F., Papaconstantinou, J., Fry, C. & Watowich, S., Jan 1 2019, In : Biochemical Pharmacology.Research output: Contribution to journal › Article
Nicotinamide N-Methyltransferase
Stem cells
Muscle Cells
Muscle
Skeletal Muscle
6
Citations
(Scopus)
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Neelakantan, H., Vance, V., Wetzel, M. D., Wang, H. Y. L., McHardy, S. F., Finnerty, C., Hommel, J. & Watowich, S., Jan 1 2018, In : Biochemical Pharmacology. 147, p. 141-152 12 p.Research output: Contribution to journal › Article
Nicotinamide N-Methyltransferase
High Fat Diet
Nutrition
Obesity
Fats
4
Citations
(Scopus)
Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential
Langsjoen, R., Auguste, A. J., Rossi, S., Roundy, C. M., Penate, H. N., Kastis, M., Schnizlein, M. K., Le, K. C., Haller, S. L., Chen, R., Watowich, S. & Weaver, S., Jul 1 2017, In : Antiviral Research. 143, p. 246-251 6 p.Research output: Contribution to journal › Article
Chikungunya virus
Protein Disulfide-Isomerases
Auranofin
Alphavirus
Pharmaceutical Preparations
10
Citations
(Scopus)
Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity
Neelakantan, H., Vance, V., Wang, H. Y. L., McHardy, S. F. & Watowich, S., Feb 14 2017, In : Biochemistry. 56, 6, p. 824-832 9 p.Research output: Contribution to journal › Article
Nicotinamide N-Methyltransferase
Assays
Monitoring
Substrates
Methionine
11
Citations
(Scopus)
Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
Neelakantan, H., Wang, H. Y., Vance, V., Hommel, J., McHardy, S. F. & Watowich, S., Jun 22 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 5015-5028 14 p.Research output: Contribution to journal › Article
Nicotinamide N-Methyltransferase
Structure-Activity Relationship
Inhibitory Concentration 50
Binding Sites
Ligands