Tapas Hazra, PhD

  • 7149 Citations
  • 51 h-Index
1992 …2020

Research output per year

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Research Output

2020

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

Research output: Contribution to journalArticle

Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning

Banerjee, S., Mukherjee, S., Bhattacharya, A., Basak, U., Chakraborty, S., Paul, S., Khan, P., Jana, K., Hazra, T. K. & Das, T., May 20 2020, In : Free Radical Biology and Medicine. 152, p. 152-165 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. K. & Sarkar, P. S., Apr 2019, In : eLife. 8, e42988.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T. K., Vlahopoulos, S. A., Bacsi, A., Brasier, A., Ba, X. & Boldogh, I., Sep 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T. K., Boldogh, I., Dizdaroglu, M. & Sur, S., Dec 2018, In : Clinical and Experimental Allergy. 48, 12, p. 1676-1687 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Pivotal role of DNA repair in infection mediated-inflammation and cancer

Sahan, A. Z., Hazra, T. K. & Das, S., Apr 11 2018, In : Frontiers in Microbiology. 9, APR, 663.

Research output: Contribution to journalReview article

9 Scopus citations
2017

Feeling Stressed under the Sun? RPA1 Acetylation to the Rescue

Chakravarti, D. & Hazra, T., Aug 29 2017, In : Cell Reports. 20, 9, p. 1995-1996 2 p.

Research output: Contribution to journalShort survey

Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T. K., Boldogh, I. & Sur, S., Nov 2017, In : Journal of Allergy and Clinical Immunology. 140, 5, p. 1436-1439.e5

Research output: Contribution to journalArticle

5 Scopus citations

PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2

Chakraborti, S., Chakraborty, S., Saha, S., Manna, A., Banerjee, S., Adhikary, A., Sarwar, S., Hazra, T., Das, T. & Chakrabarti, P., Feb 1 2017, In : Free Radical Biology and Medicine. 103, p. 35-47 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

54 Scopus citations

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation

Hosoki, K., Boldogh, I., Aguilera-Aguirre, L., Sun, Q., Itazawa, T., Hazra, T., Brasier, A. R., Kurosky, A. & Sur, S., May 1 2016, In : Journal of Allergy and Clinical Immunology. 137, 5, p. 1506-1513.e2

Research output: Contribution to journalArticle

11 Scopus citations

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journalArticle

65 Scopus citations
2015

Amphotericin B and anidulafungin directly interact with DNA and induce oxidative damage in the mammalian genome

Mandal, S. M., Chakraborty, A., Hossain, M., Mahata, D., Porto, W. F., Chakraborty, R., Mukhopadhyay, C. K., Franco, O. L., Hazra, T. & Basak, A., Jul 13 2015, In : Molecular BioSystems. 11, 9, p. 2551-2559 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

30 Scopus citations

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease

Suganya, R., Chakraborty, A., Miriyala, S., Hazra, T. K. & Izumi, T., Mar 1 2015, In : DNA Repair. 27, p. 40-48 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

38 Scopus citations
2014

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Mandal, S. M., Roy, A., Ghosh, A. K., Hazra, T. K., Basak, A. & Franco, O. L., 2014, In : Frontiers in Pharmacology. 5 MAY, 105.

Research output: Contribution to journalReview article

55 Scopus citations

Controlling resistant bacteria with a novel class of β 2-lactamase inhibitor peptides: From rational design to in vivo analyses

Mandal, S. M., Migliolo, L., Silva, O. N., Fensterseifer, I. C. M., Faria-Junior, C., Dias, S. C., Basak, A., Hazra, T. K. & Franco, O. L., Aug 11 2014, In : Scientific reports. 4, 6015.

Research output: Contribution to journalArticle

9 Scopus citations

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 177-189 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

17 Scopus citations

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In : PloS one. 9, 3, e90261.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M. L., Ba, X. & Boldogh, I., Oct 1 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

Research output: Contribution to journalArticle

56 Scopus citations

Thirdhand smoke causes DNA damage in human cells

Hang, B., Sarker, A. H., Havel, C., Saha, S., Hazra, T. K., Schick, S., Jacob, P., Rehan, V. K., Chenna, A., Sharan, D., Sleiman, M., Destaillats, H. & Gundel, L. A., Jul 1 2013, In : Mutagenesis. 28, 4, p. 381-391 11 p.

Research output: Contribution to journalArticle

73 Scopus citations
2012

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. K. & Boldogh, I., Feb 15 2012, In : Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties

Mandal, S. M., Migliolo, L., Das, S., Mandal, M., Franco, O. L. & Hazra, T. K., Jan 1 2012, In : Journal of Cellular Biochemistry. 113, 1, p. 184-193 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 1 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

Research output: Contribution to journalArticle

93 Scopus citations

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
2011

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Ma, H., Wang, J., Abdel-Rahman, S. Z., Hazra, T. K., Boor, P. J. & Khan, M. F., Feb 15 2011, In : Toxicology and Applied Pharmacology. 251, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

89 Scopus citations
2010

Functions of disordered regions in mammalian early base excision repair proteins

Hegde, M. L., Hazra, T. K. & Mitra, S., Nov 1 2010, In : Cellular and Molecular Life Sciences. 67, 21, p. 3573-3587 15 p.

Research output: Contribution to journalReview article

44 Scopus citations

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCδ to mitochondria in spinocerebellar ataxia 10

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T. K., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. S. & Ashizawa, T., Jun 2010, In : PLoS genetics. 6, 6, p. 1-12 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

Theriot, C. A., Hegde, M. L., Hazra, T. K. & Mitra, S., Jun 4 2010, In : DNA Repair. 9, 6, p. 643-652 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: Potential etiological linkage to neurodegenerative diseases

Hegde, M. L., Hegde, P. M., Holthauzen, L. M. F., Hazra, T. K., Rao, K. S. J. & Mitra, S., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28812-28825 14 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction

Chodaczek, G., Bacsi, A., Dharajiya, N., Sur, S., Hazra, T. K. & Boldogh, I., Aug 1 2009, In : Molecular Immunology. 46, 13, p. 2505-2514 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil

Thiviyanathan, V., Somasunderam, A., Volk, D. E., Hazra, T. K., Mitra, S. & Gorenstein, D. G., Feb 15 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 752-757 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

Hegde, M. L., Hazra, T. K. & Mitra, S., Jan 1 2008, In : Cell Research. 18, 1, p. 27-47 21 p.

Research output: Contribution to journalReview article

398 Scopus citations

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes

Dou, H., Theriot, C. A., Das, A., Hegde, M. L., Matsumoto, Y., Boldogh, I., Hazra, T. K., Bhakat, K. K. & Mitra, S., Feb 8 2008, In : Journal of Biological Chemistry. 283, 6, p. 3130-3140 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

Maiti, A. K., Boldogh, I., Spratt, H., Mitra, S. & Hazra, T. K., Aug 2 2008, In : DNA Repair. 7, 8, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Oxanine DNA glycosylase activities in mammalian systems

Dong, L., Meira, L. B., Hazra, T. K., Samson, L. D. & Cao, W., Jan 1 2008, In : DNA Repair. 7, 1, p. 128-134 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease

Hegde, M. L., Theriot, C. A., Das, A., Hegde, P. M., Guo, Z., Gary, R. K., Hazra, T. K., Shen, B. & Mitra, S., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27028-27037 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1

Chattopadhyay, R., Das, S., Maiti, A. K., Boldogh, I., Xie, J., Hazra, T. K., Kohno, K., Mitra, S. & Bhakat, K. K., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7066-7080 15 p.

Research output: Contribution to journalArticle

90 Scopus citations