Tapas Hazra, PhD

  • 7120 Citations
  • 51 h-Index
1992 …2020

Research output per year

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Research Output

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo

Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. K. & Mitra, S., Mar 2006, In : Molecular and cellular biology. 26, 5, p. 1654-1665 12 p.

Research output: Contribution to journalArticle

126 Scopus citations

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity

Bhakat, K. K., Hazra, T. K. & Mitra, S., Aug 16 2004, In : Nucleic acids research. 32, 10, p. 3033-3039 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil

Ali, M. M., Hazra, T. K., Hong, D. & Kow, Y. W., Jun 8 2005, In : DNA Repair. 4, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M. L., Ba, X. & Boldogh, I., Oct 1 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

Biswas, T., Ramana, C. V., Srinivasan, G., Boldogh, I., Hazra, T. K., Chen, Z., Tano, K., Thompson, E. B. & Mitra, S., Jan 14 1999, In : Oncogene. 18, 2, p. 525-532 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

81 Scopus citations
93 Scopus citations

Amphotericin B and anidulafungin directly interact with DNA and induce oxidative damage in the mammalian genome

Mandal, S. M., Chakraborty, A., Hossain, M., Mahata, D., Porto, W. F., Chakraborty, R., Mukhopadhyay, C. K., Franco, O. L., Hazra, T. & Basak, A., Jul 13 2015, In : Molecular BioSystems. 11, 9, p. 2551-2559 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

AP endonuclease-independent DNA base excision repair in human cells

Wiederhold, L., Leppard, J. B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., Mitra, S. & Hazra, T. K., Jul 23 2004, In : Molecular cell. 15, 2, p. 209-220 12 p.

Research output: Contribution to journalArticle

335 Scopus citations

Application of polymerase chain reaction with specific and arbitrary primers to identification and differentiation of Leishmania parasites

Bhattacharyya, R., Singh, R., Hazra, T. K. & Majumder, H. K., Nov 15 1993, In : FEMS Microbiology Letters. 114, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil

Thiviyanathan, V., Somasunderam, A., Volk, D. E., Hazra, T. K., Mitra, S. & Gorenstein, D. G., Feb 15 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 752-757 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. K. & Boldogh, I., Feb 15 2012, In : Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Bioleaching of low-grade copper ores using Thiobacillus ferrooxidans - Scientific note

Hazra, T. K., Mukherjea, M. & Mukherjea, R. N., Mar 1 1992, In : Applied Biochemistry and Biotechnology. 34-35, 1, p. 377-382 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Mandal, S. M., Roy, A., Ghosh, A. K., Hazra, T. K., Basak, A. & Franco, O. L., 2014, In : Frontiers in Pharmacology. 5 MAY, 105.

Research output: Contribution to journalReview article

54 Scopus citations

Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII

Hazra, T. K., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M. & Mitra, S., Sep 8 2000, In : Journal of Biological Chemistry. 275, 36, p. 27762-27767 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Choreography of oxidative damage repair in mammalian genomes

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Hill, J. W. & Hazra, T. K., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

54 Scopus citations

Complexities of DNA Base Excision Repair in Mammalian Cells

Mitra, S., Hazra, T. K., Roy, R., Ikeda, S., Biswas, T., Lock, J., Boldogh, I. & Izumi, T., Jun 30 1997, In : Molecules and Cells. 7, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

Mitra, S., Boldogh, I., Izumi, T. & Hazra, T. K., Jan 1 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 180-190 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Controlling resistant bacteria with a novel class of β 2-lactamase inhibitor peptides: From rational design to in vivo analyses

Mandal, S. M., Migliolo, L., Silva, O. N., Fensterseifer, I. C. M., Faria-Junior, C., Dias, S. C., Basak, A., Hazra, T. K. & Franco, O. L., Aug 11 2014, In : Scientific reports. 4, 6015.

Research output: Contribution to journalArticle

9 Scopus citations

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

Research output: Contribution to journalArticle

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

Hegde, M. L., Hazra, T. K. & Mitra, S., Jan 1 2008, In : Cell Research. 18, 1, p. 27-47 21 p.

Research output: Contribution to journalReview article

395 Scopus citations

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T. K., Vlahopoulos, S. A., Bacsi, A., Brasier, A., Ba, X. & Boldogh, I., Sep 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Enhanced γ-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity

Das, G. C., Bacsi, A., Shrivastav, M., Hazra, T. K. & Boldogh, I., Sep 1 2006, In : Molecular Carcinogenesis. 45, 9, p. 635-647 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Erratum: Specific interaction of wild-type and truncated mouse N- methylpurine-DNA glycosylase with ethenoadenine-containing DNA (Biochemistry (January 13, 1998) 37:2 (580-589))

Roy, R., Biswas, T., Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Aug 3 1999, In : Biochemistry. 38, 31, 1 p.

Research output: Contribution to journalComment/debate

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T. K., Boldogh, I., Dizdaroglu, M. & Sur, S., Dec 2018, In : Clinical and Experimental Allergy. 48, 12, p. 1676-1687 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Feeling Stressed under the Sun? RPA1 Acetylation to the Rescue

Chakravarti, D. & Hazra, T., Aug 29 2017, In : Cell Reports. 20, 9, p. 1995-1996 2 p.

Research output: Contribution to journalShort survey

Functions of disordered regions in mammalian early base excision repair proteins

Hegde, M. L., Hazra, T. K. & Mitra, S., Nov 1 2010, In : Cellular and Molecular Life Sciences. 67, 21, p. 3573-3587 15 p.

Research output: Contribution to journalReview article

44 Scopus citations

Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties

Mandal, S. M., Migliolo, L., Das, S., Mandal, M., Franco, O. L. & Hazra, T. K., Jan 1 2012, In : Journal of Cellular Biochemistry. 113, 1, p. 184-193 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T. K., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y. W., Jaruga, P., Dizdaroglu, M. & Mitra, S., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

385 Scopus citations

Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, T. K., Kow, Y. W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S. K., Mitra, S. & Izumi, T., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30417-30420 4 p.

Research output: Contribution to journalArticle

250 Scopus citations

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

Chattopadhyay, R., Wiederhold, L., Szczesny, B., Boldogh, I., Hazra, T. K., Izumi, T. & Mitra, S., 2006, In : Nucleic acids research. 34, 7, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein

Das, A., Rajagopalan, L., Mathura, V. S., Rigby, S. J., Mitra, S. & Hazra, T. K., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47132-47138 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCδ to mitochondria in spinocerebellar ataxia 10

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T. K., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. S. & Ashizawa, T., Jun 2010, In : PLoS genetics. 6, 6, p. 1-12 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

30 Scopus citations

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Increased ROS generation in subsets of OGG1 knockout fibroblast cells

Bacsi, A., Chodaczek, G., Hazra, T. K., Konkel, D. & Boldogh, I., Nov 1 2007, In : Mechanisms of Ageing and Development. 128, 11-12, p. 637-649 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Ma, H., Wang, J., Abdel-Rahman, S. Z., Hazra, T. K., Boor, P. J. & Khan, M. F., Feb 15 2011, In : Toxicology and Applied Pharmacology. 251, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species

Das, A., Hazra, T. K., Boldogh, I., Mitra, S. & Bhakat, K. K., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35272-35280 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T. K., Boldogh, I. & Sur, S., Nov 2017, In : Journal of Allergy and Clinical Immunology. 140, 5, p. 1436-1439.e5

Research output: Contribution to journalArticle

5 Scopus citations

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes

Dou, H., Theriot, C. A., Das, A., Hegde, M. L., Matsumoto, Y., Boldogh, I., Hazra, T. K., Bhakat, K. K. & Mitra, S., Feb 8 2008, In : Journal of Biological Chemistry. 283, 6, p. 3130-3140 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris

Bonté, F., Scheffler, I. E., Roubertoux, P. L., De Grey, A. D. N. J., Krutmann, J., Szczesny, B., Chattopadhyay, R., Hazra, T. K., Bhakat, K. K., Izumi, T., Wiederhold, L. R., Boldogh, I., Mitra, S., Friguet, B., Zuliani, T., Dumas, M., Ratinaud, M. H., Salvioli, S., Capri, M., Monti, D. & 3 others, Santoro, A., Barbi, C. & Claudio Franceschi, F., Jun 1 2006, In : Bioscience Reports. 26, 3, p. 183-201 19 p.

Research output: Contribution to journalArticle

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Izumi, T., Wiederhold, L. R., Roy, G., Roy, R., Jaiswal, A., Bhakat, K. K., Mitra, S. & Hazra, T. K., Nov 15 2003, In : Toxicology. 193, 1-2, p. 43-65 23 p.

Research output: Contribution to journalReview article

165 Scopus citations

Minimum size of active human O6-methylguanine-dna methyltransference (MGMT); substrate binding parallels mgmt activity

Hazra, T. K., Roy, R., Grabowski, D. T. & Mitra, S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A967

Research output: Contribution to journalArticle

Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

Wang, G., Hazra, T. K., Mitra, S., Lee, H. M. & Englander, E. W., May 15 2000, In : Nucleic acids research. 28, 10, p. 2135-2140 6 p.

Research output: Contribution to journalArticle

133 Scopus citations

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells

Bacsi, A., Kannan, S., Lee, M. S., Hazra, T. K. & Boldogh, I., Dec 15 2005, In : Free Radical Biology and Medicine. 39, 12, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

21 Scopus citations