Tapas Hazra, PhD

  • 6832 Citations
  • 49 h-Index
1992 …2022

Research output per year

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Research Output

Article

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo

Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. K. & Mitra, S., Mar 1 2006, In : Molecular and cellular biology. 26, 5, p. 1654-1665 12 p.

Research output: Contribution to journalArticle

119 Scopus citations

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity

Bhakat, K. K., Hazra, T. K. & Mitra, S., Aug 16 2004, In : Nucleic acids research. 32, 10, p. 3033-3039 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil

Ali, M. M., Hazra, T. K., Hong, D. & Kow, Y. W., Jun 8 2005, In : DNA Repair. 4, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M. L., Ba, X. & Boldogh, I., Oct 1 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

Biswas, T., Ramana, C. V., Srinivasan, G., Boldogh, I., Hazra, T. K., Chen, Z., Tano, K., Thompson, E. B. & Mitra, S., Jan 14 1999, In : Oncogene. 18, 2, p. 525-532 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

77 Scopus citations
93 Scopus citations

Amphotericin B and anidulafungin directly interact with DNA and induce oxidative damage in the mammalian genome

Mandal, S. M., Chakraborty, A., Hossain, M., Mahata, D., Porto, W. F., Chakraborty, R., Mukhopadhyay, C. K., Franco, O. L., Hazra, T. & Basak, A., Jul 13 2015, In : Molecular BioSystems. 11, 9, p. 2551-2559 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

AP endonuclease-independent DNA base excision repair in human cells

Wiederhold, L., Leppard, J. B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., Mitra, S. & Hazra, T. K., Jul 23 2004, In : Molecular cell. 15, 2, p. 209-220 12 p.

Research output: Contribution to journalArticle

330 Scopus citations

Application of polymerase chain reaction with specific and arbitrary primers to identification and differentiation of Leishmania parasites

Bhattacharyya, R., Singh, R., Hazra, T. K. & Majumder, H. K., Nov 15 1993, In : FEMS Microbiology Letters. 114, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil

Thiviyanathan, V., Somasunderam, A., Volk, D. E., Hazra, T. K., Mitra, S. & Gorenstein, D. G., Feb 15 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 752-757 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. K. & Boldogh, I., Feb 15 2012, In : Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Bioleaching of low-grade copper ores using Thiobacillus ferrooxidans - Scientific note

Hazra, T. K., Mukherjea, M. & Mukherjea, R. N., Mar 1 1992, In : Applied Biochemistry and Biotechnology. 34-35, 1, p. 377-382 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII

Hazra, T. K., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M. & Mitra, S., Sep 8 2000, In : Journal of Biological Chemistry. 275, 36, p. 27762-27767 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Choreography of oxidative damage repair in mammalian genomes

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Hill, J. W. & Hazra, T. K., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

46 Scopus citations

Complexities of DNA Base Excision Repair in Mammalian Cells

Mitra, S., Hazra, T. K., Roy, R., Ikeda, S., Biswas, T., Lock, J., Boldogh, I. & Izumi, T., Jun 30 1997, In : Molecules and Cells. 7, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

Mitra, S., Boldogh, I., Izumi, T. & Hazra, T. K., Jan 1 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 180-190 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Controlling resistant bacteria with a novel class of β 2-lactamase inhibitor peptides: From rational design to in vivo analyses

Mandal, S. M., Migliolo, L., Silva, O. N., Fensterseifer, I. C. M., Faria-Junior, C., Dias, S. C., Basak, A., Hazra, T. K. & Franco, O. L., Aug 11 2014, In : Scientific reports. 4, 6015.

Research output: Contribution to journalArticle

8 Scopus citations

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T. K., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T., Vlahopoulos, S. A., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Sep 1 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Enhanced γ-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity

Das, G. C., Bacsi, A., Shrivastav, M., Hazra, T. K. & Boldogh, I., Sep 1 2006, In : Molecular Carcinogenesis. 45, 9, p. 635-647 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T., Boldogh, I., Dizdaroglu, M. & Sur, S., Jan 1 2018, (Accepted/In press) In : Clinical and Experimental Allergy.

Research output: Contribution to journalArticle

1 Scopus citations

Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties

Mandal, S. M., Migliolo, L., Das, S., Mandal, M., Franco, O. L. & Hazra, T. K., Jan 1 2012, In : Journal of Cellular Biochemistry. 113, 1, p. 184-193 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T. K., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y. W., Jaruga, P., Dizdaroglu, M. & Mitra, S., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

379 Scopus citations

Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, T. K., Kow, Y. W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S. K., Mitra, S. & Izumi, T., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30417-30420 4 p.

Research output: Contribution to journalArticle

247 Scopus citations

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

Chattopadhyay, R., Wiederhold, L., Szczesny, B., Boldogh, I., Hazra, T. K., Izumi, T. & Mitra, S., Sep 7 2006, In : Nucleic acids research. 34, 7, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

106 Scopus citations

Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein

Das, A., Rajagopalan, L., Mathura, V. S., Rigby, S. J., Mitra, S. & Hazra, T. K., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47132-47138 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCδ to mitochondria in spinocerebellar ataxia 10

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T. K., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. S. & Ashizawa, T., Jun 1 2010, In : PLoS genetics. 6, 6, p. 1-12 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., Jan 1 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

27 Scopus citations

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Increased ROS generation in subsets of OGG1 knockout fibroblast cells

Bacsi, A., Chodaczek, G., Hazra, T. K., Konkel, D. & Boldogh, I., Nov 1 2007, In : Mechanisms of Ageing and Development. 128, 11-12, p. 637-649 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Ma, H., Wang, J., Abdel-Rahman, S. Z., Hazra, T. K., Boor, P. J. & Khan, M. F., Feb 15 2011, In : Toxicology and Applied Pharmacology. 251, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species

Das, A., Hazra, T. K., Boldogh, I., Mitra, S. & Bhakat, K. K., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35272-35280 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T., Boldogh, I. & Sur, S., 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

5 Scopus citations

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes

Dou, H., Theriot, C. A., Das, A., Hegde, M. L., Matsumoto, Y., Boldogh, I., Hazra, T. K., Bhakat, K. K. & Mitra, S., Feb 8 2008, In : Journal of Biological Chemistry. 283, 6, p. 3130-3140 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris

Bonté, F., Scheffler, I. E., Roubertoux, P. L., De Grey, A. D. N. J., Krutmann, J., Szczesny, B., Chattopadhyay, R., Hazra, T. K., Bhakat, K. K., Izumi, T., Wiederhold, L. R., Boldogh, I., Mitra, S., Friguet, B., Zuliani, T., Dumas, M., Ratinaud, M. H., Salvioli, S., Capri, M., Monti, D. & 3 others, Santoro, A., Barbi, C. & Claudio Franceschi, F., Jun 1 2006, In : Bioscience Reports. 26, 3, p. 183-201 19 p.

Research output: Contribution to journalArticle

Minimum size of active human O6-methylguanine-dna methyltransference (MGMT); substrate binding parallels mgmt activity

Hazra, T. K., Roy, R., Grabowski, D. T. & Mitra, S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A967

Research output: Contribution to journalArticle

Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

Wang, G., Hazra, T. K., Mitra, S., Lee, H. M. & Englander, E. W., May 15 2000, In : Nucleic acids research. 28, 10, p. 2135-2140 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells

Bacsi, A., Kannan, S., Lee, M. S., Hazra, T. K. & Boldogh, I., Dec 15 2005, In : Free Radical Biology and Medicine. 39, 12, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 177-189 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. & Sarkar, P., Apr 17 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

Maiti, A. K., Boldogh, I., Spratt, H., Mitra, S. & Hazra, T. K., Aug 2 2008, In : DNA Repair. 7, 8, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation

Hosoki, K., Boldogh, I., Aguilera-Aguirre, L., Sun, Q., Itazawa, T., Hazra, T., Brasier, A. R., Kurosky, A. & Sur, S., May 1 2016, In : Journal of Allergy and Clinical Immunology. 137, 5, p. 1506-1513.e2

Research output: Contribution to journalArticle

11 Scopus citations

NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

Das, A., Wiederhold, L., Leppard, J. B., Kedar, P., Prasad, R., Wang, H., Boldogh, I., Karimi-Busheri, F., Weinfeld, M., Tomkinson, A. E., Wilson, S. H., Mitra, S. & Hazra, T. K., Dec 9 2006, In : DNA Repair. 5, 12, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In : PloS one. 9, 3, e90261.

Research output: Contribution to journalArticle

16 Scopus citations