Tapas Hazra, PhD

  • 7041 Citations
  • 51 h-Index
1992 …2022

Research output per year

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Research Output

Article

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T. K., Talbot, P. & Hang, B., Mar 3 2014, In : PloS one. 9, 3, e90261.

Research output: Contribution to journalArticle

20 Scopus citations

Oxanine DNA glycosylase activities in mammalian systems

Dong, L., Meira, L. B., Hazra, T. K., Samson, L. D. & Cao, W., Jan 1 2008, In : DNA Repair. 7, 1, p. 128-134 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer

Li, D., Zhang, W., Zhu, J., Chang, P., Sahin, A., Singletary, E., Bondy, M., Hazra, T., Mitra, S., Lau, S. S., Shen, J. & DiGiovanni, J., Sep 21 2001, In : Molecular Carcinogenesis. 31, 4, p. 214-223 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Oxidative DNA damage repair in mammalian cells: A new perspective

Hazra, T. K., Das, A., Das, S., Choudhury, S., Kow, Y. W. & Roy, R., Apr 1 2007, In : DNA Repair. 6, 4, p. 470-480 11 p.

Research output: Contribution to journalArticle

209 Scopus citations

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 1 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2

Chakraborti, S., Chakraborty, S., Saha, S., Manna, A., Banerjee, S., Adhikary, A., Sarwar, S., Hazra, T., Das, T. & Chakrabarti, P., Feb 1 2017, In : Free Radical Biology and Medicine. 103, p. 35-47 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease

Hegde, M. L., Theriot, C. A., Das, A., Hegde, P. M., Guo, Z., Gary, R. K., Hazra, T. K., Shen, B. & Mitra, S., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27028-27037 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3090-E3099

Research output: Contribution to journalArticle

55 Scopus citations

Protein phosphorylation is a regulatory mechanism for O6-alkylguanine- DNA alkyltransferase in human brain tumor cells

Srivenugopal, K. S., Mullapudi, S. R. S., Shou, J., Hazra, T. K. & Ali-Osman, F., Jan 15 2000, In : Cancer Research. 60, 2, p. 282-287 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning

Banerjee, S., Mukherjee, S., Bhattacharya, A., Basak, U., Chakraborty, S., Paul, S., Khan, P., Jana, K., Hazra, T. K. & Das, T., May 20 2020, In : Free Radical Biology and Medicine. 152, p. 152-165 14 p.

Research output: Contribution to journalArticle

Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction

Chodaczek, G., Bacsi, A., Dharajiya, N., Sur, S., Hazra, T. K. & Boldogh, I., Aug 1 2009, In : Molecular Immunology. 46, 13, p. 2505-2514 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Rates of base excision repair are not solely dependent on levels of initiating enzymes

Cappelli, E., Hazra, T., Hill, J. W., Slupphaug, G., Bogliolo, M. & Frosina, G., Mar 21 2001, In : Carcinogenesis. 22, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress

Boldogh, I., Roy, G., Lee, M. S., Bacsi, A., Hazra, T. K., Bhakat, K. K., Das, G. C. & Mitra, S., Nov 15 2003, In : Toxicology. 193, 1-2, p. 137-152 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Regulation of expression of the DNA repair gene-O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling

Boldogh, I., Ramana, C. V., Chen, Z., Biswas, T., Hazra, T. K., Grösch, S., Grombacher, T., Mitra, S. & Kaina, B., Sep 1 1998, In : Cancer Research. 58, 17, p. 3950-3956 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1

Chattopadhyay, R., Das, S., Maiti, A. K., Boldogh, I., Xie, J., Hazra, T. K., Kohno, K., Mitra, S. & Bhakat, K. K., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7066-7080 15 p.

Research output: Contribution to journalArticle

87 Scopus citations

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Hazra, T. K., Muller, J. G., Manuel, R. C., Burrows, C. J., Lloyd, R. S. & Mitra, S., May 1 2001, In : Nucleic acids research. 29, 9, p. 1967-1974 8 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

Dou, H., Mitra, S. & Hazra, T. K., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 49679-49684 6 p.

Research output: Contribution to journalArticle

257 Scopus citations

Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species

Izumi, T., Hazra, T. K., Boldogh, I., Tomkinson, A. E., Park, M. S., Ikeda, S. & Mitra, S., Jan 1 2000, In : Carcinogenesis. 21, 7, p. 1329-1334 6 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli

Bhattacharyya, D., Hazra, T. K., David Behnke, W., Chong, P. L. G., Kurosky, A., Ching Lee, J. & Mitra, S., Feb 10 1998, In : Biochemistry. 37, 6, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

Bhakat, K. K., Izumi, T., Yang, S. H., Hazra, T. K. & Mitra, S., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6299-6309 11 p.

Research output: Contribution to journalArticle

141 Scopus citations

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Role of rusticyanin in the electron transport process in Thiobacillus ferrooxidans.

Hazra, T. K., Mukherjea, M. & Mukherjea, R. N., Feb 1992, In : Indian journal of biochemistry & biophysics. 29, 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

Boldogh, I., Bacsi, A., Choudhury, B. K., Dharajiya, N., Alam, R., Hazra, T. K., Mitra, S., Goldblum, R. M. & Sur, S., Aug 1 2005, In : Journal of Clinical Investigation. 115, 8, p. 2169-2179 11 p.

Research output: Contribution to journalArticle

262 Scopus citations

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

Theriot, C. A., Hegde, M. L., Hazra, T. K. & Mitra, S., Jun 4 2010, In : DNA Repair. 9, 6, p. 643-652 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Solution structure of a DNA duplex containing 8-hydroxy-2′-deoxyguanosine opposite deoxyguanosine

Thiviyanathan, V., Somasunderam, A., Hazra, T. K., Mitra, S. & Gorenstein, D. G., Jan 1 2003, In : Journal of Molecular Biology. 325, 3, p. 433-442 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: Potential etiological linkage to neurodegenerative diseases

Hegde, M. L., Hegde, P. M., Holthauzen, L. M. F., Hazra, T. K., Rao, K. S. J. & Mitra, S., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28812-28825 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Specific interaction of wild-type and truncated mouse N-methylpurine- DNA glycosylase with ethenoadenine-containing DNA

Roy, R., Biswas, T., Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Jan 13 1998, In : Biochemistry. 37, 2, p. 580-589 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

Hazra, T. K., Roy, R., Biswas, T., Giabowski, D. T., Pegg, A. E. & Mitra, S., May 13 1997, In : Biochemistry. 36, 19, p. 5769-5776 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Stimulation of DNA glycosylase activity of OGG1 by NEIL1: Functional collaboration between two human DNA glycosylases

Mokkapati, S. K., Wiederhold, L., Hazra, T. K. & Mitra, S., Sep 14 2004, In : Biochemistry. 43, 36, p. 11596-11604 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair

Hill, J. W., Hazra, T. K., Izumi, T. & Mitra, S., Jan 15 2001, In : Nucleic acids research. 29, 2, p. 430-438 9 p.

Research output: Contribution to journalArticle

308 Scopus citations

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

Das, S., Chattopadhyay, R., Bhakat, K. K., Boldogh, I., Kohno, K., Prasad, R., Wilson, S. H. & Hazra, T. K., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28474-28484 11 p.

Research output: Contribution to journalArticle

86 Scopus citations

Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Dizdaroglu, M., Burgess, S. M., Jaruga, P., Hazra, T. K., Rodriguez, H. & Lloyd, R. S., Oct 9 2001, In : Biochemistry. 40, 40, p. 12150-12156 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease

Suganya, R., Chakraborty, A., Miriyala, S., Hazra, T. K. & Izumi, T., Mar 1 2015, In : DNA Repair. 27, p. 40-48 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications

Hazra, T. K., Izumi, T., Kow, Y. W. & Mitra, S., Feb 1 2003, In : Carcinogenesis. 24, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

The domains of mammalian base excision repair enzyme w-methylpurine-dna glycosylase: Interaction, conformational change and role in dna-binding and damage recognition

Roy, R., Kumar, A., Hazra, T. K., Roy, G., Grabowski, D. T., Lee J, J. & Mitra, S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase

Guan, X., Bai, H., Shi, G., Theriot, C. A., Hazra, T. K., Mitra, S. & Lu, A. L., Apr 1 2007, In : Nucleic acids research. 35, 8, p. 2463-2472 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

Das, A., Boldogh, I., Jae, W. L., Harrigan, J. A., Hegde, M. L., Piotrowski, J., Pinto, N. D. S., Ramos, W., Greenberg, M. M., Hazra, T. K., Mitra, S. & Bohr, V. A., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26591-26602 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation

Hazra, T. K., Izumi, T., Maidt, L., Floyd, R. A. & Mitra, S., Nov 15 1998, In : Nucleic acids research. 26, 22, p. 5116-5122 7 p.

Research output: Contribution to journalArticle

Open Access
155 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., Jan 1 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

37 Scopus citations

Thirdhand smoke causes DNA damage in human cells

Hang, B., Sarker, A. H., Havel, C., Saha, S., Hazra, T. K., Schick, S., Jacob, P., Rehan, V. K., Chenna, A., Sharan, D., Sleiman, M., Destaillats, H. & Gundel, L. A., Jul 1 2013, In : Mutagenesis. 28, 4, p. 381-391 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
Chapter

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions

Hazra, T. K., Hill, J. W., Izumi, T. & Mitra, S., Jan 1 2001, Progress in Nucleic Acid Research and Molecular Biology. Vol. 68. p. 193-205 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

105 Scopus citations
Comment/debate

Erratum: Specific interaction of wild-type and truncated mouse N- methylpurine-DNA glycosylase with ethenoadenine-containing DNA (Biochemistry (January 13, 1998) 37:2 (580-589))

Roy, R., Biswas, T., Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Aug 3 1999, In : Biochemistry. 38, 31, 1 p.

Research output: Contribution to journalComment/debate

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

17 Scopus citations
Review article

Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Mandal, S. M., Roy, A., Ghosh, A. K., Hazra, T. K., Basak, A. & Franco, O. L., Jan 1 2014, In : Frontiers in Pharmacology. 5 MAY, 105.

Research output: Contribution to journalReview article

51 Scopus citations

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

Hegde, M. L., Hazra, T. K. & Mitra, S., Jan 1 2008, In : Cell Research. 18, 1, p. 27-47 21 p.

Research output: Contribution to journalReview article

390 Scopus citations

Functions of disordered regions in mammalian early base excision repair proteins

Hegde, M. L., Hazra, T. K. & Mitra, S., Nov 1 2010, In : Cellular and Molecular Life Sciences. 67, 21, p. 3573-3587 15 p.

Research output: Contribution to journalReview article

44 Scopus citations

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Izumi, T., Wiederhold, L. R., Roy, G., Roy, R., Jaiswal, A., Bhakat, K. K., Mitra, S. & Hazra, T. K., Nov 15 2003, In : Toxicology. 193, 1-2, p. 43-65 23 p.

Research output: Contribution to journalReview article

163 Scopus citations