Tapas Hazra, PhD

  • 6832 Citations
  • 49 h-Index
1992 …2022

Research output per year

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Research Output

2007

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

Das, S., Chattopadhyay, R., Bhakat, K. K., Boldogh, I., Kohno, K., Prasad, R., Wilson, S. H. & Hazra, T. K., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28474-28484 11 p.

Research output: Contribution to journalArticle

86 Scopus citations

The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase

Guan, X., Bai, H., Shi, G., Theriot, C. A., Hazra, T. K., Mitra, S. & Lu, A. L., Apr 1 2007, In : Nucleic acids research. 35, 8, p. 2463-2472 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

Das, A., Boldogh, I., Jae, W. L., Harrigan, J. A., Hegde, M. L., Piotrowski, J., Pinto, N. D. S., Ramos, W., Greenberg, M. M., Hazra, T. K., Mitra, S. & Bohr, V. A., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26591-26602 12 p.

Research output: Contribution to journalArticle

81 Scopus citations
2006

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo

Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. K. & Mitra, S., Mar 1 2006, In : Molecular and cellular biology. 26, 5, p. 1654-1665 12 p.

Research output: Contribution to journalArticle

119 Scopus citations

Enhanced γ-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity

Das, G. C., Bacsi, A., Shrivastav, M., Hazra, T. K. & Boldogh, I., Sep 1 2006, In : Molecular Carcinogenesis. 45, 9, p. 635-647 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

Chattopadhyay, R., Wiederhold, L., Szczesny, B., Boldogh, I., Hazra, T. K., Izumi, T. & Mitra, S., Sep 7 2006, In : Nucleic acids research. 34, 7, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

106 Scopus citations

LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris

Bonté, F., Scheffler, I. E., Roubertoux, P. L., De Grey, A. D. N. J., Krutmann, J., Szczesny, B., Chattopadhyay, R., Hazra, T. K., Bhakat, K. K., Izumi, T., Wiederhold, L. R., Boldogh, I., Mitra, S., Friguet, B., Zuliani, T., Dumas, M., Ratinaud, M. H., Salvioli, S., Capri, M., Monti, D. & 3 others, Santoro, A., Barbi, C. & Claudio Franceschi, F., Jun 1 2006, In : Bioscience Reports. 26, 3, p. 183-201 19 p.

Research output: Contribution to journalArticle

NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

Das, A., Wiederhold, L., Leppard, J. B., Kedar, P., Prasad, R., Wang, H., Boldogh, I., Karimi-Busheri, F., Weinfeld, M., Tomkinson, A. E., Wilson, S. H., Mitra, S. & Hazra, T. K., Dec 9 2006, In : DNA Repair. 5, 12, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

88 Scopus citations
20 Scopus citations
2005

Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil

Ali, M. M., Hazra, T. K., Hong, D. & Kow, Y. W., Jun 8 2005, In : DNA Repair. 4, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species

Das, A., Hazra, T. K., Boldogh, I., Mitra, S. & Bhakat, K. K., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35272-35280 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells

Bacsi, A., Kannan, S., Lee, M. S., Hazra, T. K. & Boldogh, I., Dec 15 2005, In : Free Radical Biology and Medicine. 39, 12, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

Boldogh, I., Bacsi, A., Choudhury, B. K., Dharajiya, N., Alam, R., Hazra, T. K., Mitra, S., Goldblum, R. M. & Sur, S., Aug 1 2005, In : Journal of Clinical Investigation. 115, 8, p. 2169-2179 11 p.

Research output: Contribution to journalArticle

260 Scopus citations
2004

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity

Bhakat, K. K., Hazra, T. K. & Mitra, S., Aug 16 2004, In : Nucleic acids research. 32, 10, p. 3033-3039 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

AP endonuclease-independent DNA base excision repair in human cells

Wiederhold, L., Leppard, J. B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., Mitra, S. & Hazra, T. K., Jul 23 2004, In : Molecular cell. 15, 2, p. 209-220 12 p.

Research output: Contribution to journalArticle

330 Scopus citations

Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein

Das, A., Rajagopalan, L., Mathura, V. S., Rigby, S. J., Mitra, S. & Hazra, T. K., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47132-47138 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Stimulation of DNA glycosylase activity of OGG1 by NEIL1: Functional collaboration between two human DNA glycosylases

Mokkapati, S. K., Wiederhold, L., Hazra, T. K. & Mitra, S., Sep 14 2004, In : Biochemistry. 43, 36, p. 11596-11604 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2003
93 Scopus citations

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Izumi, T., Wiederhold, L. R., Roy, G., Roy, R., Jaiswal, A., Bhakat, K. K., Mitra, S. & Hazra, T. K., Nov 15 2003, In : Toxicology. 193, 1-2, p. 43-65 23 p.

Research output: Contribution to journalReview article

163 Scopus citations

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress

Boldogh, I., Roy, G., Lee, M. S., Bacsi, A., Hazra, T. K., Bhakat, K. K., Das, G. C. & Mitra, S., Nov 15 2003, In : Toxicology. 193, 1-2, p. 137-152 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

Dou, H., Mitra, S. & Hazra, T. K., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 49679-49684 6 p.

Research output: Contribution to journalArticle

252 Scopus citations

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

Bhakat, K. K., Izumi, T., Yang, S. H., Hazra, T. K. & Mitra, S., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6299-6309 11 p.

Research output: Contribution to journalArticle

141 Scopus citations

Solution structure of a DNA duplex containing 8-hydroxy-2′-deoxyguanosine opposite deoxyguanosine

Thiviyanathan, V., Somasunderam, A., Hazra, T. K., Mitra, S. & Gorenstein, D. G., Jan 1 2003, In : Journal of Molecular Biology. 325, 3, p. 433-442 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications

Hazra, T. K., Izumi, T., Kow, Y. W. & Mitra, S., Feb 1 2003, In : Carcinogenesis. 24, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

57 Scopus citations
2002

Choreography of oxidative damage repair in mammalian genomes

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Hill, J. W. & Hazra, T. K., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T. K., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y. W., Jaruga, P., Dizdaroglu, M. & Mitra, S., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

379 Scopus citations

Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, T. K., Kow, Y. W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S. K., Mitra, S. & Izumi, T., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30417-30420 4 p.

Research output: Contribution to journalArticle

247 Scopus citations
2001

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

Mitra, S., Boldogh, I., Izumi, T. & Hazra, T. K., Jan 1 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 180-190 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions

Hazra, T. K., Hill, J. W., Izumi, T. & Mitra, S., Jan 1 2001, Progress in Nucleic Acid Research and Molecular Biology. Vol. 68. p. 193-205 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer

Li, D., Zhang, W., Zhu, J., Chang, P., Sahin, A., Singletary, E., Bondy, M., Hazra, T., Mitra, S., Lau, S. S., Shen, J. & DiGiovanni, J., Sep 21 2001, In : Molecular Carcinogenesis. 31, 4, p. 214-223 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Rates of base excision repair are not solely dependent on levels of initiating enzymes

Cappelli, E., Hazra, T., Hill, J. W., Slupphaug, G., Bogliolo, M. & Frosina, G., Mar 21 2001, In : Carcinogenesis. 22, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Hazra, T. K., Muller, J. G., Manuel, R. C., Burrows, C. J., Lloyd, R. S. & Mitra, S., May 1 2001, In : Nucleic acids research. 29, 9, p. 1967-1974 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair

Hill, J. W., Hazra, T. K., Izumi, T. & Mitra, S., Jan 15 2001, In : Nucleic acids research. 29, 2, p. 430-438 9 p.

Research output: Contribution to journalArticle

303 Scopus citations

Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Dizdaroglu, M., Burgess, S. M., Jaruga, P., Hazra, T. K., Rodriguez, H. & Lloyd, R. S., Oct 9 2001, In : Biochemistry. 40, 40, p. 12150-12156 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2000

Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII

Hazra, T. K., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M. & Mitra, S., Sep 8 2000, In : Journal of Biological Chemistry. 275, 36, p. 27762-27767 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

Wang, G., Hazra, T. K., Mitra, S., Lee, H. M. & Englander, E. W., May 15 2000, In : Nucleic acids research. 28, 10, p. 2135-2140 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Protein phosphorylation is a regulatory mechanism for O6-alkylguanine- DNA alkyltransferase in human brain tumor cells

Srivenugopal, K. S., Mullapudi, S. R. S., Shou, J., Hazra, T. K. & Ali-Osman, F., Jan 15 2000, In : Cancer Research. 60, 2, p. 282-287 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species

Izumi, T., Hazra, T. K., Boldogh, I., Tomkinson, A. E., Park, M. S., Ikeda, S. & Mitra, S., Jan 1 2000, In : Carcinogenesis. 21, 7, p. 1329-1334 6 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations
1999

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

Biswas, T., Ramana, C. V., Srinivasan, G., Boldogh, I., Hazra, T. K., Chen, Z., Tano, K., Thompson, E. B. & Mitra, S., Jan 14 1999, In : Oncogene. 18, 2, p. 525-532 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Erratum: Specific interaction of wild-type and truncated mouse N- methylpurine-DNA glycosylase with ethenoadenine-containing DNA (Biochemistry (January 13, 1998) 37:2 (580-589))

Roy, R., Biswas, T., Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Aug 3 1999, In : Biochemistry. 38, 31, 1 p.

Research output: Contribution to journalComment/debate

1998

Regulation of expression of the DNA repair gene-O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling

Boldogh, I., Ramana, C. V., Chen, Z., Biswas, T., Hazra, T. K., Grösch, S., Grombacher, T., Mitra, S. & Kaina, B., Sep 1 1998, In : Cancer Research. 58, 17, p. 3950-3956 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli

Bhattacharyya, D., Hazra, T. K., David Behnke, W., Chong, P. L. G., Kurosky, A., Ching Lee, J. & Mitra, S., Feb 10 1998, In : Biochemistry. 37, 6, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Specific interaction of wild-type and truncated mouse N-methylpurine- DNA glycosylase with ethenoadenine-containing DNA

Roy, R., Biswas, T., Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Jan 13 1998, In : Biochemistry. 37, 2, p. 580-589 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation

Hazra, T. K., Izumi, T., Maidt, L., Floyd, R. A. & Mitra, S., Nov 15 1998, In : Nucleic acids research. 26, 22, p. 5116-5122 7 p.

Research output: Contribution to journalArticle

Open Access
155 Scopus citations
1997

Complexities of DNA Base Excision Repair in Mammalian Cells

Mitra, S., Hazra, T. K., Roy, R., Ikeda, S., Biswas, T., Lock, J., Boldogh, I. & Izumi, T., Jun 30 1997, In : Molecules and Cells. 7, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

Hazra, T. K., Roy, R., Biswas, T., Giabowski, D. T., Pegg, A. E. & Mitra, S., May 13 1997, In : Biochemistry. 36, 19, p. 5769-5776 8 p.

Research output: Contribution to journalArticle

53 Scopus citations
1996

Minimum size of active human O6-methylguanine-dna methyltransference (MGMT); substrate binding parallels mgmt activity

Hazra, T. K., Roy, R., Grabowski, D. T. & Mitra, S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A967

Research output: Contribution to journalArticle

The domains of mammalian base excision repair enzyme w-methylpurine-dna glycosylase: Interaction, conformational change and role in dna-binding and damage recognition

Roy, R., Kumar, A., Hazra, T. K., Roy, G., Grabowski, D. T., Lee J, J. & Mitra, S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

1993

Application of polymerase chain reaction with specific and arbitrary primers to identification and differentiation of Leishmania parasites

Bhattacharyya, R., Singh, R., Hazra, T. K. & Majumder, H. K., Nov 15 1993, In : FEMS Microbiology Letters. 114, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
1992

Bioleaching of low-grade copper ores using Thiobacillus ferrooxidans - Scientific note

Hazra, T. K., Mukherjea, M. & Mukherjea, R. N., Mar 1 1992, In : Applied Biochemistry and Biotechnology. 34-35, 1, p. 377-382 6 p.

Research output: Contribution to journalArticle

1 Scopus citations