Tapas Hazra, PhD

  • 6764 Citations
  • 48 h-Index
1992 …2022
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Research Output 1992 2019

  • 6764 Citations
  • 48 h-Index
  • 99 Article
  • 1 Short survey
  • 1 Review article
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Article
2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. & Sarkar, P., Apr 17 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Polynucleotide 5'-Hydroxyl-Kinase
Huntington Disease
Transcription
Phosphoric Monoester Hydrolases
DNA Repair
2018
6 Citations (Scopus)

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Hao, W., Qi, T., Pan, L., Wang, R., Zhu, B., Aguilera-Aguirre, L., Radak, Z., Hazra, T., Vlahopoulos, S. A., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Sep 1 2018, In : Redox Biology. 18, p. 43-53 11 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA
Genes
Gene Expression
Chromatin Immunoprecipitation
1 Citation (Scopus)

Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation

Hosoki, K., Jaruga, P., Itazawa, T., Aguilera-Aguirre, L., Coskun, E., Hazra, T., Boldogh, I., Dizdaroglu, M. & Sur, S., Jan 1 2018, (Accepted/In press) In : Clinical and Experimental Allergy.

Research output: Contribution to journalArticle

Dander
Cats
Genome
Inflammation
Lung
2017
5 Citations (Scopus)

Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways

Hosoki, K., Redding, D., Itazawa, T., Chakraborty, A., Tapryal, N., Qian, S., Qi, H., Aguilera-Aguirre, L., Brasier, A. R., Phani, V. S., Hazra, T., Boldogh, I. & Sur, S., 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Dander
Pollen
DNA Damage
Oxidative Stress
Cats
9 Citations (Scopus)

PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2

Chakraborti, S., Chakraborty, S., Saha, S., Manna, A., Banerjee, S., Adhikary, A., Sarwar, S., Hazra, T., Das, T. & Chakrabarti, P., Feb 1 2017, In : Free Radical Biology and Medicine. 103, p. 35-47 13 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
Zinc Oxide
Nanoparticles
Polyethylene glycols
DNA Damage
2016
40 Citations (Scopus)

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

Joining
genes
strands
Repair
Genes
10 Citations (Scopus)

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation

Hosoki, K., Boldogh, I., Aguilera-Aguirre, L., Sun, Q., Itazawa, T., Hazra, T., Brasier, A. R., Kurosky, A. & Sur, S., May 1 2016, In : Journal of Allergy and Clinical Immunology. 137, 5, p. 1506-1513.e2

Research output: Contribution to journalArticle

Dander
Pollen
Cats
Inflammation
Proteins
45 Citations (Scopus)

Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25553-25566 14 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Guanine
Epigenomics
Gene expression
DNA Repair
2015
3 Citations (Scopus)

Amphotericin B and anidulafungin directly interact with DNA and induce oxidative damage in the mammalian genome

Mandal, S. M., Chakraborty, A., Hossain, M., Mahata, D., Porto, W. F., Chakraborty, R., Mukhopadhyay, C. K., Franco, O. L., Hazra, T. & Basak, A., Jul 13 2015, In : Molecular BioSystems. 11, 9, p. 2551-2559 9 p.

Research output: Contribution to journalArticle

anidulafungin
Amphotericin B
Adenosine Monophosphate
Genome
DNA
23 Citations (Scopus)

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. & Sarkar, P., 2015, In : PLoS Genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Polynucleotide 5'-Hydroxyl-Kinase
polynucleotides
apoptosis
Phosphoric Monoester Hydrolases
25 Citations (Scopus)

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Mammals
Repair
Genes
Genome
4 Citations (Scopus)

Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease

Suganya, R., Chakraborty, A., Miriyala, S., Hazra, T. & Izumi, T., Mar 1 2015, In : DNA Repair. 27, p. 40-48 9 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Oxidative Phosphorylation
Fibroblasts
Transcription Factor AP-1
19 Citations (Scopus)

The C-terminal domain (CTD) of human DNA glycosylase NEIL1 is required for forming BERosome repair complex with DNA replication proteins at the replicating genome: Dominant negative function of the CTD

Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Replication
DNA Repair
Repair
Genes
33 Citations (Scopus)

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. & Hazra, T., 2015, In : PLoS Genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Polynucleotide 5'-Hydroxyl-Kinase
polynucleotides
Phosphoric Monoester Hydrolases
phosphatase
2014
31 Citations (Scopus)

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T., Brasier, A. R., Ba, X. & Boldogh, I., 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
rho GTP-Binding Proteins
DNA Repair
Polymerization
Smooth Muscle
47 Citations (Scopus)

Challenges and future prospects of antibiotic therapy: From peptides to phages utilization

Mandal, S. M., Roy, A., Ghosh, A. K., Hazra, T., Basak, A. & Franco, O. L., 2014, In : Frontiers in Pharmacology. 5 MAY, 105.

Research output: Contribution to journalArticle

Bacteriophages
Anti-Bacterial Agents
Peptides
Pharmaceutical Preparations
Food Industry
8 Citations (Scopus)

Controlling resistant bacteria with a novel class of β 2-lactamase inhibitor peptides: From rational design to in vivo analyses

Mandal, S. M., Migliolo, L., Silva, O. N., Fensterseifer, I. C. M., Faria-Junior, C., Dias, S. C., Basak, A., Hazra, T. & Franco, O. L., Aug 11 2014, In : Scientific Reports. 4, 6015.

Research output: Contribution to journalArticle

Bacteria
Peptides
Anti-Bacterial Agents
Cefotaxime
Amoxicillin
51 Citations (Scopus)

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Inflammation
DNA
Guanine Nucleotide Exchange Factors
Gene Expression
30 Citations (Scopus)

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 177-189 13 p.

Research output: Contribution to journalArticle

Phosphorylation
G2 Phase
Automatic teller machines
S Phase
Recombinational DNA Repair
17 Citations (Scopus)

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 319 1 p.

Research output: Contribution to journalArticle

Phosphorylation
Automatic teller machines
Repair
16 Citations (Scopus)

NEIL2 Protects against Oxidative DNA damage induced by sidestream smoke in human cells

Sarker, A. H., Chatterjee, A., Williams, M., Lin, S., Havel, C., Jacob, P., Boldogh, I., Hazra, T., Talbot, P. & Hang, B., Mar 3 2014, In : PLoS One. 9, 3, e90261.

Research output: Contribution to journalArticle

smoke
Smoke
DNA damage
DNA Damage
Cells
2013
40 Citations (Scopus)

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T., Hegde, M. L., Ba, X. & Boldogh, I., Oct 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Cell signaling
DNA Repair
Repair
Chemical activation
42 Citations (Scopus)

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

Bacsi, A., Aguilera-Aguirre, L., Szczesny, B., Radak, Z., Hazra, T., Sur, S., Ba, X. & Boldogh, I., Jan 1 2013, In : DNA Repair. 12, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Pneumonia
Down-Regulation
Epithelium
Ambrosia
51 Citations (Scopus)

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33

Research output: Contribution to journalArticle

DNA Glycosylases
Human Genome
DNA Replication
S Phase
Replication Protein A
63 Citations (Scopus)

Thirdhand smoke causes DNA damage in human cells

Hang, B., Sarker, A. H., Havel, C., Saha, S., Hazra, T., Schick, S., Jacob, P., Rehan, V. K., Chenna, A., Sharan, D., Sleiman, M., Destaillats, H. & Gundel, L. A., Jul 2013, In : Mutagenesis. 28, 4, p. 381-391 11 p.

Research output: Contribution to journalArticle

Smoke
DNA Damage
Cells
DNA
Tobacco
2012
76 Citations (Scopus)

Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z., Bacsi, A., Sur, S., Hazra, T. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Chemical activation
Guanine
ras Proteins
Purines
12 Citations (Scopus)

Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base

Hajas, G., Bacsi, A., Aguilerra-Aguirre, L., German, P., Radak, Z., Sur, S., Hazra, T. & Boldogh, I., Feb 15 2012, In : Free Radical Biology and Medicine. 52, 4, p. 749-756 8 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Derivatives
DNA
Nucleosides
DNA Glycosylases
27 Citations (Scopus)

Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

Hegde, M. L., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein U
DNA Repair
Repair
DNA
Oxidative stress
39 Citations (Scopus)

Identification and characterization of a bactericidal and proapoptotic peptide from cycas revoluta seeds with DNA binding properties

Mandal, S. M., Migliolo, L., Das, S., Mandal, M., Franco, O. L. & Hazra, T., Jan 2012, In : Journal of Cellular Biochemistry. 113, 1, p. 184-193 10 p.

Research output: Contribution to journalArticle

Cycas
Seed
Seeds
Peptides
DNA
23 Citations (Scopus)

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P., Abdel-Rahman, S., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
pol Gene Products
Lung Neoplasms
Repair
DNA Repair
85 Citations (Scopus)

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

Hegde, M. L., Mantha, A. K., Hazra, T., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Neurodegenerative Diseases
Mitochondrial Genome
Genome
Nervous System Diseases
50 Citations (Scopus)

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. & Hazra, T., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

Polynucleotide 5'-Hydroxyl-Kinase
DNA Glycosylases
Mitochondrial Genome
Phosphoric Monoester Hydrolases
Protein Kinases
2011
9 Citations (Scopus)

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Ma, H., Wang, J., Abdel-Rahman, S., Hazra, T., Boor, P. J. & Khan, M., Feb 15 2011, In : Toxicology and Applied Pharmacology. 251, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Toxicity
DNA Repair
Repair
Spleen
82 Citations (Scopus)

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P., Mitra, S. & Hazra, T., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein U
Repair
Genes
Cells
RNA Polymerase II
2010
42 Citations (Scopus)

Functions of disordered regions in mammalian early base excision repair proteins

Hegde, M. L., Hazra, T. & Mitra, S., Nov 2010, In : Cellular and Molecular Life Sciences. 67, 21, p. 3573-3587 15 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
Nuclear Localization Signals
Proteins
67 Citations (Scopus)

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10.

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. & Ashizawa, T., 2010, In : PLoS Genetics. 6, 6

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
apoptosis
mitochondrion
translocation
inactivation
38 Citations (Scopus)

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

Theriot, C. A., Hegde, M. L., Hazra, T. & Mitra, S., Jun 4 2010, In : DNA Repair. 9, 6, p. 643-652 10 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Glycosylases
DNA Damage
DNA
Proliferating Cell Nuclear Antigen
37 Citations (Scopus)

Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: Potential etiological linkage to neurodegenerative diseases

Hegde, M. L., Hegde, P. M., Holthauzen, L. M. F., Hazra, T., Rao, K. S. J. & Mitra, S., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28812-28825 14 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Human Genome
Neurodegenerative Diseases
Copper
Repair
2009
26 Citations (Scopus)

Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction

Chodaczek, G., Bacsi, A., Dharajiya, N., Sur, S., Hazra, T. & Boldogh, I., Aug 2009, In : Molecular Immunology. 46, 13, p. 2505-2514 10 p.

Research output: Contribution to journalArticle

Biogenic Amines
Mast Cells
Immunoglobulin E
Hexosaminidases
Antigens
2008
34 Citations (Scopus)

Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil

Thiviyanathan, V., Somasunderam, A., Volk, D. E., Hazra, T., Mitra, S. & Gorenstein, D. G., Feb 15 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 752-757 6 p.

Research output: Contribution to journalArticle

Uracil
Cytosine
Base Pairing
Derivatives
Mutation
379 Citations (Scopus)

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

Hegde, M. L., Hazra, T. & Mitra, S., Jan 2008, In : Cell Research. 18, 1, p. 27-47 21 p.

Research output: Contribution to journalArticle

DNA Repair
DNA
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Ligases
Single-Stranded DNA Breaks
108 Citations (Scopus)

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes

Dou, H., Theriot, C. A., Das, A., Hegde, M. L., Matsumoto, Y., Boldogh, I., Hazra, T., Bhakat, K. K. & Mitra, S., Feb 8 2008, In : Journal of Biological Chemistry. 283, 6, p. 3130-3140 11 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Proliferating Cell Nuclear Antigen
Repair
Genes
Genome
22 Citations (Scopus)

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

Maiti, A. K., Boldogh, I., Spratt, H., Mitra, S. & Hazra, T., Aug 2 2008, In : DNA Repair. 7, 8, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Cricetulus
DNA Replication
Repair
Cells
11 Citations (Scopus)

Oxanine DNA glycosylase activities in mammalian systems

Dong, L., Meira, L. B., Hazra, T., Samson, L. D. & Cao, W., Jan 1 2008, In : DNA Repair. 7, 1, p. 128-134 7 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Deamination
Guanine
Tissue
DNA Cleavage
68 Citations (Scopus)

Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease

Hegde, M. L., Theriot, C. A., Das, A., Hegde, P. M., Guo, Z., Gary, R. K., Hazra, T., Shen, B. & Mitra, S., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 27028-27037 10 p.

Research output: Contribution to journalArticle

Flap Endonucleases
DNA Glycosylases
Proliferating Cell Nuclear Antigen
Repair
DNA Replication
84 Citations (Scopus)

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1

Chattopadhyay, R., Das, S., Maiti, A. K., Boldogh, I., Xie, J., Hazra, T., Kohno, K., Mitra, S. & Bhakat, K. K., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7066-7080 15 p.

Research output: Contribution to journalArticle

MDR Genes
Neoplasms
Acetylation
Drug Resistance
Y-Box-Binding Protein 1
2007
35 Citations (Scopus)

Increased ROS generation in subsets of OGG1 knockout fibroblast cells

Bacsi, A., Chodaczek, G., Hazra, T., Konkel, D. & Boldogh, I., Nov 2007, In : Mechanisms of Ageing and Development. 128, 11-12, p. 637-649 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Cells
Null Lymphocytes
Cell culture
Genes
202 Citations (Scopus)

Oxidative DNA damage repair in mammalian cells: A new perspective

Hazra, T., Das, A., Das, S., Choudhury, S., Kow, Y. W. & Roy, R., Apr 1 2007, In : DNA Repair. 6, 4, p. 470-480 11 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Glycosylases
DNA Damage
Repair
Cells
84 Citations (Scopus)

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

Das, S., Chattopadhyay, R., Bhakat, K. K., Boldogh, I., Kohno, K., Prasad, R., Wilson, S. H. & Hazra, T., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28474-28484 11 p.

Research output: Contribution to journalArticle

Oxidative stress
DNA Repair
Y-Box-Binding Protein 1
Oxidative Stress
Repair
54 Citations (Scopus)

The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase

Guan, X., Bai, H., Shi, G., Theriot, C. A., Hazra, T., Mitra, S. & Lu, A. L., Apr 2007, In : Nucleic Acids Research. 35, 8, p. 2463-2472 10 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Proliferating Cell Nuclear Antigen
Cell Cycle Checkpoints
DNA Repair
Hydrogen Peroxide