Tapas Hazra, PhD

  • 6682 Citations
  • 47 h-Index
1992 …2022
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1992 2019

  • 6682 Citations
  • 47 h-Index
  • 99 Article
  • 1 Short survey
  • 1 Review article
Filter
Article
2007
79 Citations (Scopus)

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

Das, A., Boldogh, I., Jae, W. L., Harrigan, J. A., Hegde, M. L., Piotrowski, J., Pinto, N. D. S., Ramos, W., Greenberg, M. M., Hazra, T., Mitra, S. & Bohr, V. A., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26591-26602 12 p.

Research output: Contribution to journalArticle

Werner Syndrome
DNA Glycosylases
DNA Repair
DNA Damage
Repair
2006
116 Citations (Scopus)

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo

Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. & Mitra, S., Mar 2006, In : Molecular and Cellular Biology. 26, 5, p. 1654-1665 12 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Acetylation
DNA-(Apurinic or Apyrimidinic Site) Lyase
Histone Deacetylases
human oxoguanine glycosylase 1
22 Citations (Scopus)

Enhanced γ-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity

Das, G. C., Bacsi, A., Shrivastav, M., Hazra, T. & Boldogh, I., Sep 2006, In : Molecular Carcinogenesis. 45, 9, p. 635-647 13 p.

Research output: Contribution to journalArticle

Glutamate-Cysteine Ligase
Oxidative Stress
Chlorambucil
Reactive Oxygen Species
Pharmaceutical Preparations
100 Citations (Scopus)

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

Chattopadhyay, R., Wiederhold, L., Szczesny, B., Boldogh, I., Hazra, T., Izumi, T. & Mitra, S., 2006, In : Nucleic Acids Research. 34, 7, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Mitochondria
Single-Stranded DNA Breaks
Nuclear Localization Signals

LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris

Bonté, F., Scheffler, I. E., Roubertoux, P. L., De Grey, A. D. N. J., Krutmann, J., Szczesny, B., Chattopadhyay, R., Hazra, T., Bhakat, K. K., Izumi, T., Wiederhold, L., Boldogh, I., Mitra, S., Friguet, B., Zuliani, T., Dumas, M., Ratinaud, M. H., Salvioli, S., Capri, M., Monti, D. & 3 others, Santoro, A., Barbi, C. & Claudio Franceschi, F., Jun 2006, In : Bioscience Reports. 26, 3, p. 183-201 19 p.

Research output: Contribution to journalArticle

Cell Respiration
Mitochondrial Proteins
Oxidative Phosphorylation
Paris
Ultraviolet Rays
85 Citations (Scopus)

NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

Das, A., Wiederhold, L., Leppard, J. B., Kedar, P., Prasad, R., Wang, H., Boldogh, I., Karimi-Busheri, F., Weinfeld, M., Tomkinson, A. E., Wilson, S. H., Mitra, S. & Hazra, T., Dec 9 2006, In : DNA Repair. 5, 12, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

Polynucleotide 5'-Hydroxyl-Kinase
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Glycosylases
Aldehydes
Repair
19 Citations (Scopus)
DNA Glycosylases
Single-Stranded DNA
DNA Repair
Purification
Repair
2005
13 Citations (Scopus)

Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil

Ali, M. M., Hazra, T., Hong, D. & Kow, Y. W., Jun 8 2005, In : DNA Repair. 4, 6, p. 679-686 8 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Endonucleases
DNA
Polynucleotide 5'-Hydroxyl-Kinase
dihydrouracil
57 Citations (Scopus)

Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species

Das, A., Hazra, T., Boldogh, I., Mitra, S. & Bhakat, K. K., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35272-35280 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Glucose Oxidase
Reactive Oxygen Species
Oxidative stress
Luciferases
21 Citations (Scopus)

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells

Bacsi, A., Kannan, S., Lee, M. S., Hazra, T. & Boldogh, I., Dec 15 2005, In : Free Radical Biology and Medicine. 39, 12, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Chlorambucil
Double-Stranded DNA Breaks
Cells
Modulation
252 Citations (Scopus)

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

Boldogh, I., Bacsi, A., Choudhury, B., Dharajiya, N., Alam, R., Hazra, T., Mitra, S., Goldblum, R. M. & Sur, S., Aug 2005, In : Journal of Clinical Investigation. 115, 8, p. 2169-2179 11 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Pollen
Inflammation
Antigens
Glutathione Disulfide
2004
61 Citations (Scopus)

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity

Bhakat, K. K., Hazra, T. & Mitra, S., 2004, In : Nucleic Acids Research. 32, 10, p. 3033-3039 7 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Acetylation
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair Enzymes
Post Translational Protein Processing
323 Citations (Scopus)

AP endonuclease-independent DNA base excision repair in human cells

Wiederhold, L., Leppard, J. B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., Mitra, S. & Hazra, T., Jul 23 2004, In : Molecular Cell. 15, 2, p. 209-220 12 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Polynucleotide 5'-Hydroxyl-Kinase
DNA Glycosylases
DNA
26 Citations (Scopus)

Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein

Das, A., Rajagopalan, L., Mathura, V. S., Rigby, S. J., Mitra, S. & Hazra, T., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47132-47138 7 p.

Research output: Contribution to journalArticle

Zinc Fingers
Zinc
DNA Glycosylases
DNA-(Apurinic or Apyrimidinic Site) Lyase
Mutation
53 Citations (Scopus)

Stimulation of DNA glycosylase activity of OGG1 by NEIL1: Functional collaboration between two human DNA glycosylases

Mokkapati, S. K., Wiederhold, L., Hazra, T. & Mitra, S., Sep 14 2004, In : Biochemistry. 43, 36, p. 11596-11604 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA-(Apurinic or Apyrimidinic Site) Lyase
Repair
Oxidative stress
8-hydroxyguanine
2003
92 Citations (Scopus)
DNA Glycosylases
Mitochondrial DNA
Mitochondria
Uracil-DNA Glycosidase
Liver Extracts
159 Citations (Scopus)

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Izumi, T., Wiederhold, L., Roy, G., Roy, R., Jaiswal, A., Bhakat, K. K., Mitra, S. & Hazra, T., Nov 15 2003, In : Toxicology. 193, 1-2, p. 43-65 23 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Repair
DNA
Proteins
52 Citations (Scopus)

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress

Boldogh, I., Roy, G., Lee, M. S., Bacsi, A., Hazra, T., Bhakat, K. K., Das, G. C. & Mitra, S., Nov 15 2003, In : Toxicology. 193, 1-2, p. 137-152 16 p.

Research output: Contribution to journalArticle

Chlorambucil
Oxidative stress
Double-Stranded DNA Breaks
Catalytic Domain
Oxidative Stress
247 Citations (Scopus)

Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

Dou, H., Mitra, S. & Hazra, T., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 49679-49684 6 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Repair
DNA
Substrates
Single-Stranded DNA
135 Citations (Scopus)

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

Bhakat, K. K., Izumi, T., Yang, S. H., Hazra, T. & Mitra, S., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6299-6309 11 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Acetylation
Genes
Histone Deacetylases
Activating Transcription Factors
19 Citations (Scopus)

Solution structure of a DNA duplex containing 8-hydroxy-2′-deoxyguanosine opposite deoxyguanosine

Thiviyanathan, V., Somasunderam, A., Hazra, T., Mitra, S. & Gorenstein, D. G., 2003, In : Journal of Molecular Biology. 325, 3, p. 433-442 10 p.

Research output: Contribution to journalArticle

Deoxyguanosine
DNA
Base Pairing
Hydrogen Bonding
8-oxo-7-hydrodeoxyguanosine
57 Citations (Scopus)

The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications

Hazra, T., Izumi, T., Kow, Y. W. & Mitra, S., Feb 1 2003, In : Carcinogenesis. 24, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA
Enzymes
Genome
Carcinogenesis
2002
113 Citations (Scopus)

Choreography of oxidative damage repair in mammalian genomes

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Hill, J. W. & Hazra, T., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Repair
Genes
Genome
Proteins
DNA Repair
373 Citations (Scopus)

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y. W., Jaruga, P., Dizdaroglu, M. & Mitra, S., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
Escherichia coli
Catalytic Domain
244 Citations (Scopus)

Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, T., Kow, Y. W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S. K., Mitra, S. & Izumi, T., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 30417-30420 4 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Cytosine
DNA Repair
Escherichia coli
Repair
2001
101 Citations (Scopus)

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

Mitra, S., Boldogh, I., Izumi, T. & Hazra, T., 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 180-190 11 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
DNA
Reactive Oxygen Species
Enzymes
100 Citations (Scopus)

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions

Hazra, T., Hill, J. W., Izumi, T. & Mitra, S., 2001, In : Progress in Nucleic Acid Research and Molecular Biology. 68, p. 193-205 13 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Yeasts
Escherichia coli
58 Citations (Scopus)

Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer

Li, D., Zhang, W., Zhu, J., Chang, P., Sahin, A., Singletary, E., Bondy, M., Hazra, T., Mitra, S., Lau, S. S., Shen, J. & DiGiovanni, J., 2001, In : Molecular Carcinogenesis. 31, 4, p. 214-223 10 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Lyases
DNA Damage
Breast Neoplasms
Oxidative Stress
54 Citations (Scopus)

Rates of base excision repair are not solely dependent on levels of initiating enzymes

Cappelli, E., Hazra, T., Hill, J. W., Slupphaug, G., Bogliolo, M. & Frosina, G., 2001, In : Carcinogenesis. 22, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
Enzymes
Cell Extracts
DNA-(Apurinic or Apyrimidinic Site) Lyase
89 Citations (Scopus)

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Hazra, T., Muller, J. G., Manuel, R. C., Burrows, C. J., Lloyd, R. S. & Mitra, S., May 1 2001, In : Nucleic Acids Research. 29, 9, p. 1967-1974 8 p.

Research output: Contribution to journalArticle

Hydantoins
DNA Glycosylases
Electrons
Escherichia coli
Deoxyribonuclease (Pyrimidine Dimer)
294 Citations (Scopus)

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair

Hill, J. W., Hazra, T., Izumi, T. & Mitra, S., Jan 15 2001, In : Nucleic Acids Research. 29, 2, p. 430-438 9 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Glycosylases
DNA Repair
Enzymes
DNA
43 Citations (Scopus)

Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Dizdaroglu, M., Burgess, S. M., Jaruga, P., Hazra, T., Rodriguez, H. & Lloyd, R. S., Oct 9 2001, In : Biochemistry. 40, 40, p. 12150-12156 7 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Substrate Specificity
Escherichia coli
Free Radicals
Kinetics
2000
82 Citations (Scopus)

Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII

Hazra, T., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M. & Mitra, S., Sep 8 2000, In : Journal of Biological Chemistry. 275, 36, p. 27762-27767 6 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
DNA Glycosylases
Escherichia coli
Eukaryota
Repair
130 Citations (Scopus)

Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

Wang, G., Hazra, T., Mitra, S., Lee, H. M. & Englander, E., May 15 2000, In : Nucleic Acids Research. 28, 10, p. 2135-2140 6 p.

Research output: Contribution to journalArticle

PC12 Cells
Mitochondrial DNA
DNA Damage
Reactive Oxygen Species
DNA Glycosylases
42 Citations (Scopus)

Protein phosphorylation is a regulatory mechanism for O6-alkylguanine- DNA alkyltransferase in human brain tumor cells

Srivenugopal, K. S., Mullapudi, S. R. S., Shou, J., Hazra, T. & Ali-Osman, F., Jan 15 2000, In : Cancer Research. 60, 2, p. 282-287 6 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Phosphorylation
Casein Kinase II
Cyclic AMP-Dependent Protein Kinases
Proteins
155 Citations (Scopus)

Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species

Izumi, T., Hazra, T., Boldogh, I., Tomkinson, A. E., Park, M. S., Ikeda, S. & Mitra, S., 2000, In : Carcinogenesis. 21, 7, p. 1329-1334 6 p.

Research output: Contribution to journalArticle

Single-Stranded DNA Breaks
Endonucleases
Reactive Oxygen Species
DNA Breaks
Uracil
1999
61 Citations (Scopus)

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

Biswas, T., Ramana, C. V., Srinivasan, G., Boldogh, I., Hazra, T., Chen, Z., Tano, K., Thompson, E. B. & Mitra, S., Jan 14 1999, In : Oncogene. 18, 2, p. 525-532 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Glucocorticoids
Hormones
DNA
Genes

Erratum: Specific interaction of wild-type and truncated mouse N- methylpurine-DNA glycosylase with ethenoadenine-containing DNA (Biochemistry (January 13, 1998) 37:2 (580-589))

Roy, R., Biswas, T., Hazra, T., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Aug 3 1999, In : Biochemistry. 38, 31, p. 10216 1 p.

Research output: Contribution to journalArticle

Biochemistry
DNA
DNA-3-methyladenine glycosidase II
1998
79 Citations (Scopus)

Regulation of expression of the DNA repair gene-O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling

Boldogh, I., Ramana, C. V., Chen, Z., Biswas, T., Hazra, T., Grösch, S., Grombacher, T., Mitra, S. & Kaina, B., Sep 1 1998, In : Cancer Research. 58, 17, p. 3950-3956 7 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Repair
Protein Kinase C
DNA
Genes
3 Citations (Scopus)

Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli

Bhattacharyya, D., Hazra, T., David Behnke, W., Chong, P. L. G., Kurosky, A., Lee, J. & Mitra, S., Feb 10 1998, In : Biochemistry. 37, 6, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

Protein Folding
Methyltransferases
Escherichia coli
DNA
Proteins
51 Citations (Scopus)

Specific interaction of wild-type and truncated mouse N-methylpurine- DNA glycosylase with ethenoadenine-containing DNA

Roy, R., Biswas, T., Hazra, T., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G. & Mitra, S., Jan 13 1998, In : Biochemistry. 37, 2, p. 580-589 10 p.

Research output: Contribution to journalArticle

DNA
Electrophoretic mobility
Peptides
Deoxyribonuclease I
Electrophoretic Mobility Shift Assay
153 Citations (Scopus)

The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation

Hazra, T., Izumi, T., Maidt, L., Floyd, R. A. & Mitra, S., Nov 15 1998, In : Nucleic Acids Research. 26, 22, p. 5116-5122 7 p.

Research output: Contribution to journalArticle

Mutation
DNA
Enzymes
Reactive Oxygen Species
DNA Glycosylases
1997
120 Citations (Scopus)

Complexities of DNA Base Excision Repair in Mammalian Cells

Mitra, S., Hazra, T., Roy, R., Ikeda, S., Biswas, T., Lock, J., Boldogh, I. & Izumi, T., Jun 30 1997, In : Molecules and Cells. 7, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Deoxyribonuclease IV (Phage T4-Induced)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Biological Models
Lyases
DNA Repair
52 Citations (Scopus)

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

Hazra, T., Roy, R., Biswas, T., Giabowski, D. T., Pegg, A. E. & Mitra, S., May 13 1997, In : Biochemistry. 36, 19, p. 5769-5776 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Catalytic Domain
DNA
Mutant Proteins
Substrates
1996

Minimum size of active human O6-methylguanine-dna methyltransference (MGMT); substrate binding parallels mgmt activity

Hazra, T., Roy, R., Grabowski, D. T. & Mitra, S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

methyltransferases
Methyltransferases
Substrates
Cysteine
cysteine

The domains of mammalian base excision repair enzyme w-methylpurine-dna glycosylase: Interaction, conformational change and role in dna-binding and damage recognition

Roy, R., Kumar, A., Hazra, T., Roy, G., Grabowski, D. T., Lee J, J. & Mitra, S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

glycosylases
DNA repair
DNA Repair
Repair
Peptide Hydrolases
1993
25 Citations (Scopus)

Application of polymerase chain reaction with specific and arbitrary primers to identification and differentiation of Leishmania parasites

Bhattacharyya, R., Singh, R., Hazra, T. & Majumder, H. K., Nov 15 1993, In : FEMS Microbiology Letters. 114, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

Kinetoplast DNA
Leishmania
Parasites
Polymerase Chain Reaction
Skin
1992
1 Citation (Scopus)

Bioleaching of low-grade copper ores using Thiobacillus ferrooxidans - Scientific note

Hazra, T., Mukherjea, M. & Mukherjea, R. N., Mar 1992, In : Applied Biochemistry and Biotechnology. 34-35, 1, p. 377-382 6 p.

Research output: Contribution to journalArticle

Thiobacillus
Bioleaching
Ores
Copper
rusticyanin
6 Citations (Scopus)

Role of rusticyanin in the electron transport process in Thiobacillus ferrooxidans.

Hazra, T., Mukherjea, M. & Mukherjea, R. N., Feb 1992, In : Indian Journal of Biochemistry and Biophysics. 29, 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

Thiobacillus
Electron Transport
Cytochromes c
Electrons
Iron