Tatiana Nanovskaya, PhD

Associate Director, Obstetrical-Fetal Pharmacology Center

  • 1203 Citations
  • 19 h-Index
20022019
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Research Output 2002 2019

  • 1203 Citations
  • 19 h-Index
  • 55 Article
  • 2 Meeting Abstract
  • 1 Chapter
  • 1 Conference contribution
2019
2 Citations (Scopus)

M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model

Roy, S., Nanovskaya, T., Patrikeeva, S., Cochran, E., Parge, V., Guess, J., Schaeck, J., Choudhury, A., Ahmed, M. & Ling, L. E., May 1 2019, In : American journal of obstetrics and gynecology. 220, 5, p. 498.e1-498.e9

Research output: Contribution to journalArticle

Open Access
Anti-Idiotypic Antibodies
Perfusion
Immunoglobulin G
Trophoblasts
Fetus
2018
Antipyrine
High performance liquid chromatography
Paclitaxel
Photodiodes
Perfusion

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Shah, M., Xu, M., Shah, P., Wang, X-M., Clark, S., Costantine, M., West, H. A., Nanovskaya, T., Ahmed, M., Abdel-Rahman, S., Venkataramanan, R., Caritis, S. N., Hankins, G. & Rytting, E., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Indomethacin
Pharmacokinetics
Pregnancy
Genotype
Tocolytic Agents
4 Citations (Scopus)

Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin

Afrouzian, M., Al Lahham, R., Patrikeeva, S., Xu, M., Fokina, V., Fischer, W. G., Abdel-Rahman, S., Costantine, M., Ahmed, M. & Nanovskaya, T., Oct 1 2018, In : Biochemical Pharmacology. 156, p. 467-478 12 p.

Research output: Contribution to journalArticle

Pravastatin
Placenta
Trophoblasts
Membranes
Adenosine Triphosphate
2017
11 Citations (Scopus)

Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial

Nanovskaya, T. N., Oncken, C., Fokina, V. M., Feinn, R. S., Clark, S. M., West, H., Jain, S. K., Ahmed, M. S. & Hankins, G. D. V., Apr 1 2017, In : American Journal of Obstetrics and Gynecology. 216, 4, p. 420.e1-420.e9

Research output: Contribution to journalArticle

Bupropion
Placebos
Smoking Cessation
Pregnancy
Substance Withdrawal Syndrome

Characteristics of Trophoblasts in Long-Term Culture

Kolokol’tsova, T. D., Saburina, I. N., Nanovskaya, T., Patrikeeva, S. L., Vernikovskaya, D. I., Zurina, I. M., Gorkun, A. A., Kosheleva, N. V., Poltavtseva, R. A. & Sukhikh, G. T., Dec 1 2017, In : Bulletin of Experimental Biology and Medicine. 164, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

Trophoblasts
Contamination
Cell culture
Keratin-7
Vimentin

Expression of The Efflux Transporters MRP1 and BCRP in Healthy and Preeclamptic placentas

Al Lahham, R., Afrouzian, M., Popov, V., Fischer, W., Ahmed, M. S. & Nanovskaya, T., Sep 2017, In : Placenta. 57, p. 279-280

Research output: Contribution to journalMeeting Abstract

3 Citations (Scopus)

Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies

Gopalakrishnan, K., More, A. S., Hankins, G., Nanovskaya, T. & Kumar, S., 2017, In : Reproductive Sciences. 24, 6, p. 919-933 15 p.

Research output: Contribution to journalArticle

Bupropion
Smoking Cessation
Nicotine
Smoking
Drug Therapy

The role of placental carbonyl reducing enzymes in biotransformation of bupropion and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone

Fokina, V., Patrikeeva, S. L., Oncken, C., Hankins, G., Ahmed, M. & Nanovskaya, T., Mar 1 2017, In : Drug Metabolism Letters. 11, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Bupropion
Biotransformation
Alcohol Oxidoreductases
Enzymes
Placenta
2016
10 Citations (Scopus)
Bupropion
Umbilical Cord
Amniotic Fluid
Pregnancy
Pharmaceutical Preparations
2 Citations (Scopus)

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Nanovskaya, T., Petrov, I. Y., Petrov, Y., Patrikeeva, S. L., Ahmed, M., Hankins, G., Prough, D. & Esenaliev, R., 2016, Photons Plus Ultrasound: Imaging and Sensing 2016. SPIE, Vol. 9708. 97080N

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Umbilicus
Oxygenation
Photoacoustic effect
oxygenation
Fetal Blood
6 Citations (Scopus)

Pharmacokinetics of bupropion and its pharmacologically active metabolites in pregnancy

Fokina, V., Xu, M., Rytting, E., Abdel-Rahman, S., West, H., Oncken, C., Clark, S., Ahmed, M., Hankins, G. & Nanovskaya, T., 2016, In : Drug Metabolism and Disposition. 44, 11, p. 1832-1838 7 p.

Research output: Contribution to journalArticle

Bupropion
Pharmacokinetics
Pregnancy
Smoking Cessation
Alleles

Pravastatin transport by human placental plasma membrane vesicles

Nanovskaya, T., Patrikeeva, S. L., Al Lahham, R. & Ahmed, M. S., 2016, In : Placenta. 45, p. 132

Research output: Contribution to journalMeeting Abstract

5 Citations (Scopus)

Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS

Zhang, X., Vernikovskaya, D. I., Wang, X-M., Nanovskaya, T., Costantine, M., Hankins, G. & Ahmed, M., Apr 1 2016, In : Biomedical Chromatography. 30, 4, p. 548-554 7 p.

Research output: Contribution to journalArticle

Pravastatin
Metabolites
Urine
Plasmas
Liquid-Liquid Extraction
2015
16 Citations (Scopus)

Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS

Zhang, X., Wang, X-M., Vernikovskaya, D. I., Fokina, V., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 1 2015, In : Biomedical Chromatography. 29, 4, p. 560-569 10 p.

Research output: Contribution to journalArticle

Metabolites
Urine
Plasmas
Glyburide
Metformin
2014
6 Citations (Scopus)

Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus)

Rytting, E., Wang, X-M., Vernikovskaya, D. I., Zhan, Y., Bauer, C., Abdel-Rahman, S. M., Ahmed, M. & Nanovskaya, T., Oct 1 2014, In : Drug Metabolism and Disposition. 42, 10, p. 1773-1779 7 p.

Research output: Contribution to journalArticle

Papio cynocephalus
Bupropion
Papio
Postpartum Period
Pregnancy
12 Citations (Scopus)

Pharmacokinetics of indomethacin in pregnancy

Rytting, E., Nanovskaya, T., Wang, X-M., Vernikovskaya, D. I., Clark, S., Cochran, M., Abdel-Rahman, S. M., Venkataramanan, R., Caritis, S. N., Hankins, G. & Ahmed, M., 2014, In : Clinical Pharmacokinetics. 53, 6, p. 545-551 7 p.

Research output: Contribution to journalArticle

Indomethacin
Pharmacokinetics
Pregnancy
Premature Obstetric Labor
Fetal Blood
5 Citations (Scopus)
Papio
Solid Phase Extraction
Plasmas
Teicoplanin
Pregnancy
2013
8 Citations (Scopus)
Liquid chromatography
Indomethacin
Liquid Chromatography
Mass spectrometry
Mass Spectrometry
5 Citations (Scopus)

IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta

Ahmed, M., Aleksunes, L. M., Boeuf, P., Chung, M. K., Daoud, G., Desoye, G., Díaz, P., Golos, T. G., Illsley, N. P., Kikuchi, K., Komatsu, R., Lao, T., Morales-Prieto, D. M., Nanovskaya, T., Nobuzane, T., Roberts, C. T., Saffery, R., Tamura, I., Tamura, K., Than, N. G. & 8 others, Tomi, M., Umbers, A., Wang, B., Weedon-Fekjaer, M. S., Yamada, S., Yamazaki, K., Yoshie, M. & Lash, G. E., 2013, In : Placenta. 34, SUPPL

Research output: Contribution to journalArticle

Trophoblasts
Xenobiotics
Epigenomics
Placenta
Education
3 Citations (Scopus)
Famotidine
Plasma (human)
Umbilical Cord
High performance liquid chromatography
Mass spectrometry
35 Citations (Scopus)

Transplacental transfer and distribution of pravastatin

Nanovskaya, T., Patrikeeva, S. L., Paul, J., Costantine, M., Hankins, G. & Ahmed, M., Oct 2013, In : American Journal of Obstetrics and Gynecology. 209, 4

Research output: Contribution to journalArticle

Pravastatin
Mothers
Antipyrine
Paclitaxel
Isotopes
2012
5 Citations (Scopus)

Metabolism of 17-alpha-hydroxyprogesterone caproate by human placental mitochondria

Fokina, V., Zharikova, O. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Mar 2012, In : Reproductive Sciences. 19, 3, p. 290-297 8 p.

Research output: Contribution to journalArticle

Mitochondria
Perfusion
Biotransformation
Microsomes
Subcellular Fractions
19 Citations (Scopus)
Bupropion
Umbilical Cord
High performance liquid chromatography
Metabolites
Tandem Mass Spectrometry
9 Citations (Scopus)

Transplacental transfer of oseltamivir carboxylate

Nanovskaya, T., Patrikeeva, S., Zhan, Y., Hankins, G. & Ahmed, M., Nov 2012, In : Journal of Maternal-Fetal and Neonatal Medicine. 25, 11, p. 2312-2315 4 p.

Research output: Contribution to journalArticle

Mothers
Fetus
Perfusion
Isotopes
Placenta
14 Citations (Scopus)

Transplacental transfer of vancomycin and telavancin

Nanovskaya, T., Patrikeeva, S., Zhan, Y., Fokina, V., Hankins, G. & Ahmed, M., Oct 2012, In : American Journal of Obstetrics and Gynecology. 207, 4

Research output: Contribution to journalArticle

Vancomycin
Mothers
Radioisotopes
Spectrum Analysis
Perfusion
2011
10 Citations (Scopus)

Metabolism of bupropion by baboon hepatic and placental microsomes

Wang, X-M., Abdelrahman, D. R., Fokina, V., Hankins, G., Ahmed, M. & Nanovskaya, T., Aug 1 2011, In : Biochemical Pharmacology. 82, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

Bupropion
Papio
Microsomes
Metabolism
Liver
6 Citations (Scopus)

Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis

Wang, X., Nanovskaya, T., Zhan, Y., Abdel-Rahman, S. M., Jasek, M., Hankins, G. & Ahmed, M., Mar 2011, In : Journal of Maternal-Fetal and Neonatal Medicine. 24, 3, p. 444-448 5 p.

Research output: Contribution to journalArticle

Bacterial Vaginosis
Metronidazole
Pharmacokinetics
Pregnancy
Area Under Curve
1 Citation (Scopus)

The Placenta as a Functional Barrier to Fetal Drug Exposure

Nanovskaya, T., Hankins, G. & Ahmed, M., Mar 21 2011, The Placenta: From Development to Disease. Wiley-Blackwell, p. 303-309 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neonatal Abstinence Syndrome
Opioid-Related Disorders
Placenta
Single Nucleotide Polymorphism
Pharmaceutical Preparations
17 Citations (Scopus)

Transplacental transfer and metabolism of buprenorphine in preterm human placenta

Fokina, V., Patrikeeva, S. L., Zharikova, O. L., Nanovskaya, T., Hankins, G. & Ahmed, M., 2011, In : American Journal of Perinatology. 28, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Buprenorphine
Placenta
Microsomes
Third Pregnancy Trimester
Pregnancy
2010
23 Citations (Scopus)

Bupropion metabolism by human placenta

Wang, X-M., Abdelrahman, D. R., Zharikova, O. L., Patrikeeva, S. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Jun 2010, In : Biochemical Pharmacology. 79, 11, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Bupropion
Metabolism
Placenta
Pregnancy
Enzymes
55 Citations (Scopus)

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

Hemauer, S. J., Nanovskaya, T., Abdel-Rahman, S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., Mar 15 2010, In : Biochemical Pharmacology. 79, 6, p. 921-925 5 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Polymorphism
Placenta
Genes
Modulation
66 Citations (Scopus)

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

Hemauer, S. J., Patrikeeva, S. L., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 2010, In : American Journal of Obstetrics and Gynecology. 202, 4

Research output: Contribution to journalArticle

rosiglitazone
Membrane Transport Proteins
P-Glycoprotein
P-Glycoproteins
Breast Neoplasms
18 Citations (Scopus)

Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion

Hemauer, S. J., Patrikeeva, S. L., Wang, X-M., Abdelrahman, D. R., Hankins, G., Ahmed, M. & Nanovskaya, T., Oct 2010, In : Biochemical Pharmacology. 80, 7, p. 1080-1086 7 p.

Research output: Contribution to journalArticle

Bupropion
Metabolites
Smoking Cessation
Metabolism
Placenta
25 Citations (Scopus)

Transplacental transfer and metabolism of bupropion

Earhart, A. D., Patrikeeva, S., Wang, X-M., Reda Abdelrahman, D., Hankins, G., Ahmed, M. & Nanovskaya, T., May 2010, In : Journal of Maternal-Fetal and Neonatal Medicine. 23, 5, p. 409-416 8 p.

Research output: Contribution to journalArticle

Bupropion
Mothers
Smoking Cessation
Pregnancy
Antipyrine
2009
4 Citations (Scopus)

Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule

Nanovskaya, T., Bowen, R. S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., 2009, In : Journal of Maternal-Fetal and Neonatal Medicine. 22, 8, p. 646-653 8 p.

Research output: Contribution to journalArticle

Buprenorphine
Blood Proteins
Mothers
Perfusion
Antipyrine
39 Citations (Scopus)

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

Zharikova, O. L., Fokina, V., Nanovskaya, T., Hill, R. A., Mattison, D. R., Hankins, G. & Ahmed, M., Dec 15 2009, In : Biochemical Pharmacology. 78, 12, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Glyburide
Biotransformation
Metabolites
Liver
30 Citations (Scopus)

Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles

Hemauer, S. J., Patrikeeva, S. L., Nanovskaya, T., Hankins, G. & Ahmed, M., Nov 1 2009, In : Biochemical Pharmacology. 78, 9, p. 1272-1278 7 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Buprenorphine
Methadone
P-Glycoprotein
Paclitaxel
2008
29 Citations (Scopus)

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

Nanovskaya, T., Patrikeeva, S., Hemauer, S., Fokina, V., Mattison, D., Hankins, G. & Ahmed, M., 2008, In : Journal of Maternal-Fetal and Neonatal Medicine. 21, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

rosiglitazone
Glyburide
Albumins
Serum Albumin
Mothers
16 Citations (Scopus)

Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Yan, R., Nanovskaya, T., Zharikova, O. L., Mattison, D. R., Hankins, G. & Ahmed, M., May 1 2008, In : Biochemical Pharmacology. 75, 9, p. 1848-1857 10 p.

Research output: Contribution to journalArticle

17-alpha-Hydroxyprogesterone
Papio
Microsomes
Metabolism
Metabolites
13 Citations (Scopus)

The effect of esterases on 17α-hydroxyprogesterone caproate

Yan, R., Fokina, V., Hankins, G., Ahmed, M. & Nanovskaya, T., Feb 2008, In : American Journal of Obstetrics and Gynecology. 198, 2

Research output: Contribution to journalArticle

Acetylesterase
17-alpha-Hydroxyprogesterone
Butyrylthiocholine
Esterases
Hydrolysis
48 Citations (Scopus)

Transfer of methadone across the dually perfused preterm human placental lobule

Nanovskaya, T., Nekhayeva, I. A., Hankins, G. & Ahmed, M., Jan 2008, In : American Journal of Obstetrics and Gynecology. 198, 1

Research output: Contribution to journalArticle

Methadone
Placenta
P-Glycoprotein
Isotopes
Antipyrine
19 Citations (Scopus)

Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate

Hemauer, S. J., Yan, R., Patrikeeva, S. L., Mattison, D. R., Hankins, G., Ahmed, M. & Nanovskaya, T., Aug 2008, In : American Journal of Obstetrics and Gynecology. 199, 2

Research output: Contribution to journalArticle

17-alpha-Hydroxyprogesterone
Mothers
Progesterone
Fetus
Perfusion
2007
27 Citations (Scopus)

Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon

Zharikova, O. L., Ravindran, S., Nanovskaya, T., Hill, R. A., Hankins, G. & Ahmed, M., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 2012-2019 8 p.

Research output: Contribution to journalArticle

Enzyme kinetics
Papio
Glyburide
Microsomes
Metabolism
13 Citations (Scopus)

The effect of opiates on the activity of human placental aromatase/CYP19

Zharikova, O. L., Deshmukh, S. V., Kumar, M., Vargas, R., Nanovskaya, T., Hankins, G. & Ahmed, M., Jan 15 2007, In : Biochemical Pharmacology. 73, 2, p. 279-286 8 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Aromatase
Human Activities
Methadyl Acetate
Pentazocine
2006
52 Citations (Scopus)

Effect of human serum albumin on transplacental transfer of glyburide

Nanovskaya, T., Nekhayeva, I., Hankins, G. & Ahmed, M., Aug 28 2006, In : Biochemical Pharmacology. 72, 5, p. 632-639 8 p.

Research output: Contribution to journalArticle

Glyburide
Serum Albumin
Placenta
Antipyrine
Gestational Diabetes
33 Citations (Scopus)

Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons

Ravindran, S., Zharikova, O. L., Hill, R. A., Nanovskaya, T., Hankins, G. & Ahmed, M., Dec 15 2006, In : Biochemical Pharmacology. 72, 12, p. 1730-1737 8 p.

Research output: Contribution to journalArticle

Papio
Glyburide
Metabolites
Microsomes
Liver
14 Citations (Scopus)

Methadone metabolism by early gestational age placentas

Hieronymus, T. L., Nanovskaya, T., Deshmukh, S. V., Vargas, R., Hankins, G. & Ahmed, M., Jul 2006, In : American Journal of Perinatology. 23, 5, p. 287-294 8 p.

Research output: Contribution to journalArticle

Methadone
Placenta
Gestational Age
Aromatase
Enzymes
32 Citations (Scopus)

Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-α-acetylmethadol, and paclitaxel

Nekhayeva, I. A., Nanovskaya, T., Hankins, G. & Ahmed, M., Oct 2006, In : American Journal of Perinatology. 23, 7, p. 423-430 8 p.

Research output: Contribution to journalArticle

Methadyl Acetate
Buprenorphine
P-Glycoprotein
Paclitaxel
Opiate Alkaloids
19 Citations (Scopus)

The effect of methadone and buprenorphine on human placental aromatase

Zharikova, O. L., Deshmukh, S. V., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 14 2006, In : Biochemical Pharmacology. 71, 8, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

Buprenorphine
Aromatase
Methadone
Testosterone
Opiate Alkaloids