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The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
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Division:?Clinical and Experimental Immunology and Infectious Diseases
Dr. Midori-Horiuti is an Associate Professor in the department of Pediatrics in the division of Clinical and Experimental Immunology and Infectious Disease. She received her MD from Saga Medical School in Japan and her PhD from Okayama University Medical School in Japan. She completed her fellowship at the University of Texas Medical Branch.
She is a Project leader of Multidisciplinary Translational Teams (MTT) at the Institute for Translational Sciences, a Fellow of UTMB Center for Interdisciplinary Research in Women’s Health, a Member of Sealy Center for Vaccine Development and an Associate member of the Graduate Faculty, University of Texas Graduate School of Biomedical Sciences.
Research interests
Her primary research interests include cedar pollen allergies and environmental estrogen effects on allergy and asthma. She identified, cloned, sequenced and IgE epitopes identified the major allergens of mountain cedar pollen, Jun a 1 and Jun a 3. Her group has crystallized Jun a 1 and modeled Jun a 3, and mapped IgE epitopes. She has been interested in the structure and function of allergens to modify allergic reactions.
She has expended her research on the effects of environmental estrogen on the development of allergy and allergic diseases. She has found effects of a panel of environmental estrogens on allergy and asthma using the culture cells and animal models. Genome wide analyses of CD4+T and CD8+T cells from the mouse model of asthma with bisphenol A (BPA) exposure are ongoing.
Research Strategic Pillar Keywords
- Life Span Health
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Collaborations and top research areas from the last five years
Projects
- 2 Completed
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Modulation of the Allergenicity of Cedar and Ragweed Pollen Major Allergens
Midoro-Horiuti, T. (PI)
National Institute of Allergy and Infectious Diseases ( Award #5R21AI14256902)
12/1/18 → 11/30/22
Project: Research project
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Enviromental estrogens induced signals in immune cells that promote the development of asthma
Midoro-Horiuti, T. (PI)
American Lung Association - New York ( Award #AI310304)
9/1/14 → 8/31/16
Project: Research project
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Maternal exposure to bisphenol A has transgenerational effects on the development of experimental asthma through bromodomain-containing protein 4–zinc finger DHHC-type containing 1–stimulators of interferon genes axis
Midoro-Horiuti, T., Murakami, Y., Kuzume, K., Toler, R. M. & Zhang, K., 2025, (Accepted/In press) In: International Journal of Environmental Health Research.Research output: Contribution to journal › Article › peer-review
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Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma
Murakami, Y., Fahmy, S., Goldblum, R. M., Watson, C. & Midoro- Horiuti, T., May 2023, In: Molecular Immunology. 157, p. 142-145 4 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Peptide immunotherapy for aeroallergens
Midoro-Horiuti, T. & Schein, C. H., Jul 1 2023, In: Allergy and Asthma Proceedings. 44, 4, p. 237-243 7 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Serum thymus and activation-regulated chemokine (TARC) levels correlate with atopic dermatitis disease severity in patients < 6 months
Koizumi, M., Kuzume, K., Ishida, Y. & Midoro-Horiuti, T., Sep 25 2022, In: Allergy and Asthma Proceedings. 45, 5, p. 461-467 7 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Design of peptides with high affinity binding to a monoclonal antibody as a basis for immunotherapy
Negi, S. S., Goldblum, R., Braun, W. & Midoro-Horiuti, T., Nov 2021, In: Peptides. 145, 170628.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations