Tetsuro Ikegami, DVM, PhD

  • 2455 Citations
  • 27 h-Index
19992019

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2019

Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells

Hallam, H. J., Lokugamage, N. & Ikegami, T., Jan 1 2019, In : PLoS neglected tropical diseases. 13, 11, e0007904.

Research output: Contribution to journalArticle

Open Access
2018

Experimental Infection of Syrian Hamsters with Aerosolized Nipah Virus

Escaffre, O., Hill, T., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Perez, D. E., Atkins, C., Park, A., Lawrence, W., Sivasubramani, S. K., Peel, J. E., Peterson, J., Lee, B. & Freiberg, A., Oct 5 2018, In : Journal of Infectious Diseases. 218, 10, p. 1602-1610 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Favipiravir (T-705) protects against Nipah virus infection in the hamster model /631/326/22/1295 /631/326/596/1296 /13/106 /14/35 /38/77 /82/51 /96/63 article

Dawes, B. E., Kalveram, B., Ikegami, T., Juelich, T., Smith, J. K., Zhang, L., Park, A., Lee, B., Komeno, T., Furuta, Y. & Freiberg, A., Dec 1 2018, In : Scientific Reports. 8, 1, 7604.

Research output: Contribution to journalArticle

24 Scopus citations
2017

Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain

Ly, H. J., Nishiyama, S., Lokugamage, N., Smith, J. K., Zhang, L., Perez, D., Juelich, T. L., Freiberg, A. & Ikegami, T., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

5 Scopus citations

Contribution of human lung parenchyma and leukocyte influx to oxidative stress and immune systemmediated pathology following Nipah virus infection

Escaffre, O., Saito, T., Juelich, T. L., Ikegami, T., Smith, J. K., Perez, D. D., Atkins, C., Levine, C. B., Huante, M., Nusbaum, R. J., Endsley, J., Freiberg, A. & Rockx, B., Aug 1 2017, In : Journal of Virology. 91, 15, e00275-17.

Research output: Contribution to journalArticle

5 Scopus citations

Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model

Ikegami, T., Balogh, A., Nishiyama, S., Lokugamage, N., Saito, T., Morrill, J. C., Shivanna, V., Indran, S. V., Zhang, L., Smith, J. K., Perez, D., Juelich, T. L., Morozov, I., Wilson, W. C., Freiberg, A. & Richt, J. A., Dec 1 2017, In : PLoS One. 12, 12, e0189250.

Research output: Contribution to journalArticle

4 Scopus citations

Genetic stability of Rift Valley fever virus MP-12 vaccine during serial passages in culture cells

Lokugamage, N. & Ikegami, T., Dec 1 2017, In : npj Vaccines. 2, 1, 20.

Research output: Contribution to journalArticle

5 Scopus citations

Risk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain

Ly, H. J., Lokugamage, N., Nishiyama, S. & Ikegami, T., Sep 1 2017, In : PLoS One. 12, 9, e0185194.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR

Nishiyama, S., Slack, O. A. L., Lokugamage, N., Hill, T. E., Juelich, T. L., Zhang, L., Smith, J. K., Perez, D., Gong, B., Freiberg, A. & Ikegami, T., Jun 16 2016, (Accepted/In press) In : Virulence. p. 1-11 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mutational analysis of the rift valley fever virus glycoprotein precursor proteins for Gn protein expression

Phoenix, I., Lokugamage, N., Nishiyama, S. & Ikegami, T., Jun 1 2016, In : Viruses. 8, 6, 151.

Research output: Contribution to journalArticle

6 Scopus citations

N-glycans on the rift valley fever virus envelope glycoproteins Gn and Gc redundantly support viral infection via DC-SIGN

Phoenix, I., Nishiyama, S., Lokugamage, N., Hill, T. E., Huante, M., Slack, O. A. L., Carpio, V. H., Freiberg, A. & Ikegami, T., May 23 2016, In : Viruses. 8, 5

Research output: Contribution to journalArticle

8 Scopus citations

Optimized P2A for reporter gene insertion into nipah virus results in efficient ribosomal skipping and wild-type lethality

Park, A., Yun, T., Hill, T. E., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Freiberg, A. & Lee, B., Apr 1 2016, In : Journal of General Virology. 97, 4, p. 839-843 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

Ly, H. J. & Ikegami, T., Jul 2 2016, In : Virology journal. 13, 1, 118.

Research output: Contribution to journalArticle

29 Scopus citations

The L, M, and S segments of Rift Valley fever virus MP-12 vaccine independently contribute to a temperature-sensitive phenotype

Nishiyama, S., Lokugamage, N. & Ikegami, T., 2016, In : Journal of Virology. 90, 7, p. 3735-3744 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters

Gowen, B. B., Westover, J. B., Sefing, E. J., Bailey, K. W., Nishiyama, S., Wandersee, L., Scharton, D., Jung, K. H. & Ikegami, T., 2015, In : Frontiers in Microbiology. 6, JUN, 651.

Research output: Contribution to journalArticle

4 Scopus citations

Rift Valley fever virus MP-12 vaccine is fully attenuated by a combination of partial attenuations in the S, M, and L segments

Ikegami, T., Hill, T. E., Smith, J. K., Zhang, L., Juelich, T. L., Gong, B., Slack, O. A. L., Ly, H. J., Lokugamage, N. & Freiberg, A., 2015, In : Journal of Virology. 89, 14, p. 7262-7276 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
4 Scopus citations
2013

Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus

Lihoradova, O. A., Indran, S. V., Kalveram, B., Lokugamage, N., Head, J. A., Gong, B., Tigabu, B., Juelich, T. L., Freiberg, A. N. & Ikegami, T., Apr 2013, In : PLoS neglected tropical diseases. 7, 4, e2181.

Research output: Contribution to journalArticle

20 Scopus citations

Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge

Gowen, B. B., Bailey, K. W., Scharton, D., Vest, Z., Westover, J. B., Skirpstunas, R. & Ikegami, T., Apr 16 2013, In : Antiviral research. 98, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rift valley fever virus MP-12 vaccine encoding toscana virus NSs retains neuroinvasiveness in mice

Indran, S. V., Lihoradova, O. A., Phoenix, I., Lokugamage, N., Kalveram, B., Head, J. A., Tigabu, B., Smith, J. K., Zhang, L., Juelich, T. L., Gong, B., Freiberg, A. N. & Ikegami, T., Jul 1 2013, In : Journal of General Virology. 94, PART7, p. 1441-1450 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR

Kalveram, B., Lihoradova, O., Indran, S. V., Lokugamage, N., Head, J. A. & Ikegami, T., Jan 20 2013, In : Virology. 435, 2, p. 415-424 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Toscana virus NSs protein promotes degradation of double-stranded RNA-dependent protein kinase

Kalveram, B. & Ikegami, T., Apr 1 2013, In : Journal of virology. 87, 7, p. 3710-3718 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Using click chemistry to measure the effect of viral infection on host-cell RNA synthesis

Kalveram, B., Lihoradova, O., Indran, S. V., Head, J. A. & Ikegami, T., Jan 1 2013, In : Journal of visualized experiments : JoVE. 78

Research output: Contribution to journalArticle

8 Scopus citations
2012

Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines

Taniguchi, S., Sayama, Y., Nagata, N., Ikegami, T., Miranda, M. E., Watanabe, S., Iizuka, I., Fukushi, S., Mizutani, T., Ishii, Y., Saijo, M., Akashi, H., Yoshikawa, Y., Kyuwa, S. & Morikawa, S., Oct 11 2012, In : BMC Veterinary Research. 8, 189.

Research output: Contribution to journalArticle

5 Scopus citations

Functional Analysis of Rift Valley Fever Virus NSs Encoding a Partial Truncation

Head, J. A., Kalveram, B. & Ikegami, T., Sep 19 2012, In : PloS one. 7, 9, e45730.

Research output: Contribution to journalArticle

8 Scopus citations

Genetic subpopulations of rift valley fever virus strains ZH548 and MP-12 and recombinant MP-12 strains

Lokugamage, N., Freiberg, A. N., Morrill, J. C. & Ikegami, T., Dec 1 2012, In : Journal of virology. 86, 24, p. 13566-13575 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Rift valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis

Harmon, B., Schudel, B. R., Maar, D., Kozina, C., Ikegami, T., Tseng, C. T. K. & Negrete, O. A., Dec 1 2012, In : Journal of virology. 86, 23, p. 12954-12970 17 p.

Research output: Contribution to journalArticle

47 Scopus citations

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of rift valley fever virus MP-12 vaccine

Lihoradova, O., Kalveram, B., Indran, S. V., Lokugamage, N., Juelich, T. L., Hill, T. E., Tseng, C. T. K., Gong, B., Fukushi, S., Morikawa, S., Freiberg, A. N. & Ikegami, T., Jul 1 2012, In : Journal of virology. 86, 14, p. 7650-7661 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62

Kalveram, B., Lihoradova, O. & Ikegami, T., Jul 1 2011, In : Journal of virology. 85, 13, p. 6234-6243 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Using reverse genetics to manipulate the NSs gene of the rift valley fever virus MP-12 strain to improve vaccine safety and efficacy

Kalveram, B., Lihoradova, O., Indran, S. V. & Ikegami, T., Nov 2011, In : Journal of Visualized Experiments. 57, e3400.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Rapid accumulation of virulent rift valley fever virus in mice from an attenuated virus carrying a single nucleotide substitution in the M RNA

Morrill, J. C., Ikegami, T., Yoshikawa-Iwata, N., Lokugamage, N., Won, S., Terasaki, K., Zamoto-Niikura, A., Peters, C. J. & Makino, S., Sep 10 2010, In : PloS one. 5, 4, e9986.

Research output: Contribution to journalArticle

30 Scopus citations
2009

Rift Valley fever vaccines

Ikegami, T. & Makino, S., Nov 5 2009, In : Vaccine. 27, SUPPL. 4, p. D69-D72

Research output: Contribution to journalArticle

93 Scopus citations

Rift valley fever virus L protein forms a biologically active oligomer

Zamoto-Niikura, A., Terasaki, K., Ikegami, T., Peters, C. J. & Makino, S., Dec 1 2009, In : Journal of virology. 83, 24, p. 12779-12789 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2α phosphorylation

Ikegami, T., Narayanan, K., Won, S., Kamitani, W., Peters, C. J. & Makino, S., Feb 1 2009, In : PLoS pathogens. 5, 2, e1000287.

Research output: Contribution to journalArticle

150 Scopus citations
2008

Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells

Narayanan, K., Huang, C., Lokugamage, K., Kamitani, W., Ikegami, T., Tseng, C. T. K. & Makino, S., May 1 2008, In : Journal of virology. 82, 9, p. 4471-4479 9 p.

Research output: Contribution to journalArticle

114 Scopus citations
2007

Characterization of Rift Valley fever virus transcriptional terminations

Ikegami, T., Won, S., Peters, C. J. & Makino, S., Aug 1 2007, In : Journal of virology. 81, 16, p. 8421-8438 18 p.

Research output: Contribution to journalArticle

35 Scopus citations

NSm protein of rift valley fever virus suppresses virus-induced apoptosis

Won, S., Ikegami, T., Peters, C. J. & Makino, S., Dec 1 2007, In : Journal of virology. 81, 24, p. 13335-13345 11 p.

Research output: Contribution to journalArticle

118 Scopus citations
2006

NSm and 78-kilodalton proteins of Rift Valley fever virus are nonessential for viral replication in cell culture

Won, S., Ikegami, T., Peters, C. J. & Makino, S., Aug 1 2006, In : Journal of virology. 80, 16, p. 8274-8278 5 p.

Research output: Contribution to journalArticle

75 Scopus citations

Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene

Ikegami, T., Won, S., Peters, C. J. & Makino, S., Mar 1 2006, In : Journal of virology. 80, 6, p. 2933-2940 8 p.

Research output: Contribution to journalArticle

154 Scopus citations

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation

Kamitani, W., Narayanan, K., Huang, C., Lokugamage, K., Ikegami, T., Ito, N., Kubo, H. & Makino, S., Aug 22 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 34, p. 12885-12890 6 p.

Research output: Contribution to journalArticle

149 Scopus citations
2005

Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system

Ikegami, T., Peters, C. J. & Makino, S., May 1 2005, In : Journal of virology. 79, 9, p. 5606-5615 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Rift Valley fever virus NSs mRNA is transcribed from an incoming anti-viral-sense S RNA segment

Ikegami, T., Won, S., Peters, C. J. & Makino, S., Sep 1 2005, In : Journal of virology. 79, 18, p. 12106-12111 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
2004

Modification of endothelial cell functions by hantaan virus infection: Prolonged hyper-permeability induced by TNF-alplia of hantaan virus-infected endothelial cell monolayers

Niikura, M., Maeda, A., Ikegami, T., Saijo, M., Kurane, I. & Morikawa, S., Jul 1 2004, In : Archives of virology. 149, 7, p. 1279-1292 14 p.

Research output: Contribution to journalArticle

44 Scopus citations
2003

Analysis of linear B-cell epitopes of the nucleoprotein of Ebola virus that distinguish Ebola virus subtypes

Niikura, M., Ikegami, T., Saijo, M., Kurata, T., Kurane, I. & Morikawa, S., Jan 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 1, p. 83-87 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Antigen capture enzyme-linked immunosorbent assay for specific detection of reston Ebola virus nucleoprotein

Ikegami, T., Niikura, M., Saijo, M., Miranda, M. E., Calaor, A. B., Hernandez, M., Acosta, L. P., Manalo, D. L., Kurane, I., Yoshikawa, Y. & Morikawa, S., Jul 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 4, p. 552-557 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Detection of immunoglobulin G to Crimean-Congo hemorrhagic fever virus in sheep sera by recombinant nucleoprotein-based enzyme-linked immunosorbent and immunofluorescence assays

Qing, T., Saijo, M., Lei, H., Niikura, M., Maeda, A., Ikegami, T., Xinjung, W., Kurane, I. & Morikawa, S., Mar 1 2003, In : Journal of Virological Methods. 108, 1, p. 111-116 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Immunoglobulin G enzyme-linked immunosorbent assay using truncated nucleoproteins of Reston Ebola virus

Ikegami, T., Saijo, M., Niikura, M., Miranda, M. E., Calaor, A. B., Hernandez, M., Manalo, D. L., Kurane, I., Yoshikawa, Y. & Morikawa, S., Jun 1 2003, In : Epidemiology and infection. 130, 3, p. 533-539 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Chronological and spatial analysis of the 1996 Ebola Reston virus outbreak in a monkey breeding facility in the Philippines

Miranda, M. E. G., Yoshikawa, Y., Manalo, D. L., Calaor, A. B., Miranda, N. L. J., Cho, F., Ikegami, T. & Ksiazek, T. G., Apr 1 2002, In : Experimental Animals. 51, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Development of an immunofluorescence method for the detection of antibodies to Ebola virus subtype reston by the use of recombinant nucleoprotein-expressing HeLa cells

Ikegami, T., Saijo, M., Niikura, M., Miranda, M. E. G., Calaor, A. B., Hernandez, M., Manalo, D. L., Kurane, I., Yoshikawa, Y. & Morikawa, S., Jan 1 2002, In : MICROBIOLOGY and IMMUNOLOGY. 46, 9, p. 633-638 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Histopathology of natural Ebola virus subtype Reston infection in cynomolgus macaques during the Philippine outbreak in 1996

Ikegami, T., Miranda, M. E. G., Calaor, A. B., Manalo, D. L., Miranda, N. J., Niikura, M., Saijo, M., Une, Y., Nomura, Y., Kurane, I., Ksiazek, T. G., Yoshikawa, Y. & Morikawa, S., Oct 1 2002, In : Experimental Animals. 51, 5, p. 447-455 9 p.

Research output: Contribution to journalArticle

16 Scopus citations