Thomas Geisbert, PhD, MS

  • 16198 Citations
  • 70 h-Index
1989 …2024

Research output per year

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Research Output

2016

Monoclonal antibody therapy for junin virus infection

Zeitlin, L., Geisbert, J. B., Deer, D. J., Fenton, K. A., Bohorov, O., Bohorova, N., Goodman, C., Kim, D., Hiatt, A., Pauly, M. H., Velasco, J., Whaley, K. J., Altmann, F., Gruber, C., Steinkellner, H., Honko, A. N., Kuehne, A. I., Aman, M. J., Sahandi, S., Enterlein, S. & 3 others, Zhan, X., Enria, D. & Geisbert, T., Apr 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 16, p. 4458-4463 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Robinson, J. E., Hastie, K. M., Cross, R., Yenni, R. E., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Smira, A. A., Garry, C. E., Bradley, B. T., Yu, H., Shaffer, J. G., Boisen, M. L., Hartnett, J. N., Zandonatti, M. A., Rowland, M. M., Heinrich, M. L., Martinez-Sobrido, L., Cheng, B., De La Torre, J. C. & 30 others, Andersen, K. G., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Kanneh, L., Koroma, V. J., Fonnie, R., Jalloh, S. C., Kargbo, B., Vandi, M. A., Gbetuwa, M., Ikponmwosa, O., Asogun, D. A., Okokhere, P. O., Follarin, O. A., Schieffelin, J. S., Pitts, K. R., Geisbert, J. B., Kulakoski, P. C., Wilson, R. B., Happi, C. T., Sabeti, P. C., Gevao, S. M., Khan, S. H., Grant, D. S., Geisbert, T., Saphire, E. O., Branco, L. M. & Garry, R. F., May 10 2016, In : Nature Communications. 7, 11544.

Research output: Contribution to journalArticle

44 Scopus citations

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets

Satterfield, B. A., Cross, R., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. & Mirea, C. E., 2016, In : Journal of Virology. 90, 14, p. 6326-6343 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Oral and Conjunctival Exposure of Nonhuman Primates to Low Doses of Ebola Makona Virus

Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Fenton, K. A. & Geisbert, T., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S263-S267

Research output: Contribution to journalArticle

13 Scopus citations

Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Thi, E. P., Lee, A. C. H., Fenton, K. A. & Geisbert, T. W., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S367-S374

Research output: Contribution to journalArticle

20 Scopus citations

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R., Fenton, K. A., Broder, C. C. & Geisbert, T., Aug 3 2016, In : Scientific Reports. 6, 30916.

Research output: Contribution to journalArticle

32 Scopus citations

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Thi, E. P., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., Kondratowicz, A. S., MacLachlan, I., Geisbert, T. & Mire, C., Aug 22 2016, In : Nature Microbiology. 1, 16142.

Research output: Contribution to journalArticle

16 Scopus citations

Single-vector, single-injection recombinant vesicular stomatitis virus vaccines against high-containment viruses

Whitt, M. A., Geisbert, T. W. & Mire, C. E., Apr 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1403. p. 295-311 17 p. (Methods in Molecular Biology; vol. 1403).

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway

Pattabhi, S., Wilkins, C. R., Dong, R., Knoll, M. L., Posakony, J., Kaiser, S., Mire, C., Wang, M. L., Ireton, R. C., Geisbert, T., Bedard, K. M., Iadonato, S. P., Loo, Y. M. & Gale, M., 2016, In : Journal of Virology. 90, 5, p. 2372-2387 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R., Mire, C., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses

Pécheur, E. I., Borisevich, V., Halfmann, P., Morrey, J. D., Smee, D. F., Prichard, M., Mire, C., Kawaoka, Y., Geisbert, T. & Polyak, S. J., 2016, In : Journal of Virology. 90, 6, p. 3086-3092 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R., Mire, C., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. & Garry, R. F., Sep 1 2016, In : Antiviral Research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

Meyer, M., Garron, T., Lubaki, N. M., Mire, C., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T., Collins, P. L. & Bukreyev, A., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

Safronetz, D., Mire, C., Rosenke, K., Feldmann, F., Haddock, E., Geisbert, T. & Feldmann, H., Apr 17 2015, In : PLoS Neglected Tropical Diseases. 9, 4, e0003736.

Research output: Contribution to journalArticle

47 Scopus citations

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Mire, C. E., Geisbert, J. B., Versteeg, K. M., Mamaeva, N., Agans, K. N., Geisbert, T. W. & Connor, J. H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S384-S388

Research output: Contribution to journalArticle

20 Scopus citations

Comparison of the Pathogenesis of the Angola and Ravn Strains of Marburg Virus in the Outbred Guinea Pig Model

Cross, R., Fenton, K. A., Geisbert, J. B., Ebihara, H., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S258-S270

Research output: Contribution to journalArticle

24 Scopus citations

Considerations in the Use of Nonhuman Primate Models of Ebola Virus and Marburg Virus Infection

Geisbert, T., Strong, J. E. & Feldmann, H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S91-S97

Research output: Contribution to journalArticle

54 Scopus citations

Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever

Hartnett, J. N., Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Muncy, I. J., Goba, A., Momoh, M., Fullah, M., Mire, C., Geisbert, J. B., Geisbert, T., Holton, D. L., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Moses, L. M., Khan, S. H., Gevao, S. M. & 6 others, Grant, D. S., Robinson, J. E., Happi, C., Pitts, K. R., Garry, R. F. & Branco, L. M., May 1 2015, In : Future Virology. 10, 5, p. 559-584 26 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development of Prototype Filovirus Recombinant Antigen Immunoassays

Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Bornholdt, Z. A., Fusco, M. L., Abelson, D. M., Oda, S. I., Hartnett, J. N., Rowland, M. M., Heinrich, M. L., Akdag, M., Goba, A., Momoh, M., Fullah, M., Baimba, F., Gbakie, M., Safa, S., Fonnie, R. & 14 others, Kanneh, L., Cross, R., Geisbert, J. B., Geisbert, T., Kulakosky, P. C., Grant, D. S., Shaffer, J. G., Schieffelin, J. S., Wilson, R. B., Saphire, E. O., Branco, L. M., Garry, R. F., Khan, S. H. & Pitts, K. R., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S359-S367

Research output: Contribution to journalArticle

12 Scopus citations
6 Scopus citations

Lack of Marburg Virus Transmission from Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats

Paweska, J. T., Van Vuren, P. J., Fenton, K. A., Graves, K., Grobbelaar, A. A., Moolla, N., Leman, P., Weyer, J., Storm, N., McCulloch, S. D., Scott, T. P., Markotter, W., Odendaal, L., Clift, S. J., Geisbert, T., Hale, M. J. & Kemp, A., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S109-S118

Research output: Contribution to journalArticle

27 Scopus citations

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Zhou, J. Z., Agans, K. N., Snead, N. M., Deer, D. J., Barnard, T. R., Fenton, K. A., Maclachlan, I. & Geisbert, T., May 21 2015, In : Nature. 521, 7552, p. 362-365 4 p.

Research output: Contribution to journalArticle

143 Scopus citations

Modeling the Disease Course of Zaire ebolavirus Infection in the Outbred Guinea Pig

Cross, R., Fenton, K. A., Geisbert, J. B., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S305-S315

Research output: Contribution to journalArticle

28 Scopus citations

Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in sierra leone prior to the 2014 outbreak

Boisen, M. L., Schieffelin, J. S., Goba, A., Oottamasathien, D., Jones, A. B., Shaffer, J. G., Hastie, K. M., Hartnett, J. N., Momoh, M., Fullah, M., Gabiki, M., Safa, S., Zandonatti, M., Fusco, M., Bornholdt, Z., Abelson, D., Gire, S. K., Andersen, K. G., Tariyal, R., Stremlau, M. & 13 others, Cross, R. W., Geisbert, J. B., Pitts, K. R., Geisbert, T. W., Kulakoski, P., Wilson, R. B., Henderson, L., Sabeti, P. C., Grant, D. S., Garry, R. F., Saphire, E. O., Branco, L. M. & Khan, S. H., Feb 1 2015, In : Viral Immunology. 28, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Safety of recombinant VSV-Ebola virus vaccine vector in pigs

De Wit, E., Marzi, A., Bushmaker, T., Brining, D., Scott, D., Richt, J. A., Geisbert, T. W. & Feldmann, H., Jan 1 2015, In : Emerging infectious diseases. 21, 4, p. 702-704 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus

Mire, C., Matassov, D., Geisbert, J. B., Latham, T. E., Agans, K. N., Xu, R., Ota-Setlik, A., Egan, M. A., Fenton, K. A., Clarke, D. K., Eldridge, J. H. & Geisbert, T., Apr 30 2015, In : Nature. 520, 7549, p. 688-691 4 p.

Research output: Contribution to journalArticle

66 Scopus citations

Stat1-Deficient Mice Are Not an Appropriate Model for Efficacy Testing of Recombinant Vesicular Stomatitis Virus-Based Filovirus Vaccines

Marzi, A., Kercher, L., Marceau, J., York, A., Callsion, J., Gardner, D. J., Geisbert, T. & Feldmann, H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S404-S409

Research output: Contribution to journalArticle

13 Scopus citations

The broad-spectrum antiviral favipiravir protects Guinea pigs from lethal Lassa virus infection post-disease onset

Safronetz, D., Rosenke, K., Westover, J. B., Martellaro, C., Okumura, A., Furuta, Y., Geisbert, J., Saturday, G., Komeno, T., Geisbert, T. W., Feldmann, H. & Gowen, B. B., Oct 12 2015, In : Scientific reports. 5, 14775.

Research output: Contribution to journalArticle

52 Scopus citations

The immunomodulating v and W proteins of Nipah virus determine disease course

Satterfield, B. A., Cross, R., Fenton, K. A., Agans, K. N., Basler, C. F., Geisbert, T. & Mire, C., Jun 24 2015, In : Nature Communications. 6, 7483.

Research output: Contribution to journalArticle

24 Scopus citations

Vaccination with a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge with a Lethal Dose of Ebola Virus

Matassov, D., Marzi, A., Latham, T., Xu, R., Ota-Setlik, A., Feldmann, F., Geisbert, J. B., Mire, C. E., Hamm, S., Nowak, B., Egan, M. A., Geisbert, T. W., Eldridge, J. H., Feldmann, H. & Clarke, D. K., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S443-S451

Research output: Contribution to journalArticle

31 Scopus citations

Vesicular stomatitis virus–based vaccines against lassa and ebola viruses

Marzi, A., Feldmann, F., Geisbert, T. W., Feldmann, H. & Safronetz, D., Jan 1 2015, In : Emerging infectious diseases. 21, 2, p. 305-307 3 p.

Research output: Contribution to journalArticle

37 Scopus citations
2014

A recombinant Hendra Virus G glycoprotein subunit vaccine protects nonhuman primates against hendra virus challenge

Mire, C. E., Geisbert, J. B., Agans, K. N., Feng, Y. R., Fenton, K. A., Bossart, K. N., Yan, L., Chan, Y. P., Broder, C. C. & Geisbert, T. W., May 2014, In : Journal of virology. 88, 9, p. 4624-4631 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., 2014, In : mBio. 5, 6, p. e02011

Research output: Contribution to journalArticle

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

42 Scopus citations

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Satterfield, B. A., Versteeg, K. M., Fritz, E. A., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Apr 23 2014, In : PloS one. 9, 4, e94355.

Research output: Contribution to journalArticle

41 Scopus citations

Lassa Fever in Post-Conflict Sierra Leone

Shaffer, J. G., Grant, D. S., Schieffelin, J. S., Boisen, M. L., Goba, A., Hartnett, J. N., Levy, D. C., Yenni, R. E., Moses, L. M., Fullah, M., Momoh, M., Fonnie, M., Fonnie, R., Kanneh, L., Koroma, V. J., Kargbo, K., Ottomassathien, D., Muncy, I. J., Jones, A. B., Illick, M. M. & 31 others, Kulakosky, P. C., Haislip, A. M., Bishop, C. M., Elliot, D. H., Brown, B. L., Zhu, H., Hastie, K. M., Andersen, K. G., Gire, S. K., Tabrizi, S., Tariyal, R., Stremlau, M., Matschiner, A., Sampey, D. B., Spence, J. S., Cross, R. W., Geisbert, J. B., Folarin, O. A., Happi, C. T., Pitts, K. R., Geske, F. J., Geisbert, T. W., Saphire, E. O., Robinson, J. E., Wilson, R. B., Sabeti, P. C., Henderson, L. A., Khan, S. H., Bausch, D. G., Branco, L. M. & Garry, R. F., Mar 2014, In : PLoS neglected tropical diseases. 8, 3, e2748.

Research output: Contribution to journalArticle

80 Scopus citations

Marburg and Ebola Hemorrhagic Fevers (Filoviruses)

Geisbert, T., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 1995-1999.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Thi, E. P., Mire, C. E., Ursic-Bedoya, R., Geisbert, J. B., Lee, A. C. H., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., MacLachlan, I. & Geisbert, T. W., Aug 20 2014, In : Science Translational Medicine. 6, 250, 250ra116.

Research output: Contribution to journalArticle

44 Scopus citations

Medical research: Ebola therapy protects severely ill monkeys

Geisbert, T. W., Oct 2 2014, In : Nature. 514, 7520, p. 41-43 3 p.

Research output: Contribution to journalShort survey

13 Scopus citations

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Edwards, M. R., Johnson, B., Mire, C. E., Xu, W., Shabman, R. S., Speller, L. N., Leung, D. W., Geisbert, T. W., Amarasinghe, G. K. & Basler, C. F., Mar 27 2014, In : Cell Reports. 6, 6, p. 1017-1025 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody

Geisbert, T. W., Mire, C. E., Geisbert, J. B., Chan, Y. P., Agans, K. N., Feldmann, F., Fenton, K. A., Zhu, Z., Dimitrov, D. S., Scott, D. P., Bossart, K. N., Feldmann, H. & Broder, C. C., Jun 25 2014, In : Science Translational Medicine. 6, 242, 242ra82.

Research output: Contribution to journalArticle

51 Scopus citations

Transcriptional Correlates of Disease Outcome in Anticoagulant-Treated Non-Human Primates Infected with Ebolavirus

Garamszegi, S., Yen, J. Y., Honko, A. N., Geisbert, J. B., Rubins, K. H., Geisbert, T. W., Xia, Y., Hensley, L. E. & Connor, J. H., Jul 2014, In : PLoS neglected tropical diseases. 8, 7, e3061.

Research output: Contribution to journalArticle

13 Scopus citations

Vaccines and antivirals for filoviruses

Mire, C. & Geisbert, T., Jan 1 2014, Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., p. 587-620 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Viral-vectored vaccines to control pathogenic filoviruses

Mire, C. & Geisbert, T., Jul 1 2014, Novel Technologies for Vaccine Development. Springer-Verlag Wien, Vol. 9783709118184. p. 33-60 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

Animal models for highly pathogenic emerging viruses

Safronetz, D., Geisbert, T. W. & Feldmann, H., Apr 2013, In : Current Opinion in Virology. 3, 2, p. 205-209 5 p.

Research output: Contribution to journalReview article

18 Scopus citations

Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

Marzi, A., Engelmann, F., Feldmann, F., Haberthur, K., Shupert, W. L., Brining, D., Scott, D. P., Geisbert, T. W., Kawaoka, Y., Katze, M. G., Feldmann, H. & Messaoudi, I., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1893-1898 6 p.

Research output: Contribution to journalArticle

151 Scopus citations

A recently isolated Lassa virus from Mali demonstrates atypical clinical disease manifestations and decreased virulence in cynomolgus macaques

Safronetz, D., Strong, J. E., Feldmann, F., Haddock, E., Sogoba, N., Brining, D., Geisbert, T. W., Scott, D. P. & Feldmann, H., Apr 15 2013, In : Journal of Infectious Diseases. 207, 8, p. 1316-1327 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

A treatment for and vaccine against the deadly Hendra and Nipah viruses

Broder, C. C., Xu, K., Nikolov, D. B., Zhu, Z., Dimitrov, D. S., Middleton, D., Pallister, J., Geisbert, T. W., Bossart, K. N. & Wang, L. F., Aug 13 2013, In : Antiviral research. 100, 1, p. 8-13 6 p.

Research output: Contribution to journalReview article

49 Scopus citations

Filoviridae: Marburg and ebola viruses

Feldmann, H., Sanchez, A. & Geisbert, T., May 21 2013, Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1.

Research output: Chapter in Book/Report/Conference proceedingChapter

79 Scopus citations