Thomas Geisbert, PhD, MS

  • 16198 Citations
  • 70 h-Index
1989 …2024

Research output per year

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Research Output

2013

Interferon- therapy prolongs survival in rhesus macaque models of ebola and marburg hemorrhagic fever

Smith, L. M., Hensley, L. E., Geisbert, T. W., Johnson, J., Stossel, A., Honko, A., Yen, J. Y., Geisbert, J., Paragas, J., Fritz, E., Olinger, G., Young, H. A., Rubins, K. H. & Karp, C. L., Jul 15 2013, In : Journal of Infectious Diseases. 208, 2, p. 310-318 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Mutual antagonism between the ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

Luthra, P., Ramanan, P., Mire, C. E., Weisend, C., Tsuda, Y., Yen, B., Liu, G., Leung, D. W., Geisbert, T. W., Ebihara, H., Amarasinghe, G. K. & Basler, C. F., Jul 17 2013, In : Cell Host and Microbe. 14, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease

Mire, C. E., Versteeg, K. M., Cross, R. W., Agans, K. N., Fenton, K. A., Whitt, M. A. & Geisbert, T. W., Dec 13 2013, In : Virology journal. 10, 353.

Research output: Contribution to journalArticle

34 Scopus citations

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

Mire, C. E., Geisbert, J. B., Marzi, A., Agans, K. N., Feldmann, H. & Geisbert, T. W., Jan 1 2013, In : PLoS neglected tropical diseases. 7, 12, e2600.

Research output: Contribution to journalArticle

54 Scopus citations
2012

A Hendra virus G glycoprotein subunit vaccine protects African green monkeys from Nipah virus challenge

Bossart, K. N., Rockx, B., Feldmann, F., Brining, D., Scott, D., LaCasse, R., Geisbert, J. B., Feng, Y. R., Chan, Y. P., Hickey, A. C., Broder, C. C., Feldmann, H. & Geisbert, T. W., Aug 8 2012, In : Science Translational Medicine. 4, 146, 146ra107.

Research output: Contribution to journalArticle

65 Scopus citations

Animal challenge models of henipavirus infection and pathogenesis

Geisbert, T. W., Feldmann, H. & Broder, C. C., Nov 8 2012, Henipavirus: Ecology, Molecular Virology, and Pathogenesis. Lee, B. & Rota, P. (eds.). p. 153-177 25 p. (Current Topics in Microbiology and Immunology; vol. 359).

Research output: Chapter in Book/Report/Conference proceedingChapter

43 Scopus citations

Animal models for viral hemorrhagic fevers

Warfield, K. L. & Geisbert, T., Jan 1 2012, Biodefense Research Methodology and Animal Models, Second Edition. CRC Press, p. 271-310 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunization strategies against henipaviruses

Broder, C. C., Geisbert, T. W., Xu, K., Nikolov, D. B., Wang, L. F., Middleton, D., Pallister, J. & Bossart, K. N., Nov 8 2012, Henipavirus: Ecology, Molecular Virology, and Pathogenesis. Lee, B. & Rota, P. (eds.). p. 197-223 27 p. (Current Topics in Microbiology and Immunology; vol. 359).

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 1 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

65 Scopus citations
2011

CD8 + cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

Sullivan, N. J., Hensley, L., Asiedu, C., Geisbert, T. W., Stanley, D., Johnson, J., Honko, A., Olinger, G., Bailey, M., Geisbert, J. B., Reimann, K. A., Bao, S., Rao, S., Roederer, M., Jahrling, P. B., Koup, R. A. & Nabel, G. J., Sep 1 2011, In : Nature Medicine. 17, 9, p. 1128-1131 4 p.

Research output: Contribution to journalArticle

143 Scopus citations

Ebola haemorrhagic fever

Feldmann, H. & Geisbert, T. W., Jan 1 2011, In : The Lancet. 377, 9768, p. 849-862 14 p.

Research output: Contribution to journalReview article

794 Scopus citations

Infectious disease: A neutralizing human monoclonal antibody protects African green monkeys from Hendra virus challenge

Bossart, K. N., Geisbert, T. W., Feldmann, H., Zhu, Z., Feldmann, F., Geisbert, J. B., Yan, L., Feng, Y. R., Brining, D., Scott, D., Wang, Y., Dimitrov, A. S., Callison, J., Chan, Y. P., Hickey, A. C., Dimitrov, D. S., Broder, C. C. & Rockx, B., Oct 19 2011, In : Science Translational Medicine. 3, 105, 105ra103.

Research output: Contribution to journalArticle

88 Scopus citations

Label-free multiplexed virus detection using spectral reflectance imaging

Lopez, C. A., Daaboul, G. G., Vedula, R. S., Özkumur, E., Bergstein, D. A., Geisbert, T. W., Fawcett, H. E., Goldberg, B. B., Connor, J. H. & Ünlü, M. S., Apr 15 2011, In : Biosensors and Bioelectronics. 26, 8, p. 3432-3437 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Label-free pathogen sensing: Microarray studies for clinical and research applictions

Lopez, C. A., Daaboul, G. G., Yu, C., Genco, C. A., Geisbert, T. W., Connor, J. H., Goldberg, B. B. & Ünlü, M. S., Dec 12 2011, Proceedings - OMN2011: 16th International Conference on Optical MEMS and Nanophotonics. p. 125-126 2 p. 6031111. (International Conference on Optical MEMS and Nanophotonics).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Management of accidental exposure to Ebola virus in the biosafety Level 4 Laboratory, Hamburg, Germany

Günther, S., Feldmann, H., Geisbert, T. W., Hensley, L. E., Rollin, P. E., Nichol, S. T., Ströher, U., Artsob, H., Peters, C. J., Ksiazek, T. G., Becker, S., Ter Meulen, J., Ölschläger, S., Schmidt-Chanasit, J., Sudeck, H., Burchard, G. D. & Schmiedel, S., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S785-S790

Research output: Contribution to journalArticle

103 Scopus citations

Pathogenesis of lassa fever in cynomolgus macaques

Hensley, L. E., Smith, M. A., Geisbert, J. B., Fritz, E. A., Daddario-Dicaprio, K. M., Larsen, T. & Geisbert, T. W., May 10 2011, In : Virology journal. 8, 205.

Research output: Contribution to journalArticle

65 Scopus citations

Pathogenesis of marburg hemorrhagic fever in cynomolgus macaques

Hensley, L. E., Alves, D. A., Geisbert, J. B., Fritz, E. A., Reed, C., Larsen, T. & Geisbert, T. W., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1021-S1031

Research output: Contribution to journalArticle

52 Scopus citations

Progress in filovirus vaccine development: Evaluating the potential for clinical use

Falzarano, D., Geisbert, T. W. & Feldmann, H., Jan 1 2011, In : Expert review of vaccines. 10, 1, p. 63-77 15 p.

Research output: Contribution to journalReview article

76 Scopus citations

Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to ad5 and protect nonhuman primates against ebolavirus challenge

Geisbert, T. W., Bailey, M., Hensley, L., Asiedu, C., Geisbert, J., Stanley, D., Honko, A., Johnson, J., Mulangu, S., Pau, M. G., Custers, J., Vellinga, J., Hendriks, J., Jahrling, P., Roederer, M., Goudsmit, J., Koup, R. & Sullivan, N. J., May 1 2011, In : Journal of virology. 85, 9, p. 4222-4233 12 p.

Research output: Contribution to journalArticle

113 Scopus citations

Recombinant vesicular stomatitis virus-based vaccines against Ebola and marburg virus infections

Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1075-S1081

Research output: Contribution to journalArticle

119 Scopus citations

Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with bundibugyo ebolavirus

Falzarano, D., Feldmann, F., Grolla, A., Leung, A., Ebihara, H., Strong, J. E., Marzi, A., Takada, A., Jones, S., Gren, J., Geisbert, J., Jones, S. M., Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1082-S1089

Research output: Contribution to journalArticle

40 Scopus citations

Therapeutics of Ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation

Yen, J. Y., Garamszegi, S., Geisbert, J. B., Rubins, K. H., Geisbert, T. W., Honko, A., Xia, Y., Connor, J. H. & Hensley, L. E., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1043-S1052

Research output: Contribution to journalArticle

28 Scopus citations

Vesicular stomatitis virus-based Ebola vaccines with improved cross-protective efficacy

Marzi, A., Ebihara, H., Callison, J., Groseth, A., Williams, K. J., Geisbert, T. W. & Feldmann, H., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S1066-S1074

Research output: Contribution to journalArticle

68 Scopus citations
2010

An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media

Yanik, A. A., Huang, M., Kamohara, O., Artar, A., Geisbert, T. W., Connor, J. H. & Altug, H., Dec 8 2010, In : Nano Letters. 10, 12, p. 4962-4969 8 p.

Research output: Contribution to journalArticle

276 Scopus citations

A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment

Rockx, B., Bossart, K. N., Feldmann, F., Geisbert, J. B., Hickey, A. C., Brining, D., Callison, J., Safronetz, D., Marzi, A., Kercher, L., Long, D., Broder, C. C., Feldmann, H. & Geisbert, T. W., Oct 2010, In : Journal of virology. 84, 19, p. 9831-9839 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Development of an acute and highly pathogenic nonhuman primate model of nipah virus infection

Geisbert, T. W., Daddario-Dicaprio, K. M., Hickey, A. C., Smith, M. A., Chan, Y. P., Wang, L. F., Mattapallil, J. J., Geisbert, J. B., Bossart, K. N. & Broder, C. C., Sep 17 2010, In : PloS one. 5, 5, e10690.

Research output: Contribution to journalArticle

85 Scopus citations

Inhibition of heat-shock protein 90 reduces Ebola virus replication

Smith, D. R., McCarthy, S., Chrovian, A., Olinger, G., Stossel, A., Geisbert, T. W., Hensley, L. E. & Connor, J. H., Aug 1 2010, In : Antiviral research. 87, 2, p. 187-194 8 p.

Research output: Contribution to journalArticle

70 Scopus citations

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

Geisbert, T. W., Lee, A. CH., Robbins, M., Geisbert, J. B., Honko, A. N., Sood, V., Johnson, J. C., de Jong, S., Tavakoli, I., Judge, A., Hensley, L. E. & MacLachlan, I., May 31 2010, In : The Lancet. 375, 9729, p. 1896-1905 10 p.

Research output: Contribution to journalArticle

342 Scopus citations

Postexposure treatment of marburg virus infection

Geisbert, T. W., Hensley, L. E., Geisbert, J. B., Leung, A., Johnson, J. C., Grolla, A. & Feldmann, H., Jul 1 2010, In : Emerging infectious diseases. 16, 7, p. 1119-1122 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations

Kuhn, J. H., Becker, S., Ebihara, H., Geisbert, T. W., Johnson, K. M., Kawaoka, Y., Lipkin, W. I., Negredo, A. I., Netesov, S. V., Nichol, S. T., Palacios, G., Peters, C. J., Tenorio, A., Volchkov, V. E. & Jahrling, P. B., Dec 2010, In : Archives of virology. 155, 12, p. 2083-2103 21 p.

Research output: Contribution to journalArticle

299 Scopus citations

Prospects for immunisation against Marburg and Ebola viruses

Geisbert, T. W., Bausch, D. G. & Feldmann, H., Nov 1 2010, In : Reviews in Medical Virology. 20, 6, p. 344-357 14 p.

Research output: Contribution to journalReview article

63 Scopus citations

Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates

Geisbert, T. W., Bailey, M., Geisbert, J. B., Asiedu, C., Roederer, M., Grazia-Pau, M., Custers, J., Jahrling, P., Goudsmit, J., Koup, R. & Sullivan, N. J., Oct 2010, In : Journal of virology. 84, 19, p. 10386-10394 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Drug targets in infections with Ebola and Marburg viruses

Gene, O. G., Julia, B. E., Vanessa, M. R., Victoria, W. J., Thomas, G. W. & Lisa, H. E., Jan 1 2009, In : Infectious Disorders - Drug Targets. 9, 2, p. 191-200 10 p.

Research output: Contribution to journalReview article

14 Scopus citations

Potential impact of a 2-person security rule on BioSafety Level 4 laboratory workers

LeDuc, J. W., Anderson, K., Bloom, M. E., Carrion, R., Feldmann, H., Fitch, J. P., Geisbert, J. B., Geisbert, T. W., Holbrook, M. R., Jahrling, P. B., Ksiazek, T. G., Patterson, J. & Rollin, P. E., Jul 1 2009, In : Emerging infectious diseases. 15, 7

Research output: Contribution to journalShort survey

3 Scopus citations

Responses to Ebola and Marburg virus infections

Geisbert, T., Feldmann, F., Geisbert, J. & Feldmann, H., Jan 1 2009, RNA Viruses: Host Gene Responses to Infections. World Scientific Publishing Co., p. 371-390 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Single-injection vaccine protects nonhuman primates against infection with Marburg virus and three species of Ebola virus

Geisbert, T. W., Geisbert, J. B., Leung, A., Daddario-DiCaprio, K. M., Hensley, L. E., Grolla, A. & Feldmann, H., Jul 1 2009, In : Journal of virology. 83, 14, p. 7296-7304 9 p.

Research output: Contribution to journalArticle

180 Scopus citations
2008

Cellular immune response to marburg virus infection in cynomolgus macaques

Fritz, E. A., Geisbert, J. B., Geisbert, T. W., Hensley, L. E. & Reed, D. S., Sep 1 2008, In : Viral Immunology. 21, 3, p. 355-363 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Filoviruses

Olinger, G., Geisbert, T. & Hensley, L. E., Jan 1 2008, Encyclopedia of Virology. Elsevier Ltd, p. 198-205 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Framework for leadership and training of biosafety level 4 laboratory workers

Le Duc, J. W., Anderson, K., Bloom, M. E., Estep, J. E., Feldmann, H., Geisbert, J. B., Geisbert, T. W., Hensley, L., Holbrook, M., Jahrling, P. B., Ksiazek, T. G., Korch, G., Patterson, J., Skvorak, J. P. & Weingartl, H., Nov 1 2008, In : Emerging infectious diseases. 14, 11, p. 1685-1688 4 p.

Research output: Contribution to journalShort survey

18 Scopus citations

Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates

Geisbert, T. W., Daddario-DiCaprio, K. M., Williams, K. J. N., Geisbert, J. B., Leung, A., Feldmann, F., Hensley, L. E., Feldmann, H. & Jones, S. M., Jun 1 2008, In : Journal of virology. 82, 11, p. 5664-5668 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Vesicular stomatitis virus-based Ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates

Geisbert, T. W., Daddario-DiCaprio, K. M., Lewis, M. G., Geisbert, J. B., Grolla, A., Leung, A., Paragas, J., Matthias, L., Smith, M. A., Jones, S. M., Hensley, L. E., Feldmann, H. & Jahrling, P. B., Nov 1 2008, In : PLoS pathogens. 4, 11, e1000225.

Research output: Contribution to journalArticle

140 Scopus citations

Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses

Geisbert, T. W., Daddario-DiCaprio, K. M., Geisbert, J. B., Reed, D. S., Feldmann, F., Grolla, A., Ströher, U., Fritz, E. A., Hensley, L. E., Jones, S. M. & Feldmann, H., Dec 9 2008, In : Vaccine. 26, 52, p. 6894-6900 7 p.

Research output: Contribution to journalArticle

142 Scopus citations
2007

Development of vaccines for Marburg hemorrhagic fever

Bausch, D. G. & Geisbert, T. W., Feb 1 2007, In : Expert review of vaccines. 6, 1, p. 57-74 18 p.

Research output: Contribution to journalReview article

14 Scopus citations

Ebola hemorrhagic fever: Evaluation of passive immunotherapy in nonhuman primates

Jahrling, P. B., Geisbert, J. B., Swearengen, J. R., Larsen, T. & Geisbert, T. W., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S400-S403

Research output: Contribution to journalArticle

95 Scopus citations

Effective post-exposure treatment of ebola infection

Feldmann, H., Jones, S. M., Daddario-DiCaprio, K. M., Geisbert, J. B., Ströher, U., Grolla, A., Bray, M., Fritz, E. A., Fernando, L., Feldmann, F., Hensley, L. E. & Geisbert, T. W., Jan 1 2007, In : PLoS pathogens. 3, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

223 Scopus citations

Epitopes required for antibody-dependent enhancement of Ebola virus infection

Takada, A., Ebihara, H., Feldmann, H., Geisbert, T. W. & Kawaoka, Y., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S347-S356

Research output: Contribution to journalArticle

50 Scopus citations

Filoviruses: Recent advances and future challenges

Feldmann, H., Geisbert, T. & Kawaoka, Y., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S129-S130

Research output: Contribution to journalArticle

11 Scopus citations

In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein

Ebihara, H., Theriault, S., Neumann, G., Alimonti, J. B., Geisbert, J. B., Hensley, L. E., Groseth, A., Jones, S. M., Geisbert, T. W., Kawaoka, Y. & Feldmann, H., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S313-S322

Research output: Contribution to journalArticle

57 Scopus citations

Lymphocyte death in a mouse model of ebola virus infection

Bradfute, S. B., Braun, D. R., Shamblin, J. D., Geisbert, J. B., Paragas, J., Garrison, A., Hensley, L. E. & Geisbert, T. W., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S296-S304

Research output: Contribution to journalArticle

61 Scopus citations

Marburg virus Angola infection of rhesus macaques: Pathogenesis and treatment with recombinant nematode anticoagulant protein c2

Geisbert, T. W., Daddario-DiCaprio, K. M., Geisbert, J. B., Young, H. A., Formenty, P., Fritz, E. A., Larsen, T. & Hensley, L. E., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S372-S381

Research output: Contribution to journalArticle

90 Scopus citations