Thomas Geisbert, PhD, MS

  • 16198 Citations
  • 70 h-Index
1989 …2024

Research output per year

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Research Output

2007

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys

Oswald, W. B., Geisbert, T. W., Davis, K. J., Geisbert, J. B., Sullivan, N. J., Jahrling, P. B., Parren, P. W. H. I. & Burton, D. R., Jan 1 2007, In : PLoS pathogens. 3, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

167 Scopus citations

Outbreaks of filovirus hemorrhagic fever: Time to refocus on the patient

Bausch, D. G., Feldmann, H., Geisbert, T. W., Bray, M., Sprecher, A. G., Boumandouki, P., Rollin, P. E. & Roth, C., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S136-S141

Research output: Contribution to journalArticle

45 Scopus citations

Panmicrobial Oligonucleotide Array for Diagnosis of Infectious Diseases

Palacios, G., Quan, P. L., Jabado, O. J., Conlan, S., Hirschberg, D. L., Liu, Y., Zhai, J., Renwick, N., Hui, J., Hegyi, H., Grolla, A., Strong, J. E., Towner, J. S., Geisbert, T. W., Jahrling, P. B., Büchen-Osmond, C., Ellerbrok, H., Sanchez-Seco, M. P., Lussier, Y., Formenty, P. & 4 others, Nichol, S. T., Feldmann, H., Briese, T. & Lipkin, W. I., Jan 2007, In : Emerging infectious diseases. 13, 1, p. 73-81 9 p.

Research output: Contribution to journalArticle

Open Access
218 Scopus citations

Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus

Larsen, T., Stevens, E. L., Davis, K. J., Geisbert, J. B., Daddario-DiCaprio, K. M., Jahrling, P. B., Hensley, L. E. & Geisbert, T. W., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S323-S328

Research output: Contribution to journalArticle

45 Scopus citations

Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates

Neumann, G., Geisbert, T. W., Ebihara, H., Geisbert, J. B., Daddario-DiCaprio, K. M., Feldmann, H. & Kawaoka, Y., Mar 1 2007, In : Journal of virology. 81, 6, p. 2995-2998 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

Recombinant human activated protein C for the postexposure treatment of ebola hemorrhagic fever

Hensley, L. E., Stevens, E. L., Yan, S. B., Geisbert, J. B., Macias, W. L., Larsen, T., Daddario-DiCaprio, K. M., Cassell, G. H., Jahrling, P. B. & Geisbert, T. W., Nov 15 2007, In : Journal of Infectious Diseases. 196, SUPPL. 2, p. S390-S399

Research output: Contribution to journalArticle

123 Scopus citations

The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever

Rubins, K. H. K. H., Hensley, L. E., Wahl-Jensen, V., Daddario DiCaprio, K. M., Young, H. A., Reed, D. S., Jahrling, P. B., Brown, P. O., Relman, D. A. & Geisbert, T. W., Jan 1 2007, In : Genome Biology. 8, 8, R174.

Research output: Contribution to journalArticle

72 Scopus citations
2006

Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine

Daddario-DiCaprio, K. M., Geisbert, T. W., Geisbert, J. B., Ströher, U., Hensley, L. E., Grolla, A., Fritz, E. A., Feldmann, F., Feldmann, H. & Jones, S. M., Oct 1 2006, In : Journal of virology. 80, 19, p. 9659-9666 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Development of treatment strategies to combat Ebola and Marburg viruses

Paragas, J. & Geisbert, T. W., Feb 1 2006, In : Expert Review of Anti-Infective Therapy. 4, 1, p. 67-76 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs

Sullivan, N. J., Geisbert, T. W., Geisbert, J. B., Shedlock, D. J., Xu, L., Lamoreaux, L., Custers, J. H. H. V., Popernack, P. M., Yang, Z. Y., Pau, M. G., Roederer, M., Koup, R. A., Goudsmit, J., Jahrling, P. B. & Nabel, G. J., Jul 10 2006, In : PLoS Medicine. 3, 6, p. 865-873 9 p.

Research output: Contribution to journalArticle

156 Scopus citations

MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fevers

Palacios, G., Briese, T., Kapoor, V., Jabado, O., Liu, Z., Venter, M., Zhai, J., Renwick, N., Grolla, A., Geisbert, T. W., Drosten, C., Towner, J., Ju, J., Paweska, J., Nichol, S. T., Swanepoel, R., Feldmann, H., Jahrling, P. B. & Lipkin, W. I., Apr 2006, In : Emerging infectious diseases. 12, 4, p. 692-695 4 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment

Daddario-DiCaprio, K. M., Geisbert, T. W., Ströher, U., Geisbert, J. B., Grolla, A., Fritz, E. A., Fernando, L., Kagan, E., Jahrling, P. B., Hensley, L. E., Jones, S. M. & Feldmann, H., Apr 29 2006, In : Lancet. 367, 9520, p. 1399-1404 6 p.

Research output: Contribution to journalArticle

133 Scopus citations

Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

Geisbert, T. W., Hensley, L. E., Kagan, E., Yu, E. Z., Geisbert, J. B., Daddario-DiCaprio, K., Fritz, E. A., Jahrling, P. B., McClintock, K., Phelps, J. R., Lee, A. C. H., Judge, A., Jeffs, L. B. & MacLachlan, I., Jun 15 2006, In : Journal of Infectious Diseases. 193, 12, p. 1650-1657 8 p.

Research output: Contribution to journalArticle

192 Scopus citations

Viral Hemorrhagic Fevers

Marty, A. M., Jahrling, P. B. & Geisbert, T. W., Jun 1 2006, In : Clinics in Laboratory Medicine. 26, 2, p. 345-386 42 p.

Research output: Contribution to journalReview article

57 Scopus citations
2005

Analysis of the expressed heavy chain variable-region genes of Macaca fascicularis and isolation of monoclonal antibodies specific for the Ebola virus' soluble glycoprotein

Druar, C., Saini, S. S., Cossitt, M. A., Yu, F., Qiu, X., Geisbert, T. W., Jones, S., Jahrling, P. B., Stewart, D. I. H. & Wiersma, E. J., Nov 1 2005, In : Immunogenetics. 57, 10, p. 730-738 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Development of a new vaccine for the prevention of Lassa fever

Geisbert, T. W., Jones, S., Fritz, E. A., Shurtleff, A. C., Geisbert, J. B., Liebscher, R., Grolla, A., Ströher, U., Fernando, L., Daddario, K. M., Guttieri, M. C., Mothé, B. R., Larsen, T., Hensley, L. E., Jahrling, P. B. & Feldmann, H., Jul 25 2005, In : PLoS Medicine. 2, 6, p. 537-545 9 p.

Research output: Contribution to journalArticle

164 Scopus citations

Ebola and Marburg viruses: Pathogenesis and development of countermeasures

Hensley, L. E., Jones, S. M., Feldmann, H., Jahrling, P. B. & Geisbert, T. W., Dec 1 2005, In : Current molecular medicine. 5, 8, p. 761-772 12 p.

Research output: Contribution to journalReview article

41 Scopus citations
175 Scopus citations

Editorial

Geisbert, T. W., Dec 1 2005, In : Current molecular medicine. 5, 8, p. 733-734 2 p.

Research output: Contribution to journalEditorial

Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses

Jones, S. M., Feldmann, H., Ströher, U., Geisbert, J. B., Fernando, L., Grolla, A., Klenk, H. D., Sullivan, N. J., Volchkov, V. E., Fritz, E. A., Daddario, K. M., Hensley, L. E., Jahrling, P. B. & Geisbert, T. W., Jul 1 2005, In : Nature Medicine. 11, 7, p. 786-790 5 p.

Research output: Contribution to journalArticle

449 Scopus citations

The contribution of the endothelium to the development of coagulation disorders that characterize Ebola hemorrhagic fever in primates

Hensley, L. E. & Geisbert, T. W., Aug 1 2005, In : Thrombosis and Haemostasis. 94, 2, p. 254-261 8 p.

Research output: Contribution to journalReview article

37 Scopus citations

Therapy and prophylaxis of Ebola virus infections

Feldmann, H., Jones, S. M., Schnittler, H. J. & Geisbert, T., Aug 1 2005, In : Current Opinion in Investigational Drugs. 6, 8, p. 823-830 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques

Reed, D. S., Hensley, L. E., Geisbert, J. B., Jahrling, P. B. & Geisbert, T. W., Sep 29 2004, In : Viral Immunology. 17, 3, p. 390-400 11 p.

Research output: Contribution to journalArticle

119 Scopus citations

Detection and identification of Variola virus in fixed human tissue after prolonged archival storage

Schoepp, R. J., Morin, M. D., Martinez, M. J., Kulesh, D. A., Hensley, L., Geisbert, T., Brady, D. R. & Jahrling, P. B., Jan 1 2004, In : Laboratory Investigation. 84, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Detection and identification of Variola virus in fixed human tissue after prolonged archival storage

Schoepp, R. J., Morin, M. D., Martinez, M. J., Kulesh, D. A., Hensley, L., Geisbert, T. W., Brady, D. R. & Jahrling, P. B., 2004, In : Laboratory Investigation. 84, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Ebola virus: New insights into disease aetiopathology and possible therapeutic interventions

Geisbert, T. W. & Hensley, L. E., Sep 1 2004, In : Expert reviews in molecular medicine. 6, 20

Research output: Contribution to journalReview article

74 Scopus citations

Exotic emerging viral diseases: Progress and challenges

Geisbert, T. W. & Jahrling, P. B., Dec 2004, In : Nature Medicine. 10, 12S, p. S110-S121

Research output: Contribution to journalReview article

349 Scopus citations

Interferon-β 1a and SARS Coronavirus Replication

Hensley, L. E., Fritz, E. A., Jahrling, P. B., Karp, C. L., Huggins, J. W. & Geisbert, T. W., Feb 2004, In : Emerging infectious diseases. 10, 2, p. 317-319 3 p.

Research output: Contribution to journalArticle

Open Access
78 Scopus citations

Microscopy in the hot zone: From the discovery of Ebola virus to a possible treatment

Geisbert, T. W., Sep 24 2004, In : Microscopy and Microanalysis. 10, SUPPL. 2, p. 234-235 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The host response to smallpox: Analysis of the gene expression program in peripheral blood cells in a nonhuman primate model

Rubins, K. H., Hensley, L. E., Jahrling, P. B., Whitney, A. R., Geisbert, T. W., Huggins, J. W., Owen, A., LeDuc, J. W., Brown, P. O. & Relman, D. A., Oct 19 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 42, p. 15190-15195 6 p.

Research output: Contribution to journalArticle

94 Scopus citations
2003

Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates

Sullivan, N. J., Geisbert, T. W., Gelsbert, J. B., Xu, L., Yang, Z. Y., Roederer, M., Koup, R. A., Jahrling, P. B. & Nabel, G. J., Aug 7 2003, In : Nature. 424, 6949, p. 681-684 4 p.

Research output: Contribution to journalArticle

383 Scopus citations

Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells

Markotic, A., Hensley, L., Geisbert, T., Spik, K. & Schmaljohn, C., Aug 1 2003, In : Journal of General Virology. 84, 8, p. 2197-2202 6 p.

Research output: Contribution to journalShort survey

40 Scopus citations

Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages Is a Key Event

Geisbert, T. W., Young, H. A., Jahrling, P. B., Davis, K. J., Kagan, E. & Hensley, L. E., Dec 1 2003, In : Journal of Infectious Diseases. 188, 11, p. 1618-1629 12 p.

Research output: Contribution to journalArticle

273 Scopus citations

Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques: Evidence that Dendritic Cells are Early and Sustained Targets of Infection

Geisbert, T. W., Hensley, L. E., Larsen, T., Young, H. A., Reed, D. S., Geisbert, J. B., Scott, D. P., Kagan, E., Jahrling, P. B. & Davis, K. J., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2347-2370 24 p.

Research output: Contribution to journalArticle

408 Scopus citations

Pathogenesis of Ebola Hemorrhagic Fever in Primate Models: Evidence that Hemorrhage Is Not a Direct Effect of Virus-Induced Cytolysis of Endothelial Cells

Geisbert, T. W., Young, H. A., Jahrling, P. B., Davis, K. J., Larsen, T., Kagan, E. & Hensley, L. E., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2371-2382 12 p.

Research output: Contribution to journalArticle

239 Scopus citations

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

Yount, B., Curtis, K. M., Fritz, E. A., Hensley, L. E., Jahrling, P. B., Prentice, E., Denison, M. R., Geisbert, T. W. & Baric, R. S., Oct 28 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 22, p. 12995-13000 6 p.

Research output: Contribution to journalArticle

213 Scopus citations

Towards a vaccine against Ebola virus

Geisbert, T. W. & Jahrling, P. B., Dec 1 2003, In : Expert review of vaccines. 2, 6, p. 777-789 13 p.

Research output: Contribution to journalReview article

41 Scopus citations

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: A study in rhesus monkeys

Geisbert, T. W., Hensley, L. E., Jahrling, P. B., Larsen, T., Geisbert, J. B., Paragas, J., Young, H. A., Fredeking, T. M., Rote, W. E. & Vlasuk, G. P., Dec 13 2003, In : Lancet. 362, 9400, p. 1953-1958 6 p.

Research output: Contribution to journalArticle

293 Scopus citations
2002

3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice

Bray, M., Raymond, J. L., Geisbert, T. & Baker, R. O., Jun 29 2002, In : Antiviral research. 55, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

Detection of antibodies against the four subtypes of ebola virus in Sera from any species using a novel antibody-phage indicator assay

Meissner, F., Maruyama, T., Frentsch, M., Hessell, A. J., Rodriguez, L. L., Geisbert, T. W., Jahrling, P. B., Burton, D. R. & Parren, P. W. H. I., Jan 1 2002, In : Virology. 300, 2, p. 236-243 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evaluation in nonhuman primates of vaccines against Ebola virus

Geisbert, T. W., Pushko, P., Anderson, K., Smith, J., Davis, K. J. & Jahrling, P. B., Jan 1 2002, In : Emerging infectious diseases. 8, 5, p. 503-507 5 p.

Research output: Contribution to journalReview article

Open Access
196 Scopus citations

Evidence against an important role for infectivity-enhancing antibodies in Ebola virus infections

Geisbert, T. W., Hensley, L. E., Geisbert, J. B. & Jahrling, P. B., Jan 1 2002, In : Virology. 293, 1, p. 15-19 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis

Liang, M. H., Geisbert, T., Yao, Y., Hinrichs, S. H. & Giam, C. Z., Apr 6 2002, In : Journal of virology. 76, 8, p. 4022-4033 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Lipid raft microdomains: A gateway for compartmentalized trafficking of Ebola and Marburg viruses

Bavari, S., Bosio, C. M., Wiegand, E., Ruthel, G., Will, A. B., Geisbert, T. W., Hevey, M., Schmaljohn, C., Schmaljohn, A. & Javad Aman, M., Mar 4 2002, In : Journal of Experimental Medicine. 195, 5, p. 593-602 10 p.

Research output: Contribution to journalArticle

358 Scopus citations

Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Parren, P. W. H. I., Geisbert, T. W., Maruyama, T., Jahrling, P. B. & Burton, D. R., Jun 5 2002, In : Journal of virology. 76, 12, p. 6408-6412 5 p.

Research output: Contribution to journalArticle

163 Scopus citations

Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily

Hensley, L. E., Young, H. A., Jahrling, P. B. & Geisbert, T. W., Mar 1 2002, In : Immunology Letters. 80, 3, p. 169-179 11 p.

Research output: Contribution to journalArticle

190 Scopus citations
2001

Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice

Gibb, T. R., Bray, M., Geisbert, T. W., Steele, K. E., Kell, W. M., Davis, K. J. & Jaax, N. K., Jan 1 2001, In : Journal of Comparative Pathology. 125, 4, p. 233-242 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis)

Zaucha, G. M., Jahrling, P. B., Geisbert, T. W., Swearengen, J. R. & Hensley, L., Jan 1 2001, In : Laboratory Investigation. 81, 12, p. 1581-1600 20 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
2000

Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses

Geisbert, T. W., Hensley, L. E., Gibb, T. R., Steele, K. E., Jaax, N. K. & Jahrling, P. B., Feb 2000, In : Laboratory Investigation. 80, 2, p. 171-186 16 p.

Research output: Contribution to journalArticle

Open Access
234 Scopus citations

Pathology of fatal west nile virus infections in native and exotic birds during the 1999 outbreak in New York City, New York

Steele, K. E., Linn, M. J., Schoepp, R. J., Komar, N., Geisbert, T. W., Manduca, R. M., Calle, P. P., Raphael, B. L., Clippinger, T. L., Larsen, T., Smith, J., Lanciotti, R. S., Panella, N. A. & McNamara, T. S., Jan 1 2000, In : Veterinary Pathology. 37, 3, p. 208-224 17 p.

Research output: Contribution to journalArticle

Open Access
340 Scopus citations