Thomas Ksiazek, DVM, PhD, MS

  • 32037 Citations
  • 96 h-Index
1977 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S-J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

2018

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development review-article

Hallam, H. J., Hallam, S., Rodriguez, S., Barrett, A., Beasley, D., Chua, A., Ksiazek, T., Milligan, G., Sathiyamoorthy, V. & Reece, L. M., Dec 1 2018, In : npj Vaccines. 3, 1, 11.

Research output: Contribution to journalArticle

26 Scopus citations

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region

Flyak, A. I., Kuzmina, N., Murin, C. D., Bryan, C., Davidson, E., Gilchuk, P., Gulka, C. P., Ilinykh, P. A., Shen, X., Huang, K., Ramanathan, P., Turner, H., Fusco, M. L., Lampley, R., Kose, N., King, H., Sapparapu, G., Doranz, B. J., Ksiazek, T., Wright, D. W. & 4 others, Saphire, E. O., Ward, A. B., Bukreyev, A. & Crowe, J. E., May 7 2018, (Accepted/In press) In : Nature Microbiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Complete genome sequences of a hantavirus isolate from New York

McMullan, L. K., Albariño, C. G., Ksiazek, T., Nichol, S. T. & Spiropoulou, C. F., Mar 1 2018, In : Genome Announcements. 6, 12, e00188-18.

Research output: Contribution to journalArticle

2 Scopus citations

Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies

Ilinykh, P. A., Graber, J., Kuzmina, N. A., Huang, K., Ksiazek, T., Crowe, J. E. & Bukreyev, A., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S418-S422

Research output: Contribution to journalArticle

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

McAuley, A. J., Sawatsky, B., Ksiazek, T., Torres, M., Korva, M., Lotrič-Furlan, S., Avšič-Županc, T., Von Messling, V., Holbrook, M. R., Freiberg, A., Beasley, D. & Bente, D., Dec 1 2017, In : npj Vaccines. 2, 1, 9.

Research output: Contribution to journalArticle

8 Scopus citations

Evaluation of TRIzol LS inactivation of viruses

Kochel, T. J., Kocher, G. A., Ksiazek, T. & Burans, J. P., Jun 1 2017, In : Applied Biosafety. 22, 2, p. 52-55 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genome sequences of Crimean-Congo hemorrhagic fever virus strains isolated in South Africa, Namibia, and Turkey

Zivcec, M., Albarino, C. G., Guerrero, L. I. W., Ksiazek, T., Nichol, S. T., Swanepoel, R., Rollin, P. E. & Spiropoulou, C. F., Oct 1 2017, In : Genome Announcements. 5, 42, e01060-17.

Research output: Contribution to journalArticle

2 Scopus citations

Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

Cajimat, M. N. B., Rodriguez, S., Schuster, I. U. E., Swetnam, D. M., Ksiazek, T., Habela, M. A., Negredo, A. I., Estrada-Peña, A., Barrett, A. & Bente, D., Oct 1 2017, In : Vector-Borne and Zoonotic Diseases. 17, 10, p. 714-719 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Innate immune responses of bat and human cells to filoviruses: Commonalities and distinctions

Kuzmin, I. V., Schwarz, T. M., Ilinykh, P. A., Jordan, I., Ksiazek, T., Sachidanandam, R., Basler, C. F. & Bukreyev, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02471-16.

Research output: Contribution to journalArticle

16 Scopus citations

Insights into Reston virus spillovers and adaption from virus whole genome sequences

Albariño, C. G., Guerrero, L. W., Jenks, H. M., Chakrabarti, A. K., Ksiazek, T., Rollin, P. E. & Nichol, S. T., May 1 2017, In : PLoS One. 12, 5, e0178224.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Chimeric filoviruses for identification and characterization of monoclonal antibodies

Ilinykh, P. A., Shen, X., Flyak, A. I., Kuzmina, N., Ksiazek, T., Crowe, J. E. & Bukreyev, A., Apr 1 2016, In : Journal of Virology. 90, 8, p. 3890-3901 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

Flyak, A. I., Shen, X., Murin, C. D., Turner, H. L., David, J. A., Fusco, M. L., Lampley, R., Kose, N., Ilinykh, P. A., Kuzmina, N., Branchizio, A., King, H., Brown, L., Bryan, C., Davidson, E., Doranz, B. J., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. & 4 others, Saphire, E. O., Ward, A. B., Bukreyev, A. & Crowe, J. E., Jan 28 2016, In : Cell. 164, 3, p. 392-405 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

Growth characteristics of alkhumra hemorrhagic fever virus in mammalian cell lines

Madani, T. A., Abuelzein, E. T. M. E., Azhar, E. I., Al-Bar, H. M. S., Hassan, A. M. & Ksiazek, T., Nov 1 2016, In : Vector-Borne and Zoonotic Diseases. 16, 11, p. 722-727 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Infectious causes of encephalitis and meningoencephalitis in Thailand, 2003–2005

LHCb collaboration, 2015, In : Emerging Infectious Diseases. 21, 2, p. 280-289 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

Flyak, A. I., Ilinykh, P. A., Murin, C. D., Garron, T., Shen, X., Fusco, M. L., Hashiguchi, T., Bornholdt, Z. A., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G., Ward, A. B., Saphire, E. O., Bukreyev, A. & Crowe, J. E., Feb 26 2015, In : Cell. 160, 5, p. 893-903 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

The Risk of Nosocomial Transmission of Rift Valley Fever

Al-Hamdan, N. A., Panackal, A. A., Al Bassam, T. H., Alrabea, A., Al Hazmi, M., Al Mazroa, Y., Al Jefri, M., Khan, A. S. & Ksiazek, T., Dec 22 2015, In : PLoS Neglected Tropical Diseases. 9, 12, e0004314.

Research output: Contribution to journalArticle

10 Scopus citations

The Role of a National Biocontainment Laboratory in Emergencies

LeDuc, J. & Ksiazek, T., Sep 1 2015, In : Health security. 13, 5, p. 345-348 4 p.

Research output: Contribution to journalArticle

2014

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus

Tao, X., Mei, F., Agrawal, A., Peters, C. J., Ksiazek, T. G., Cheng, X. & Tseng, C. T. K., Apr 2014, In : Journal of virology. 88, 7, p. 3902-3910 9 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus

Tao, X., Mei, F., Agrawal, A., Peters, C. J., Ksiazek, T., Cheng, X. & Tseng, C-T., Jan 1 2014, In : Journal of Virology. 88, 7, p. 3902-3910 9 p.

Research output: Contribution to journalArticle

Comparison of RT-PCR assay and virus isolation in cell culture for the detection of alkhumra hemorrhagic fever virus

Madani, T. A., Abuelzein, E. T. M. E., Azhar, E. I., Al-Bar, H. M. S., Abu-Araki, H. & Ksiazek, T. G., Jul 2014, In : Journal of Medical Virology. 86, 7, p. 1176-1180 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Complete genome sequencing and genetic characterization of alkhumra hemorrhagic fever virus isolated from Najran, Saudi Arabia

Madani, T. A., Azhar, E. I., Abuelzein, E. T. M. E., Kao, M., Al-Bar, H. M. S., Farraj, S. A., Masri, B. E., Al-Kaiedi, N. A., Shakil, S., Sohrab, S. S., Santalucia, J. & Ksiazek, T. G., Aug 2014, In : Intervirology. 57, 5, p. 300-310 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Propagation and titration of Alkhumra hemorrhagic fever virus in the brains of newborn Wistar rats

Madani, T. A., Kao, M., Abuelzein, E. T. M. E., Azhar, E. I., Al-Bar, H. M. S., Abu-Araki, H., Bokhary, R. Y. & Ksiazek, T. G., Apr 1 2014, In : Journal of Virological Methods. 199, p. 39-45 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Bilateral entry and release of middle east respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells

Tao, X., Hill, T. E., Morimoto, C., Peters, C. J., Ksiazek, T. G. & Tseng, C. T. K., Sep 5 2013, In : Journal of virology. 87, 17, p. 9953-9958 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cell culture and electron microscopy for identifying viruses in diseases of unknown cause

Goldsmith, C. S., Ksiazek, T. G., Rollin, P. E., Comer, J. A., Nicholson, W. L., Peret, T. C. T., Erdman, D. D., Bellini, W. J., Harcourt, B. H., Rota, P. A., Bhatnagar, J., Bowen, M. D., Erickson, B. R., McMullan, L. K., Nichol, S. T., Shieh, W. J., Paddock, C. D. & Zaki, S. R., Jun 1 2013, In : Emerging infectious diseases. 19, 6, p. 886-891 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs

Gong, B., Lee, Y. S., Lee, I., Shelite, T. R., Kunkeaw, N., Xu, G., Lee, K., Jeon, S. H., Johnson, B. H., Chang, Q., Ha, T., Mendell, N. L., Cheng, X., Bouyer, D. H., Boor, P. J., Ksiazek, T. G. & Walker, D. H., Jun 23 2013, In : BMC Infectious Diseases. 13, 1, 285.

Research output: Contribution to journalArticle

20 Scopus citations

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

Gong, B., Shelite, T., Mei, F. C., Ha, T., Hu, Y., Xu, G., Chang, Q., Wakamiya, M., Ksiazek, T. G., Boor, P. J., Bouyer, D. H., Popov, V. L., Chen, J., Walker, D. H. & Cheng, X., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19615-19620 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Identification of a new newcastle disease virus isolate from Indonesia represents an ancestral lineage of class II genotype XIII

Forrester, N. L., Widen, S. G., Wood, T. G., Travassos Da Rosa, A. P., Ksiazek, T. G., Vasilakis, N. & Tesh, R. B., Aug 1 2013, In : Virus Genes. 47, 1, p. 168-172 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Susceptibility of tick cell lines to infection with alkhumra haemorrhagic fever virus

Madani, T. A., Abuelzein, E. T. M. E., Bell-Sakyi, L., Azhar, E. I., Al-Bar, H. M. S., Abu-Araki, H., Hassan, A. M., Masri, B. E. & Ksiazek, T. G., Dec 1 2013, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 107, 12, p. 806-811 6 p., trt087.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Date palm sap linked to nipah virus outbreak in bangladesh, 2008

Rahman, M. A., Hossain, M. J., Sultana, S., Homaira, N., Khan, S. U., Rahman, M., Gurley, E. S., Rollin, P. E., Lo, M. K., Comer, J. A., Lowe, L., Rota, P. A., Ksiazek, T. G., Kenah, E., Sharker, Y. & Luby, S. P., Jan 1 2012, In : Vector-Borne and Zoonotic Diseases. 12, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Identification of Previously Unrecognized Viruses by Using Tissue Culture and Electron Microscopy

Goldsmith, C. S., Ksiazek, T., Rollin, P. E., Comer, J. A., Nicholson, W. L., Peret, C. T., Erdman, D. D., Bellini, W. J., Bowen, M. D., Erickson, B. R., Nichol, S. T., Bhatnagar, J., McMullan, L. K., Paddock, C. D. & Zaki, S. R., 2012, In : Microscopy and Microanalysis. 18, S2, p. 174-175 2 p.

Research output: Contribution to journalArticle

Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection

Amman, B. R., Carroll, S. A., Reed, Z. D., Sealy, T. K., Balinandi, S., Swanepoel, R., Kemp, A., Erickson, B. R., Comer, J. A., Campbell, S., Cannon, D. L., Khristova, M. L., Atimnedi, P., Paddock, C. D., Kent Crockett, R. J., Flietstra, T. D., Warfield, K. L., Unfer, R., Katongole-Mbidde, E., Downing, R. & 6 others, Tappero, J. W., Zaki, S. R., Rollin, P. E., Ksiazek, T. G., Nichol, S. T. & Towner, J. S., Oct 1 2012, In : PLoS pathogens. 8, 10, e1002877.

Research output: Contribution to journalArticle

161 Scopus citations

Successful propagation of Alkhumra (misnamed as Alkhurma) virus in C6/36 mosquito cells

Madani, T. A., Kao, M., Azhar, E. I., Abuelzein, E. T. M. E., Al-Bar, H. M. S., Abu-Araki, H. & Ksiazek, T. G., Mar 1 2012, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 106, 3, p. 180-185 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Superiority of the buffy coat over serum or plasma for the detection of Alkhumra virus RNA using real time RT-PCR

Madani, T. A., Abuelzein, E. T. M. E., Azhar, E. I., Kao, M., Al-Bar, H. M. S., Abu-Araki, H. & Ksiazek, T. G., May 1 2012, In : Archives of virology. 157, 5, p. 819-823 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Alkhumra (Alkhurma) virus outbreak in Najran, Saudi Arabia: Epidemiological, clinical, and Laboratory characteristics

Madani, T. A., Azhar, E. I., Abuelzein, E. T. M. E., Kao, M., Al-Bar, H. M. S., Abu-Araki, H., Niedrig, M. & Ksiazek, T. G., Jan 1 2011, In : Journal of Infection. 62, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Filovirus outbreak detection and surveillance: Lessons from bundibugyo

MacNeil, A., Farnon, E. C., Morgan, O. W., Gould, P., Boehmer, T. K., Blaney, D. D., Wiersma, P., Tappero, J. W., Nichol, S. T., Ksiazek, T. G. & Rollin, P. E., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S761-S767

Research output: Contribution to journalArticle

53 Scopus citations

Management of accidental exposure to Ebola virus in the biosafety Level 4 Laboratory, Hamburg, Germany

Günther, S., Feldmann, H., Geisbert, T. W., Hensley, L. E., Rollin, P. E., Nichol, S. T., Ströher, U., Artsob, H., Peters, C. J., Ksiazek, T. G., Becker, S., Ter Meulen, J., Ölschläger, S., Schmidt-Chanasit, J., Sudeck, H., Burchard, G. D. & Schmiedel, S., Nov 1 2011, In : Journal of Infectious Diseases. 204, SUPPL. 3, p. S785-S790

Research output: Contribution to journalArticle

102 Scopus citations
2010

Cluster of nipah virus infection, kushtia district, Bangladesh, 2007

Homaira, N., Rahman, M., Hossain, M. J., Nahar, N., Khan, R., Rahman, M., Podder, G., Nahar, K., Khan, D., Gurley, E. S., Rollin, P. E., Comer, J. A., Ksiazek, T. G. & Luby, S. P., Nov 17 2010, In : PloS one. 5, 10, e13570.

Research output: Contribution to journalArticle

21 Scopus citations

Demonstration of cross-protective vaccine immunity against an emerging pathogenic ebolavirus species

Hensley, L. E., Mulangu, S., Asiedu, C., Johnson, J., Honko, A. N., Stanley, D., Fabozzi, G., Nichol, S. T., Ksiazek, T. G., Rollin, P. E., Wahl-Jensen, V., Bailey, M., Jahrling, P. B., Roederer, M., Koup, R. A. & Sullivan, N. J., May 2010, In : PLoS pathogens. 6, 5, p. 1-9 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

High diversity and ancient common ancestry of lymphocytic choriomeningitis virus

Albariño, C. G., Palacios, G., Khristova, M. L., Erickson, B. R., Carrol, S. A., Comer, J. A., Hui, J., Briese, T., St. George, K., Ksiazek, T. G., Ian Lipkin, W. & Nichol, S. T., Jul 2010, In : Emerging infectious diseases. 16, 7, p. 1093-1100 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007

Homaira, N., Rahman, M., Hossain, M. J., Epstein, J. H., Sultana, R., Khan, M. S. U., Podder, G., Nahar, K., Ahmed, B., Gurley, E. S., Daszak, P., Lipkin, W. I., Rollin, P. E., Comer, J. A., Ksiazek, T. G. & Luby, S. P., Nov 1 2010, In : Epidemiology and infection. 138, 11, p. 1630-1636 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Pathology of Black Creek Canal virus infection in juvenile hispid cotton rats (Sigmodon hispidus)

Billings, A. N., Rollin, P. E., Milazzo, M. L., Molina, C. P., Eyzaguirre, E. J., Livingstone, W., Ksiazek, T. G. & Fulhorst, C. F., Aug 1 2010, In : Vector-Borne and Zoonotic Diseases. 10, 6, p. 621-628 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda

MacNeil, A., Farnon, E. C., Wamala, J., Okware, S., Cannon, D. L., Reed, Z., Towner, J. S., Tappero, J. W., Lutwama, J., Downing, R., Nichol, S. T., Ksiazek, T. G. & Rollin, P. E., Dec 1 2010, In : Emerging infectious diseases. 16, 12, p. 1969-1972 4 p.

Research output: Contribution to journalArticle

86 Scopus citations

Sin nombre virus-specific immunoglobulin M and G kinetics in hantavirus pulmonary syndrome and the role played by serologic responses in predicting disease outcome

MacNeil, A., Comer, J. A., Ksiazek, T. G. & Rollin, P. E., Jul 15 2010, In : Journal of Infectious Diseases. 202, 2, p. 242-246 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Discovery of swine as a host for the reston ebolavirus

Barrette, R. W., Metwally, S. A., Rowland, J. M., Xu, L., Zaki, S. R., Nichol, S. T., Rollin, P. E., Towner, J. S., Shieh, W. J., Batten, B., Sealy, T. K., Carrillo, C., Moran, K. E., Bracht, A. J., Mayr, G. A., Sirios-Cruz, M., Catbagan, D. P., Lautner, E. A., Ksiazek, T. G., White, W. R. & 1 others, Mcintosh, M. T., Jul 10 2009, In : Science. 325, 5937, p. 204-206 3 p.

Research output: Contribution to journalArticle

255 Scopus citations

Genetic diversity among Bolivian arenaviruses

Cajimat, M. N. B., Milazzo, M. L., Rollin, P. E., Nichol, S. T., Bowen, M. D., Ksiazek, T. G. & Fulhorst, C. F., Mar 1 2009, In : Virus Research. 140, 1-2, p. 24-31 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human febrile illness caused by encephalomyocarditis virus infection, peru

Oberste, M. S., Gotuzzo, E., Blair, P., Nix, W. A., Ksiazek, T. G., Comer, J. A., Rollin, P., Goldsmith, C. S., Olson, J. & Kochel, T. J., Apr 1 2009, In : Emerging infectious diseases. 15, 4, p. 640-646 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Isolation of genetically diverse Marburg viruses from Egyptian fruit bats

Towner, J. S., Amman, B. R., Sealy, T. K., Reeder Carroll, S. A., Comer, J. A., Kemp, A., Swanepoel, R., Paddock, C. D., Balinandi, S., Khristova, M. L., Formenty, P. B. H., Albarino, C. G., Miller, D. M., Reed, Z. D., Kayiwa, J. T., Mills, J. N., Cannon, D. L., Greer, P. W., Byaruhanga, E., Farnon, E. C. & 9 others, Atimnedi, P., Okware, S., Katongole-Mbidde, E., Downing, R., Tappero, J. W., Zaki, S. R., Ksiazek, T. G., Nichol, S. T. & Rollin, P. E., Jul 1 2009, In : PLoS pathogens. 5, 7, e1000536.

Research output: Contribution to journalArticle

330 Scopus citations