• 4666 Citations
  • 33 h-Index
20002022

Research output per year

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Research Output

Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

Arjona, A., Foellmer, H. G., Town, T., Leng, L., McDonald, C., Wang, T., Wong, S. J., Montgomery, R. R., Fikrig, E. & Bucala, R., Oct 1 2007, In : Journal of Clinical Investigation. 117, 10, p. 3059-3066 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

A chikungunya fever vaccine utilizing an insect-specific virus platform

Erasmus, J. H., Auguste, A. J., Kaelber, J. T., Luo, H., Rossi, S. L., Fenton, K., Leal, G., Kim, D. Y., Chiu, W., Wang, T., Frolov, I., Nasar, F. & Weaver, S. C., Feb 1 2017, In : Nature Medicine. 23, 2, p. 192-199 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

A Hamster-Derived West Nile Virus Isolate Induces Persistent Renal Infection in Mice

Saxena, V., Xie, G., Li, B., Farris, T., Welte, T., Gong, B., Boor, P., Wu, P., Tang, S. J., Tesh, R. & Wang, T., Jun 2013, In : PLoS neglected tropical diseases. 7, 6, e2275.

Research output: Contribution to journalArticle

22 Scopus citations

A hamster-derived West Nile virus strain is highly attenuated and induces a differential proinflammatory cytokine response in two murine cell lines

Saxena, V., Welte, T., Bao, X., Xie, G., Wang, J., Higgs, S., Tesh, R. B. & Wang, T., Aug 1 2012, In : Virus Research. 167, 2, p. 179-187 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In : Nature Medicine. 23, 6, p. 763-767 5 p.

Research output: Contribution to journalArticle

131 Scopus citations

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

67 Scopus citations

A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis.

Wang, T., Magnarelli, L. A., Anderson, J. F., Gould, L. H., Bushmich, S. L., Wong, S. J. & Fikrig, E., Jan 1 2002, In : Vector borne and zoonotic diseases (Larchmont, N.Y.). 2, 2, p. 105-109 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

A recombinant envelope protein vaccine against West Nile virus

Ledizet, M., Kar, K., Foellmer, H. G., Wang, T., Bushmich, S. L., Anderson, J. F., Fikrig, E. & Koski, R. A., Jun 10 2005, In : Vaccine. 23, 30, p. 3915-3924 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 487-499.e5

Research output: Contribution to journalArticle

15 Scopus citations

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S., Wang, T. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

12 Scopus citations

A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways

Xie, G., Welte, T., Wang, J., Whiteman, M. C., Wicker, J. A., Saxena, V., Cong, Y., Barrett, A. D. T. & Wang, T., Aug 28 2013, In : Vaccine. 31, 38, p. 4143-4151 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

Xie, G., Luo, H., Tian, B., Mann, B., Bao, X., McBride, J., Tesh, R., Barrett, A. D. & Wang, T., Feb 11 2015, In : Vaccine. 33, 7, p. 869-878 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex

Shi, X., Leng, L., Wang, T., Wang, W., Du, X., Li, J., McDonald, C., Chen, Z., Murphy, J. W., Lolis, E., Noble, P., Knudson, W. & Bucala, R., Oct 1 2006, In : Immunity. 25, 4, p. 595-606 12 p.

Research output: Contribution to journalArticle

388 Scopus citations
14 Scopus citations

Detection of Human Anti-Flavivirus Antibodies with a West Nile Virus Recombinant Antigen Microsphere Immunoassay

Wong, S. J., Demarest, V. L., Boyle, R. H., Wang, T., Ledizet, M., Kar, K., Kramer, L. D., Fikrig, E. & Koski, R. A., Jan 1 2004, In : Journal of Clinical Microbiology. 42, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis

Wang, S., Welte, T., McGargill, M., Town, T., Thompson, J., Anderson, J. F., Flavell, R. A., Fikrig, E., Hedrick, S. M. & Wang, T., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 2084-2091 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M., Campbell, G., Milligan, G., Cong, Y., Barrett, A. & Wang, T., 2016, In : Journal of Virology. 90, 3, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In : Journal of Immunology. 190, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Effects of Chikungunya virus immunity on Mayaro virus disease and epidemic potential

Webb, E. M., Azar, S. R., Haller, S. L., Langsjoen, R. M., Cuthbert, C. E., Ramjag, A. T., Luo, H., Plante, K., Wang, T., Simmons, G., Carrington, C. V. F., Weaver, S. C., Rossi, S. L. & Auguste, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 20399.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation (Nature Cell Biology (2016) 18 (632-644))

Welte, T., Kim, I. S., Tian, L., Gao, X., Wang, H., Li, J., Holdman, X. B., Herschkowitz, J. I., Pond, A., Xie, G., Kurley, S., Nguyen, T., Liao, L., Dobrolecki, L. E., Pang, L., Mo, Q., Edwards, D. P., Huang, S., Xin, L., Xu, J. & 6 others, Li, Y., Lewis, M. T., Wang, T., Westbrook, T. F., Rosen, J. M. & Zhang, X. H. F., Jun 28 2016, In : Nature Cell Biology. 18, 7, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Flavivirus Immunity in Disease Control and Viral Pathogenesis

Wang, T., Jan 1 2020, In : Viral Immunology. 33, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In : Cell Reports. 21, 5, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection

Shrestha, B., Wang, T., Samuel, M. A., Whitby, K., Craft, J., Fikrig, E. & Diamond, M. S., Jun 1 2006, In : Journal of virology. 80, 11, p. 5338-5348 11 p.

Research output: Contribution to journalArticle

135 Scopus citations

Genotypic and phenotypic characterization of West Nile virus NS5 methyltransferase mutants

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T. G., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells

Kolli, D., Bao, X., Liu, T., Hong, C., Wang, T., Garofalo, R. P. & Casola, A., Jul 1 2011, In : Journal of Immunology. 187, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Identification of relevant regions on structural and nonstructural proteins of Zika virus for vaccine and diagnostic test development: an in silico approach

Salvador, E. A., Pires de Souza, G. A., Cotta Malaquias, L. C., Wang, T. & Leomil Coelho, L. F., May 1 2019, In : New Microbes and New Infections. 29, 100506.

Research output: Contribution to journalArticle

Open Access

IFN-γ-producing γδ T cells help control murine West Nile virus infection

Wang, T., Scully, E., Yin, Z., Kim, J. H., Wang, S., Yan, J., Mamula, M., Anderson, J. F., Craft, J. & Fikrig, E., Sep 1 2003, In : Journal of Immunology. 171, 5, p. 2524-2531 8 p.

Research output: Contribution to journalArticle

148 Scopus citations

Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain

Welte, T., Xie, G., Wicker, J. A., Whitemanb, M. C., Li, L., Rachamallu, A., Barrett, A. & Wang, T., Jun 24 2011, In : Vaccine. 29, 29-30, p. 4853-4861 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Immunity to West Nile virus

Wang, T. & Fikrig, E., Aug 1 2004, In : Current Opinion in Immunology. 16, 4, p. 519-523 5 p.

Research output: Contribution to journalReview article

42 Scopus citations

Immunization of mice against west nile virus with recombinant envelope protein

Wang, T., Anderson, J. F., Magnarelli, L. A., Wong, S. J., Koski, R. A. & Fikrig, E., Nov 1 2001, In : Journal of Immunology. 167, 9, p. 5273-5277 5 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations

Immunization of Mice with Recombinant Mosquito Salivary Protein D7 Enhances Mortality from Subsequent West Nile Virus Infection via Mosquito Bite

Reagan, K. L., Machain-Williams, C., Wang, T. & Blair, C. D., Dec 1 2012, In : PLoS neglected tropical diseases. 6, 12, e1935.

Research output: Contribution to journalArticle

23 Scopus citations

Immunization with culex tarsalis mosquito salivary gland extract modulates west nile virus infection and disease in mice

Machain-Williams, C., Reagan, K., Wang, T., Zeidner, N. S. & Blair, C. D., Feb 1 2013, In : Viral Immunology. 26, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Wang, T., Akkoyunlu, M., Banerjee, R. & Fikrig, E., Nov 1 2004, In : FEMS Immunology and Medical Microbiology. 42, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

In vitro analysis of MyD88-mediated cellular immune response to West Nile virus mutant strain infection

Xie, G., Whiteman, M. C., Wicker, J. A., Barrett, A. & Wang, T., Nov 27 2014, In : Journal of visualized experiments : JoVE. 93, p. e52121

Research output: Contribution to journalArticle

1 Scopus citations

Japanese encephalitis vaccine-specific envelope protein E138K mutation does not attenuate virulence of West Nile virus

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T. G., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Dec 1 2019, In : npj Vaccines. 4, 1, 50.

Research output: Contribution to journalArticle

Open Access

Lessons from the murine models of West Nile virus infection

McGruder, B., Saxena, V. & Wang, T., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1435. p. 61-69 9 p. (Methods in Molecular Biology; vol. 1435).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B. H., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. D. & Wang, T., Jan 1 2017, In : Journal of virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

4 Scopus citations

Memory T cells in flavivirus vaccination

Li, G., Teleki, C. & Wang, T., Dec 1 2018, In : Vaccines. 6, 4, 73.

Research output: Contribution to journalArticle

5 Scopus citations

MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

Yoo, S. A., Leng, L., Kim, B. J., Du, X., Tilstam, P. V., Kim, K. H., Kong, J. S., Yoon, H. J., Liu, A., Wang, T., Song, Y., Sauler, M., Bernhagen, J., Ritchlin, C. T., Lee, P., Cho, C. S., Kim, W. U. & Bucala, R., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7917-E7926

Research output: Contribution to journalArticle

19 Scopus citations

Murine neutrophils require α 1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum

Carlyon, J. A., Akkoyunlu, M., Xia, L., Yago, T., Wang, T., Cummings, R. D., McEver, R. P. & Fikrig, E., Nov 1 2003, In : Blood. 102, 9, p. 3387-3395 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis

Ren, J., Kolli, D., Deng, J., Fang, R., Gong, B., Xue, M., Casola, A., Garafalo, R. P., Wang, T. & Bao, X., Sep 1 2013, In : Virus Research. 176, 1-2, p. 241-250 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

Welte, T., Kim, I. S., Tian, L., Gao, X., Wang, H., Li, J., Holdman, X. B., Herschkowitz, J. I., Pond, A., Xie, G., Kurley, S., Nguyen, T., Liao, L., Dobrolecki, L. E., Pang, L., Mo, Q., Edwards, D. P., Huang, S., Xin, L., Xu, J. & 6 others, Li, Y., Lewis, M. T., Wang, T., Westbrook, T. F., Rosen, J. M. & Zhang, X. H. F., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 632-644 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice

Wang, S., Weite, T., Fang, H., Chang, G. J. J., Born, W. K., O'Brien, R. L., Sun, B., Fujii, H., Kosuna, K. I. & Wang, T., Mar 1 2009, In : Journal of Nutrition. 139, 3, p. 598-602 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V., Shi, P-Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S-J., Zhang, W., Aguilar, P. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H. G., Wang, T., Zheng, J. & Yan, J., Oct 28 2011, In : Immunity. 35, 4, 1 p.

Research output: Contribution to journalComment/debate

33 Scopus citations

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H. G., Wang, T., Zheng, J. & Yan, J., Oct 28 2011, In : Immunity. 35, 4, p. 596-610 15 p.

Research output: Contribution to journalArticle

506 Scopus citations