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2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access

Effects of Chikungunya virus immunity on Mayaro virus disease and epidemic potential

Webb, E. M., Azar, S. R., Haller, S. L., Langsjoen, R. M., Cuthbert, C. E., Ramjag, A. T., Luo, H., Plante, K., Wang, T., Simmons, G., Carrington, C. V. F., Weaver, S. C., Rossi, S. L. & Auguste, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 20399.

Research output: Contribution to journalArticle

Open Access

Genotypic and phenotypic characterization of West Nile virus NS5 methyltransferase mutants

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T. G., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Identification of relevant regions on structural and nonstructural proteins of Zika virus for vaccine and diagnostic test development: an in silico approach

Salvador, E. A., Pires de Souza, G. A., Cotta Malaquias, L. C., Wang, T. & Leomil Coelho, L. F., May 1 2019, In : New Microbes and New Infections. 29, 100506.

Research output: Contribution to journalArticle

Open Access

Japanese encephalitis vaccine-specific envelope protein E138K mutation does not attenuate virulence of West Nile virus

Kaiser, J. A., Luo, H., Widen, S. G., Wood, T. G., Huang, C. Y. H., Wang, T. & Barrett, A. D. T., Dec 1 2019, In : npj Vaccines. 4, 1, 50.

Research output: Contribution to journalArticle

Open Access

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo Giraldo, M., Vasconcelos, P. F. C., Weaver, S., Wang, T., Rajsbaum Gorodezky, R. & Shi, P-Y., Dec 1 2018, In : Nature Communications. 9, 1, 414.

Research output: Contribution to journalArticle

64 Scopus citations

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S., Weaver, S., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P-Y., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 487-499.e5

Research output: Contribution to journalArticle

11 Scopus citations

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S., Wang, T. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

9 Scopus citations

Memory T cells in flavivirus vaccination

Li, G., Teleki, C. & Wang, T., Dec 1 2018, In : Vaccines. 6, 4, 73.

Research output: Contribution to journalArticle

5 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V., Shi, P-Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S-J., Zhang, W., Aguilar, P. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells

Luo, H., Winkelmann, E. R., Fernandez-Salas, I., Li, L., Mayer, S. V., Danis-Lozano, R., Sanchez-Casas, R. M., Vasilakis, N., Tesh, R., Barrett, A., Weaver, S. & Wang, T., Mar 1 2018, In : Antiviral Research. 151, p. 55-62 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

A chikungunya fever vaccine utilizing an insect-specific virus platform

Erasmus, J. H., Auguste, A. J., Kaelber, J. T., Luo, H., Rossi, S., Fenton, K., Leal, G., Kim, D. Y., Chiu, W., Wang, T., Frolov, I., Nasar, F. & Weaver, S., Feb 1 2017, In : Nature Medicine. 23, 2, p. 192-199 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A., Wang, T., Weaver, S., Vasconcelos, P. F. C., Rossi, S. & Shi, P-Y., Apr 10 2017, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

119 Scopus citations

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S., Wang, T., Weaver, S. & Shi, P-Y., Oct 31 2017, In : Cell Reports. 21, 5, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection

Luo, H., Winkelmann, E., Xie, G., Fang, R., Peng, B., Li, L., Lazear, H. M., Paessler, S., Diamond, M. S., Gale, M., Barrett, A. & Wang, T., 2017, In : Journal of Virology. 91, 6, e02097-16.

Research output: Contribution to journalArticle

3 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

TLR7 signaling regulates Th17 cells and autoimmunity: Novel potential for autoimmune therapy

Ye, J., Wang, Y., Liu, X., Li, L., Opejin, A., Hsueh, E. C., Luo, H., Wang, T., Hawiger, D. & Peng, G., Aug 1 2017, In : Journal of Immunology. 199, 3, p. 941-954 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A., Weaver, S., Vasconcelos, P. F. C., Rossi, S., Ciaramella, G., Mysorekar, I. U. & 3 others, Pierson, T. C., Shi, P-Y. & Diamond, M. S., Jul 13 2017, In : Cell. 170, 2, p. 273-283.e12

Research output: Contribution to journalArticle

92 Scopus citations

West Nile Virus

Saxena, V., Bolling, B. G. & Wang, T., 2017, (Accepted/In press) In : Clinics in Laboratory Medicine.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M., Campbell, G., Milligan, G., Cong, Y., Barrett, A. & Wang, T., 2016, In : Journal of Virology. 90, 3, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

Yoo, S. A., Leng, L., Kim, B. J., Du, X., Tilstam, P. V., Kim, K. H., Kong, J. S., Yoon, H. J., Liu, A., Wang, T., Song, Y., Sauler, M., Bernhagen, J., Ritchlin, C. T., Lee, P., Cho, C. S., Kim, W. U. & Bucala, R., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7917-E7926

Research output: Contribution to journalArticle

19 Scopus citations

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

Welte, T., Kim, I. S., Tian, L., Gao, X., Wang, H., Li, J., Holdman, X. B., Herschkowitz, J. I., Pond, A., Xie, G., Kurley, S., Nguyen, T., Liao, L., Dobrolecki, L. E., Pang, L., Mo, Q., Edwards, D. P., Huang, S., Xin, L., Xu, J. & 6 others, Li, Y., Lewis, M. T., Wang, T., Westbrook, T. F., Rosen, J. M. & Zhang, X. H. F., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 632-644 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

West nile virus infection in human and mouse cornea tissue

Blitvich, B. J., Wang, T., Saxena, V., Zeng, S., Harmon, K. M., Raymond, M. D., Goins, K. M., Reed, C. R., Mullins, R. F. & Greiner, M. A., Nov 1 2016, In : American Journal of Tropical Medicine and Hygiene. 95, 5, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

Xie, G., Luo, H., Tian, B., Mann, B., Bao, X., McBride, J., Tesh, R., Barrett, A. & Wang, T., Feb 11 2015, In : Vaccine. 33, 7, p. 869-878 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations

γδ T cells in infection and autoimmunity

Hou, L., Wang, T. & Sun, J., Feb 17 2015, (Accepted/In press) In : International Immunopharmacology.

Research output: Contribution to journalArticle

4 Scopus citations
2014

In vitro analysis of MyD88-mediated cellular immune response to West Nile virus mutant strain infection

Xie, G., Whiteman, M. C., Wicker, J. A., Barrett, A. & Wang, T., Nov 27 2014, In : Journal of visualized experiments : JoVE. 93, p. e52121

Research output: Contribution to journalArticle

1 Scopus citations

The co-stimulatory effects of MyD88-dependent toll-like receptor signaling on activation of murine γδ T Cells

Zhang, J., Wang, J., Pang, L., Xie, G., Welte, T., Saxena, V., Wicker, J., Mann, B., Soong, L., Barrett, A., Born, W., O'Brien, R. & Wang, T., Sep 18 2014, In : PLoS One. 9, 9, A1350.

Research output: Contribution to journalArticle

12 Scopus citations
2013

A Hamster-Derived West Nile Virus Isolate Induces Persistent Renal Infection in Mice

Saxena, V., Xie, G., Li, B., Farris, T., Welte, T., Gong, B., Boor, P., Wu, P., Tang, S-J., Tesh, R. & Wang, T., Jun 2013, In : PLoS Neglected Tropical Diseases. 7, 6, e2275.

Research output: Contribution to journalArticle

21 Scopus citations

A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways

Xie, G., Welte, T., Wang, J., Whiteman, M. C., Wicker, J. A., Saxena, V., Cong, Y., Barrett, A. & Wang, T., Aug 28 2013, In : Vaccine. 31, 38, p. 4143-4151 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In : Journal of Immunology. 190, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Immunization with culex tarsalis mosquito salivary gland extract modulates west nile virus infection and disease in mice

Machain-Williams, C., Reagan, K., Wang, T., Zeidner, N. S. & Blair, C. D., Feb 1 2013, In : Viral Immunology. 26, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis

Ren, J., Kolli, D., Deng, J., Fang, R., Gong, B., Xue, M., Casola, A., Garafalo, R. P., Wang, T. & Bao, X., Sep 2013, In : Virus Research. 176, 1-2, p. 241-250 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Role of natural killer and Gamma-delta T cells in West Nile virus infection

Wang, T. & Welte, T., Sep 20 2013, In : Viruses. 5, 9, p. 2298-2310 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

A hamster-derived West Nile virus strain is highly attenuated and induces a differential proinflammatory cytokine response in two murine cell lines

Saxena, V., Welte, T., Bao, X., Xie, G., Wang, J., Higgs, S., Tesh, R. B. & Wang, T., Aug 2012, In : Virus Research. 167, 2, p. 179-187 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Immunization of Mice with Recombinant Mosquito Salivary Protein D7 Enhances Mortality from Subsequent West Nile Virus Infection via Mosquito Bite

Reagan, K. L., Machain-Williams, C., Wang, T. & Blair, C. D., Dec 2012, In : PLoS Neglected Tropical Diseases. 6, 12, e1935.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells

Kolli, D., Bao, X., Liu, T., Hong, C., Wang, T., Garofalo, R. & Casola, A., Jul 1 2011, In : Journal of Immunology. 187, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain

Welte, T., Xie, G., Wicker, J. A., Whitemanb, M. C., Li, L., Rachamallu, A., Barrett, A. & Wang, T., Jun 24 2011, In : Vaccine. 29, 29-30, p. 4853-4861 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H. G., Wang, T., Zheng, J. & Yan, J., Oct 28 2011, In : Immunity. 35, 4, p. 596-610 15 p.

Research output: Contribution to journalArticle

494 Scopus citations

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., Jala, V. R., Zhang, H. G., Wang, T., Zheng, J. & Yan, J., Oct 28 2011, In : Immunity. 35, 4, p. 649 1 p.

Research output: Contribution to journalArticle

33 Scopus citations

Role of γδ T cells in West Nile virus-induced encephalitis: Friend or foe?

Wang, T., Dec 15 2011, In : Journal of Neuroimmunology. 240-241, p. 22-27 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Vγ4+ T cells regulate host immune response to West Nile virus infection

Welte, T., Aronson, J., Gong, B., Rachamallu, A., Mendell, N., Tesh, R., Paessler, S., Born, W. K., O'Brien, R. L. & Wang, T., Nov 2011, In : FEMS Immunology and Medical Microbiology. 63, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction.

Wang, T., Campbell, R. V., Yi, M. K., Lemon, S. M. & Weinman, S. A., Nov 2010, In : Journal of Viral Hepatitis. 17, 11, p. 784-793 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

γδ T cells promote the maturation of dendritic cells during West Nile virus infection

Fang, H., Welte, T., Zheng, X., Chang, G. J. J., Holbrook, M. R., Soong, L. & Wang, T., Jun 2010, In : FEMS Immunology and Medical Microbiology. 59, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2009

Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice

Wang, S., Weite, T., Fang, H., Chang, G. J. J., Born, W. K., O'Brien, R. L., Sun, B., Fujii, H., Kosuna, K. I. & Wang, T., Mar 2009, In : Journal of Nutrition. 139, 3, p. 598-602 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection

Welte, T., Reagan, K., Fang, H., Machain-Williams, C., Zheng, X., Mendell, N., Chang, G. J. J., Wu, P., Blair, C. D. & Wang, T., 2009, In : Journal of General Virology. 90, 11, p. 2660-2668 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

Town, T., Bai, F., Wang, T., Kaplan, A. T., Qian, F., Montgomery, R. R., Anderson, J. F., Flavell, R. A. & Fikrig, E., Feb 20 2009, In : Immunity. 30, 2, p. 242-253 12 p.

Research output: Contribution to journalArticle

142 Scopus citations
2008

Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis

Wang, S., Welte, T., McGargill, M., Town, T., Thompson, J., Anderson, J. F., Flavell, R. A., Fikrig, E., Hedrick, S. M. & Wang, T., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 2084-2091 8 p.

Research output: Contribution to journalArticle

41 Scopus citations