Victor E. Reyes, PhD

PhD

  • 3521 Citations
  • 32 h-Index
1984 …2020

Research output per year

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Article
2020

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells

Sayed, I. M., Sahan, A. Z., Venkova, T., Chakraborty, A., Mukhopadhyay, D., Bimczok, D., Beswick, E. J., Reyes, V. E., Pinchuk, I., Sahoo, D., Ghosh, P., Hazra, T. K. & Das, S., Aug 7 2020, In : The Journal of biological chemistry. 295, 32, p. 11082-11098 17 p.

Research output: Contribution to journalArticle

2018

Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Beswick, E. J., Grim, C., Singh, A., Aguirre, J. E., Tafoya, M., Qiu, S., Rogler, G., McKee, R., Samedi, V., Ma, T. Y., Reyes, V. E., Powell, D. W. & Pinchuk, I. V., May 30 2018, In : Frontiers in immunology. 9, MAY, 1125.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion

Lina, T. T., Alzahrani, S., House, J., Yamaoka, Y., Sharpe, A. H., Rampy, B. A., Pinchuk, I. V. & Reyes, V. E., Mar 25 2015, In : PloS one. 10, 3, e0121841.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis

Jain, S. K., Baggerman, E. W., MohanKumar, K., Namachivayam, K., Jagadeeswaran, R., Reyes, V. E. & Maheshwari, A., Mar 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 5, p. G361-G369

Research output: Contribution to journalArticle

21 Scopus citations

Diagnostics for statistical variable selection methods for prediction of peptic ulcer disease in Helicobacter pylori infection

Ju, H., Brasier, A. R., Kurosky, A., Xu, B., Reyes, V. E. & Graham, D. Y., 2014, In : Journal of Proteomics and Bioinformatics. 7, 4, p. 95-101 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effect of Helicobacter pylori on gastric epithelial cells

Alzahrani, S., Lina, T. T., Gonzalez, J., Pinchuk, I., Beswick, E. J. & Reyes, V., Sep 28 2014, In : World Journal of Gastroenterology. 20, 36, p. 12767-12780 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+stromal cells

Beswick, E. J., Johnson, J. R., Saada, J. I., Humen, M., House, J., Dann, S., Qiu, S., Brasier, A. R., Powell, D. W., Reyes, V. E. & Pinchuk, I. V., Sep 1 2014, In : Journal of Immunology. 193, 5, p. 2218-2229 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
2013

CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection

Lina, T. T., Pinchuk, I. V., House, J., Yamaoka, Y., Graham, D. Y., Beswick, E. J. & Reyes, V. E., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3838-3846 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

Human colonic myofibroblasts promote expansion of CD4+ CD25 high Foxp3+ regulatory T cells

Pinchuk, I. V., Beswick, E. J., Saada, J. I., Boya, G., Schmitt, D., Raju, G. S., Brenmoehl, J., Rogler, G., Reyes, V. E. & Powell, D. W., Jun 2011, In : Gastroenterology. 140, 7, p. 2019-2030 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Role of gastric epithelial cell-derived transforming growth factor β in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection

Beswick, E. J., Pinchuk, I. V., Earley, R. B., Schmitt, D. A. & Reyes, V. E., Jul 2011, In : Infection and immunity. 79, 7, p. 2737-2745 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008
32 Scopus citations

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

Pinchuk, I. V., Saada, J. I., Beswick, E. J., Boya, G., Qiu, S. M., Mifflin, R. C., Raju, G. S., Reyes, V. E. & Powell, D. W., Oct 2008, In : Gastroenterology. 135, 4, p. 1228-1237.e2

Research output: Contribution to journalArticle

73 Scopus citations
2007

Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells

Beswick, E. J., Pinchuk, I. V., Das, S., Powell, D. W. & Reyes, V. E., Sep 1 2007, In : Infection and immunity. 75, 9, p. 4334-4341 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains

Lu, H., Jeng, Y. W., Beswick, E. J., Ohno, T., Odenbreit, S., Haas, R., Reyes, V. E., Kita, M., Graham, D. Y. & Yamaoka, Y., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6242-6254 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells

Ding, S. Z., Minohara, Y., Xue, J. F., Wang, J., Reyes, V. E., Patel, J., Dirden-Kramer, B., Boldogh, I., Ernst, P. B. & Crowe, S. E., Aug 2007, In : Infection and immunity. 75, 8, p. 4030-4039 10 p.

Research output: Contribution to journalArticle

139 Scopus citations

Helicobacter pylori neutrophil activating protein's potential as tool in therapeutic immune modulation

Reyes, V. E. & Beswick, E. J., Oct 1 2007, In : Expert Opinion on Therapeutic Patents. 17, 10, p. 1315-1320 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin A: Relevance to staphylococcal enterotoxigenic disease

Pinchuk, I. V., Beswick, E. J., Saada, J. I., Suarez, G., Winston, J., Mifflin, R. C., Di Mari, J. F., Powell, D. W. & Reyes, V. E., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 8097-8106 10 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
2006

Expression of B7-H1 on gastric epithelial cells: Its potential role in regulating T cells during Helicobacter pylori infection

Das, S., Suarez, G., Beswick, E. J., Sierra, J. C., Graham, D. Y. & Reyes, V. E., Mar 1 2006, In : Journal of Immunology. 176, 5, p. 3000-3009 10 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events

Beswick, E. J., Pinchuk, I. V., Suarez, G., Sierra, J. C. & Reyes, V. E., Jun 1 2006, In : Journal of Immunology. 176, 11, p. 6794-6801 8 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

H pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptic response

Bland, D. A., Suarez, G., Beswick, E. J., Sierra, J. C. & Reyes, V. E., Sep 7 2006, In : World journal of gastroenterology. 12, 33, p. 5306-5310 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

H pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response

Bland, D. A., Suarez, G., Beswick, E. J., Sierra, J. C. & Reyes, V. E., Aug 7 2006, In : World journal of gastroenterology. 12, 29, p. 4689-4693 5 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa

Saada, J. I., Pinchuk, I. V., Barrera, C. A., Adegboyega, P. A., Suarez, G., Mifflin, R. C., Di Mari, J. F., Reyes, V. E. & Powell, D. W., Nov 1 2006, In : Journal of Immunology. 177, 9, p. 5968-5979 12 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-κB activation and interleukin-8 production

Beswick, E. J., Pinchuk, I. V., Minch, K., Suarez, G., Sierra, J. C., Yamaoka, Y. & Reyes, V. E., Feb 2006, In : Infection and immunity. 74, 2, p. 1148-1155 8 p.

Research output: Contribution to journalArticle

59 Scopus citations
2005

Differential protein expression profiles of gastric epithelial cells following Helicobacter pylori infection using ProteinChips

Das, S., Sierra, J. C., Soman, K. V., Suarez, G., Mohammad, A. A., Dang, T. A. T., Luxon, B. A. & Reyes, V. E., May 1 2005, In : Journal of Proteome Research. 4, 3, p. 920-930 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production

Beswick, E. J., Bland, D. A., Suarez, G., Barrera, C. A., Fan, X. & Reyes, V. E., May 2005, In : Infection and immunity. 73, 5, p. 2736-2743 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression

Beswick, E. J., Das, S., Pinchuk, I. V., Adegboyega, P., Suarez, G., Yamaoka, Y. & Reyes, V. E., Jul 1 2005, In : Journal of Immunology. 175, 1, p. 171-176 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Polarized expression of CD74 by gastric epithelial cells

Barrera, C. A., Beswick, E. J., Sierra, J. C., Bland, D., Espejo, R., Mifflin, R., Adegboyega, P., Crowe, S. E., Ernst, P. B. & Reyes, V. E., Dec 2005, In : Journal of Histochemistry and Cytochemistry. 53, 12, p. 1481-1489 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2004

Class II MHC-expressing myofibroblasts play a role in the immunopathogenesis associated with staphylococcal enterotoxins

Barrera, C. A., Pinchuk, I. V., Saada, J. I., Suarez, G., Bland, D. A., Beswick, E., Adegboyega, P. A., Mifflin, R. C., Powell, D. W. & Reyes, V. E., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1029, p. 313-318 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells

Ding, S. Z., O'Hara, A. M., Denning, T. L., Dirden-Kramer, B., Mifflin, R. C., Reyes, V. E., Ryan, K. A., Elliott, S. N., Izumi, T., Boldogh, I., Mitra, S., Ernst, P. B. & Crowe, S. E., Sep 2004, In : Gastroenterology. 127, 3, p. 845-858 14 p.

Research output: Contribution to journalArticle

71 Scopus citations

Intestinal myofibroblasts and immune tolerance

Saada, J. I., Barrera, C. A., Reyes, V. E., Adegboyega, P. A., Suarez, G., Tamerisa, R. A., Pang, K. F., Bland, D. A., Mifflin, R. C., Di Mari, J. F. & Powell, D. W., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1029, p. 379-381 3 p.

Research output: Contribution to journalArticle

14 Scopus citations
2003

Ii-CS on gastric epithelial cells interacts with CD44 on T cells and induces their proliferation

Barrera, C. A., Chan, T., Crowe, S. E., Ernst, P. B. & Reyes, V. E., Jan 1 2003, In : Annals of the New York Academy of Sciences. 987, p. 285-287 3 p.

Research output: Contribution to journalArticle

Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells

Poussin, M. A., Fuller, C. L., Goluszko, E., Reyes, V. E., Braciale, V. L. & Christadoss, P., Jan 1 2003, In : Journal of Neuroimmunology. 134, 1-2, p. 104-110 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2002

Differential glycosylation of MHC class II molecules on gastric epithelial cells: Implications in local immune responses

Barrera, C., Espejo, R. & Reyes, V. E., May 27 2002, In : Human Immunology. 63, 5, p. 384-393 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2001

Expression of cathepsins B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses

Barrera, C., Ye, G., Espejo, R., Gunasena, S., Almanza, R., Leary, J., Crowe, S., Ernst, P. & Reyes, V. E., Jan 1 2001, In : Human Immunology. 62, 10, p. 1081-1091 11 p.

Research output: Contribution to journalArticle

39 Scopus citations
2000

Expression of IL-10 receptors on epithelial cells from the murine small and large intestine

Denning, T. L., Campbell, N. A., Song, F., Garofalo, R. P., Klimpel, G. R., Reyes, V. E. & Ernst, P. B., Jan 1 2000, In : International immunology. 12, 2, p. 133-139 7 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions

Wang, J., Fan, X., Lindholm, C., Bennett, M., O'Connoll, J., Shanahan, F., Brooks, E. G., Reyes, V. E. & Ernst, P. B., Jul 2000, In : Infection and immunity. 68, 7, p. 4303-4311 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis

Fan, X., Gunasena, H., Cheng, Z., Espejo, R., Crowe, S. E., Ernst, P. B. & Reyes, V. E., Aug 15 2000, In : Journal of Immunology. 165, 4, p. 1918-1924 7 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
1999

Regulation of the mucosal immune response

Ernst, P. B., Song, F., Klimpel, G. R., Haeberle, H., Bamford, K. B., Crowe, S. E., Ye, G. & Reyes, V. E., Apr 1999, In : American Journal of Tropical Medicine and Hygiene. 60, 4 SUPPL., p. 2-9 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
1998

Class II MHC molecules on gastric epithelial cells act as receptors for Helicobacter pylori urease and signal apoptosis of the epithelium

Fan, X. J., Gunasena, H., Gonzales, M., Almanza, R., Cheng, Z., Ye, G., Barrera, C., Crowe, S. E., Ernst, P. B. & Reyes, V. E., Mar 20 1998, In : FASEB Journal. 12, 5, p. A1089

Research output: Contribution to journalArticle

Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype

Bamford, K. B., Fan, X., Crowe, S. E., Leary, J. F., Gourley, W. K., Luthra, G. K., Brooks, E. G., Graham, D. Y., Reyes, V. E. & Ernst, P. B., Jan 1 1998, In : Gastroenterology. 114, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

477 Scopus citations

The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: A mechanism for T helper cell type 1-mediated damage

Fan, X., Crowe, S. E., Behar, S., Gunasena, H., Ye, G., Haeberle, H., Van Houten, N., Gourley, W. K., Ernst, P. B. & Reyes, V. E., May 18 1998, In : Journal of Experimental Medicine. 187, 10, p. 1659-1669 11 p.

Research output: Contribution to journalArticle

176 Scopus citations
1997

Antigen presentation of mucosal pathogens: The players and the rules

Reyes, V. E., Ye, G., Ogra, P. L. & Garofalo, R., Jan 1 1997, In : International Archives of Allergy and Immunology. 112, 2, p. 103-114 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa

Haeberle, H. A., Kubin, M., Bamford, K. B., Garofalo, R., Graham, D. Y., El-Zaatari, F., Karttunen, R., Crowe, S. E., Reyes, V. E. & Ernst, P. B., Oct 1997, In : Infection and immunity. 65, 10, p. 4229-4235 7 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations

Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells. Potential role in CD4+ T cell activation during Helicobacter pylori infection

Ye, G., Barrera, C., Fan, X., Gourley, W. K., Crowe, S. E., Ernst, P. B. & Reyes, V. E., Apr 1 1997, In : Journal of Clinical Investigation. 99, 7, p. 1628-1636 9 p.

Research output: Contribution to journalArticle

Open Access
121 Scopus citations

How does Helicobacter pylori cause mucosal damage? The inflammatory response

Ernst, P. B., Crowe, S. E. & Reyes, V. E., Jan 1 1997, In : Gastroenterology. 113, 6 SUPPL., p. S35-S42

Research output: Contribution to journalArticle

105 Scopus citations
1996

Respiratory Syncytial Virus Infection of Human Respiratory Epithelial Cells Up-Regulates Class I MHC Expression Through the Induction of IFN-β and IL-1β

Garofalo, R., Mei, F., Espejo, R., Ye, G., Haeberle, H., Baron, S., Ogra, P. L. & Reyes, V. E., Sep 15 1996, In : Journal of Immunology. 157, 6, p. 2506-2513 8 p.

Research output: Contribution to journalArticle

84 Scopus citations
1995

Structural analysis of invariant chain subsets as a function of their association with MHC Class II Chains

Nguyen, Q. V., Reyes, V. E. & Humphreys, R. E., Feb 20 1995, In : Archives of Biochemistry and Biophysics. 317, 1, p. 128-132 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
1994

Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow A staged pattern

Xu, M., Capraro, G. A., Daibata, M., Reyes, V. E. & Humphreys, R. E., Jul 1994, In : Molecular Immunology. 31, 10, p. 723-731 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Invariant Chain Dissociation from Class II MHC Is a Catalyst for Foreign Peptide Binding

REYES, V. E., DAIBATA, M., ESPEJO, R. & HUMPHREYS, R. E., Sep 1994, In : Annals of the New York Academy of Sciences. 730, 1, p. 338-341 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release

Daibata, M., Xu, M., Humphreys, R. E. & Reyes, V. E., Mar 1994, In : Molecular Immunology. 31, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

22 Scopus citations