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Personal profile
Personal profile
Dr. Bao is an Associate Professor of Pediatrics in the Division of Clinic and Experimental Immunology and Infectious Disease. She received her PhD in the Cellular Physiology and Molecular Biophysics from the University of Texas Medical Branch in Galveston. Dr. Bao continued her education as a J.Kempner scholar for the year 2003-2004 and completed her postdoctoral fellowship in a NIAID-supported T32 training program for emerging and reemerging infectious in UTMB. One of her research interests focuses on biological roles of small non-coding RNAs (sncRNAs), especially the newly discovered sncRNA derived from tRNA, in response to viral infection and environmental stimuli. Biological function studies of sncRNAs are a burgeoning field of interdisciplinary research that crosses the path from chemistry, molecular biology, bioinformatics and computer sciences. The ultimate goal of her sncRNA research is to control viral replication or stress-induced cellular responses by regulating the expression of sncRNAs. Her other research interests include identifying the mechanisms associated with immune evasion of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), the two leading causes of lower respiratory tract infection in children, and developing therapeutic molecules and attenuated vaccine candidates to combat or prevent these two viral infections.
Research interests
The research in my lab focuses on molecular mechanisms underlying the pathogenesis and host immune responses associated with RSV and hMPV infections, the two leading causes of lower respiratory tract infections in infants. We aim to identify antiviral pathways, viral evasion mechanisms, and roles of sncRNAs in RSV/hMPV infection. The ultimate goal of our research is to develop effective preventive and therapeutic strategies against respiratory virus-associated viral replication and inflammation.
Research Strategic Pillar Keywords
- Life Span Health
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Collaborations and top research areas from the last five years
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tRNA-derived RNA fragment (tRF) as prognostic and diagnostic biomarkers for Alzheimer's disease
3/15/23 → 2/28/26
Project: Other project
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Biogenesis and Function of tRNA-derived RNA Fragments in Alzheimer's Disease: Novel Biomarkers
Darrell K. Royal Research Fund for Alzhe
9/1/22 → 8/31/26
Project: Other project
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tRNA-derived RNA Fragments and their Role in Nasal SARS-COVID-2 Infection
National Inst of Allergy & Infectious Di
7/1/22 → 6/30/24
Project: Other project
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Editorial: Small non-coding RNAs in diseases
Zhang, K., Lee, Y. S., Lee, I. & Bao, X., Jan 4 2023, In: Frontiers in Molecular Biosciences. 9, 1086768.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Identification of common sequence motifs shared exclusively among selectively packed exosomal pathogenic microRNAs during rickettsial infections
Bei, J., Qiu, Y., Cockrell, D., Chang, Q., Husseinzadeh, S., Zhou, C., Fang, X., Bao, X., Jin, Y., Gaitas, A., Khanipov, K., Saito, T. & Gong, B., 2023, (Accepted/In press) In: Journal of Cellular Physiology.Research output: Contribution to journal › Article › peer-review
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A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccine
Adam, A., Shi, Q., Wang, B., Zou, J., Mai, J., Osman, S. R., Wu, W., Xie, X., Aguilar, P. V., Bao, X., Shi, P. Y., Shen, H. & Wang, T., Nov 2022, In: Translational Research. 249, p. 13-27 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Changes of Small Non-coding RNAs by Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Wu, W., Choi, E-J., Wang, B., Zhang, K., Adam, A., Huang, G., Tunkle, L., Huang, P., Goru, R., Imirowicz, I., Henry, L., Lee, I., Dong, J., Wang, T. & Bao, X., Feb 23 2022, In: Frontiers in Molecular Biosciences. 9, 821137.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
IFN-γ Attenuates Eosinophilic Inflammation but Is Not Essential for Protection against RSV-Enhanced Asthmatic Comorbidity in Adult Mice
Muralidharan, A., Uddin, M. B., Bauer, C., Wu, W., Bao, X. & Sun, K., Jan 2022, In: Viruses. 14, 1, 147.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations