Yingxin Zhao, PhD

  • 1692 Citations
  • 24 h-Index
20022021

Research output per year

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Research Output

  • 1692 Citations
  • 24 h-Index
  • 55 Article
  • 3 Chapter
  • 2 Conference contribution
2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

3 Scopus citations

Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation to Maintain Proteostasis and Extracellular Matrix Production

Zhang, J., Jamaluddin, M., Zhang, Y., Widen, S. G., Sun, H., Brasier, A. R. & Zhao, Y., Sep 6 2019, In : Journal of Proteome Research. 18, 9, p. 3447-3460 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. & Brasier, A. R., Jun 1 2018, In : Journal of Virology. 92, 11, e00441-18.

Research output: Contribution to journalArticle

8 Scopus citations

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W., Sur, S. & Brasier, A. R., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

7 Scopus citations

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

11 Scopus citations

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

Tian, B., Widen, S., Yang, J., Wood, T., Kudlicki, A., Zhao, Y. & Brasier, A. R., Jan 1 2018, In : Journal of Biological Chemistry. 293, 42, p. 16528-16545 18 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. & Brasier, A. R., 2017, In : Journal of Virology. 91, 6, e00007-17.

Research output: Contribution to journalArticle

22 Scopus citations

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

Zhao, Y., Tilton, R., Brasier, A., Ijaz, T., Finnerty, C., Herndon, D., Tilton, R. & Jamaluddin, M., Feb 9 2017, In : Cell Death and Disease.

Research output: Contribution to journalArticle

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

Ijaz, T., Jamaluddin, M., Zhao, Y., Zhang, Y., Jay, J., Finnerty, C., Herndon, D., Tilton, R. & Brasier, A. R., Feb 9 2017, In : Cell death & disease. 8, 2, p. e2606

Research output: Contribution to journalArticle

15 Scopus citations

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Maroto, R., Zhao, Y., Jamaluddin, M., Popov, V., Wang, H., Kalubowilage, M., Zhang, Y., Luisi, J., Sun, H., Culbertson, C. T., Bossmann, S. H., Motamedi, M. & Brasier, A. R., Dec 1 2017, In : Journal of Extracellular Vesicles. 6, 1, 1359478.

Research output: Contribution to journalArticle

32 Scopus citations

Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification-Mass Spectrometry-based Protein-Protein Interaction Analysis

Zhang, Y., Sun, H., Zhang, J., Brasier, A. R. & Zhao, Y., Aug 4 2017, In : Journal of Proteome Research. 16, 8, p. 3068-3082 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples

Zhao, Y., Zhang, Y., Sun, H., Maroto, R. & Brasier, A. R., Aug 4 2017, In : Journal of Proteome Research. 16, 8, p. 2983-2992 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus-induced lower respiratory tract infections

Zhao, Y., Jamaluddin, M., Zhang, Y., Sun, H., Ivanciuc, T., Garofalo, R. & Brasier, A. R., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3345-3364 20 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016
28 Scopus citations
9 Scopus citations

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

Zhao, Y., Tian, B., Sadygov, R., Zhang, Y. & Brasier, A. R., Oct 4 2016, In : Journal of Proteomics. 148, p. 126-138 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

Chondronikola, M., Asghar, R., Zhang, X., Dillon, E., Durham, W. J., Wu, Z., Porter, C., Camacho-Hughes, M., Zhao, Y., Brasier, A. R., Volpi, E., Sheffield-Moore, M., Abate, N., Sidossis, L. & Tuvdendorj, D., Feb 18 2016, (Accepted/In press) In : Clinical Nutrition.

Research output: Contribution to journalArticle

2 Scopus citations

Qualification and verification of protein biomarker candidates

Zhao, Y. & Brasier, A. R., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 919. p. 493-514 22 p. (Advances in Experimental Medicine and Biology; vol. 919).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2015

Improved detection of invasive pulmonary aspergillosis arising during leukemia treatment using a panel of host response proteins and fungal antigens

Brasier, A. R., Zhao, Y., Spratt, H., Wiktorowicz, J. E., Ju, H., Wheat, L. J., Baden, L., Stafford, S., Wu, Z., Issa, N., Caliendo, A. M., Denning, D. W., Soman, K., Clancy, C. J., Nguyen, M. H., Sugrue, M. W., Alexander, B. D. & Wingard, J. R., Nov 1 2015, In : PLoS One. 10, 11, 0143165.

Research output: Contribution to journalArticle

13 Scopus citations

Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

Desai, P., Yang, J., Tian, B., Sun, H., Kalita, M., Ju, H., Paulucci-Holthauzen, A., Zhao, Y., Brasier, A. R. & Sadygov, R., Jul 1 2015, In : Cellular Signalling. 27, 7, p. 1413-1425 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Molecular classification of outcomes from dengue virus -3 infections

Brasier, A. R., Zhao, Y., Wiktorowicz, J. E., Spratt, H., Nascimento, E. J. M., Cordeiro, M. T., Soman, K. V., Ju, H., Recinos, A., Stafford, S., Wu, Z., Marques, E. T. A. & Vasilakis, N., Mar 1 2015, In : Journal of Clinical Virology. 64, p. 97-106 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD Box (DDX)-5/17 RNA helicases

Yang, J., Zhao, Y., Kalita, M., Li, X., Jamaluddin, M., Tian, B., Edeh, C. B., Wiktorowicz, J. E., Kudlicki, A. & Brasier, A. R., Oct 1 2015, In : Molecular and Cellular Proteomics. 14, 10, p. 2701-2721 21 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

ATM regulates NF-κB-dependent immediate-early genes via RelA ser 276 phosphorylation coupled to CDK9 promoter recruitment

Fang, L., Choudhary, S., Zhao, Y., Edeh, C. B., Yang, C., Boldogh, I. & Brasier, A. R., 2014, In : Nucleic Acids Research. 42, 13, p. 8416-8432 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R., Starkey, J., Spratt, H., Luxon, B. A., Dineley, K. & Denner, L., 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: Coordinated dynamics emerging from cell-level noise

Bertolusso, R., Tian, B., Zhao, Y., Vergara, L., Sabree, A., Iwanaszko, M., Lipniacki, T., Brasier, A. R. & Kimmel, M., Apr 7 2014, In : PLoS One. 9, 4, e93396.

Research output: Contribution to journalArticle

19 Scopus citations

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

Ray, S., Zhao, Y., Jamaluddin, M., Edeh, C. B., Lee, C. & Brasier, A. R., 2014, In : Cellular Signalling. 26, 7, p. 1445-1455 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Measurement of the innate immune response in the airway

Brasier, A. R. & Zhao, Y., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 233-254 22 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Measurement of the innate immune response in the airway

Brasier, A. R. & Zhao, Y., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 233-254 22 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Modulation of gene expression regulated by the transcription factor nf-κb/rela

Li, X., Zhao, Y., Tian, B., Jamaluddin, M., Mitra, A., Yang, J., Rowicka-Kudlicka, M., Brasier, A. R. & Kudlicki, A., Apr 25 2014, In : Journal of Biological Chemistry. 289, 17, p. 11927-11944 18 p.

Research output: Contribution to journalArticle

19 Scopus citations

Translational studies in older men using testosterone to treat sarcopenia

Urban, R., Dillon, E., Choudhary, S., Zhao, Y., Horstman, A. M., Tilton, R. & Sheffield-Moore, M., 2014, In : Transactions of the American Clinical and Climatological Association. 125

Research output: Contribution to journalArticle

18 Scopus citations
2013

Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathways

Zhao, Y. & Brasier, A. R., Jun 15 2013, In : Methods. 61, 3, p. 313-322 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. & Brasier, A. R., Jun 2013, In : Journal of Virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

37 Scopus citations

Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R., Starkey, J., Luxon, B. A., Spratt, H., Dewitt, D., Prough, D. & Denner, L., May 1 2013, In : Journal of Neurotrauma. 30, 9, p. 775-788 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inducible Tumor Necrosis Factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation

Choudhary, S., Kalita, M., Fang, L., Patel, K. V., Tian, B., Zhao, Y., Edeh, C. B. & Brasier, A. R., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14612-14623 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry

Zhao, Y., Tian, B., Edeh, C. B. & Brasier, A. R., Jun 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1513-1529 17 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

Denner, L., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R., Starkey, J., Spratt, H., Luxon, B. A., Wood, T. & Dineley, K., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In : PLoS Neglected Tropical Diseases. 6, 5, e1659.

Research output: Contribution to journalArticle

39 Scopus citations
2011

Methods for biomarker verification and assay development

Zhao, Y. & Brasier, A. R., Jul 2011, In : Current Proteomics. 8, 2, p. 138-152 15 p.

Research output: Contribution to journalArticle

3 Scopus citations
34 Scopus citations
2010

Altered retinoic acid metabolism in diabetic mouse kidney identified by 18O isotopic labeling and 2D mass spectrometry

Starkey, J., Zhao, Y., Sadygov, R., Haidacher, S. J., S.LeJeune, W., Dey, N., Luxon, B. A., Kane, M. A., Napoli, J. L., Denner, L. & Tilton, R., 2010, In : PLoS One. 5, 6, e11095.

Research output: Contribution to journalArticle

33 Scopus citations

Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors

Yore, M. A., Im, D., Webb, L. K., Zhao, Y., Chadwick, J. G., Molenda-Figueira, H. A., Haidacher, S. J., Denner, L. & Tetel, M. J., Sep 2010, In : Neuroscience. 169, 3, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Using power spectrum analysis to evaluate 18o-water labeling data acquired from low resolution mass spectrometers

Sadygov, R., Zhao, Y., Haidacher, S. J., Starkey, J., Tilton, R. & Denner, L., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4306-4312 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Comprehensive analysis of the mouse renal cortex using two-dimensional HPLC - Tandem mass spectrometry

Zhao, Y., Denner, L., Haidacher, S. J., LeJeune, W. S. & Tilton, R., May 23 2008, In : Proteome Science. 6, 15.

Research output: Contribution to journalArticle

19 Scopus citations

Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes

Molenda-Figueira, H. A., Murphy, S. D., Shea, K. L., Siegal, N. K., Zhao, Y., Chadwick, J. G., Denner, L. & Tetel, M. J., Oct 2008, In : Endocrinology. 149, 10, p. 5272-5279 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2007

Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry

Tilton, R., Haidacher, S. J., LeJeune, W. S., Zhang, X., Zhao, Y., Kurosky, A., Brasier, A. R. & Denner, L., May 2007, In : Proteomics. 7, 10, p. 1729-1742 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Toward a global characterization of the phosphoproteome in prostate cancer cells: Identification of phosphoproteins in the LNCaP cell line

Giorgianni, F., Zhao, Y., Desiderio, D. M. & Beranova-Giorgianni, S., Jun 2007, In : Electrophoresis. 28, 12, p. 2027-2034 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2006

Global identification of O-GlcNAc-modified proteins

Nandi, A., Sprung, R., Barma, D. K., Zhao, Y., Kim, S. C., Falck, J. R. & Zhao, Y., Jan 15 2006, In : Analytical Chemistry. 78, 2, p. 452-458 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Phosphoproteomic analysis of the human pituitary

Beranova-Giorgianni, S., Zhao, Y., Desiderio, D. M. & Giorgianni, F., Jun 2006, In : Pituitary. 9, 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2005

Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation

Cheng, J., Zhang, D., Kim, K., Zhao, Y., Zhao, Y. & Su, B., Jul 2005, In : Molecular and Cellular Biology. 25, 14, p. 5955-5964 10 p.

Research output: Contribution to journalArticle

31 Scopus citations