Yingzi Cong, PhD, MS

Director, Germ-Free Mouse Facility

  • 6818 Citations
  • 42 h-Index
1988 …2020

Research output per year

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Research Output

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2020

Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases

Yu, Y., Yang, W., Li, Y. & Cong, Y., Jan 1 2020, In : Inflammatory bowel diseases. 26, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Increased Ileal Immunoglobulin A Production and Immunoglobulin A-Coated Bacteria in Diarrhea-Predominant Irritable Bowel Syndrome

Liu, Y., Yuan, X., Li, L., Lin, L., Zuo, X., Cong, Y. & Li, Y., Mar 1 2020, In : Clinical and Translational Gastroenterology. 11, 3, p. e00146

Research output: Contribution to journalArticle

Open Access

Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses

Aguirre, J. E., Beswick, E. J., Grim, C., Uribe, G., Tafoya, M., Palma, G. C., Samedi, V., McKee, R., Villeger, R., Fofanov, Y., Cong, Y., Yochum, G., Koltun, W., Powell, D. & Pinchuk, I., Jan 1 2020, In : International immunology. 32, 1, p. 57-68 12 p.

Research output: Contribution to journalArticle

Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy

Zhao, R., Sujuan, D. U., Liu, Y., Cong, L. V., Song, Y., Chen, X., Zhang, B., Li, D., Gao, S., Wei, C. U. I., Plikus, M. V., Hou, X., Wu, K., Liu, Z., Liu, Z., Cong, Y., Li, Y. & Yu, Z., 2020, In : Theranostics. 10, 8, p. 3594-3611 18 p.

Research output: Contribution to journalArticle

Open Access

Neonatal injury increases gut permeability by epigenetically suppressing e-cadherin in adulthood

Kline, K. T., Lian, H., Zhong, X. S., Luo, X., Winston, J. H., Cong, Y., Savidge, T. C., Dashwood, R. H., Powell, D. & Li, Q., Feb 15 2020, In : Journal of Immunology. 204, 4, p. 980-989 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling

Xu, J., Tang, Y., Sheng, X., Tian, Y., Deng, M., Du, S., Lv, C., Li, G., Pan, Y., Song, Y., Lou, P., Luo, Y., Li, Y., Zhang, B., Chen, Y., Liu, Z., Cong, Y., Plikus, M. V., Meng, Q., Zhou, Z. & 1 others, Yu, Z., Apr 1 2020, In : EMBO Journal. 39, 7, e103255.

Research output: Contribution to journalArticle

2019

Critical Role of CD6 high CD4 + T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD

Ma, C., Wu, W., Lin, R., Ge, Y., Zhang, C., Sun, S., Cong, Y., Li, X. & Liu, Z., Mar 30 2019, In : Journal of Crohn's and Colitis. 13, 4, p. 510-524 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity

Alamer, E., Carpio, V. H., Ibitokou, S. A., Kirtley, M. L., Phoenix, I. R., Opata, M. M., Wilson, K. D., Cong, Y., Dann, S. M., Chopra, A. K. & Stephens, R., Jul 1 2019, In : Parasitology research. 118, 7, p. 2277-2285 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interleukin-33 Promotes REG3γ Expression in Intestinal Epithelial Cells and Regulates Gut Microbiota

Xiao, Y., Huang, X., Zhao, Y., Chen, F., Sun, M., Yang, W., Chen, L., Yao, S., Peniche, A., Dann, S. M., Sun, J., Golovko, G., Fofanov, Y., Miao, Y., Liu, Z., Chen, D. & Cong, Y., 2019, In : CMGH. 8, 1, p. 21-36 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells' Differentiation and Function in Induction of Colitis

Chen, L., Sun, M., Wu, W., Yang, W., Huang, X., Xiao, Y., Ma, C., Xu, L., Yao, S., Liu, Z. & Cong, Y., Sep 1 2019, In : Inflammatory bowel diseases. 25, 9, p. 1450-1461 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Microbiota metabolite short-chain fatty acids facilitate mucosal adjuvant activity of cholera toxin through GPR43

Yang, W., Xiao, Y., Huang, X., Chen, F., Sun, M., Bilotta, A. J., Xu, L., Lu, Y., Yao, S., Zhao, Q., Liu, Z. & Cong, Y., 2019, In : Journal of Immunology. 203, 1, p. 282-292 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases

Ge, Y., Sun, M., Wu, W., Ma, C., Zhang, C., He, C., Li, J., Cong, Y., Zhang, D. & Liu, Z., Jul 2019, In : Journal of Autoimmunity. 101, p. 109-120 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice

Tian, Y., Xu, J., Li, Y., Zhao, R., Du, S., Lv, C., Wu, W., Liu, R., Sheng, X., Song, Y., Bi, X., Li, G., Li, M., Wu, X., Lou, P., You, H., Cui, W., Sun, J., Shuai, J., Ren, F. & 11 others, Zhang, B., Guo, M., Hou, X., Wu, K., Xue, L., Zhang, H., Plikus, M. V., Cong, Y., Lengner, C. J., Liu, Z. & Yu, Z., Jun 2019, In : Gastroenterology. 156, 8, p. 2281-2296.e6

Research output: Contribution to journalArticle

19 Scopus citations

RORγt represses IL-10 production in Th17 cells to maintain their pathogenicity in inducing intestinal inflammation

Sun, M., He, C., Chen, L., Yang, W., Wu, W., Chen, F., Cao, A. T., Yao, S., Dann, S. M., Dhar, T. G. M., Salter-Cid, L., Zhao, Q., Liu, Z. & Cong, Y., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 79-92 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Anti-TNF Therapy Induces CD4+ T-Cell Production of IL-22 and Promotes Epithelial Repairs in Patients with Crohn's Disease

Fang, L., Pang, Z., Shu, W., Wu, W., Sun, M., Cong, Y. & Liu, Z., Aug 16 2018, In : Inflammatory Bowel Diseases. 24, 9, p. 1733-1744 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD

Zhou, G., Yu, L., Fang, L., Yang, W., Yu, T., Miao, Y., Chen, M., Wu, K., Chen, F., Cong, Y. & Liu, Z., Jun 1 2018, In : Gut. 67, 6, p. 1052-1063 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

CD177+ neutrophils suppress epithelial cell tumourigenesis in colitis-associated cancer and predict good prognosis in colorectal cancer

Zhou, G., Peng, K., Song, Y., Yang, W., Shu, W., Yu, T., Yu, L., Lin, M., Wei, Q., Chen, C., Yin, L., Cong, Y. & Liu, Z., Feb 1 2018, In : Carcinogenesis. 39, 2, p. 272-282 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Zhao, Y., Chen, F., Wu, W., Sun, M., Bilotta, A. J., Yao, S., Xiao, Y., Huang, X., Eaves-Pyles, T. D., Golovko, G., Fofanov, Y., D'Souza, W., Zhao, Q., Liu, Z. & Cong, Y., May 1 2018, In : Mucosal Immunology. 11, 3, p. 752-762 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

Sun, M., Wu, W., Chen, L., Yang, W., Huang, X., Ma, C., Chen, F., Xiao, Y., Zhao, Y., Ma, C., Yao, S., Carpio, V. H., Dann, S. M., Zhao, Q., Liu, Z. & Cong, Y., Dec 1 2018, In : Nature communications. 9, 1, 3555.

Research output: Contribution to journalArticle

50 Scopus citations

Microbiota dysbiosis and its pathophysiological significance in bowel obstruction

Hegde, S., Lin, Y. M., Golovko, G., Khanipov, K., Cong, Y., Savidge, T., Fofanov, Y. & Shi, X. Z., Dec 1 2018, In : Scientific reports. 8, 1, 13044.

Research output: Contribution to journalArticle

8 Scopus citations

Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life

Zhong, X. S., Winston, J. H., Luo, X., Kline, K. T., Nayeem, S. Z., Cong, Y., Savidge, T. C., Dashwood, R. H., Powell, D. W. & Li, Q., Jan 1 2018, In : CMGH. 6, 1, p. 65-78 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Neutrophils promote amphiregulin production in intestinal epithelial cells through TGF-β and contribute to intestinal homeostasis

Chen, F., Yang, W., Huang, X., Cao, A. T., Bilotta, A. J., Xiao, Y., Sun, M., Chen, L., Ma, C., Liu, X., Liu, C. G., Yao, S., Dann, S. M., Liu, Z. & Cong, Y., Oct 15 2018, In : Journal of Immunology. 201, 8, p. 2492-2501 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

Jie, Z., Yang, J. Y., Gu, M., Wang, H., Xie, X., Li, Y., Liu, T., Zhu, L., Shi, J., Zhang, L., Zhou, X., Joo, D., Brightbill, H. D., Cong, Y., Lin, D., Cheng, X. & Sun, S. C., Nov 1 2018, In : Nature Immunology. 19, 11, p. 1224-1235 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function

Shi, Y., He, C., Ma, C., Yu, T., Cong, Y., Cai, W. & Liu, Z., May 1 2018, In : Mucosal Immunology. 11, 3, p. 835-845 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
8 Scopus citations
2017

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection

Yi, P., Liang, Y., Yuan, D. M. K., Jie, Z., Kwota, Z., Chen, Y., Cong, Y., Fan, X. & Sun, J., Dec 1 2017, In : Scientific reports. 7, 1, 3857.

Research output: Contribution to journalArticle

3 Scopus citations

Critical role of ROCK2 activity in facilitating mucosal CD4+ T cell activation in inflammatory bowel disease

Yang, W., Zhou, G., Yu, T., Chen, L., Yu, L., Guo, Y., Cong, Y. & Liu, Z., Jan 1 2017, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

15 Scopus citations

Hypoxia inducible factor-1α-induced interleukin-33 expression in intestinal epithelia contributes to mucosal homeostasis in inflammatory bowel disease

Sun, M., He, C., Wu, W., Zhou, G., Liu, F., Cong, Y. & Liu, Z., Mar 1 2017, In : Clinical and Experimental Immunology. 187, 3, p. 428-440 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Wu, W., Sun, M., Chen, F., Cao, A. T., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., Liu, Z. & Cong, Y., Jul 1 2017, In : Mucosal Immunology. 10, 4, p. 946-956 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1

He, C., Yu, T., Shi, Y., Ma, C., Yang, W., Fang, L., Sun, M., Wu, W., Xiao, F., Guo, F., Chen, M., Yang, H., Qian, J., Cong, Y. & Liu, Z., May 1 2017, In : Gastroenterology. 152, 6, p. 1434-1448.e15

Research output: Contribution to journalArticle

49 Scopus citations

Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In : Journal of Immunology. 198, 9, p. 3448-3460 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Commensal A4 bacteria inhibit intestinal Th2-cell responses through induction of dendritic cell TGF-β production

Wu, W., Liu, H. P., Chen, F., Liu, H., Cao, A. T., Yao, S., Sun, M., Evans-Marin, H. L., Zhao, Y., Zhao, Q., Duck, L. W., Elson, C. O., Liu, Z. & Cong, Y., 2016, (Accepted/In press) In : European Journal of Immunology.

Research output: Contribution to journalArticle

18 Scopus citations

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M., Campbell, G., Milligan, G., Cong, Y., Barrett, A. & Wang, T., 2016, In : Journal of Virology. 90, 3, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
4 Scopus citations

MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In : Journal of Immunology. 196, 10, p. 4390-4399 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A. K., Nov 10 2016, In : Frontiers in Cellular and Infection Microbiology. 6, NOV, 148.

Research output: Contribution to journalArticle

8 Scopus citations

TLR5 mediates CD172α + intestinal lamina propria dendritic cell induction of Th17 cells

Liu, H., Chen, F., Wu, W., Cao, A. T., Xue, X., Yao, S., Evans-Marin, H. L., Li, Y. Q. & Cong, Y., Feb 24 2016, In : Scientific Reports. 6, 22040.

Research output: Contribution to journalArticle

18 Scopus citations

Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients

Zhou, X. Y., Li, M., Li, X., Long, X., Zuo, X. L., Hou, X. H., Cong, Y. & Li, Y. Q., Jun 14 2016, In : World Journal of Gastroenterology. 22, 22, p. 5211-5227 17 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease

Wu, W., Song, Y., He, C., Liu, C., Wu, R., Fang, L., Cong, Y., Miao, Y. & Liu, Z., Nov 17 2015, In : Scientific Reports. 5, 16344.

Research output: Contribution to journalArticle

19 Scopus citations

Endomicroscopy will track injected mesenchymal stem cells in rat colitis models

Li, M., Zhang, Y. X., Zhang, Z., Zhou, X. Y., Zuo, X. L., Cong, Y. & Li, Y. Q., Jun 12 2015, In : Inflammatory bowel diseases. 21, 9, p. 2068-2077 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

Almahariq, M., Mei, F. C., Wang, H., Cao, A. T., Yao, S., Soong, L., Sun, J., Cong, Y., Chen, J. & Cheng, X., Jan 15 2015, In : Biochemical Journal. 465, p. 295-303 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Gut homing molecule regulation of the pathogenesis and treatment of inflammatory bowel diseases

Evans-Marin, H. L. & Cong, Y., Dec 1 2015, In : Inflammation and Allergy - Drug Targets. 14, 1, p. 4-12 9 p.

Research output: Contribution to journalArticle

IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia

Dann-Grice, S., Manthey, C. F., Le, C., Miyamoto, Y., Gima, L., Abrahim, A., Cao, A. T., Hanson, E. M., Kolls, J. K., Raz, E., Cong, Y. & Eckmann, L., Sep 1 2015, In : Experimental Parasitology. 156, p. 68-78 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Interleukin (IL)-21 promotes intestinal IgA response to microbiota

Cao, A. T., Yao, S., Gong, B., Nurieva, R. I., Elson, C. O. & Cong, Y., Sep 19 2015, In : Mucosal Immunology. 8, 5, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

Wu, W., He, C., Liu, C., Cao, A. T., Xue, X., Evans-Marin, H. L., Sun, M., Fang, L., Yao, S., Pinchuk, I., Powell, D. W., Liu, Z. & Cong, Y., Nov 1 2015, In : Gut. 64, 11, p. 1755-1764 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD

He, C., Shi, Y., Wu, R., Sun, M., Fang, L., Wu, W., Liu, C., Tang, M., Li, Z., Wang, P., Cong, Y. & Liu, Z., Sep 3 2015, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

53 Scopus citations

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

Liu, H. P., Cao, A. T., Feng, T., Li, Q., Zhang, W., Yao, S., Dann, S. M., Elson, C. O. & Cong, Y., Apr 1 2015, In : European Journal of Immunology. 45, 4, p. 1010-1018 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Unexpected regulatory role of CCR9 in regulatory T cell development

Evans-Marin, H. L., Cao, A. T., Yao, S., Chen, F., He, C., Liu, H., Wu, W., Gonzalez, M. G., Dann, S. M. & Cong, Y., Jul 31 2015, In : PloS one. 10, 7, e0134100.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium

Dann, S. M., Le, C., Choudhury, B. K., Liu, H., Saldarriaga, O., Hanson, E. M., Cong, Y. & Eckmann, L., May 2014, In : Infection and immunity. 82, 5, p. 1949-1958 10 p.

Research output: Contribution to journalArticle

14 Scopus citations