Yonju Ha, PhD

  • 616 Citations
  • 15 h-Index
20032020
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Research Output 2003 2020

  • 616 Citations
  • 15 h-Index
  • 31 Article
  • 1 Chapter
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Article
2020

Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Liu, W., Ha, Y., Xia, F., Zhu, S., Li, Y., Shi, S., Mei, F. C., Merkley, K., Vizzeri, G., Motamedi, M., Cheng, X., Liu, H. & Zhang, W., Apr 6 2020, In : The Journal of experimental medicine. 217, 4

Research output: Contribution to journalArticle

Ocular Hypertension
Retinal Ganglion Cells
Glaucoma
Retina
Calcium-Calmodulin-Dependent Protein Kinase Type 2
2019
4 Citations (Scopus)

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury

Liu, W., Xia, F., Ha, Y., Zhu, S., Li, Y., Folorunso, O., Pashaei-Marandi, A., Lin, P. Y., Tilton, R., Pierce, A. P., Liu, H. & Zhang, W., Mar 1 2019, In : Investigative ophthalmology & visual science. 60, 4, p. 965-977 13 p.

Research output: Contribution to journalArticle

Open Access
Neuroprotective Agents
Reperfusion Injury
Ischemia
Reperfusion
Retinal Ganglion Cells
2018
2 Citations (Scopus)

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R., Motamedi, M., Kayed, R. & Zhang, W., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Nerve Crush
Retinal Ganglion Cells
Optic Nerve
Down-Regulation
2017
11 Citations (Scopus)
Optic Nerve Injuries
Nerve Crush
CXC Chemokines
Chemokine Receptors
Optic Nerve
7 Citations (Scopus)

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

Phenotype
Intercellular Signaling Peptides and Proteins
Posterior Uveitis
Eye Abnormalities
Pathology
2016
10 Citations (Scopus)

Hydrogen sulfide contributes to retinal neovascularization in Ischemia-Induced retinopathy

Gersztenkorn, D., Coletta, C., Zhu, S., Ha, Y., Liu, H., Tie, H., Zhou, J., Szabo, C., Zhang, W. & Motamedi, M., Jun 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3002-3009 8 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Hydrogen Sulfide
Lyases
Cystathionine
Ischemia
2015
26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
22 Citations (Scopus)

Posttranslational modification of Sirt6 activity by peroxynitrite

Hu, S., Liu, H., Ha, Y., Luo, X., Motamedi, M., Gupta, M. P., Ma, J. X., Tilton, R. & Zhang, W., 2015, In : Free Radical Biology and Medicine. 79, p. 176-185 10 p.

Research output: Contribution to journalArticle

Nitration
Peroxynitrous Acid
Post Translational Protein Processing
Tyrosine
Reactive Nitrogen Species
2014
47 Citations (Scopus)

Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

Liu, R., Liu, H., Ha, Y., Tilton, R. & Zhang, W., 2014, In : BioMed Research International. 2014, 902842.

Research output: Contribution to journalArticle

Oxidative stress
Cell Aging
Endothelial cells
Oxidative Stress
Down-Regulation
30 Citations (Scopus)

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Retina
Transcriptome
Proto-Oncogene Proteins c-bcl-2
Cell Death
31 Citations (Scopus)

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Microglia
Ligands
Lipopolysaccharides
15 Citations (Scopus)

TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization

Ameri, H., Liu, H., Liu, R., Ha, Y., Paulucci-Holthauzen, A. A., Hu, S., Motamedi, M., Godley, B. F., Tilton, R. & Zhang, W., Jan 9 2014, In : Investigative Ophthalmology and Visual Science. 55, 2, p. 801-813 13 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Hypoxia-Inducible Factor 1
Retinal Vessels
Hyperoxia
Endothelial Cells
2013
11 Citations (Scopus)

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A., Ha, Y., Gnana-Prakasam, J., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Retina
Cystathionine
Liver
Enzyme Assays
27 Citations (Scopus)

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PLoS One. 8, 1, e54692.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Medical problems
diabetes
Chemical activation
Cells
6 Citations (Scopus)

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Bone
Bone Marrow
Bone and Bones
Oxidative Stress
2012
32 Citations (Scopus)

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor

Ha, Y., Saul, A., Tawfik, A., Zorrilla, E. P., Ganapathy, V. & Smith, S. B., Nov 30 2012, In : Molecular Vision. 18, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Intraocular Pressure
Neuroprotective Agents
Oxidative Stress
2011
30 Citations (Scopus)

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

Ganapathy, P. S., Perry, R. L., Tawfik, A., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Retinal Ganglion Cells
Homocysteine
Mitochondria
Ganglia
36 Citations (Scopus)

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)

Ha, Y., Saul, A., Tawfik, A., Williams, C., Bollinger, K., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7749-7760 12 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Lenses
Retina
Optic Nerve Diseases
Molecular Chaperones
54 Citations (Scopus)

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons

Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V. & Smith, S. B., Jan 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 527-540 14 p.

Research output: Contribution to journalArticle

Retinal Neurons
Pentazocine
Endoplasmic Reticulum Stress
Oxidative Stress
Phosphorylation
52 Citations (Scopus)

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., William Caldwell, R., Kumar, S., Black, S. M. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Homocysteine
N-Methyl-D-Aspartate Receptors
D-Aspartic Acid
Ganglia
2010
26 Citations (Scopus)

Molecular and biochemical characterization of folate transport proteins in retinal müller cells

Renee Bozard, B., Ganapathy, P. S., Duplantier, J., Mysona, B., Ha, Y., Roon, P., Smith, R., David Goldman, I., Prasad, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Ependymoglial Cells
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
Folic Acid
20 Citations (Scopus)

Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine sensitivity of RGC-5 cells to homocysteine

Ganapathy, P. S., Dun, Y., Ha, Y., Duplantier, J., Allen, J. B., Farooq, A., Bozard, B. R. & Smith, S. B., Jan 2010, In : Current Eye Research. 35, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Staurosporine
Homocysteine
Cell Death
Ganglia
Neurites
2009
35 Citations (Scopus)

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: Role of cystine/glutamate exchanger

Gnana-Prakasam, J. P., Thangaraju, M., Liu, K., Ha, Y., Martin, P. M., Smith, S. B. & Ganapathy, V., Dec 1 2009, In : Biochemical Journal. 424, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Retinal Pigments
Cystine
Retinal Pigment Epithelium
Glutamic Acid
2008
13 Citations (Scopus)

Effects of aromatase inhibitor (Fadrozole)-induced sex-reversal on gonadal differentiation and mRNA expression of P450arom, AMH and ERα in embryos and growth in posthatching quail

Koba, N., Mori, M., Ha, Y., Mizushima, S., Tsukada, A., Saito, N., Ono, T. & Shimada, K., 2008, In : Journal of Poultry Science. 45, 2, p. 116-124 9 p.

Research output: Contribution to journalArticle

fadrozole
sex reversal
hormone receptors
quails
embryo (animal)
4 Citations (Scopus)

Expression of P450arom, AMH and ERα mRNA in gonads of turkey, duck and goose within one week of age

Koba, N., Ohfuji, T., Ha, Y., Mizushima, S., Tsukada, A., Saito, N. & Shimada, K., 2008, In : Journal of Poultry Science. 45, 3, p. 220-226 7 p.

Research output: Contribution to journalArticle

geese
ducks
gonads
hormones
sexual development
7 Citations (Scopus)

Identification of differently expressed genes involved in the regression and development of the chicken müllerian duct

Ha, Y., Tsukada, A., Saito, N., Zadworny, D. & Shimada, K., 2008, In : International Journal of Developmental Biology. 52, 8, p. 1135-1141 7 p.

Research output: Contribution to journalArticle

Chickens
Messenger RNA
Genes
Polymerase Chain Reaction
Up-Regulation
13 Citations (Scopus)

Profiles of mRNA expression of FOXL2, P450arom, DMRT1, AMH, P450 c17, SF1, ERα and AR, in relation to gonadal sex differentiation in duck embryo

Koba, N., Ohfuji, T., Ha, Y., Mizushima, S., Tsukada, A., Saito, N. & Shimada, K., 2008, In : Journal of Poultry Science. 45, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

sexual development
ducks
gonads
embryo (animal)
duck eggs
2005
2 Citations (Scopus)

In vivo and in vitro screening of endocrine disrupting chemicals with estrogenic activity in Japanese quail

Shimada, K., Ha, Y., Tsukada, A., Saito, N., Maekawa, S., Nishizuka, M. & Imagawa, M., 2005, In : Avian and Poultry Biology Reviews. 16, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

estrogenic properties
endocrine-disrupting chemicals
quails
incubation
egg
2004
19 Citations (Scopus)

Changes in mRNA expression of MMP-2 in the Müllerian duct of chicken embryo

Ha, Y., Tsukada, A., Saito, N. & Shimada, K., Nov 2004, In : General and Comparative Endocrinology. 139, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

gelatinase A
Matrix Metalloproteinases
Chickens
embryo (animal)
Embryonic Structures
13 Citations (Scopus)

Expression of estrogen receptor α mRNA in theca and granulosa layers of the ovary in relation to follicular growth in quail

Hrabia, A., Ha, Y. & Shimada, K., 2004, In : Folia Biologica. 52, 3-4, p. 191-195 5 p.

Research output: Contribution to journalArticle

Quail
Estrogen Receptor alpha
quails
Estrogen Receptors
Ovary
2003
11 Citations (Scopus)

Effect of Endocrine Disrupters on mRNA Expression of Vitellogenin (VTG) II and Very Low Density Lipoprotein (apo VLDL) II in the Liver of Quail Embryos

Ichikawa, K., Ha, Y., Tsukada, A., Saito, N. & Shimada, K., 2003, In : Journal of Poultry Science. 40, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

endocrine-disrupting chemicals
very low density lipoprotein
vitellogenin
quails
embryo (animal)