Yuhui Yin, MD, PhD

  • 1089 Citations
  • 14 h-Index
1996 …2023

Research output per year

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Research Output

  • 1089 Citations
  • 14 h-Index
  • 30 Article
  • 1 Comment/debate
  • 1 Review article
2020

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

Singh, A., Pandey, M., Nandakumar, D., Raney, K. D., Yin, Y. W. & Patel, S. S., Jan 1 2020, (Accepted/In press) In : EMBO Journal. e103367.

Research output: Contribution to journalArticle

Open Access

Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

Anderson, A. P., Luo, X., Russell, W. & Yin, Y. W., Jan 24 2020, In : Nucleic acids research. 48, 2, p. 817-829 13 p.

Research output: Contribution to journalArticle

Open Access

Structural Energy Landscapes and Plasticity of the Microstates of Apo Escherichia coli cAMP Receptor Protein

Chkheidze, R., Evangelista, W., White, M. A., Yin, Y. W. & Lee, J. C., Feb 4 2020, In : Biochemistry. 59, 4, p. 460-470 11 p.

Research output: Contribution to journalArticle

Transcription polymerase-catalyzed emergence of novel RNA replicons

Jain, N., Blauch, L. R., Szymanski, M. R., Das, R., Tang, S. K. Y., Yin, Y. W. & Fire, A. Z., Apr 10 2020, In : Science. 368, 6487, eaay0688.

Research output: Contribution to journalArticle

2019

Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase

Sowers, M. L., Anderson, A. P. P., Wrabl, J. O. & Yin, Y. W., Jul 10 2019, In : Journal of the American Chemical Society. 141, 27, p. 10821-10829 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

Wen, J. J., Yin, Y. & Garg, N., May 1 2018, In : PLoS Pathogens. 14, 5, e1007065.

Research output: Contribution to journalArticle

9 Scopus citations
2017

A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Szymanski, M. R., Yu, W., Gmyrek, A. M., White, M., Molineux, I. J., Lee, J. C. & Yin, Y., Jan 1 2017, In : Nature Communications. 8, 14959.

Research output: Contribution to journalArticle

7 Scopus citations

Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based

Williams, T. L., Yin, Y. W. & Carter, C. W., Jan 1 2016, In : Journal of Biological Chemistry. 291, 1, p. 255-265 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

The DNA polymerase gamma R953C mutant is associated with antiretroviral therapy-induced mitochondrial toxicity

Li, M., Mislak, A. C., Foli, Y., Agbosu, E., Bose, V., Bhandari, S., Szymanski, M. R., Shumate, C. K., Yin, Y., Anderson, K. S. & Paintsil, E., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5608-5611 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA

Ramachandran, A., Nandakumar, D., Deshpande, A. P., Lucas, T. P., R-Bhojappa, R., Tang, G. Q., Raney, K., Yin, Y. & Patel, S. S., Aug 5 2016, In : Journal of Biological Chemistry. 291, 32, p. 16828-16839 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y., Jul 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8596-8601 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

Szymanski, M. R., Kuznetsov, V. B., Shumate, C., Meng, Q., Lee, Y. S., Patel, G., Patel, S. & Yin, Y., 2015, In : EMBO Journal. 34, 14, p. 1959-1970 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

Meyer, A. J., Garry, D. J., Hall, B., Byrom, M. M., McDonald, H. G., Yang, X., Yin, Y. & Ellington, A. D., Jul 7 2015, In : Nucleic Acids Research. 43, 15, p. 7480-7488 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Yeast mitochondrial transcription factor Mtf1 determines the precision of promoter-directed initiation of RNA polymerase Rpo41

Yang, X., Chang, H. R. & Yin, Y., Sep 2 2015, In : PLoS One. 10, 9, e0136879.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence

Theruvathu, J. A., Yin, Y. W., Pettitt, B. M. & Sowers, L. C., Nov 26 2013, In : Biochemistry. 52, 47, p. 8590-8598 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Exonuclease of human DNA polymerase gamma disengages its strand displacement function

He, Q., Shumate, C. K., White, M. A., Molineux, I. J. & Yin, Y. W., Nov 1 2013, In : Mitochondrion. 13, 6, p. 592-601 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Structural insight on processivity, human disease and antiviral drug toxicity

Yin, Y. W., Feb 1 2011, In : Current Opinion in Structural Biology. 21, 1, p. 83-91 9 p.

Research output: Contribution to journalReview article

2 Scopus citations
2010

A single mutation in human mitochondrial DNA polymerase Pol γA affects both polymerization and proofreading activities of only the holoenzyme

Lee, Y. S., Johnson, K. A., Molineux, I. J. & Yin, Y. W., Sep 3 2010, In : Journal of Biological Chemistry. 285, 36, p. 28105-28116 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity

Lee, Y. S., Lee, S., Demeler, B., Molineux, I. J., Johnson, K. A. & Yin, Y. W., Jan 19 2010, In : Journal of Biological Chemistry. 285, 2, p. 1490-1499 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

Lee, Y. S., Kennedy, W. D. & Yin, Y. W., Oct 16 2009, In : Cell. 139, 2, p. 312-324 13 p.

Research output: Contribution to journalArticle

128 Scopus citations

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations (DOI:10.1016/j.cell.2009.07.050)

Lee, Y. S., Kennedy, W. D. & Yin, Y. W., Nov 13 2009, In : Cell. 139, 4, 1 p.

Research output: Contribution to journalComment/debate

2007

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease

Challa, M., Malladi, S., Pellock, B. J., Dresnek, D., Varadarajan, S., Yin, Y. W., White, K. & Bratton, S. B., Jul 11 2007, In : EMBO Journal. 26, 13, p. 3144-3156 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Mechanism for De Novo RNA Synthesis and Initiating Nucleotide Specificity by T7 RNA Polymerase

Kennedy, W. P., Momand, J. R. & Yin, Y. W., Jul 6 2007, In : Journal of Molecular Biology. 370, 2, p. 256-268 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

Accuracy, lesion bypass, strand displacement and translocation by DNA polymerases

Steitz, T. A. & Yin, Y. W., Jan 29 2004, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 359, 1441, p. 17-23 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

The structural mechanism of translocation and helicase activity in T7 RNA polymerase

Yin, Y. W. & Steitz, T. A., Feb 6 2004, In : Cell. 116, 3, p. 393-404 12 p.

Research output: Contribution to journalArticle

237 Scopus citations
2003

Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: Structures of ATP bound to open and closed, pre-transition-state conformations

Retailleau, P., Huang, X., Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V. & Carter, C. W., Jan 1 2003, In : Journal of Molecular Biology. 325, 1, p. 39-63 25 p.

Research output: Contribution to journalArticle

70 Scopus citations
2002

Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

Yin, Y. W. & Steitz, T. A., Nov 15 2002, In : Science. 298, 5597, p. 1387-1395 9 p.

Research output: Contribution to journalArticle

246 Scopus citations
2001

High-resolution experimental phases for tryptophanyl-tRNA synthetase (TrpRS) complexed with tryptophanyl-5′AMP

Retailleau, P., Yin, Y., Hu, M., Roach, J., Bricogne, G., Vonrhein, C., Roversi, P., Blanc, E., Sweet, R. M. & Carter, J., Nov 20 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 11, p. 1595-1608 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2000

2.9 Å Crystal structure of ligand-free tryptophanyl-tRNA synthetase: Domain movements fragment the adenine nucleotide binding site

Ilyin, V. A., Temple, B., Hu, M., Li, G., Yin, Y., Vachette, P. & Carter, C. W., Mar 13 2000, In : Protein Science. 9, 2, p. 218-231 14 p.

Research output: Contribution to journalArticle

62 Scopus citations
1996
27 Scopus citations