Yumei Ye, MD

  • 2640 Citations
  • 28 h-Index
20002020

Research output per year

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Research Output

  • 2640 Citations
  • 28 h-Index
  • 66 Article
  • 6 Review article
  • 2 Comment/debate
  • 1 Editorial
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Article
2020

Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay

Chen, H., Tran, D., Yang, H. C., Nylander, S., Birnbaum, Y. & Ye, Y., Jan 1 2020, (Accepted/In press) In : Cardiovascular Drugs and Therapy.

Research output: Contribution to journalArticle

Does Inhibition of Nuclear Factor Kappa B Explain the Protective Effect of Ticagrelor on Myocardial Ischemia-Reperfusion Injury?

Birnbaum, Y., Ye, Y. & Perez-Polo, J. R., Feb 1 2020, In : Journal of cardiovascular pharmacology. 75, 2, p. 108-111 4 p.

Research output: Contribution to journalArticle

2019

DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome

Birnbaum, Y., Tran, D., Bajaj, M. & Ye, Y., Sep 1 2019, In : Basic Research in Cardiology. 114, 5, 35.

Research output: Contribution to journalArticle

7 Scopus citations

The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury

Siebert, V., Allencherril, J., Ye, Y., Wehrens, X. H. T. & Birnbaum, Y., Aug 15 2019, In : Cardiovascular Drugs and Therapy. 33, 4, p. 489-498 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
2 Scopus citations
2018

Circulating miRNA Expression Profiling and Target Prediction in Patients Receiving Dexmedetomidine

Yang, X., Chen, H., Chen, Y., Birnbaum, Y., Liang, R., Ye, Y. & Qian, J., Oct 1 2018, In : Cellular Physiology and Biochemistry. 50, 2, p. 569-584 16 p.

Research output: Contribution to journalArticle

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

Birnbaum, Y., Bajaj, M., Yang, H. C. & Ye, Y., Mar 5 2018, (Accepted/In press) In : Cardiovascular Drugs and Therapy. p. 1-11 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Dapagliflozin Attenuates Na+/H+ Exchanger-1 in Cardiofibroblasts via AMPK Activation

Ye, Y., Jia, X., Bajaj, M. & Birnbaum, Y., Jan 1 2018, (Accepted/In press) In : Cardiovascular Drugs and Therapy.

Research output: Contribution to journalArticle

14 Scopus citations

Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy

Yang, Y., Chen, H., Ding, N., Wang, S., Duan, Z., Birnbaum, Y., Ye, Y. & Qian, J., May 1 2018, In : Cellular Physiology and Biochemistry. 46, 6, p. 2284-2296 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

GLP-1 Receptor Agonists and Cardiovascular Disease: a Meta-Analysis of Recent Cardiac Outcome Trials

Jia, X., Alam, M., Ye, Y., Bajaj, M. & Birnbaum, Y., Feb 14 2018, (Accepted/In press) In : Cardiovascular Drugs and Therapy. p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Size matters in STEMI: time for translation of ticagrelor?

Birnbaum, Y. & Ye, Y., Dec 1 2018, In : Cardiovascular Research. 114, 14, p. 1817-1818 2 p.

Research output: Contribution to journalArticle

2017

Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ Agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia

Chen, Y., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M., Ye, Y. & Qian, J., Mar 1 2017, In : Diabetes and Vascular Disease Research. 14, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
58 Scopus citations

Unraveling the Interaction of Aspirin, Ticagrelor, and Rosuvastatin on the Progression of Atherosclerosis and Inflammation in Diabetic Mice

Ye, Y., Nylander, S. & Birnbaum, Y., Nov 28 2017, (Accepted/In press) In : Cardiovascular Drugs and Therapy. p. 1-12 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Aleglitazar, a Balanced Dual PPARα and -γ Agonist, Protects the Heart Against Ischemia-Reperfusion Injury

Qian, J., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M. & Ye, Y., Feb 10 2016, (Accepted/In press) In : Cardiovascular Drugs and Therapy. p. 1-13 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

Birnbaum, Y., Bajaj, M., Qian, J. & Ye, Y., Aug 1 2016, In : BMJ Open Diabetes Research and Care. 4, 1, e000227.

Research output: Contribution to journalArticle

29 Scopus citations

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

Birnbaum, Y., Birnbaum, G. D., Birnbaum, I., Nylander, S. & Ye, Y., Dec 1 2016, In : Cardiovascular Drugs and Therapy. 30, 6, p. 539-550 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Type 2 diabetes and cardiovascular disease: A metabolic overview of recent clinical trials

Birnbaum, Y., Ye, Y. & Bajaj, M., 2016, (Accepted/In press) In : Journal of Diabetes and its Complications.

Research output: Contribution to journalArticle

1 Scopus citations
2015
15 Scopus citations

Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction

Ye, Y., Birnbaum, G. D., Perez-Polo, J. R., Nanhwan, M. K., Nylander, S. & Birnbaum, Y., Aug 25 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 8, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

61 Scopus citations
2014

Chronic treatment with ticagrelor limits myocardial infarct size: An adenosine and cyclooxygenase-2-dependent effect

Nanhwan, M. K., Ling, S., Kodakandla, M., Nylander, S., Ye, Y. & Birnbaum, Y., Sep 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 9, p. 2078-2085 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins

Birnbaum, Y., Nanhwan, M. K., Ling, S., Perez-Polo, J. R., Ye, Y. & Bajaj, M., Oct 1 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 447-457 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Dickkopf-1 (DKK1) phosphatase and tensin homolog on chromosome 10 (PTEN) crosstalk via microRNA interference in the diabetic heart

Ling, S., Birnbaum, Y., Nanhwan, M. K., Thomas, B., Bajaj, M., Li, Y., Li, Y. & Ye, Y., May 2 2013, In : Basic Research in Cardiology. 108, 3, 352.

Research output: Contribution to journalArticle

20 Scopus citations

MicroRNA-dependent cross-talk between VEGF and HIF1α in the diabetic retina

Ling, S., Birnbaum, Y., Nanhwan, M. K., Thomas, B., Bajaj, M. & Ye, Y., Dec 2013, In : Cellular Signalling. 25, 12, p. 2840-2847 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Modulation of microRNAs in hypertension-induced arterial remodeling through the β1 and β3-adrenoreceptor pathways

Ling, S., Nanhwan, M., Qian, J., Kodakandla, M., Castillo, A. C., Thomas, B., Liu, H. & Ye, Y., Dec 1 2013, In : Journal of Molecular and Cellular Cardiology. 65, p. 127-136 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Nebivolol induces distinct changes in profibrosis MicroRNA expression compared with atenolol, in salt-sensitive hypertensive rats

Ye, H., Ling, S., Castillo, A. C., Thomas, B., Long, B., Qian, J., Perez-Polo, J. R., Ye, Y., Chen, X. & Birnbaum, Y., May 1 2013, In : Hypertension. 61, 5, p. 1008-1013 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes

Ye, Y., Qian, J., Castillo, A. C., Ling, S., Ye, H., Perez-Polo, J. R., Bajaj, M. & Birnbaum, Y., Jan 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 1, p. H131-H141

Research output: Contribution to journalArticle

19 Scopus citations
2012

Phosphodiesterase III Inhibition Increases cAMP levels and augments the infarct size limiting effect of a dpp-4 inhibitor in mice with type-2 diabetes mellitus

Birnbaum, Y., Castillo, A. C., Qian, J., Ling, S., Ye, H., Perez-Polo, J. R., Bajaj, M. & Ye, Y., Dec 1 2012, In : Cardiovascular Drugs and Therapy. 26, 6, p. 445-456 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of phosphatase and tensin homolog on chromosome 10 in response to Hypoxia

Qian, J., Ling, S., Castillo, A. C., Long, B., Birnbaum, Y. & Ye, Y., May 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 9, p. H1806-H1817

Research output: Contribution to journalArticle

18 Scopus citations

The effect of pioglitazone treatment on 15-epi-lipoxin A 4 levels in patients with type 2 diabetes

Gutierrez, A. D., Sathyanarayana, P., Konduru, S., Ye, Y., Birnbaum, Y. & Bajaj, M., Jul 1 2012, In : Atherosclerosis. 223, 1, p. 204-208 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice

Ye, Y., Qian, J., Castillo, A. C., Perez-Polo, J. R. & Birnbaum, Y., Dec 1 2011, In : Cardiovascular Drugs and Therapy. 25, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effect of miR-23 on Oxidant-induced injury in human retinal pigment epithelial cells

Lin, H., Qian, J., Castillo, A. C., Long, B., Keyes, K. T., Chen, G. & Ye, Y., Aug 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6308-6314 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Impact of HMG-CoA reductase inhibition on oxidant-induced injury in human retinal pigment epithelium cells

Qian, J., Keyes, K. T., Long, B., Chen, G. & Ye, Y., Sep 1 2011, In : Journal of Cellular Biochemistry. 112, 9, p. 2480-2489 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

Birnbaum, Y., Long, B., Qian, J., Perez-Polo, J. R. & Ye, Y., May 1 2011, In : Basic Research in Cardiology. 106, 3, p. 431-446 16 p.

Research output: Contribution to journalArticle

36 Scopus citations
2010

Additive effect of TAK-491, a new angiotensin receptor blocker, and pioglitazone, in reducing myocardial infarct size

Ye, Y., Keyes, K. T., Zhang, C. F., Perez-Polo, J. R., Lin, Y. & Birnbaum, Y., Apr 1 2010, In : Cardiovascular Drugs and Therapy. 24, 2, p. 107-120 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dipyridamole with low-dose aspirin augments the infarct size-limiting effects of simvastatin

Ye, Y., Long, B., Qian, J., Perez-Polo, J. R. & Birnbaum, Y., Dec 1 2010, In : Cardiovascular Drugs and Therapy. 24, 5-6, p. 391-399 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γagonist protects against myocardial ischaemia-reperfusion injury

Ye, Y., Hu, Z., Lin, Y., Zhang, C. & Perez-Polo, J. R., Aug 2010, In : Cardiovascular research. 87, 3, p. 535-544 10 p.

Research output: Contribution to journalArticle

162 Scopus citations

Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction

Keyes, K. T., Xu, J., Long, B., Zhang, C., Hu, Z. & Ye, Y., Apr 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 4, p. H1198-H1208

Research output: Contribution to journalArticle

76 Scopus citations

Protecting against ischemia-reperfusion injury: Antiplatelet drugs, statins, and their potential interactions

Ye, Y., Perez-Polo, J. R. & Birnbaum, Y., Jan 1 2010, In : Annals of the New York Academy of Sciences. 1207, p. 76-82 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Resolvin E1 protects the rat heart against reperfusion injury

Keyes, K. T., Ye, Y., Lin, Y., Zhang, C., Perez-Polo, J. R., Gjorstrup, P. & Birnbaum, Y., Jul 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 1, p. H153-H164

Research output: Contribution to journalArticle

107 Scopus citations

The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA

Ye, Y., Keyes, K. T., Zhang, C., Perez-Polo, J. R., Lin, Y. & Birnbaum, Y., May 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 5, p. H1454-H1465

Research output: Contribution to journalArticle

130 Scopus citations
2008

Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat

Ye, Y., Abu Said, G. H., Lin, Y., Manickavasagam, S., Hughes, M. G., McAdoo, D. J., Perez-Polo, R. J. & Birnbaum, Y., Aug 1 2008, In : Cardiovascular Drugs and Therapy. 22, 4, p. 275-282 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone

Ye, Y., Lin, Y., Perez-Polo, J. R. & Birnbaum, Y., Dec 1 2008, In : Cardiovascular Drugs and Therapy. 22, 6, p. 429-436 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylation of 5-lipoxygenase at Ser523 by protein kinase A determines whether pioglitazone and atorvastatin induce proinflammatory leukotriene B4 or anti-inflammatory 15-epi-lipoxin A4 production

Ye, Y., Lin, Y., Perez-Polo, J. R., Uretsky, B. F., Ye, Z., Tieu, B. C. & Birnbaum, Y., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3515-3523 9 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice

Ye, Y., Lin, Y., Manickavasagam, S., Perez-Polo, J. R., Tieu, B. C. & Birnbaum, Y., Dec 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 6, p. H2436-H2446

Research output: Contribution to journalArticle

39 Scopus citations

Pretreatment with high-dose statin, but not low-dose statin, ezetimibe, or the combination of low-dose statin and ezetimibe, limits infarct size in the rat

Birnbaum, Y., Lin, Y., Ye, Y., Merla, R., Perez-Polo, J. R. & Uretsky, B. F., Mar 1 2008, In : Journal of Cardiovascular Pharmacology and Therapeutics. 13, 1, p. 72-79 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

The role of eNOS, iNOS, and NF-κB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin

Ye, Y., Martinez, J. D., Perez-Polo, R. J., Lin, Y., Uretsky, B. F. & Birnbaum, Y., Jul 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 1, p. H343-H351

Research output: Contribution to journalArticle

63 Scopus citations
2007

Activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2

Ye, Y., Nishi, S. P., Manickavasagam, S., Lin, Y., Huang, M. H., Perez-Polo, J. R., Uretsky, B. F. & Birnbaum, Y., Aug 1 2007, In : Prostaglandins and Other Lipid Mediators. 84, 1-2, p. 43-53 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart

Birnbaum, Y., Ye, Y., Lin, Y., Freeberg, S. Y., Huang, M. H., Perez-Polo, J. R. & Uretsky, B. F., Feb 1 2007, In : Prostaglandins and Other Lipid Mediators. 83, 1-2, p. 89-98 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Aspirin before reperfusion blunts the infarct size limiting effect of atorvastatin

Birnbaum, Y., Lin, Y., Ye, Y., Martinez, J. D., Huang, M. H., Lui, C. Y., Perez-Polo, J. R. & Uretsky, B. F., Jun 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 6, p. H2891-H2897

Research output: Contribution to journalArticle

23 Scopus citations