Projects per year
Personal profile
Research Strategic Pillar
The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Research interests
"Mechano-medicine" is an emerging concept that tries to prevent and cure diseases by combining mechanobiology with biomedicine. The Chen lab focuses its research on the interface of mechanobiology, vascular biology and biomedicine. We use multidisciplinary approaches to 1) understand the mechanobiology of cells and molecules, including force-regulated molecular binding and conformational change, cell adhesion and mechano-signaling, in the vascular system; 2) shed light on the mechanobiology-related pathogenesis of vascular dysfunctions like thrombosis, atherosclerosis and cancer metastasis; and 3) eventually, develop mechanobiology-inspired therapeutics and research/diagnostic tools abiding the concept of ‘mechano-medicine’. The approaches of Chen lab can be summarized in seven M’s: Mechanics (investigating the mechanobiology of cell physiology and pathology); Microscopy (combining super-resolution imaging with force spectroscopy); Microfabrication (manufacturing microfluidic devices to realize high-throughput experimentation and develop mechanobiology-based diagnostic tools); Molecular engineering (designing and making protein mutants to understand disease pathology and explore potential therapeutic strategies); Molecular dynamics simulation (via collaboration, understanding the mechanisms underlying mechanobiological molecular behaviors); Mouse models (use transgenic mice to create disease models); and finally Mechano-medicine (designing and testing new therapeutics).
Research Strategic Pillar Keywords
- Specialized Health
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Collaborations and top research areas from the last five years
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Projects
- 2 Completed
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High-throughput 3D profiling of single T-cells in neurodegenerative diseases
Chen, Y. (PI)
University of Pennsylvania ( Award #10086034)
9/1/22 → 8/31/23
Project: Research project
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Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasis
Chen, Y. (PI)
National Heart, Lung and Blood Institute ( Award #5R00HL15367805)
4/1/22 → 3/31/25
Project: Research project
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CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation
Younis, D. A., Marosvari, M., Liu, W., Pulikkot, S., Cao, Z., Zhou, B., Vella, A. T., McArdle, S., Hu, L., Chen, Y., Gan, W., Yu, J., Bruscia, E. M. & Fan, Z., Jan 21 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 3, e2412717122.Research output: Contribution to journal › Article › peer-review
Open Access -
Conformational response of αIIbβ3 and αVβ3 integrins to force
Kolasangiani, R., Farzanian, K., Chen, Y., Schwartz, M. A. & Bidone, T. C., Feb 6 2025, In: Structure. 33, 2, p. 289-299.e4Research output: Contribution to journal › Article › peer-review
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Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
Wu, Y., Cao, Z., Liu, W., Cahoon, J. G., Wang, K., Wang, P., Hu, L., Chen, Y., Moser, M., Vella, A. T., Ley, K., Wen, L. & Fan, Z., Dec 2025, In: Cell Communication and Signaling. 23, 1, 12.Research output: Contribution to journal › Article › peer-review
Open Access -
Force-Regulated Spontaneous Conformational Changes of Integrins α5β1and αVβ3
Chen, Y., Li, Z., Kong, F., Ju, L. A. & Zhu, C., Jan 9 2024, In: ACS Nano. 18, 1, p. 299-313 15 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Monitoring Circulating Myeloid Cells in Peritonitis with an In Vivo Imaging Flow Cytometer
Pulikkot, S., Paul, S., Hall, A., Gardner, B., Liu, W., Hu, L., Vella, A. T., Chen, Y. & Fan, Z., Aug 2024, In: Biomolecules. 14, 8, 886.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations