Projects per year
Personal profile
Research interests
"Mechano-medicine" is an emerging concept that tries to prevent and cure diseases by combining mechanobiology with biomedicine. The Chen lab focuses its research on the interface of mechanobiology, vascular biology and biomedicine. We use multidisciplinary approaches to 1) understand the mechanobiology of cells and molecules, including force-regulated molecular binding and conformational change, cell adhesion and mechano-signaling, in the vascular system; 2) shed light on the mechanobiology-related pathogenesis of vascular dysfunctions like thrombosis, atherosclerosis and cancer metastasis; and 3) eventually, develop mechanobiology-inspired therapeutics and research/diagnostic tools abiding the concept of ‘mechano-medicine’. The approaches of Chen lab can be summarized in seven M’s: Mechanics (investigating the mechanobiology of cell physiology and pathology); Microscopy (combining super-resolution imaging with force spectroscopy); Microfabrication (manufacturing microfluidic devices to realize high-throughput experimentation and develop mechanobiology-based diagnostic tools); Molecular engineering (designing and making protein mutants to understand disease pathology and explore potential therapeutic strategies); Molecular dynamics simulation (via collaboration, understanding the mechanisms underlying mechanobiological molecular behaviors); Mouse models (use transgenic mice to create disease models); and finally Mechano-medicine (designing and testing new therapeutics).
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Collaborations and top research areas from the last five years
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Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasis
4/1/22 → 3/31/25
Project: Other project
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High-throughput 3D profiling of single T-cells in neurodegenerative diseases
9/1/22 → 8/31/23
Project: Other project
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High-throughput 3D profiling of single T-cells in neurodegenerative diseases
9/1/22 → 8/31/23
Project: Other project
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Memory in repetitive protein-protein interaction series
Rosado, A. M., Zhang, Y., Choi, H. K., Chen, Y., Ehrlich, S. M., Jin, F., Grakoui, A., Evavold, B. D. & Zhu, C., Mar 1 2023, In: APL Bioengineering. 7, 1, 016102.Research output: Contribution to journal › Article › peer-review
Open Access -
Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: A translational study
Chen, Y., Fu, W., Zheng, Y., Yang, J., Liu, Y., Qi, Z., Wu, M., Fan, Z., Yin, K., Chen, Y., Gao, W., Ding, Z., Dong, J., Li, Q., Zhang, S. & Hu, L., Oct 7 2022, In: European Heart Journal. 43, 37, p. 3556-3574 19 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Generation, Transmission, and Regulation of Mechanical Forces in Embryonic Morphogenesis
Sutlive, J., Xiu, H., Chen, Y., Gou, K., Xiong, F., Guo, M. & Chen, Z., Feb 10 2022, In: Small. 18, 6, 2103466.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Integrin Regulators in Neutrophils
Pulikkot, S., Hu, L., Chen, Y., Sun, H. & Fan, Z., Jul 1 2022, In: Cells. 11, 13, 2025.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Nexinhib20 Inhibits Neutrophil Adhesion and b2 Integrin Activation by Antagonizing Rac-1-Guanosine 59-Triphosphate Interaction
Liu, W., Cronin, C. G., Cao, Z., Wang, C., Ruan, J., Pulikkot, S., Hall, A., Sun, H., Groisman, A., Chen, Y., Vella, A. T., Hu, L., Liang, B. T. & Fan, Z., Oct 15 2022, In: Journal of Immunology. 209, 8, p. 1574-1585 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations