Developing an Ideal First Use Agent to Prevent Sepsis in Trauma Wounds During Care Under Fire (CUF)

Scope of Work: UTMB will perform the SOW as follows:

1. Submission of the animal protocol to the UTMB- IACUC and follow up with addressing the reviewers' comments
2. Perform an animal study using 4 pigs that will consist of the following:

1. Perform a wound excision-infection model following an agreed-on protocol
2. Treat wounds with transforming powder for 7 days
3. Collect skin biopsies at 3 and 7 days to be divided by 2 for:

1. Determination of bacterial load using microbiology techniques using one-half of the biopsy
2. Fix the rest of the biopsies, process, and paraffin embed the tissue using the second half of the biopsy