Exploiting Integrin Signaling to Overcome Resistance to Immunotherapy

Dr. Gupta’s laboratory in the Department of Internal Medicine at University of Texas Medical Branch (UTMB) will conduct in vitro and in vivo mechanistic work, as proposed in Aim 1. This also includes in vitro functional assays with isolated myeloid cell populations. The Gupta laboratory will also perform qRT-PCR based analyses on a subset of genes identified from RNAseq assays, as proposed in Aim 1. Dr. Gupta identified the CD11b small molecule agonist ADH-503 in his laboratory and will also provide this reagent for all the proposed studies in this grant application. Additionally, The CD11b-KI mice, as proposed in this grant application, were generated in the Gupta laboratory and will be made available for the proposed studies