Increased Activity and Lifespan Through Low Frequency Ultrasound Therapy

Overall, the mechanical reversal of aging by LFU can have significant benefits for the elderly and further improvements in the therapy can potentially extend healthy lifespans by well over 20% in the near future. A goal of the lab research is to prolong the lifespan of animals to a similar extent that we can prolong aged cell growth, i.e. about two-fold. This is an ambitious but possibly achievable goal for mice. There are cytoskeleton binding drugs that increase LFU-induced senescent cell growth by two-fold and those compounds are approved for cancer chemotherapy at much higher levels than the levels needed to enhance rejuvenation of aged cells by LFU. Since SASP levels correlate with frailty, measurements of blood levels in mice will determine how well aging symptoms are reduced by treatment as well as DNA methylation levels (Picca et al., 2022). Using these markers, it will be possible to establish the best combination of drugs and LFU parameters to maximally increase lifespan with high activity levels.