Project Details
Description
Generate lipid nanoparticle-formulated vaccines against Sin Nombre and Hantaan virus based on U-mRNA, 1-methylpseudouridine-mRNA and circular RNA. Generate polymer nanoparticle formulations of vaccines against Sin Nombre and Hantaan virus and compare their immunogenicity and protective efficacy with their respective lipid nanoparticle formulations. To investigate the protective efficacy and immunogenicity of the vaccine constructs and formulations in animal models.
Bukreyev, Alexander PD/Pl
Abbott, Robert Co-PD/Pl
Ksiazek, Thomas Co-PD/Pl
| Status | Active |
|---|---|
| Effective start/end date | 8/20/24 → 7/31/27 |
Funding
- Vanderbilt University Medical Center ( Award #1U19AI18197901): $1,712,000.00
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