Tau-RNA crosstalk: Alternative Poly-Adenylation (APA) Regulation in Alzheimer's Disease

The proposed research is relevant to public health because it focuses on identifying key alternative poly-adenylated mRNA isoforms underpinning the detrimental action of pathological tau oligomers that characterize various tauopathies including Alzheimer’s disease (AD) and AD related dementia (ADRD). This is ultimately expected to drive the development of a novel, effective preventive/curative therapy for AD and tauopathies, thus improving patients’ health while driving down the societal cost for their care, which is expected to increase to unbearable proportions by the year 2050. Thus, the proposed research is relevant to the part of NIH’s mission concerned with fostering creative discoveries by new generation of neuroscientists, and their application to advance the nation’s capacity to protect and improve human health