α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model

H. Nakazawa, T. O. Gustafsson, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Inhalation injury is a dominant cause of mortality in thermally injured individuals. After acute lung injury induced by smoke inhalation, lung lymph flow (Q̇L) increased and pulmonary microvascular reflection coefficient to protein (σ) decreased, α-Trinositol (PP56, 1D-myo-inositol 1,2,6- trisphosphate) can decrease edema formation after thermal injury. We therefore tested the hypothesis that α-trinositol could decrease the pulmonary edema noted with inhalation injury. Seven days after surgical preparation, sheep were insufflated with smoke from burning cotton towels. The α-trinositol group (n = 8) were treated with α-trinositol (2 mg/kg + 3.5 mg · kg-1 · h-1). The sham group (n = 7) received an equal volume of 0.9% NaCl. The sham group showed a large increase in Q̇L (9.3 ± 1.7 to 54.1 ± 8.8 ml/h) and a decrease in σ (0.79 ± 0.03 to 0.48 ± 0.03) 24 h after smoke inhalation. α-Trinositol attenuated the increase in Q̇L (8.1 ± 1.2 to 25.6 ± 6.9 ml/h) and the decrease in σ (0.76 ± 0.03 to 0.60 ± 0.03) noted with smoke inhalation. α-Trinositol thus decreased the changes in pulmonary microvascular permeability and transvascular fluid flux noted with inhalation injury.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalJournal of Applied Physiology
Volume76
Issue number1
StatePublished - 1994

Fingerprint

Smoke
Inhalation
Edema
Sheep
Lung
Wounds and Injuries
Acute Lung Injury
Capillary Permeability
Lymph
Inositol
Pulmonary Edema
Hot Temperature
Mortality
Proteins

Keywords

  • burns
  • inhalation injury
  • inositol phosphates
  • lung lymph flow
  • reflection coefficient

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Nakazawa, H., Gustafsson, T. O., Traber, L. D., Herndon, D., & Traber, D. L. (1994). α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model. Journal of Applied Physiology, 76(1), 278-282.

α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model. / Nakazawa, H.; Gustafsson, T. O.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Applied Physiology, Vol. 76, No. 1, 1994, p. 278-282.

Research output: Contribution to journalArticle

Nakazawa, H, Gustafsson, TO, Traber, LD, Herndon, D & Traber, DL 1994, 'α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model', Journal of Applied Physiology, vol. 76, no. 1, pp. 278-282.
Nakazawa H, Gustafsson TO, Traber LD, Herndon D, Traber DL. α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model. Journal of Applied Physiology. 1994;76(1):278-282.
Nakazawa, H. ; Gustafsson, T. O. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model. In: Journal of Applied Physiology. 1994 ; Vol. 76, No. 1. pp. 278-282.
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