β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas

Q. Quentin Li, Gangduo Wang, Huasheng Liang, Jueli M. Li, Furong Huang, Piyush K. Agarwal, Yuhua Zhong, Eddie Reed

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Cisplatin-based combination treatment is the most effective systemic chemotherapy for bladder cancer; however, resistance to cisplatin remains a significant problem in the treatment of this disease. β-Elemene is a new natural compound that blocks cell-cycle progression and has a broad spectrum of antitumor activity. This study was conducted to explore the potential of β-elemene as a chemosensitizer for enhancing the therapeutic efficacy and potency of cisplatin in bladder cancer and other solid carcinomas. β-Elemene not only markedly inhibited cell growth and proliferation but also substantially increased cisplatin cytotoxicity towards human bladder cancer 5637 and T-24 cells. Similarly, β-elemene also enhanced cisplatin sensitivity and augmented cisplatin cytotoxicity in small-cell lung cancer and carcinomas of the brain, breast, cervix, ovary, and colorectal tract in vitro, with dose-modifying factors ranging from 5 to 124. β-Elemene-enhanced cisplatin cytotoxicity was associated with increased apoptotic cell death, as determined by DNA fragmentation, and increased activities of caspase-3, -7, -8, -9, and -10 in bladder cancer cell lines. Collectively, these results suggest that β-elemene augments the antitumor activity of cisplatin in human bladder cancer by enhancing the induction of cellular apoptosis via a caspase-dependent mechanism. Cisplatin combined with β-elemene as a chemosensitizer warrants further pre-clinical therapeutic studies and may be useful for the treatment of cisplatin-resistant bladder cancer and other types of carcinomas.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalAnticancer Research
Volume33
Issue number4
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Cisplatin
Cell Death
Carcinoma
Small Cell Lung Carcinoma
elemene
Caspase 7
Therapeutics
DNA Fragmentation
Caspases
Cervix Uteri
Brain Neoplasms
Caspase 3
Ovary
Cell Cycle
Breast
Cell Proliferation
Apoptosis
Drug Therapy
Cell Line

Keywords

  • β-elemene
  • Apoptosis
  • Bladder cancer
  • Caspases
  • Chinese medicine
  • Cisplatin resistance

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Quentin Li, Q., Wang, G., Liang, H., Li, J. M., Huang, F., Agarwal, P. K., ... Reed, E. (2013). β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas. Anticancer Research, 33(4), 1421-1428.

β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas. / Quentin Li, Q.; Wang, Gangduo; Liang, Huasheng; Li, Jueli M.; Huang, Furong; Agarwal, Piyush K.; Zhong, Yuhua; Reed, Eddie.

In: Anticancer Research, Vol. 33, No. 4, 04.2013, p. 1421-1428.

Research output: Contribution to journalArticle

Quentin Li, Q, Wang, G, Liang, H, Li, JM, Huang, F, Agarwal, PK, Zhong, Y & Reed, E 2013, 'β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas', Anticancer Research, vol. 33, no. 4, pp. 1421-1428.
Quentin Li Q, Wang G, Liang H, Li JM, Huang F, Agarwal PK et al. β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas. Anticancer Research. 2013 Apr;33(4):1421-1428.
Quentin Li, Q. ; Wang, Gangduo ; Liang, Huasheng ; Li, Jueli M. ; Huang, Furong ; Agarwal, Piyush K. ; Zhong, Yuhua ; Reed, Eddie. / β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas. In: Anticancer Research. 2013 ; Vol. 33, No. 4. pp. 1421-1428.
@article{278751f160cb45e09eeaa7a52a60c185,
title = "β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas",
abstract = "Cisplatin-based combination treatment is the most effective systemic chemotherapy for bladder cancer; however, resistance to cisplatin remains a significant problem in the treatment of this disease. β-Elemene is a new natural compound that blocks cell-cycle progression and has a broad spectrum of antitumor activity. This study was conducted to explore the potential of β-elemene as a chemosensitizer for enhancing the therapeutic efficacy and potency of cisplatin in bladder cancer and other solid carcinomas. β-Elemene not only markedly inhibited cell growth and proliferation but also substantially increased cisplatin cytotoxicity towards human bladder cancer 5637 and T-24 cells. Similarly, β-elemene also enhanced cisplatin sensitivity and augmented cisplatin cytotoxicity in small-cell lung cancer and carcinomas of the brain, breast, cervix, ovary, and colorectal tract in vitro, with dose-modifying factors ranging from 5 to 124. β-Elemene-enhanced cisplatin cytotoxicity was associated with increased apoptotic cell death, as determined by DNA fragmentation, and increased activities of caspase-3, -7, -8, -9, and -10 in bladder cancer cell lines. Collectively, these results suggest that β-elemene augments the antitumor activity of cisplatin in human bladder cancer by enhancing the induction of cellular apoptosis via a caspase-dependent mechanism. Cisplatin combined with β-elemene as a chemosensitizer warrants further pre-clinical therapeutic studies and may be useful for the treatment of cisplatin-resistant bladder cancer and other types of carcinomas.",
keywords = "β-elemene, Apoptosis, Bladder cancer, Caspases, Chinese medicine, Cisplatin resistance",
author = "{Quentin Li}, Q. and Gangduo Wang and Huasheng Liang and Li, {Jueli M.} and Furong Huang and Agarwal, {Piyush K.} and Yuhua Zhong and Eddie Reed",
year = "2013",
month = "4",
language = "English (US)",
volume = "33",
pages = "1421--1428",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4",

}

TY - JOUR

T1 - β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas

AU - Quentin Li, Q.

AU - Wang, Gangduo

AU - Liang, Huasheng

AU - Li, Jueli M.

AU - Huang, Furong

AU - Agarwal, Piyush K.

AU - Zhong, Yuhua

AU - Reed, Eddie

PY - 2013/4

Y1 - 2013/4

N2 - Cisplatin-based combination treatment is the most effective systemic chemotherapy for bladder cancer; however, resistance to cisplatin remains a significant problem in the treatment of this disease. β-Elemene is a new natural compound that blocks cell-cycle progression and has a broad spectrum of antitumor activity. This study was conducted to explore the potential of β-elemene as a chemosensitizer for enhancing the therapeutic efficacy and potency of cisplatin in bladder cancer and other solid carcinomas. β-Elemene not only markedly inhibited cell growth and proliferation but also substantially increased cisplatin cytotoxicity towards human bladder cancer 5637 and T-24 cells. Similarly, β-elemene also enhanced cisplatin sensitivity and augmented cisplatin cytotoxicity in small-cell lung cancer and carcinomas of the brain, breast, cervix, ovary, and colorectal tract in vitro, with dose-modifying factors ranging from 5 to 124. β-Elemene-enhanced cisplatin cytotoxicity was associated with increased apoptotic cell death, as determined by DNA fragmentation, and increased activities of caspase-3, -7, -8, -9, and -10 in bladder cancer cell lines. Collectively, these results suggest that β-elemene augments the antitumor activity of cisplatin in human bladder cancer by enhancing the induction of cellular apoptosis via a caspase-dependent mechanism. Cisplatin combined with β-elemene as a chemosensitizer warrants further pre-clinical therapeutic studies and may be useful for the treatment of cisplatin-resistant bladder cancer and other types of carcinomas.

AB - Cisplatin-based combination treatment is the most effective systemic chemotherapy for bladder cancer; however, resistance to cisplatin remains a significant problem in the treatment of this disease. β-Elemene is a new natural compound that blocks cell-cycle progression and has a broad spectrum of antitumor activity. This study was conducted to explore the potential of β-elemene as a chemosensitizer for enhancing the therapeutic efficacy and potency of cisplatin in bladder cancer and other solid carcinomas. β-Elemene not only markedly inhibited cell growth and proliferation but also substantially increased cisplatin cytotoxicity towards human bladder cancer 5637 and T-24 cells. Similarly, β-elemene also enhanced cisplatin sensitivity and augmented cisplatin cytotoxicity in small-cell lung cancer and carcinomas of the brain, breast, cervix, ovary, and colorectal tract in vitro, with dose-modifying factors ranging from 5 to 124. β-Elemene-enhanced cisplatin cytotoxicity was associated with increased apoptotic cell death, as determined by DNA fragmentation, and increased activities of caspase-3, -7, -8, -9, and -10 in bladder cancer cell lines. Collectively, these results suggest that β-elemene augments the antitumor activity of cisplatin in human bladder cancer by enhancing the induction of cellular apoptosis via a caspase-dependent mechanism. Cisplatin combined with β-elemene as a chemosensitizer warrants further pre-clinical therapeutic studies and may be useful for the treatment of cisplatin-resistant bladder cancer and other types of carcinomas.

KW - β-elemene

KW - Apoptosis

KW - Bladder cancer

KW - Caspases

KW - Chinese medicine

KW - Cisplatin resistance

UR - http://www.scopus.com/inward/record.url?scp=84876775015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876775015&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 1421

EP - 1428

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4

ER -